ABCD Study publications are authored by ABCD investigators, collaborators, and non-ABCD researchers. The analysis methodologies, findings, and interpretations expressed in these publications are those of the authors and do not constitute an endorsement by the ABCD Study®.

Please note that the publications listed here include empirical as well as non-empirical papers (e.g., focused review articles, editorials).

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Title Journal Authors Year Details
Toggle The relationship between brain structure and general psychopathology in preadolescents. Journal of child psychology and psychiatry, and allied disciplines Mewton L, Lees B, Squeglia LM, et al. 2021
PubMed Record

Abstract

An emerging body of literature has indicated that broad, transdiagnostic dimensions of psychopathology are associated with alterations in brain structure across the life span. The current study aimed to investigate the relationship between brain structure and broad dimensions of psychopathology in the critical preadolescent period when psychopathology is emerging.

Journal

Journal of child psychology and psychiatry, and allied disciplines

Published

2021/09/01

Authors

Mewton L, Lees B, Squeglia LM, Forbes MK, Sunderland M, Krueger R, Koch FC, Baillie A, Slade T, Hoy N, Teesson M

Keywords

Generalized psychopathology, brain structure, externalizing, internalizing, preadolescence

DOI

10.1111/jcpp.13513
Toggle Neural response to monetary loss among youth with disruptive behavior disorders and callous-unemotional traits in the ABCD study. NeuroImage. Clinical Byrd AL, Hawes SW, Waller R, et al. 2021
PubMed Record

Abstract

Etiological models highlight reduced punishment sensitivity as a core risk factor for disruptive behavior disorders (DBD) and callous-unemotional (CU) traits. The current study examined neural sensitivity to the anticipation and receipt of loss, one key aspect of punishment sensitivity, among youth with DBD, comparing those with and without CU traits. Data were obtained from the Adolescent Brain and Cognitive Development (ABCD) Study (N = 11,874; Mage = 9.51; 48% female). Loss-related fMRI activity during the monetary incentive delay task was examined across 16 empirically-derived a priori brain regions (e.g., striatum, amygdala, insula, anterior cingulate cortex, medial prefrontal cortex) and compared across the following groups: (1) typically developing (n = 693); (2) DBD (n = 995), subdivided into those (3) with CU traits (DBD + CU, n = 198), and (4) without CU traits (DBD-only, n = 276). Latent variable modeling was also employed to examine network-level activity. There were no significant between-group differences in brain activity to loss anticipation or receipt. Null findings were confirmed with and without covariates, using alternative grouping approaches, and in dimensional models. Network-level analyses also demonstrated comparable activity across groups during loss anticipation and receipt. Findings suggest that differences in punishment sensitivity among youth with DBD are unrelated to loss anticipation or receipt. More precise characterizations of other aspects punishment sensitivity are needed to understand risk for DBD and CU traits.

Journal

NeuroImage. Clinical

Published

2021/09/01

Authors

Byrd AL, Hawes SW, Waller R, Delgado MR, Sutherland MT, Dick AS, Trucco EM, Riedel MC, Pacheco-Colón I, Laird AR, Gonzalez R

Keywords

ABCD, Antisocial behavior, Callous-unemotional, Conduct problems, Imaging, Punishment sensitivity, fMRI

DOI

10.1016/j.nicl.2021.102810
Toggle Widespread Positive Direct and Indirect Effects of Regular Physical Activity on the Developing Functional Connectome in Early Adolescence. Cerebral cortex (New York, N.Y. : 1991) Brooks SJ, Parks SM, Stamoulis C 2021
PubMed Record

Abstract

Adolescence is a period of profound but incompletely understood changes in the brain’s neural circuitry (the connectome), which is vulnerable to risk factors such as unhealthy weight, but may be protected by positive factors such as regular physical activity. In 5955 children (median age = 120 months; 50.86% females) from the Adolescent Brain Cognitive Development (ABCD) cohort, we investigated direct and indirect (through impact on body mass index [BMI]) effects of physical activity on resting-state networks, the backbone of the functional connectome that ubiquitously affects cognitive function. We estimated significant positive effects of regular physical activity on network connectivity, efficiency, robustness and stability (P ≤ 0.01), and on local topologies of attention, somatomotor, frontoparietal, limbic, and default-mode networks (P < 0.05), which support extensive processes, from memory and executive control to emotional processing. In contrast, we estimated widespread negative BMI effects in the same network properties and brain regions (P < 0.05). Additional mediation analyses suggested that physical activity could also modulate network topologies leading to better control of food intake, appetite and satiety, and ultimately lower BMI. Thus, regular physical activity may have extensive positive effects on the development of the functional connectome, and may be critical for improving the detrimental effects of unhealthy weight on cognitive health.

Journal

Cerebral cortex (New York, N.Y. : 1991)

Published

2021/08/26

Authors

Brooks SJ, Parks SM, Stamoulis C

Keywords

BMI, adolescence, brain networks, functional connectome, physical activity

DOI

10.1093/cercor/bhab126
Toggle Association Between Discrimination Stress and Suicidality in Preadolescent Children. Journal of the American Academy of Child and Adolescent Psychiatry Argabright ST, Visoki E, Moore TM, et al. 2021
PubMed Record

Abstract

Youth suicide rates in the United States have been increasing in recent years, especially in Black Americans, the reasons for which are unclear. Environmental adversity is key in youth suicidality; hence there is a need to study stressors that have a disproportionate impact on Black youths. We aimed to disentangle the unique contribution of racial/ethnic discrimination from other adversities associated with childhood suicidal ideation and attempts (suicidality).

Journal

Journal of the American Academy of Child and Adolescent Psychiatry

Published

2021/08/20

Authors

Argabright ST, Visoki E, Moore TM, Ryan DT, DiDomenico GE, Njoroge WFM, Taylor JH, Guloksuz S, Gur RC, Gur RE, Benton TD, Barzilay R

Keywords

child psychiatry, discrimination, exposome, race, suicide

DOI

10.1016/j.jaac.2021.08.011
Toggle Similar but distinct - Effects of different socioeconomic indicators on resting state functional connectivity: Findings from the Adolescent Brain Cognitive Development (ABCD) Study®. Developmental cognitive neuroscience Rakesh D, Zalesky A, Whittle S 2021
PubMed Record

Abstract

Early socioeconomic status (SES) has consistently been associated with child health and cognitive outcomes, in addition to alterations in brain function and connectivity. The goal of the present study was to probe the effects of different facets of SES (parent education, income, and neighborhood disadvantage), that likely represent varying aspects of the environment, on resting state functional connectivity (rsFC). We investigated this question in a large sample of 9475 children (aged 9-10 years) from the Adolescent Brain Cognitive Development (ABCD) Study. Specifically, we analyzed the association between household SES (parent education, income-to-needs ratio) and neighborhood disadvantage, and system-level rsFC using within-sample split-half replication. We then tested whether the associations were unique to each SES measure, and whether household SES and neighborhood disadvantage had interactive effects on rsFC. SES measures had both common and distinct effects on rsFC, with sensory-motor systems (e.g., sensorimotor network) and cognitive networks (e.g., front-parietal network) particularly implicated. Further, the association between neighborhood disadvantage and sensorimotor network connectivity was less pronounced in the presence of high income-to-needs. Findings demonstrate that different facets of SES have distinct and interacting effects on rsFC, highlighting the importance of considering different indicators when studying the effects of SES on the brain.

Journal

Developmental cognitive neuroscience

Published

2021/08/14

Authors

Rakesh D, Zalesky A, Whittle S

Keywords

ABCD study, Adolescence, Disadvantage, Education, Income, Neighborhood socioeconomic status, Resting state functional connectivity, Socioeconomic status, fMRI

DOI

10.1016/j.dcn.2021.101005
Toggle Relationships between apparent cortical thickness and working memory across the lifespan - Effects of genetics and socioeconomic status. Developmental cognitive neuroscience Krogsrud SK, Mowinckel AM, Sederevicius D, et al. 2021
PubMed Record

Abstract

Working memory (WM) supports several higher-level cognitive abilities, yet we know less about factors associated with development and decline in WM compared to other cognitive processes. Here, we investigated lifespan changes in WM capacity and their structural brain correlates, using a longitudinal sample including 2358 magnetic resonance imaging (MRI) scans and WM scores from 1656 participants (4.4-86.4 years, mean follow-up interval 4.3 years). 8764 participants (9.0-10.9 years) with MRI, WM scores and genetic information from the Adolescent Brain Cognitive Development study were used for follow-up analyses. Results showed that both the information manipulation component and the storage component of WM improved during childhood and adolescence, but the age-decline could be fully explained by reductions in passive storage capacity alone. Greater WM function in development was related to apparent thinner cortex in both samples, also when general cognitive function was accounted for. The same WM-apparent thickness relationship was found for young adults. The WM-thickness relationships could not be explained by SNP-based co-heritability or by socioeconomic status. A larger sample with genetic information may be necessary to disentangle the true gene-environment effects. In conclusion, WM capacity changes greatly through life and has anatomically extended rather than function-specific structural cortical correlates.

Journal

Developmental cognitive neuroscience

Published

2021/08/08

Authors

Krogsrud SK, Mowinckel AM, Sederevicius D, Vidal-Piñeiro D, Amlien IK, Wang Y, Sørensen Ø, Walhovd KB, Fjell AM

Keywords

Cortical thickness, Development, Digit span, Heritability, Lifespan, Working memory

DOI

10.1016/j.dcn.2021.100997
Toggle Association of Local Variation in Neighborhood Disadvantage in Metropolitan Areas With Youth Neurocognition and Brain Structure. JAMA pediatrics Hackman DA, Cserbik D, Chen JC, et al. 2021
PubMed Record

Abstract

Neighborhood disadvantage is an important social determinant of health in childhood and adolescence. Less is known about the association of neighborhood disadvantage with youth neurocognition and brain structure, and particularly whether associations are similar across metropolitan areas and are attributed to local differences in disadvantage.

Journal

JAMA pediatrics

Published

2021/08/02

Authors

Hackman DA, Cserbik D, Chen JC, Berhane K, Minaravesh B, McConnell R, Herting MM

Keywords

DOI

10.1001/jamapediatrics.2021.0426
Toggle Prevalence of Perceived Racism and Discrimination Among US Children Aged 10 and 11 Years: The Adolescent Brain Cognitive Development (ABCD) Study. JAMA pediatrics Nagata JM, Ganson KT, Sajjad OM, et al. 2021
PubMed Record

Abstract

This cross-sectional study uses data from the Adolescent Brain Cognitive Development Study to assess the prevalence of perceived racism and discrimination among US children aged 10 through 11 years.

Journal

JAMA pediatrics

Published

2021/08/01

Authors

Nagata JM, Ganson KT, Sajjad OM, Benabou SE, Bibbins-Domingo K

Keywords

DOI

10.1001/jamapediatrics.2021.1022
Toggle Genetic and environmental influences on executive functions and intelligence in middle childhood. Developmental science Freis SM, Morrison CL, Lessem JM, et al. 2021
PubMed Record

Abstract

Executive functions (EFs) and intelligence (IQ) are phenotypically correlated. In twin studies, latent variables for EFs and IQ display moderate to high heritability estimates; however, they show variable genetic correlations in twin studies spanning childhood to middle age. We analyzed data from over 11,000 children (9- to 10-year-olds, including 749 twin pairs) in the Adolescent Brain Cognitive Development (ABCD) Study to examine the phenotypic and genetic relations between EFs and IQ in childhood. We identified two EF factors-Common EF and Updating-Specific-which were both related to IQ (rs = 0.64-0.81). Common EF and IQ were heritable (53%-67%), and their genetic correlation (rG = 0.86) was not significantly different than 1. These results suggest that EFs and IQ are phenotypically but not genetically separable in middle childhood, meaning that this phenotypic separability may be influenced by environmental factors.

Journal

Developmental science

Published

2021/07/29

Authors

Freis SM, Morrison CL, Lessem JM, Hewitt JK, Friedman NP

Keywords

cognitive control, executive control, general cognitive ability, heritability, inhibition, working memory

DOI

10.1111/desc.13150
Toggle Substance use patterns in 9-10 year olds: Baseline findings from the adolescent brain cognitive development (ABCD) study. Drug and alcohol dependence Lisdahl KM, Tapert S, Sher KJ, et al. 2021
PubMed Record

Abstract

The Adolescent Brain Cognitive Development ™ Study (ABCD Study®) is an open-science, multi-site, prospective, longitudinal study following over 11,800 9- and 10-year-old youth into early adulthood. The ABCD Study aims to prospectively examine the impact of substance use (SU) on neurocognitive and health outcomes. Although SU initiation typically occurs during teen years, relatively little is known about patterns of SU in children younger than 12.

Journal

Drug and alcohol dependence

Published

2021/07/29

Authors

Lisdahl KM, Tapert S, Sher KJ, Gonzalez R, Nixon SJ, Feldstein Ewing SW, Conway KP, Wallace A, Sullivan R, Hatcher K, Kaiver C, Thompson W, Reuter C, Bartsch H, Wade NE, Jacobus J, Albaugh MD, Allgaier N, Anokhin AP, Bagot K, Baker FC, Banich MT, Barch DM, Baskin-Sommers A, Breslin FJ, Brown SA, Calhoun V, Casey BJ, Chaarani B, Chang L, Clark DB, Cloak C, Constable RT, Cottler LB, Dagher RK, Dapretto M, Dick A, Do EK, Dosenbach NUF, Dowling GJ, Fair DA, Florsheim P, Foxe JJ, Freedman EG, Friedman NP, Garavan HP, Gee DG, Glantz MD, Glaser P, Gonzalez MR, Gray KM, Grant S, Haist F, Hawes S, Heeringa SG, Hermosillo R, Herting MM, Hettema JM, Hewitt JK, Heyser C, Hoffman EA, Howlett KD, Huber RS, Huestis MA, Hyde LW, Iacono WG, Isaiah A, Ivanova MY, James RS, Jernigan TL, Karcher NR, Kuperman JM, Laird AR, Larson CL, LeBlanc KH, Lopez MF, Luciana M, Luna B, Maes HH, Marshall AT, Mason MJ, McGlade E, Morris AS, Mulford C, Nagel BJ, Neigh G, Palmer CE, Paulus MP, Pecheva D, Prouty D, Potter A, Puttler LI, Rajapakse N, Ross JM, Sanchez M, Schirda C, Schulenberg J, Sheth C, Shilling PD, Sowell ER, Speer N, Squeglia L, Sripada C, Steinberg J, Sutherland MT, Tomko R, Uban K, Vrieze S, Weiss SRB, Wing D, Yurgelun-Todd DA, Zucker RA, Heitzeg MM

Keywords

ABCD study, Alcohol, Alcohol sipping, Caffeine, Cannabis, Children, Externalizing behaviors, Nicotine

DOI

10.1016/j.drugalcdep.2021.108946
Toggle Prenatal caffeine exposure: association with neurodevelopmental outcomes in 9- to 11-year-old children. Journal of child psychology and psychiatry, and allied disciplines Zhang R, Manza P, Volkow ND 2021
PubMed Record

Abstract

Despite the widespread use of caffeine including consumption during pregnancy, the effect of prenatal caffeine exposure on child brain development and behavior is unclear.

Journal

Journal of child psychology and psychiatry, and allied disciplines

Published

2021/07/27

Authors

Zhang R, Manza P, Volkow ND

Keywords

ABCD study, Prenatal caffeine exposure, brain structural development, childhood obesity, childhood outcomes, psychopathology

DOI

10.1111/jcpp.13495
Toggle Is executive dysfunction a risk marker or consequence of psychopathology? A test of executive function as a prospective predictor and outcome of general psychopathology in the adolescent brain cognitive development study®. Developmental cognitive neuroscience Romer AL, Pizzagalli DA 2021
PubMed Record

Abstract

A general psychopathology (‘p’) factor captures shared variation across mental disorders. One hypothesis is that poor executive function (EF) contributes to p. Although EF is related to p concurrently, it is unclear whether EF predicts or is a consequence of p. For the first time, we examined prospective relations between EF and p in 9845 preadolescents (aged 9-12) from the Adolescent Brain Cognitive Development Study® longitudinally over two years. We identified higher-order factor models of psychopathology at baseline and one- and two-year follow-up waves. Consistent with previous research, a cross-sectional inverse relationship between EF and p emerged. Using residualized-change models, baseline EF prospectively predicted p factor scores two years later, controlling for prior p, sex, age, race/ethnicity, parental education, and family income. Baseline p factor scores also prospectively predicted change in EF two years later. Tests of specificity revealed that bi-directional prospective relations between EF and p were largely generalizable across externalizing, internalizing, neurodevelopmental, somatization, and detachment symptoms. EF consistently predicted change in externalizing and neurodevelopmental symptoms. These novel results suggest that executive dysfunction is both a risk marker and consequence of general psychopathology. EF may be a promising transdiagnostic intervention target to prevent the onset and maintenance of psychopathology.

Journal

Developmental cognitive neuroscience

Published

2021/07/22

Authors

Romer AL, Pizzagalli DA

Keywords

Executive function, General psychopathology, Longitudinal, Risk factor, Transdiagnostic, p Factor

DOI

10.1016/j.dcn.2021.100994
Toggle Heterogeneity Within Youth With Childhood-Onset Conduct Disorder in the ABCD Study. Frontiers in psychiatry Brislin SJ, Martz ME, Cope LM, et al. 2021
PubMed Record

Abstract

The purpose of this study was to examine if personality traits can be used to characterize subgroups of youth diagnosed with childhood-onset conduct disorder (CD). Participants were 11,552 youth from the Adolescent Brain Cognitive Development study. Data used in this report came from doi: 10.15154/1504041 ( age 9.92; 45.3% female, 49.6% white, 19.0% Hispanic). A subset of this sample ( = 365) met criteria for CD. Latent profile analyses (LPA) were performed on this subgroup ( = 365) to define profiles of individuals with CD based on self-report measures of impulsivity, punishment sensitivity, reward response, and callous-unemotional traits. Follow up analyses determined if these groups differed on clinically relevant variables including psychopathology, environmental risk factors, social risk factors, and neurocognitive functioning. Participants with a CD diagnosis scored significantly higher on psychological, environmental, social, and neurocognitive risk factors. The LPA revealed three unique profiles, which differed significantly on liability for broad psychopathology and domain-specific liability for externalizing psychopathology but were largely matched on environmental and social risk factors. These unique configurations provide a useful way to further parse clinically relevant subgroups within youth who meet criteria for childhood-onset CD, setting the stage for prospective longitudinal research using these latent profiles to better understand the development of youth with childhood-onset CD.

Journal

Frontiers in psychiatry

Published

2021/07/16

Authors

Brislin SJ, Martz ME, Cope LM, Hardee JE, Weigard A, Heitzeg MM

Keywords

BIS/BAS, CU traits, UPPS-P impulsive behavior scale, conduct disorder, impulsivity, latent profile analysis

DOI

10.3389/fpsyt.2021.701199
Toggle Psychotic-like Experiences and Polygenic Liability in the Adolescent Brain Cognitive Development Study. Biological psychiatry. Cognitive neuroscience and neuroimaging Karcher NR, Paul SE, Johnson EC, et al. 2021
PubMed Record

Abstract

Childhood psychotic-like experiences (PLEs) often precede the development of later severe psychopathology. This study examined whether childhood PLEs are associated with several psychopathology-related polygenic scores (PGSs) and additionally examined possible neural and behavioral mechanisms.

Journal

Biological psychiatry. Cognitive neuroscience and neuroimaging

Published

2021/07/13

Authors

Karcher NR, Paul SE, Johnson EC, Hatoum AS, Baranger DAA, Agrawal A, Thompson WK, Barch DM, Bogdan R

Keywords

Educational attainment, MRI, Polygenic, Psychopathology, Psychotic-like experiences, Schizophrenia

DOI

10.1016/j.bpsc.2021.06.012
Toggle Imaging and health metrics in incidental cerebellar tonsillar ectopia: findings from the Adolescent Brain Cognitive Development Study (ABCD). Neuroradiology Nwotchouang BST, Ibrahimy A, Loth DM, et al. 2021
PubMed Record

Abstract

Incidental cerebellar tonsillar ectopia (ICTE) that meets the radiographic criterion for Chiari malformation type I (CMI) is an increasingly common finding in the clinical setting, but its significance is unclear. The present study examined posterior cranial fossa (PCF) morphometrics and a broad range of health instruments of pediatric ICTE cases and matched controls extracted from the Adolescent Brain Cognitive Development (ABCD) dataset.

Journal

Neuroradiology

Published

2021/07/11

Authors

Nwotchouang BST, Ibrahimy A, Loth DM, Labuda E, Labuda N, Eppleheimer M, Labuda R, Bapuraj JR, Allen PA, Klinge P, Loth F

Keywords

Adolescent Brain Cognitive Development (ABCD) pediatric study, Brain morphometrics, Chiari malformation type I, Incidental cerebellar tonsillar ectopia, Magnetic resonance imaging

DOI

10.1007/s00234-021-02759-y
Toggle Psychiatric comorbidity of eating disorders in children between the ages of 9 and 10. Journal of child psychology and psychiatry, and allied disciplines Convertino AD, Blashill AJ 2021
PubMed Record

Abstract

Eating disorders exhibit high comorbidity with other psychiatric disorders, most notably mood, substance use, and anxiety disorders. However, most studies examining psychiatric comorbidity are conducted in adolescents and adults. Therefore, the comorbidity among children living with eating disorders is unknown. The aim of this study was to characterize co-occurring psychiatric disorders with eating disorders in a US sample of children aged 9-10 years old utilizing the Adolescent Brain Cognitive Development study.

Journal

Journal of child psychology and psychiatry, and allied disciplines

Published

2021/07/05

Authors

Convertino AD, Blashill AJ

Keywords

Eating disorder, anorexia nervosa, binge eating, bulimia nervosa

DOI

10.1111/jcpp.13484
Toggle Distinct Regionalization Patterns of Cortical Morphology are Associated with Cognitive Performance Across Different Domains. Cerebral cortex (New York, N.Y. : 1991) Palmer CE, Zhao W, Loughnan R, et al. 2021
PubMed Record

Abstract

Cognitive performance in children is predictive of academic and social outcomes; therefore, understanding neurobiological mechanisms underlying individual differences in cognition during development may be important for improving quality of life. The belief that a single, psychological construct underlies many cognitive processes is pervasive throughout society. However, it is unclear if there is a consistent neural substrate underlying many cognitive processes. Here, we show that a distributed configuration of cortical surface area and apparent thickness, when controlling for global imaging measures, is differentially associated with cognitive performance on different types of tasks in a large sample (N = 10 145) of 9-11-year-old children from the Adolescent Brain and Cognitive DevelopmentSM (ABCD) study. The minimal overlap in these regionalization patterns of association has implications for competing theories about developing intellectual functions. Surprisingly, not controlling for sociodemographic factors increased the similarity between these regionalization patterns. This highlights the importance of understanding the shared variance between sociodemographic factors, cognition and brain structure, particularly with a population-based sample such as ABCD.

Journal

Cerebral cortex (New York, N.Y. : 1991)

Published

2021/07/05

Authors

Palmer CE, Zhao W, Loughnan R, Zou J, Fan CC, Thompson WK, Dale AM, Jernigan TL

Keywords

adolescence, cognition, cortical morphology, development, multivariate, neuroimaging

DOI

10.1093/cercor/bhab054
Toggle Morphometrical Brain Markers of Sex Difference. Cerebral cortex (New York, N.Y. : 1991) Brennan D, Wu T, Fan J 2021
PubMed Record

Abstract

Many major neuropsychiatric pathologies, some of which appear in adolescence, show differentiated prevalence, onset, and symptomatology across the biological sexes. Therefore, mapping differences in brain structure between males and females during this critical developmental period may provide information about the neural mechanisms underlying the dimorphism of these pathologies. Utilizing a large dataset collected through the Adolescent Brain Cognitive Development study, we investigated the differences of adolescent (9-10 years old) male and female brains (n = 8325) by using a linear Support-Vector Machine Classifier to predict sex based on morphometry and image intensity values of structural brain imaging data. The classifier correctly classified the sex of 86% individuals with the insula, the precentral and postcentral gyri, and the pericallosal sulcus as the most discernable features. These results demonstrate the existence of complex, yet robustly measurable morphometrical brain markers of sex difference.

Journal

Cerebral cortex (New York, N.Y. : 1991)

Published

2021/07/05

Authors

Brennan D, Wu T, Fan J

Keywords

ABCD, brain morphology, machine learning, sex dimorphism

DOI

10.1093/cercor/bhab037
Toggle Motor abnormalities, depression risk, and clinical course in adolescence. Biological psychiatry global open science Damme KSF, Park JS, Vargas T, et al. 2021
PubMed Record

Abstract

Motor abnormalities, such as psychomotor agitation and retardation, are widely recognized as core features of depression. However, it is not currently known if motor abnormalities connote risk for depression.

Journal

Biological psychiatry global open science

Published

2021/07/03

Authors

Damme KSF, Park JS, Vargas T, Walther S, Shankman SA, Mittal VA

Keywords

DOI

10.1016/j.bpsgos.2021.06.011
Toggle Symptom-Based Profiling and Multimodal Neuroimaging of a Large Preteenage Population Identifies Distinct Obsessive-Compulsive Disorder-like Subtypes With Neurocognitive Differences. Biological psychiatry. Cognitive neuroscience and neuroimaging Wu X, Yu G, Zhang K, et al. 2021
PubMed Record

Abstract

Obsessive-compulsive disorder (OCD) is characterized by both internalizing (anxiety) and externalizing (compulsivity) symptoms. Currently, little is known about their interrelationships and their relative contributions to disease heterogeneity. Our goal is to resolve affective and cognitive symptom heterogeneity related to internalized and externalized symptom dimensions by determining subtypes of children with OCD symptoms, and to identify any corresponding neural differences.

Journal

Biological psychiatry. Cognitive neuroscience and neuroimaging

Published

2021/07/02

Authors

Wu X, Yu G, Zhang K, Feng J, Zhang J, Sahakian BJ, Robbins TW

Keywords

ABCD Study, Anxiety, Compulsivity, Heterogeneity, Pediatric OCD, Subtypes

DOI

10.1016/j.bpsc.2021.06.011
Toggle Association of Multigenerational Family History of Depression With Lifetime Depressive and Other Psychiatric Disorders in Children: Results from the Adolescent Brain Cognitive Development (ABCD) Study. JAMA psychiatry van Dijk MT, Murphy E, Posner JE, et al. 2021
PubMed Record

Abstract

Three-generation family studies of depression have established added risk of psychopathology for offspring with 2 previous generations affected with depression compared with 1 or none. Because of their rigorous methodology, there are few of these studies, and existing studies are limited by sample sizes. Consequently, the 3-generation family risk paradigm established in family studies can be a critical neuropsychiatric tool if similar transmission patterns are reliably demonstrated with the family history method.

Journal

JAMA psychiatry

Published

2021/07/01

Authors

van Dijk MT, Murphy E, Posner JE, Talati A, Weissman MM

Keywords

DOI

10.1001/jamapsychiatry.2021.0350
Toggle Child reward neurocircuitry and parental substance use history: Findings from the Adolescent Brain Cognitive Development Study. Addictive behaviors Kwarteng AE, Rahman MM, Gee DG, et al. 2021
PubMed Record

Abstract

Substance use research has focused on family history of alcohol use disorders but less on other addictions in biological family members. We examined how parental substance use history relates to reward system functioning, specifically nucleus accumbens (NAcc) and putamen activation at age 9-10 in the Adolescent Brain Cognitive Development (ABCD) Study. This research hopes to address limitations in prior literature by focusing analyses on a large, substance-naïve sample.

Journal

Addictive behaviors

Published

2021/06/29

Authors

Kwarteng AE, Rahman MM, Gee DG, Infante MA, Tapert SF, Curtis BL

Keywords

ABCD Study, Monetary Incentive Delay task, Reward anticipation, Substance use history, fMRI

DOI

10.1016/j.addbeh.2021.107034
Toggle Concurrent and prospective associations between fitbit wearable-derived RDoC arousal and regulatory constructs and adolescent internalizing symptoms. Journal of child psychology and psychiatry, and allied disciplines Nelson BW, Flannery JE, Flournoy J, et al. 2021
PubMed Record

Abstract

Adolescence is characterized by alterations in biobehavioral functioning, during which individuals are at heightened risk for onset of psychopathology, particularly internalizing disorders. Researchers have proposed using digital technologies to index daily biobehavioral functioning, yet there is a dearth of research examining how wearable metrics are associated with mental health.

Journal

Journal of child psychology and psychiatry, and allied disciplines

Published

2021/06/29

Authors

Nelson BW, Flannery JE, Flournoy J, Duell N, Prinstein MJ, Telzer E

Keywords

Adolescence, fitbit, heart rate, internalizing symptoms, sleep, steps, wearables

DOI

10.1111/jcpp.13471
Toggle Contemporary screen time usage among children 9-10-years-old is associated with higher body mass index percentile at 1-year follow-up: A prospective cohort study. Pediatric obesity Nagata JM, Iyer P, Chu J, et al. 2021
PubMed Record

Abstract

There is a paucity of prospective research exploring the relationship among contemporary screen time modalities (e.g., video streaming, video chatting, texting and social networking) and body mass index (BMI) percentile. The objective of this study was to determine the prospective associations between screen time behaviours in a large and demographically diverse population-based cohort of 9-10-year-old children and BMI percentile at 1-year follow-up.

Journal

Pediatric obesity

Published

2021/06/28

Authors

Nagata JM, Iyer P, Chu J, Baker FC, Gabriel KP, Garber AK, Murray SB, Bibbins-Domingo K, Ganson KT

Keywords

adolescents, body mass index, obesity, paediatrics, screen time, smart phone, social media, television, weight

DOI

10.1111/ijpo.12827
Toggle QSIPrep: an integrative platform for preprocessing and reconstructing diffusion MRI data. Nature methods Cieslak M, Cook PA, He X, et al. 2021
PubMed Record

Abstract

Diffusion-weighted magnetic resonance imaging (dMRI) is the primary method for noninvasively studying the organization of white matter in the human brain. Here we introduce QSIPrep, an integrative software platform for the processing of diffusion images that is compatible with nearly all dMRI sampling schemes. Drawing on a diverse set of software suites to capitalize on their complementary strengths, QSIPrep facilitates the implementation of best practices for processing of diffusion images.

Journal

Nature methods

Published

2021/06/21

Authors

Cieslak M, Cook PA, He X, Yeh FC, Dhollander T, Adebimpe A, Aguirre GK, Bassett DS, Betzel RF, Bourque J, Cabral LM, Davatzikos C, Detre JA, Earl E, Elliott MA, Fadnavis S, Fair DA, Foran W, Fotiadis P, Garyfallidis E, Giesbrecht B, Gur RC, Gur RE, Kelz MB, Keshavan A, Larsen BS, Luna B, Mackey AP, Milham MP, Oathes DJ, Perrone A, Pines AR, Roalf DR, Richie-Halford A, Rokem A, Sydnor VJ, Tapera TM, Tooley UA, Vettel JM, Yeatman JD, Grafton ST, Satterthwaite TD

Keywords

DOI

10.1038/s41592-021-01185-5
Toggle Brain structure is linked to the association between family environment and behavioral problems in children in the ABCD study. Nature communications Gong W, Rolls ET, Du J, et al. 2021
PubMed Record

Abstract

Children’s behavioral problems have been associated with their family environments. Here, we investigate whether specific features of brain structures could relate to this link. Using structural magnetic resonance imaging of 8756 children aged 9-11 from the Adolescent Brain Cognitive Developmental study, we show that high family conflict and low parental monitoring scores are associated with children’s behavioral problems, as well as with smaller cortical areas of the orbitofrontal cortex, anterior cingulate cortex, and middle temporal gyrus. A longitudinal analysis indicates that psychiatric problems scores are associated with increased family conflict and decreased parental monitoring 1 year later, and mediate associations between the reduced cortical areas and family conflict, and parental monitoring scores. These results emphasize the relationships between the brain structure of children, their family environments, and their behavioral problems.

Journal

Nature communications

Published

2021/06/18

Authors

Gong W, Rolls ET, Du J, Feng J, Cheng W

Keywords

DOI

10.1038/s41467-021-23994-0
Toggle Meaningful associations in the adolescent brain cognitive development study. NeuroImage Dick AS, Lopez DA, Watts AL, et al. 2021
PubMed Record

Abstract

The Adolescent Brain Cognitive Development (ABCD) Study is the largest single-cohort prospective longitudinal study of neurodevelopment and children’s health in the United States. A cohort of n = 11,880 children aged 9-10 years (and their parents/guardians) were recruited across 22 sites and are being followed with in-person visits on an annual basis for at least 10 years. The study approximates the US population on several key sociodemographic variables, including sex, race, ethnicity, household income, and parental education. Data collected include assessments of health, mental health, substance use, culture and environment and neurocognition, as well as geocoded exposures, structural and functional magnetic resonance imaging (MRI), and whole-genome genotyping. Here, we describe the ABCD Study aims and design, as well as issues surrounding estimation of meaningful associations using its data, including population inferences, hypothesis testing, power and precision, control of covariates, interpretation of associations, and recommended best practices for reproducible research, analytical procedures and reporting of results.

Journal

NeuroImage

Published

2021/06/18

Authors

Dick AS, Lopez DA, Watts AL, Heeringa S, Reuter C, Bartsch H, Fan CC, Kennedy DN, Palmer C, Marshall A, Haist F, Hawes S, Nichols TE, Barch DM, Jernigan TL, Garavan H, Grant S, Pariyadath V, Hoffman E, Neale M, Stuart EA, Paulus MP, Sher KJ, Thompson WK

Keywords

Adolescent brain cognitive development study, Covariate Adjustments, Effect Sizes, Genetics, Hypothesis testing, Population neuroscience, Reproducibility

DOI

10.1016/j.neuroimage.2021.118262
Toggle Baseline brain function in the preadolescents of the ABCD Study. Nature neuroscience Chaarani B, Hahn S, Allgaier N, et al. 2021
PubMed Record

Abstract

The Adolescent Brain Cognitive Development (ABCD) Study is a 10-year longitudinal study of children recruited at ages 9 and 10. A battery of neuroimaging tasks are administered biennially to track neurodevelopment and identify individual differences in brain function. This study reports activation patterns from functional MRI (fMRI) tasks completed at baseline, which were designed to measure cognitive impulse control with a stop signal task (SST; N = 5,547), reward anticipation and receipt with a monetary incentive delay (MID) task (N = 6,657) and working memory and emotion reactivity with an emotional N-back (EN-back) task (N = 6,009). Further, we report the spatial reproducibility of activation patterns by assessing between-group vertex/voxelwise correlations of blood oxygen level-dependent (BOLD) activation. Analyses reveal robust brain activations that are consistent with the published literature, vary across fMRI tasks/contrasts and slightly correlate with individual behavioral performance on the tasks. These results establish the preadolescent brain function baseline, guide interpretation of cross-sectional analyses and will enable the investigation of longitudinal changes during adolescent development.

Journal

Nature neuroscience

Published

2021/06/07

Authors

Chaarani B, Hahn S, Allgaier N, Adise S, Owens MM, Juliano AC, Yuan DK, Loso H, Ivanciu A, Albaugh MD, Dumas J, Mackey S, Laurent J, Ivanova M, Hagler DJ, Cornejo MD, Hatton S, Agrawal A, Aguinaldo L, Ahonen L, Aklin W, Anokhin AP, Arroyo J, Avenevoli S, Babcock D, Bagot K, Baker FC, Banich MT, Barch DM, Bartsch H, Baskin-Sommers A, Bjork JM, Blachman-Demner D, Bloch M, Bogdan R, Bookheimer SY, Breslin F, Brown S, Calabro FJ, Calhoun V, Casey BJ, Chang L, Clark DB, Cloak C, Constable RT, Constable K, Corley R, Cottler LB, Coxe S, Dagher RK, Dale AM, Dapretto M, Delcarmen-Wiggins R, Dick AS, Do EK, Dosenbach NUF, Dowling GJ, Edwards S, Ernst TM, Fair DA, Fan CC, Feczko E, Feldstein-Ewing SW, Florsheim P, Foxe JJ, Freedman EG, Friedman NP, Friedman-Hill S, Fuemmeler BF, Galvan A, Gee DG, Giedd J, Glantz M, Glaser P, Godino J, Gonzalez M, Gonzalez R, Grant S, Gray KM, Haist F, Harms MP, Hawes S, Heath AC, Heeringa S, Heitzeg MM, Hermosillo R, Herting MM, Hettema JM, Hewitt JK, Heyser C, Hoffman E, Howlett K, Huber RS, Huestis MA, Hyde LW, Iacono WG, Infante MA, Irfanoglu O, Isaiah A, Iyengar S, Jacobus J, James R, Jean-Francois B, Jernigan T, Karcher NR, Kaufman A, Kelley B, Kit B, Ksinan A, Kuperman J, Laird AR, Larson C, LeBlanc K, Lessov-Schlagger C, Lever N, Lewis DA, Lisdahl K, Little AR, Lopez M, Luciana M, Luna B, Madden PA, Maes HH, Makowski C, Marshall AT, Mason MJ, Matochik J, McCandliss BD, McGlade E, Montoya I, Morgan G, Morris A, Mulford C, Murray P, Nagel BJ, Neale MC, Neigh G, Nencka A, Noronha A, Nixon SJ, Palmer CE, Pariyadath V, Paulus MP, Pelham WE, Pfefferbaum D, Pierpaoli C, Prescot A, Prouty D, Puttler LI, Rajapaske N, Rapuano KM, Reeves G, Renshaw PF, Riedel MC, Rojas P, de la Rosa M, Rosenberg MD, Ross MJ, Sanchez M, Schirda C, Schloesser D, Schulenberg J, Sher KJ, Sheth C, Shilling PD, Simmons WK, Sowell ER, Speer N, Spittel M, Squeglia LM, Sripada C, Steinberg J, Striley C, Sutherland MT, Tanabe J, Tapert SF, Thompson W, Tomko RL, Uban KA, Vrieze S, Wade NE, Watts R, Weiss S, Wiens BA, Williams OD, Wilbur A, Wing D, Wolff-Hughes D, Yang R, Yurgelun-Todd DA, Zucker RA, Potter A, Garavan HP

Keywords

DOI

10.1038/s41593-021-00867-9
Toggle Polygenic risk scores for alcohol involvement relate to brain structure in substance-naïve children: Results from the ABCD study. Genes, brain, and behavior Hatoum AS, Johnson EC, Baranger DAA, et al. 2021
PubMed Record

Abstract

Brain imaging-derived structural correlates of alcohol involvement have largely been speculated to arise as a consequence of alcohol exposure. However, they may also reflect predispositional risk. In substance naïve children of European ancestry who completed the baseline session of the Adolescent Brain Cognitive Development (ABCD) Study (n = 3013), mixed-effects models estimated whether polygenic risk scores (PRS) for problematic alcohol use (PAU-PRS) and drinks per week (DPW-PRS) are associated with magnetic resonance imaging-derived brain structure phenotypes (i.e., total and regional: cortical thickness, surface area and volume; subcortical volume; white matter volume, fractional anisotropy, mean diffusivity). Follow-up analyses evaluated whether any identified regions were also associated with polygenic risk among substance naïve children of African ancestry (n = 898). After adjustment for multiple testing correction, polygenic risk for PAU was associated with lower volume of the left frontal pole and greater cortical thickness of the right supramarginal gyrus (|βs| > 0.009; ps < 0.001; ps  < 0.046; r s < 0.004). PAU PRS and DPW PRS showed nominally significant associations with a host of other regional brain structure phenotypes (e.g., insula surface area and volume). None of these regions showed any, even nominal association among children of African ancestry. Genomic liability to alcohol involvement may manifest as variability in brain structure during middle childhood prior to alcohol use initiation. Broadly, alcohol-related variability in brain morphometry may partially reflect predisposing genomic influence. Larger discovery genome-wide association studies and target samples of diverse ancestries are needed to determine whether observed associations may generalize across ancestral origins.

Journal

Genes, brain, and behavior

Published

2021/06/06

Authors

Hatoum AS, Johnson EC, Baranger DAA, Paul SE, Agrawal A, Bogdan R

Keywords

DTI, adolescence, alcohol use, alcohol use disorder, cortical gray matter, drug naive, imaging genetics, multi-site study, polygenic risk scores, subcortical gray matter

DOI

10.1111/gbb.12756
Toggle Evaluation of Attention-Deficit/Hyperactivity Disorder Medications, Externalizing Symptoms, and Suicidality in Children. JAMA network open Shoval G, Visoki E, Moore TM, et al. 2021
PubMed Record

Abstract

Childhood suicidality (ie, suicidal ideation or attempts) rates are increasing, and attention-deficit/hyperactivity disorder (ADHD) and externalizing symptoms are common risk factors associated with suicidality. More data are needed to describe associations of ADHD pharmacotherapy with childhood suicidality.

Journal

JAMA network open

Published

2021/06/01

Authors

Shoval G, Visoki E, Moore TM, DiDomenico GE, Argabright ST, Huffnagle NJ, Alexander-Bloch AF, Waller R, Keele L, Benton TD, Gur RE, Barzilay R

Keywords

DOI

10.1001/jamanetworkopen.2021.11342
Toggle Parents' Perceived Neighborhood Safety and Children's Cognitive Performance: Complexities by Race, Ethnicity, and Cognitive Domain. Urban science (Basel, Switzerland) Assari S, Boyce S, Mistry R, et al. 2021
PubMed Record

Abstract

To examine racial/ethnic variations in the effect of parents’ subjective neighborhood safety on children’s cognitive performance.

Journal

Urban science (Basel, Switzerland)

Published

2021/06/01

Authors

Assari S, Boyce S, Mistry R, Thomas A, Nicholson HL, Cobb RJ, Cuevas AG, Lee DB, Bazargan M, Caldwell CH, Curry TJ, Zimmerman MA

Keywords

children, cognition, cognitive performance, ethnicity, population groups, race

DOI

10.3390/urbansci5020046
Toggle Responsible Use of Open-Access Developmental Data: The Adolescent Brain Cognitive Development (ABCD) Study. Psychological science Simmons C, Conley MI, Gee DG, et al. 2021
PubMed Record

Abstract

Journal

Psychological science

Published

2021/05/27

Authors

Simmons C, Conley MI, Gee DG, Baskin-Sommers A, Barch DM, Hoffman EA, Huber RS, Iacono WG, Nagel BJ, Palmer CE, Sheth CS, Sowell ER, Thompson WK, Casey BJ

Keywords

DOI

10.1177/09567976211003564
Toggle Prediction of suicidal ideation and attempt in 9 and 10 year-old children using transdiagnostic risk features. PloS one Harman G, Kliamovich D, Morales AM, et al. 2021
PubMed Record

Abstract

The objective of the current study was to build predictive models for suicidal ideation in a sample of children aged 9-10 using features previously implicated in risk among older adolescent and adult populations. This case-control analysis utilized baseline data from the Adolescent Brain and Cognitive Development (ABCD) Study, collected from 21 research sites across the United States (N = 11,369). Several regression and ensemble learning models were compared on their ability to classify individuals with suicidal ideation and/or attempt from healthy controls, as assessed by the Kiddie Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version. When comparing control participants (mean age: 9.92±0.62 years; 4944 girls [49%]) to participants with suicidal ideation (mean age: 9.89±0.63 years; 451 girls [40%]), both logistic regression with feature selection and elastic net without feature selection predicted suicidal ideation with an AUC of 0.70 (CI 95%: 0.70-0.71). The random forest with feature selection trained to predict suicidal ideation predicted a holdout set of children with a history of suicidal ideation and attempt (mean age: 9.96±0.62 years; 79 girls [41%]) from controls with an AUC of 0.77 (CI 95%: 0.76-0.77). Important features from these models included feelings of loneliness and worthlessness, impulsivity, prodromal psychosis symptoms, and behavioral problems. This investigation provided an unprecedented opportunity to identify suicide risk in youth. The use of machine learning to examine a large number of predictors spanning a variety of domains provides novel insight into transdiagnostic factors important for risk classification.

Journal

PloS one

Published

2021/05/25

Authors

Harman G, Kliamovich D, Morales AM, Gilbert S, Barch DM, Mooney MA, Feldstein Ewing SW, Fair DA, Nagel BJ

Keywords

DOI

10.1371/journal.pone.0252114
Toggle Sex Differences in Psychopathology in a Large Cohort of Nine and Ten-Year-Olds. Psychiatry research Loso HM, Dube SL, Chaarani B, et al. 2021
PubMed Record

Abstract

The current study quantified sex differences in psychopathology among 9 and 10-year-olds, examined sex differences among those with clinically elevated symptoms and investigated if puberty moderates the relationship between sex and psychopathology. Data were obtained from the Adolescent Brain and Cognitive Development (ABCD)® Study’s NDA data release 2.0. Results suggest that males have higher scores and greater frequency of clinically meaningful levels of psychopathology across several domains. Puberty did not interact with sex to affect psychopathology. However, as puberty advanced, the percentage of males and females with elevated scores increased.

Journal

Psychiatry research

Published

2021/05/24

Authors

Loso HM, Dube SL, Chaarani B, Garavan H, Albaugh M, Ivanova M, Potter A

Keywords

Epidemiology, Pediatric mental health, Psychopathology

DOI

10.1016/j.psychres.2021.114026
Toggle Feasibility of Race by Sex Intersectionality Research on Suicidality in the Adolescent Brain Cognitive Development (ABCD) Study. Children (Basel, Switzerland) Assari S, Boyce S, Bazargan M 2021
PubMed Record

Abstract

Intersectional research on childhood suicidality requires studies with a reliable and valid measure of suicidality, as well as a large sample size that shows some variability of suicidality across sex by race intersectional groups.

Journal

Children (Basel, Switzerland)

Published

2021/05/23

Authors

Assari S, Boyce S, Bazargan M

Keywords

children, race, sex, suicidality, suicide

DOI

10.3390/children8060437
Toggle Commentary: Reply to 'Transgender and mental health' by Philip Graham. Journal of child psychology and psychiatry, and allied disciplines Potter A 2021
PubMed Record

Abstract

The letter to the editor from Philip Graham regarding the manuscript ‘Early adolescent gender diversity and mental health in the Adolescent Brain Cognitive Development study’ (Potter et al., 2021) raises several points that highlight the complexity of the conversation around gender development in youth. While there is an agreement between the original manuscript and much of the letter, some of the issues raised warrant further discussion and clarification.

Journal

Journal of child psychology and psychiatry, and allied disciplines

Published

2021/05/19

Authors

Potter A

Keywords

DOI

10.1111/jcpp.13441
Toggle Race, Family Conflict and Suicidal Thoughts and Behaviors among 9-10-Year-Old American Children Int J Environ Res Public Health Assari S, Boyce S, Bazargan M, et al. 2021
PubMed Record

Abstract

Family conflict is known to operate as a major risk factor for children’s suicidal thoughts and behaviors (STBs). However, it is unknown whether this effect is similar or different in Black and White children.

Objectives: We compared Black and White children for the association between family conflict and STBs in a national sample of 9-10-year-old American children.

Methods: This cross-sectional study used data from the Adolescent Brain Cognitive Development (ABCD) study. This study included 9918 White or Black children between the ages of 9 and 10 living in married households. The predictor variable was family conflict. Race was the moderator. The outcome variable was STBs, treated as a count variable, reflecting positive STB items that were endorsed. Covariates included ethnicity, sex, age, immigration status, family structure, parental education, and parental employment, and household income. Poisson regression was used for data analysis.

Results: Of all participants, 7751 were Whites, and 2167 were Blacks. In the pooled sample and in the absence of interaction terms, high family conflict was associated with higher STBs. A statistically significant association was found between Black race and family conflict, suggesting that the association between family conflict and STBs is stronger in Black than White children.

Conclusion: The association between family conflict and STBs is stronger in Black than White children. Black children with family conflict may be at a higher risk of STBs than White children with the same family conflict level. These findings align with the literature on the more significant salience of social relations as determinants of mental health of Black than White people. Reducing family conflict should be regarded a significant element of suicide prevention for Black children in the US.

Journal

Int J Environ Res Public Health

Published

2021/05/18

Authors

Assari S, Boyce S, Bazargan M, Caldwell CH

Keywords

children; family relations; race; suicidal thoughts and behaviors; suicide

DOI

DOI: 10.3390/ijerph18105399
Toggle Parental Educational Attainment, the Superior Temporal Cortical Surface Area, and Reading Ability among American Children: A Test of Marginalization-Related Diminished Returns. Children (Basel, Switzerland) Assari S, Boyce S, Bazargan M, et al. 2021
PubMed Record

Abstract

Recent studies have shown that parental educational attainment is associated with a larger superior temporal cortical surface area associated with higher reading ability in children. Simultaneously, the marginalization-related diminished returns (MDRs) framework suggests that, due to structural racism and social stratification, returns of parental education are smaller for black and other racial/ethnic minority children compared to their white counterparts.

Journal

Children (Basel, Switzerland)

Published

2021/05/18

Authors

Assari S, Boyce S, Bazargan M, Thomas A, Cobb RJ, Hudson D, Curry TJ, Nicholson HL, Cuevas AG, Mistry R, Chavous TM, Caldwell CH, Zimmerman MA

Keywords

adolescents, brain development, child, cortical surface, magnetic resonance imaging, population groups, reading, school performance, socioeconomic factors

DOI

10.3390/children8050412
Toggle Association between Hippocampal Volume and Working Memory in 10,000+ 9-10-Year-Old Children: Sex Differences. Children (Basel, Switzerland) Assari S, Boyce S, Jovanovic T 2021
PubMed Record

Abstract

This study tested sex differences in the association between hippocampal volume and working memory of a national sample of 9-10-year-old children in the US. As the hippocampus is functionally lateralized (especially in task-related activities), we explored the results for the right and the left hippocampus.

Journal

Children (Basel, Switzerland)

Published

2021/05/18

Authors

Assari S, Boyce S, Jovanovic T

Keywords

children, list sorting working memory, right and left hippocampal volume, sex, sex difference

DOI

10.3390/children8050411
Toggle Associations of family income with cognition and brain structure in USA children: prevention implications. Molecular psychiatry Tomasi D, Volkow ND 2021
PubMed Record

Abstract

Poverty, as assessed by several socioeconomic (SES) factors, has been linked to worse cognitive performance and reduced cortical brain volumes in children. However, the relative contributions of the various SES factors on brain development and the mediating effects between cognition and brain morphometry have not been investigated. Here we used cross-sectional data from the ABCD Study to evaluate associations among various SES and demographic factors, brain morphometrics, and cognition and their reproducibility in two independent subsamples of 3892 children. Among the SES factors, family income (FI) best explained individual differences in cognitive test scores (stronger for crystallized than for fluid cognition), cortical volume (CV), and thickness (CT). Other SES factors that showed significant associations with cognition and brain morphometrics included parental education and neighborhood deprivation, but when controlling for FI, their effect sizes were negligible and their regional brain patterns were not reproducible. Mediation analyses showed that cognitive scores, which we used as surrogate markers of the children’s level of cognitive stimulation, partially mediated the association of FI and CT, whereas the mediations of brain morphometrics on the association of FI and cognition were not significant. These results suggest that lack of supportive/educational stimulation in children from low-income families might drive the reduced CV and CT. Thus, strategies to enhance parental supportive stimulation and the quality of education for children in low-income families could help counteract the negative effects of poverty on children’s brain development.

Journal

Molecular psychiatry

Published

2021/05/14

Authors

Tomasi D, Volkow ND

Keywords

DOI

10.1038/s41380-021-01130-0
Toggle Polygenic Risk for Insomnia in Adolescents of Diverse Ancestry. Frontiers in genetics Ma T, Chen H, Lu Q, et al. 2021
PubMed Record

Abstract

Insomnia is a common mental disorder, affecting nearly one fifth of the pre-adult population in the United States. The recent, largest genome-wide association study (GWAS) conducted on the United Kingdom Biobank cohort identified hundreds of significant single-nucleotide polymorphism (SNP), allowing the epidemiologists to quantify individual genetic predisposition in the subsequent studies the polygenic risk scoring technique. The nucleotide polymorphisms and risk scoring, while being able to generalize to other adult populations of European origin, are not yet tested on pediatric and adolescent populations of diverse racial-ethnic backgrounds, and our study intends to fill these gaps. We took the summary of the same United Kingdom Biobank study and conducted a polygenic risk score (PRS) analysis on a multi-ethnicity, pre-adult population provided by the Adolescent Brain Cognitive Development (ABCD) Study. The PRSs according to the significant nucleotide polymorphisms found in white British adults is a strong predictor of insomnia in children of similar European background but lacks power in non-European groups. Through polygenic risk scoring, the knowledge of insomnia genetics summarized from a white adult study population is transferable to a younger age group, which aids the search of actionable targets of early insomnia prevention. Yet population stratification may prevent the easy generalization across ethnic lines; therefore, it is necessary to conduct group specific studies to aid people of non-European genetic background.

Journal

Frontiers in genetics

Published

2021/05/10

Authors

Ma T, Chen H, Lu Q, Tong X

Keywords

adolescent, ancestry, genetic, insomnia, polygenic risk score

DOI

10.3389/fgene.2021.654717
Toggle Amygdalar Activation as a Neurobiological Marker of Differential Sensitivity in the Effects of Family Rearing Experiences on Socioemotional Adjustment in Youths. Biological psychiatry. Cognitive neuroscience and neuroimaging Liu S, Oshri A, Kogan SM, et al. 2021
PubMed Record

Abstract

Substantial heterogeneity exists in how rearing environments influence youths’ socioemotional outcomes. This heterogeneity, as suggested by the biological sensitivity to context theory and the differential susceptibility theory, is associated with emotional reactivity patterns and underlying neural functions. The present study investigated amygdalar reactivity to emotional stimuli as a neural signature that amplified the influence of rearing environments on youths’ socioemotional outcomes.

Journal

Biological psychiatry. Cognitive neuroscience and neuroimaging

Published

2021/05/05

Authors

Liu S, Oshri A, Kogan SM, Wickrama KAS, Sweet L

Keywords

Amygdala, Differential susceptibility, Early-life stress, Family rearing environments, Internalizing and externalizing symptoms, Parenting

DOI

10.1016/j.bpsc.2021.04.017
Toggle A Researcher's Guide to the Measurement and Modeling of Puberty in the ABCD Study at Baseline. Frontiers in endocrinology Cheng TW, Magis-Weinberg L, Guazzelli Williamson V, et al. 2021
PubMed Record

Abstract

The Adolescent Brain Cognitive Development℠ (ABCD) Study is an ongoing, diverse, longitudinal, and multi-site study of 11,880 adolescents in the United States. The ABCD Study provides open access to data about pubertal development at a large scale, and this article is a researcher’s guide that both describes its pubertal variables and outlines recommendations for use. These considerations are contextualized with reference to cross-sectional empirical analyses of pubertal measures within the baseline ABCD dataset by Herting, Uban, and colleagues (2021). We discuss strategies to capitalize on strengths, mitigate weaknesses, and appropriately interpret study limitations for researchers using pubertal variables within the ABCD dataset, with the aim of building toward a robust science of adolescent development.

Journal

Frontiers in endocrinology

Published

2021/05/05

Authors

Cheng TW, Magis-Weinberg L, Guazzelli Williamson V, Ladouceur CD, Whittle SL, Herting MM, Uban KA, Byrne ML, Barendse MEA, Shirtcliff EA, Pfeifer JH

Keywords

DHEA, adolescent brain cognitive development study, estradiol, puberty, salivary hormones, testosterone

DOI

10.3389/fendo.2021.608575
Toggle Rates of Incidental Findings in Brain Magnetic Resonance Imaging in Children. JAMA neurology Li Y, Thompson WK, Reuter C, et al. 2021
PubMed Record

Abstract

Incidental findings (IFs) are unexpected abnormalities discovered during imaging and can range from normal anatomic variants to findings requiring urgent medical intervention. In the case of brain magnetic resonance imaging (MRI), reliable data about the prevalence and significance of IFs in the general population are limited, making it difficult to anticipate, communicate, and manage these findings.

Journal

JAMA neurology

Published

2021/05/01

Authors

Li Y, Thompson WK, Reuter C, Nillo R, Jernigan T, Dale A, Sugrue LP, , Brown J, Dougherty RF, Rauschecker A, Rudie J, Barch DM, Calhoun V, Hagler D, Hatton S, Tanabe J, Marshall A, Sher KJ, Heeringa S, Hermosillo R, Banich MT, Squeglia L, Bjork J, Zucker R, Neale M, Herting M, Sheth C, Huber R, Reeves G, Hettema JM, Howlett KD, Cloak C, Baskin-Sommers A, Rapuano K, Gonzalez R, Karcher N, Laird A, Baker F, James R, Sowell E, Dick A, Hawes S, Sutherland M, Bagot K, Bodurka J, Breslin F, Morris A, Paulus M, Gray K, Hoffman E, Weiss S, Rajapakse N, Glantz M, Nagel B, Ewing SF, Goldstone A, Pfefferbaum A, Prouty D, Rosenberg M, Bookheimer S, Tapert S, Infante M, Jacobus J, Giedd J, Shilling P, Wade N, Uban K, Haist F, Heyser C, Palmer C, Kuperman J, Hewitt J, Cottler L, Isaiah A, Chang L, Edwards S, Ernst T, Heitzeg M, Puttler L, Sripada C, Iacono W, Luciana M, Clark D, Luna B, Schirda C, Foxe J, Freedman E, Mason M, McGlade E, Renshaw P, Yurgelun-Todd D, Albaugh M, Allgaier N, Chaarani B, Potter A, Ivanova M, Lisdahl K, Do E, Maes H, Bogdan R, Anokhin A, Dosenbach N, Glaser P, Heath A, Casey BJ, Gee D, Garavan HP, Dowling G, Brown S

Keywords

DOI

10.1001/jamaneurol.2021.0306
Toggle Association of adverse prenatal exposure burden with child psychopathology in the Adolescent Brain Cognitive Development (ABCD) Study. PloS one Roffman JL, Sipahi ED, Dowling KF, et al. 2021
PubMed Record

Abstract

Numerous adverse prenatal exposures have been individually associated with risk for psychiatric illness in the offspring. However, such exposures frequently co-occur, raising questions about their cumulative impact. We evaluated effects of cumulative adverse prenatal exposure burden on psychopathology risk in school-aged children.

Journal

PloS one

Published

2021/04/28

Authors

Roffman JL, Sipahi ED, Dowling KF, Hughes DE, Hopkinson CE, Lee H, Eryilmaz H, Cohen LS, Gilman J, Doyle AE, Dunn EC

Keywords

DOI

10.1371/journal.pone.0250235
Toggle Extracurricular Activities, Screen Media Activity, and Sleep May Be Modifiable Factors Related to Children's Cognitive Functioning: Evidence From the ABCD Study. Child development Kirlic N, Colaizzi JM, Cosgrove KT, et al. 2021
PubMed Record

Abstract

This study used a machine learning framework in conjunction with a large battery of measures from 9,718 school-age children (ages 9-11) from the Adolescent Brain Cognitive Development (ABCD) Study to identify factors associated with fluid cognitive functioning (FCF), or the capacity to learn, solve problems, and adapt to novel situations. The identified algorithm explained 14.74% of the variance in FCF, replicating previously reported socioeconomic and mental health contributors to FCF, and adding novel and potentially modifiable contributors, including extracurricular involvement, screen media activity, and sleep duration. Pragmatic interventions targeting these contributors may enhance cognitive performance and protect against their negative impact on FCF in children.

Journal

Child development

Published

2021/04/26

Authors

Kirlic N, Colaizzi JM, Cosgrove KT, Cohen ZP, Yeh HW, Breslin F, Morris AS, Aupperle RL, Singh MK, Paulus MP

Keywords

DOI

10.1111/cdev.13578
Toggle Breastfeeding Duration Is Associated With Domain-Specific Improvements in Cognitive Performance in 9-10-Year-Old Children. Frontiers in public health Lopez DA, Foxe JJ, Mao Y, et al. 2021
PubMed Record

Abstract

Significant immunological, physical and neurological benefits of breastfeeding in infancy are well-established, but to what extent these gains persist into later childhood remain uncertain. This study examines the association between breastfeeding duration and subsequent domain-specific cognitive performance in a diverse sample of 9-10-year-olds enrolled in the Adolescent Brain Cognitive Development (ABCD) Study®. The analyses included 9,116 children that attended baseline with their biological mother and had complete neurocognitive and breastfeeding data. Principal component analysis was conducted on data from an extensive battery of neurocognitive tests using varimax-rotation to extract a three-component model encompassing General Ability, Executive Functioning, and Memory. Propensity score weighting using generalized boosted modeling was applied to balance the distribution of observed covariates for children breastfed for 0, 1-6, 7-12, and more than 12 months. Propensity score-adjusted linear regression models revealed significant association between breastfeeding duration and performance on neurocognitive tests representing General Ability, but no evidence of a strong association with Executive Function or Memory. Benefits on General Ability ranged from a 0.109 (1-6 months) to 0.301 (>12 months) standardized beta coefficient difference compared to those not breastfed. Results indicate clear cognitive benefits of breastfeeding but that these do not generalize to all measured domains, with implications for public health policy as it pertains to nutrition during infancy.

Journal

Frontiers in public health

Published

2021/04/26

Authors

Lopez DA, Foxe JJ, Mao Y, Thompson WK, Martin HJ, Freedman EG

Keywords

breastfeeding, child, cognitive development, neurocognition, public health

DOI

10.3389/fpubh.2021.657422
Toggle The association between latent trauma and brain structure in children. Translational psychiatry Jeong HJ, Durham EL, Moore TM, et al. 2021
PubMed Record

Abstract

The developing brain is marked by high plasticity, which can lead to vulnerability to early life stressors. Previous studies indicate that childhood maltreatment is associated with structural aberrations across a number of brain regions. However, prior work is limited by small sample sizes, heterogeneous age groups, the examination of one structure in isolation, the confounding of different types of early life stressors, and not accounting for socioeconomic status. These limitations may contribute to high variability across studies. The present study aimed to investigate how trauma is specifically associated with cortical thickness and gray matter volume (GMV) differences by leveraging a large sample of children (N = 9270) from the Adolescent Brain Cognitive Development Study (ABCD Study). A latent measure of trauma exposure was derived from DSM-5 traumatic events, and we related this measure of trauma to the brain using structural equation modeling. Trauma exposure was associated with thinner cortices in the bilateral superior frontal gyri and right caudal middle frontal gyrus (p-values < .001) as well as thicker cortices in the left isthmus cingulate and posterior cingulate (p-values ≤ .027), after controlling age, sex, and race/ethnicity. Furthermore, trauma exposure was associated with smaller GMV in the right amygdala and right putamen (p-values ≤ .048). Sensitivity analyses that controlled for income and parental education were largely consistent with the main findings for cortical thickness. These results suggest that trauma may be an important risk factor for structural aberrations, specifically for cortical thickness differences in frontal and cingulate regions in children.

Journal

Translational psychiatry

Published

2021/04/24

Authors

Jeong HJ, Durham EL, Moore TM, Dupont RM, McDowell M, Cardenas-Iniguez C, Micciche ET, Berman MG, Lahey BB, Kaczkurkin AN

Keywords

DOI

10.1038/s41398-021-01357-z
Toggle Ecological stress, amygdala reactivity, and internalizing symptoms in preadolescence: Is parenting a buffer? Cortex; a journal devoted to the study of the nervous system and behavior Demidenko MI, Ip KI, Kelly DP, et al. 2021
PubMed Record

Abstract

Ecological stress during adolescent development may increase the sensitivity to negative emotional processes that can contribute to the onset and progression of internalizing behaviors during preadolescence. Although a small number of studies have considered the link among the relations between ecological stress, amygdala reactivity, and internalizing symptoms in childhood and adolescence, these studies have largely been small, cross-sectional, and often do not consider unique roles of parenting or sex. In the current study, we evaluated the interrelations between ecological stress, amygdala reactivity, subsequent internalizing symptoms, and the moderating roles of parenting and sex among 9- and 10-year-old preadolescents from the Adolescent Brain Cognitive Development (ABCD) Study ®. A subset of participants who met a priori quality control criteria for bilateral amygdala activation during the EN-back faces versus places contrast (N = 7,385; Mean Age = 120 months, SD = 7.52; 49.5% Female) were included in the study. A confirmatory factor analysis was performed to create a latent variable of ecological stress, and multiple structural equation models were tested to evaluate the association among baseline ecological stress and internalizing symptoms one year later, the mediating role of amygdala reactivity, and moderating effects of parental acceptance and sex. The results revealed a significant association between ecological stress and subsequent internalizing symptoms, which was greater in males than females. There was no association between amygdala reactivity during the Faces versus Places contrast and ecological stress or subsequent internalizing symptoms, and no mediating role of amygdala or moderating effect of parental acceptance on the association between ecological stress and internalizing symptoms. An alternative mediation model was tested which revealed that there was a small mediating effect of parental acceptance on the association between ecological stress and internalizing symptoms, demonstrating lower internalizing symptoms among preadolescents one year later. Given the lack of association in brain function, ecological stress and internalizing symptoms in preadolescents in this registered report, effects from comparable small studies should be reconsidered in larger samples.

Journal

Cortex; a journal devoted to the study of the nervous system and behavior

Published

2021/04/15

Authors

Demidenko MI, Ip KI, Kelly DP, Constante K, Goetschius LG, Keating DP

Keywords

Amygdala, Environment, Internalizing, Parenting, Preadolescence, Sex

DOI

10.1016/j.cortex.2021.02.032
Toggle Conduct disorder symptomatology is associated with an altered functional connectome in a large national youth sample. Development and psychopathology Tillem S, Conley MI, Baskin-Sommers A 2021
PubMed Record

Abstract

Conduct disorder (CD), characterized by youth antisocial behavior, is associated with a variety of neurocognitive impairments. However, questions remain regarding the neural underpinnings of these impairments. To investigate novel neural mechanisms that may support these neurocognitive abnormalities, the present study applied a graph analysis to resting-state functional magnetic resonance imaging (fMRI) data collected from a national sample of 4,781 youth, ages 9-10, who participated in the baseline session of the Adolescent Brain Cognitive Development Study (ABCD Study®). Analyses were then conducted to examine the relationships among levels of CD symptomatology, metrics of global topology, node-level metrics for subcortical structures, and performance on neurocognitive assessments. Youth higher on CD displayed higher global clustering (β = .039, 95% CI [.0027 .0771]), but lower Degree (β = -.052, 95% CI [-.0916 -.0152]). Youth higher on CD had worse performance on a general neurocognitive assessment (β = -.104, 95% CI [-.1328 -.0763]) and an emotion recognition memory assessment (β = -.061, 95% CI [-.0919 -.0290]). Finally, global clustering mediated the relationship between CD and general neurocognitive functioning (indirect β = -.002, 95% CI [-.0044 -.0002]), and Degree mediated the relationship between CD and emotion recognition memory performance (indirect β = -.002, 95% CI [-.0046 -.0005]). CD appears associated with neuro-topological abnormalities and these abnormalities may represent neural mechanisms supporting CD-related neurocognitive disruptions.

Journal

Development and psychopathology

Published

2021/04/14

Authors

Tillem S, Conley MI, Baskin-Sommers A

Keywords

conduct disorder, graph analysis, neural topology, neurocognitive functioning, subcortical structures

DOI

10.1017/S0954579421000237
Toggle Associations between frontal lobe structure, parent-reported obstructive sleep disordered breathing and childhood behavior in the ABCD dataset. Nature communications Isaiah A, Ernst T, Cloak CC, et al. 2021
PubMed Record

Abstract

Parents frequently report behavioral problems among children who snore. Our understanding of the relationship between symptoms of obstructive sleep disordered breathing (oSDB) and childhood behavioral problems associated with brain structural alterations is limited. Here, we examine the associations between oSDB symptoms, behavioral measures such as inattention, and brain morphometry in the Adolescent Brain Cognitive Development (ABCD) study comprising 10,140 preadolescents. We observe that parent-reported symptoms of oSDB are associated with composite and domain-specific problem behaviors measured by parent responses to the Child Behavior Checklist. Alterations of brain structure demonstrating the strongest negative associations with oSDB symptoms are within the frontal lobe. The relationships between oSDB symptoms and behavioral measures are mediated by significantly smaller volumes of multiple frontal lobe regions. These results provide population-level evidence for an association between regional structural alterations in cortical gray matter and problem behaviors reported in children with oSDB.

Journal

Nature communications

Published

2021/04/13

Authors

Isaiah A, Ernst T, Cloak CC, Clark DB, Chang L

Keywords

DOI

10.1038/s41467-021-22534-0
Toggle Correction to: Multimethod investigation of the neurobiological basis of ADHD symptomatology in children aged 9-10: baseline data from the ABCD study. Translational psychiatry Owens MM, Allgaier N, Hahn S, et al. 2021
PubMed Record

Abstract

Journal

Translational psychiatry

Published

2021/04/12

Authors

Owens MM, Allgaier N, Hahn S, Yuan D, Albaugh M, Adise S, Chaarani B, Ortigara J, Juliano A, Potter A, Garavan H

Keywords

DOI

10.1038/s41398-021-01320-y
Toggle Gastric symptoms and low perceived maternal warmth are associated with eating disorder symptoms in young adolescent girls. The International journal of eating disorders Kerr KL, Ralph-Nearman C, Colaizzi JM, et al. 2021
PubMed Record

Abstract

This study sought to determine whether gastric symptoms are associated with later eating disorder (ED) symptoms during early adolescence, and whether this relationship is moderated by parental warmth/acceptance and/or the child’s sex.

Journal

The International journal of eating disorders

Published

2021/04/09

Authors

Kerr KL, Ralph-Nearman C, Colaizzi JM, DeVille DC, Breslin FJ, Aupperle RL, Paulus MP, Morris AS

Keywords

adolescents, eating disorders, females, gastrointestinal symptoms, maternal acceptance, parenting, paternal acceptance, risk factors, sex

DOI

10.1002/eat.23516
Toggle Shared heritability of human face and brain shape. Nature genetics Naqvi S, Sleyp Y, Hoskens H, et al. 2021
PubMed Record

Abstract

Evidence from model organisms and clinical genetics suggests coordination between the developing brain and face, but the role of this link in common genetic variation remains unknown. We performed a multivariate genome-wide association study of cortical surface morphology in 19,644 individuals of European ancestry, identifying 472 genomic loci influencing brain shape, of which 76 are also linked to face shape. Shared loci include transcription factors involved in craniofacial development, as well as members of signaling pathways implicated in brain-face cross-talk. Brain shape heritability is equivalently enriched near regulatory regions active in either forebrain organoids or facial progenitors. However, we do not detect significant overlap between shared brain-face genome-wide association study signals and variants affecting behavioral-cognitive traits. These results suggest that early in embryogenesis, the face and brain mutually shape each other through both structural effects and paracrine signaling, but this interplay may not impact later brain development associated with cognitive function.

Journal

Nature genetics

Published

2021/04/05

Authors

Naqvi S, Sleyp Y, Hoskens H, Indencleef K, Spence JP, Bruffaerts R, Radwan A, Eller RJ, Richmond S, Shriver MD, Shaffer JR, Weinberg SM, Walsh S, Thompson J, Pritchard JK, Sunaert S, Peeters H, Wysocka J, Claes P

Keywords

DOI

10.1038/s41588-021-00827-w
Toggle "I Don't Understand": Who Is Missed When We Ask Early Adolescents, "Are You Transgender"? Archives of sexual behavior Dube S, Ivanova M, Potter A 2021
PubMed Record

Abstract

Journal

Archives of sexual behavior

Published

2021/04/05

Authors

Dube S, Ivanova M, Potter A

Keywords

DOI

10.1007/s10508-021-01986-x
Toggle Obesity and Eating Disorder Disparities Among Sexual and Gender Minority Youth. JAMA pediatrics Schvey NA, Pearlman AT, Klein DA, et al. 2021
PubMed Record

Abstract

This study assesses obesity, binge eating disorder, anorexia nervosa, and bulimia nervosa among sexual and gender minority children.

Journal

JAMA pediatrics

Published

2021/04/01

Authors

Schvey NA, Pearlman AT, Klein DA, Murphy MA, Gray JC

Keywords

DOI

10.1001/jamapediatrics.2020.5152
Toggle The Elusive Phenotype of Preadolescent Suicidal Thoughts and Behaviors: Can Neuroimaging Deliver on Its Promise? The American journal of psychiatry Auerbach RP, Chase HW, Brent DA 2021
PubMed Record

Abstract

Journal

The American journal of psychiatry

Published

2021/04/01

Authors

Auerbach RP, Chase HW, Brent DA

Keywords

Neuroimaging, Suicide and Self-Harm

DOI

10.1176/appi.ajp.2020.21010022
Toggle Race, Socioeconomic Status, and Cerebellum Cortex Fractional Anisotropy in Pre-Adolescents. Adolescents (Basel, Switzerland) Assari S, Boyce S 2021
PubMed Record

Abstract

Cerebellum cortex fractional anisotropy is a proxy of the integrity of the cerebellum cortex. However, less is known about how it is shaped by race and socioeconomic status (SES) indicators such as parental education and household income.

Journal

Adolescents (Basel, Switzerland)

Published

2021/03/31

Authors

Assari S, Boyce S

Keywords

MRI, brain development, cerebellum cortex, parental education and household income, pre-adolescents, socioeconomic position

DOI

10.3390/adolescents1020007
Toggle Children with ADHD Have a Greater Lifetime History of Concussion: Results from the ABCD Study. Journal of neurotrauma Cook NE, Karr JE, Iverson GL 2021
PubMed Record

Abstract

This case-control study using baseline data from the population cohort Adolescent Brain Cognitive Development (ABCD) Study compared lifetime history of concussion between children with and without attention-deficit/hyperactivity disorder (ADHD). We hypothesized that children with ADHD would have a greater lifetime history of concussion than children without ADHD. Children were recruited from schools across the United States, sampled to provide strong generalizability to the US population. The current sample included 10,585 children (age: mean = 9.9; standard deviation = 0.6; range 9-10 years; 48.9% girls; 64.6% White), including 1085 with ADHD and 9500 without ADHD. The prevalence of prior concussion among children with ADHD was 7.2% (95% CI: 6.6-7.8%) compared with 3.2% (3.1-3.3%) among children without ADHD, meaning current ADHD status was associated with twice the odds of experiencing a prior concussion [ = 44.54;  < 0.001; odds ratio = 2.34 (1.81-3.03)]. No significant differences were observed in proportion of boys and girls with ADHD who had a prior concussion history. The number of current ADHD symptoms were not meaningfully associated with prior concussion history. Lower socioeconomic status was associated with lower rates of reported concussion, but not differentially in association with ADHD. ADHD is associated with twice the lifetime prevalence of prior concussion before age 11 among children from the general U.S. population. Boys and girls with ADHD did not differ in proportions with prior concussion and concussion history was not related to the number of ADHD symptoms reported by parents.

Journal

Journal of neurotrauma

Published

2021/03/30

Authors

Cook NE, Karr JE, Iverson GL

Keywords

attention-deficit/hyperactivity disorder, children, mild traumatic brain injury

DOI

10.1089/neu.2021.0019
Toggle Multimodal brain predictors of current weight and weight gain in children enrolled in the ABCD study ®. Developmental cognitive neuroscience Adise S, Allgaier N, Laurent J, et al. 2021
PubMed Record

Abstract

Multimodal neuroimaging assessments were utilized to identify generalizable brain correlates of current body mass index (BMI) and predictors of pathological weight gain (i.e., beyond normative development) one year later. Multimodal data from children enrolled in the Adolescent Brain Cognitive Development Study® at 9-to-10-years-old, consisted of structural magnetic resonance imaging (MRI), diffusion tensor imaging (DTI), resting state (rs), and three task-based functional (f) MRI scans assessing reward processing, inhibitory control, and working memory. Cross-validated elastic-net regression revealed widespread structural associations with BMI (e.g., cortical thickness, surface area, subcortical volume, and DTI), which explained 35% of the variance in the training set and generalized well to the test set (R = 0.27). Widespread rsfMRI inter- and intra-network correlations were related to BMI (R = 0.21; R = 0.14), as were regional activations on the working memory task (R = 0.20; (R = 0.16). However, reward and inhibitory control tasks were unrelated to BMI. Further, pathological weight gain was predicted by structural features (Area Under the Curve (AUC) = 0.83; AUC = 0.83, p < 0.001), but not by fMRI nor rsfMRI. These results establish generalizable brain correlates of current weight and future pathological weight gain. These results also suggest that sMRI may have particular value for identifying children at risk for pathological weight gain.

Journal

Developmental cognitive neuroscience

Published

2021/03/30

Authors

Adise S, Allgaier N, Laurent J, Hahn S, Chaarani B, Owens M, Yuan D, Nyugen P, Mackey S, Potter A, Garavan HP

Keywords

Childhood obesity, Inhibitory control, Machine-learning, Reward, Weight gain, Weight stability, fMRI

DOI

10.1016/j.dcn.2021.100948
Toggle Association Between Parental Educational Attainment and Children's Negative Urgency: Sex Differences. International journal of epidemiologic research Assari S 2021
PubMed Record

Abstract

Negative urgency reflects a specific facet of impulsivity and correlates with a wide range of health-related risk behaviors, including, but not limited to, problematic substance use. Negative urgency is also shaped by family socioeconomic position (SEP), such as parental educational attainment (PEA). This study aimed to explore sex differences regarding protective effects of PEA on children’s negative urgency in the US.

Journal

International journal of epidemiologic research

Published

2021/03/30

Authors

Assari S

Keywords

Children, Negative urgency, Parental educational attainment, Personality, Socioeconomic status

DOI

10.34172/IJER.2021.04
Toggle Polygenic risk scores for major psychiatric and neurodevelopmental disorders contribute to sleep disturbance in childhood: Adolescent Brain Cognitive Development (ABCD) Study. Translational psychiatry Ohi K, Ochi R, Noda Y, et al. 2021
PubMed Record

Abstract

Sleep disturbance is a common symptom of psychiatric and neurodevelopmental disorders and, especially in childhood, can be a precursor to various mental disorders. However, the genetic etiology of mental illness that contributes to sleep disturbance during childhood is poorly understood. We investigated whether the polygenic features of psychiatric and neurodevelopmental disorders are associated with sleep disturbance during childhood. We conducted polygenic risk score (PRS) analyses by utilizing large-scale genome-wide association studies (GWASs) (n = 46,350-500,199) of five major psychiatric and neurodevelopmental disorders (autism spectrum disorder, schizophrenia, attention-deficit/hyperactivity disorder (ADHD), major depressive disorder (MDD), and bipolar disorder) and, additionally, anxiety disorders as base datasets. We used the data of 9- to 10-year-olds from the Adolescent Brain Cognitive Development study (n = 9683) as a target dataset. Sleep disturbance was assessed based on the Sleep Disturbance Scale for Children (SDSC) scores. The effects of PRSs for these psychiatric and neurodevelopmental disorders on the total scores and six subscale scores of the SDSC were investigated. Of the PRSs for the five psychiatric and neurodevelopmental disorders, the PRSs for ADHD and MDD positively correlated with sleep disturbance in children (ADHD: R = 0.0033, p = 6.19 × 10, MDD: R = 0.0042, p = 5.69 × 10). Regarding the six subscale scores of the SDSC, the PRSs for ADHD positively correlated with both disorders of initiating and maintaining sleep (R = 0.0028, p = 2.31 × 10) and excessive somnolence (R = 0.0023, p = 8.44 × 10). Furthermore, the PRSs for MDD primarily positively correlated with disorders of initiating and maintaining sleep (R = 0.0048, p = 1.26 × 10), followed by excessive somnolence (R = 0.0023, p = 7.74 × 10) and sleep hyperhidrosis (R = 0.0014, p = 9.55 × 10). Despite high genetic overlap between MDD and anxiety disorders, PRSs for anxiety disorders correlated with different types of sleep disturbances such as disorders of arousal or nightmares (R = 0.0013, p = 0.011). These findings suggest that greater genetic susceptibility to specific psychiatric and neurodevelopmental disorders, as represented by ADHD, MDD, and anxiety disorders, may contribute to greater sleep problems among children.

Journal

Translational psychiatry

Published

2021/03/26

Authors

Ohi K, Ochi R, Noda Y, Wada M, Sugiyama S, Nishi A, Shioiri T, Mimura M, Nakajima S

Keywords

DOI

10.1038/s41398-021-01308-8
Toggle Associations Between Neighborhood Disadvantage, Resting-State Functional Connectivity, and Behavior in the Adolescent Brain Cognitive Development Study: The Moderating Role of Positive Family and School Environments. Biological psychiatry. Cognitive neuroscience and neuroimaging Rakesh D, Seguin C, Zalesky A, et al. 2021
PubMed Record

Abstract

Neighborhood disadvantage has consistently been associated with mental health and cognitive function, in addition to alterations in brain function and connectivity. However, positive environmental influences may buffer these effects. The aim of this study was to examine the association between neighborhood disadvantage and resting-state functional connectivity (rsFC), the moderating role of positive parenting and school environment, and relationships between disadvantage-associated rsFC patterns and mental health and cognition.

Journal

Biological psychiatry. Cognitive neuroscience and neuroimaging

Published

2021/03/23

Authors

Rakesh D, Seguin C, Zalesky A, Cropley V, Whittle S

Keywords

Adolescence, Neighborhood socioeconomic status, Positive parenting, Resting-state functional connectivity, School environment, fMRI

DOI

10.1016/j.bpsc.2021.03.008
Toggle Parental Education and Left Lateral Orbitofrontal Cortical Activity during N-Back Task: An fMRI Study of American Adolescents. Brain sciences Assari S, Boyce S, Saqib M, et al. 2021
PubMed Record

Abstract

The Orbitofrontal Cortex (OFC) is a cortical structure that has implications in cognition, memory, reward anticipation, outcome evaluation, decision making, and learning. As such, OFC activity correlates with these cognitive brain abilities. Despite research suggesting race and socioeconomic status (SES) indicators such as parental education may be associated with OFC activity, limited knowledge exists on multiplicative effects of race and parental education on OFC activity and associated cognitive ability. Using functional brain imaging data from the Adolescent Brain Cognitive Development (ABCD) study, we tested the multiplicative effects of race and parental education on left lateral OFC activity during an N-Back task. In our study, we used a sociological rather than biological theory that conceptualizes race and SES as proxies of access to the opportunity structure and exposure to social adversities rather than innate and non-modifiable brain differences. We explored racial variation in the effect of parental educational attainment, a primary indicator of SES, on left lateral OFC activity during an N-Back task between Black and White 9-10 years old adolescents. The ABCD study is a national, landmark, multi-center brain imaging investigation of American adolescents. The total sample was 4290 9-10 years old Black or White adolescents. The independent variables were SES indicators, namely family income, parental education, and neighborhood income. The primary outcome was the average beta weight for N-Back (2 back versus 0 back contrast) in ASEG ROI left OFC activity, measured by functional Magnetic Resonance Imaging (fMRI) during an N-Back task. Ethnicity, age, sex, subjective SES, and family structure were the study covariates. For data analysis, we used linear regression models. In White but not Black adolescents, parental education was associated with higher left lateral OFC activity during the N-Back task. In the pooled sample, we found a significant interaction between race and parental education on the outcome, suggesting that high parental education is associated with a larger increase in left OFC activity of White than Black adolescents. For American adolescents, race and SES jointly influence left lateral OFC activity correlated with cognition, memory, decision making, and learning. Given the central role of left lateral OFC activity in learning and memory, our finding calls for additional research on contextual factors that reduce the gain of SES for Black adolescents. Cognitive inequalities are not merely due to the additive effects of race and SES but also its multiplicative effects.

Journal

Brain sciences

Published

2021/03/22

Authors

Assari S, Boyce S, Saqib M, Bazargan M, Caldwell CH

Keywords

N-Back, adolescents, brain development, cognitive, fMRI, learning, memory, orbitofrontal cortex, population groups, socioeconomic factors

DOI

10.3390/brainsci11030401
Toggle Parents' Perceived Neighborhood Safety and Children's Internalizing Symptoms: Race and Socioeconomic Status Differences. Journal of mental health & clinical psychology Assari S 2021
PubMed Record

Abstract

In the United States, due to residential segregation, racial minorities and families with low socioeconomic status (SES) tend to live in less safe neighborhoods than their White and high SES counterparts. As such, in the US, race and SES closely correlate with neighborhood safety. Due to the high chronicity of stress in unsafe neighborhoods, perceived neighborhood safety may be a mechanism through which race and SES are linked to children’s mental health. Simultaneously, race and SES may alter the effects of perceived neighborhood safety on children’s mental health.

Journal

Journal of mental health & clinical psychology

Published

2021/03/19

Authors

Assari S

Keywords

children, depressive symptoms, ethnicity, internalizing symptoms, neighborhood safety, population groups, race, socioeconomic status

DOI

Toggle Gene-environment correlations and causal effects of childhood maltreatment on physical and mental health: a genetically informed approach. The lancet. Psychiatry Warrier V, Kwong ASF, Luo M, et al. 2021
PubMed Record

Abstract

Childhood maltreatment is associated with poor mental and physical health. However, the mechanisms of gene-environment correlations and the potential causal effects of childhood maltreatment on health are unknown. Using genetics, we aimed to delineate the sources of gene-environment correlation for childhood maltreatment and the causal relationship between childhood maltreatment and health.

Journal

The lancet. Psychiatry

Published

2021/03/16

Authors

Warrier V, Kwong ASF, Luo M, Dalvie S, Croft J, Sallis HM, Baldwin J, Munafò MR, Nievergelt CM, Grant AJ, Burgess S, Moore TM, Barzilay R, McIntosh A, van IJzendoorn MH, Cecil CAM

Keywords

DOI

10.1016/S2215-0366(20)30569-1
Toggle Deep learning based segmentation of brain tissue from diffusion MRI. NeuroImage Zhang F, Breger A, Cho KIK, et al. 2021
PubMed Record

Abstract

Segmentation of brain tissue types from diffusion MRI (dMRI) is an important task, required for quantification of brain microstructure and for improving tractography. Current dMRI segmentation is mostly based on anatomical MRI (e.g., T1- and T2-weighted) segmentation that is registered to the dMRI space. However, such inter-modality registration is challenging due to more image distortions and lower image resolution in dMRI as compared with anatomical MRI. In this study, we present a deep learning method for diffusion MRI segmentation, which we refer to as DDSeg. Our proposed method learns tissue segmentation from high-quality imaging data from the Human Connectome Project (HCP), where registration of anatomical MRI to dMRI is more precise. The method is then able to predict a tissue segmentation directly from new dMRI data, including data collected with different acquisition protocols, without requiring anatomical data and inter-modality registration. We train a convolutional neural network (CNN) to learn a tissue segmentation model using a novel augmented target loss function designed to improve accuracy in regions of tissue boundary. To further improve accuracy, our method adds diffusion kurtosis imaging (DKI) parameters that characterize non-Gaussian water molecule diffusion to the conventional diffusion tensor imaging parameters. The DKI parameters are calculated from the recently proposed mean-kurtosis-curve method that corrects implausible DKI parameter values and provides additional features that discriminate between tissue types. We demonstrate high tissue segmentation accuracy on HCP data, and also when applying the HCP-trained model on dMRI data from other acquisitions with lower resolution and fewer gradient directions.

Journal

NeuroImage

Published

2021/03/16

Authors

Zhang F, Breger A, Cho KIK, Ning L, Westin CF, O'Donnell LJ, Pasternak O

Keywords

DOI

10.1016/j.neuroimage.2021.117934
Toggle Contributions from resting state functional connectivity and familial risk to early adolescent-onset MDD: Results from the Adolescent Brain Cognitive Development study. Journal of affective disorders Cai Y, Elsayed NM, Barch DM 2021
PubMed Record

Abstract

Family history of Major Depressive Disorder (MDD) is a robust predictor of MDD onset, especially in early adolescence. We examined the relationships between familial risk for depression and alterations to resting state functional connectivity (rsFC) within the default mode network (wDMN) and between the DMN and the left/right hippocampus (DMN-LHIPP/DMN-RHIPP) to the risk for early adolescent MDD onset.

Journal

Journal of affective disorders

Published

2021/03/16

Authors

Cai Y, Elsayed NM, Barch DM

Keywords

Adolescence, Depression, Familial risk, Functional Connectivity

DOI

10.1016/j.jad.2021.03.031
Toggle Identification and Validation of Distinct Latent Neurodevelopmental Profiles in the Adolescent Brain and Cognitive Development Study. Biological psychiatry. Cognitive neuroscience and neuroimaging Lichenstein SD, Roos C, Kohler R, et al. 2021
PubMed Record

Abstract

Regardless of the precise mechanism, all neurodevelopmental models of risk assume that, at the population level, there exist subgroups of individuals that share similar patterns of neural function and development-and that these subgroups somehow relate to psychiatric risk. However, the existence of multiple neurodevelopmental subgroups at the population level has not been assessed previously.

Journal

Biological psychiatry. Cognitive neuroscience and neuroimaging

Published

2021/03/09

Authors

Lichenstein SD, Roos C, Kohler R, Kiluk B, Carroll KM, Worhunsky PD, Witkiewitz K, Yip SW

Keywords

Adolescence, Latent profile analysis, Psychopathology, Risk factors, Split-half validation, fMRI

DOI

10.1016/j.bpsc.2021.02.013
Toggle Design issues and solutions for stop-signal data from the Adolescent Brain Cognitive Development (ABCD) study. eLife Bissett PG, Hagen MP, Jones HM, et al. 2021
PubMed Record

Abstract

The Adolescent Brain Cognitive Development (ABCD) study is an unprecedented longitudinal neuroimaging sample that tracks the brain development of over 9-10 year olds through adolescence. At the core of this study are the three tasks that are completed repeatedly within the MRI scanner, one of which is the stop-signal task. In analyzing the available stopping experimental code and data, we identified a set of design issues that we believe significantly compromise its value. These issues include but are not limited to variable stimulus durations that violate basic assumptions of dominant stopping models, trials in which stimuli are incorrectly not presented, and faulty stop-signal delays. We present eight issues, show their effect on the existing ABCD data, suggest prospective solutions including task changes for future data collection and preliminary computational models, and suggest retrospective solutions for data users who wish to make the most of the existing data.

Journal

eLife

Published

2021/03/04

Authors

Bissett PG, Hagen MP, Jones HM, Poldrack RA

Keywords

big data, brain development, child development, human, neuroscience, race models, stop-signal paradigm

DOI

10.7554/eLife.60185
Toggle Resting-State Functional Connectivity between Putamen and Salience Network and Childhood Body Mass Index. Neurology international Assari S, Boyce S 2021
PubMed Record

Abstract

Although the putamen has a significant role in reward-seeking and motivated behaviors, including eating and food-seeking, minorities’ diminished returns (MDRs) suggest that individual-level risk and protective factors have weaker effects for Non-Hispanic Black than Non-Hispanic White individuals. However, limited research is available on the relevance of MDRs in terms of the role of putamen functional connectivity on body mass index (BMI).

Journal

Neurology international

Published

2021/03/04

Authors

Assari S, Boyce S

Keywords

body mass index, brain development, children, fMRI, functional connectivity, obesity, population groups, putamen

DOI

10.3390/neurolint13010009
Toggle Contemporary screen time modalities among children 9-10 years old and binge-eating disorder at one-year follow-up: A prospective cohort study. The International journal of eating disorders Nagata JM, Iyer P, Chu J, et al. 2021
PubMed Record

Abstract

To determine the prospective associations between contemporary screen time modalities in a nationally representative cohort of 9-10-year-old children and binge-eating disorder at one-year follow-up.

Journal

The International journal of eating disorders

Published

2021/03/01

Authors

Nagata JM, Iyer P, Chu J, Baker FC, Pettee Gabriel K, Garber AK, Murray SB, Bibbins-Domingo K, Ganson KT

Keywords

adolescents, binge eating, binge-eating disorder, disordered eating, eating disorder, pediatrics, screen time, smart phone, social media, television

DOI

10.1002/eat.23489
Toggle Reported autism diagnosis is associated with psychotic-like symptoms in the Adolescent Brain Cognitive Development cohort. European child & adolescent psychiatry Jutla A, Donohue MR, Veenstra-VanderWeele J, et al. 2021
PubMed Record

Abstract

Although the schizophrenia (SCZ) rate is increased in autism spectrum disorder (ASD), it is difficult to identify which ASD youth will develop psychosis. We explored the relationship between ASD and emerging psychotic-like experiences (PLS) in a sample of 9127 youth aged 9-11 from the Adolescent Brain Cognitive Development (ABCD) cohort. We predicted that parent-reported ASD would be associated with PLS severity, and that ASD youth with PLS (ASD+/PLS+) would differ from ASD youth without PLS (ASD+/PLS-) and youth with PLS but not ASD (ASD-/PLS+) in cognitive function. We fit regression models that included parent-reported ASD, family history of psychosis, lifetime trauma, executive function, processing speed, working memory, age, sex, race, ethnicity, and income-to-needs ratio as predictors of Prodromal Questionnaire-Brief Child (PQ-BC) distress score, a continuous index of PLS severity. We assessed cognitive differences using regression models with ASD/PLS status and relevant covariates as predictors of NIH Toolbox measures. ASD increased raw PQ-BC distress scores by 2.47 points (95% CI 1.33-3.61), an effect at least as large as Black race (1.27 points, 95% CI 0.75-1.78), family history of psychosis (1.05 points, 95% CI 0.56-1.54), and Latinx ethnicity (0.99 points, 95% CI 0.53-1.45. We did not identify differences in cognition for ASD+/PLS+ youth relative to other groups. Our finding of association between ASD and PLS in youth is consistent with previous literature and adds new information in suggesting that ASD may be a strong risk factor for PLS even compared to established SCZ risk factors.

Journal

European child & adolescent psychiatry

Published

2021/03/01

Authors

Jutla A, Donohue MR, Veenstra-VanderWeele J, Foss-Feig JH

Keywords

Autism spectrum disorder, Early diagnosis, Neurodevelopmental disorders, Psychotic-like symptoms, Schizophrenia

DOI

10.1007/s00787-021-01738-1
Toggle Does maternal psychopathology bias reports of offspring symptoms? A study using moderated non-linear factor analysis. Journal of child psychology and psychiatry, and allied disciplines Olino TM, Michelini G, Mennies RJ, et al. 2021
PubMed Record

Abstract

Mood-state biases in maternal reports of emotional and behavioral problems in their children have been a major concern for the field. However, few studies have addressed this issue from a measurement invariance perspective.

Journal

Journal of child psychology and psychiatry, and allied disciplines

Published

2021/02/26

Authors

Olino TM, Michelini G, Mennies RJ, Kotov R, Klein DN

Keywords

Maternal bias, maternal psychopathology, youth psychopathology

DOI

10.1111/jcpp.13394
Toggle Association Between Habitual Snoring and Cognitive Performance Among a Large Sample of Preadolescent Children. JAMA otolaryngology-- head & neck surgery Isaiah A, Ernst T, Cloak CC, et al. 2021
PubMed Record

Abstract

Previous studies have identified an association between habitual snoring and lower cognitive performance in children. However, whether and to what extent this association is confounded by pertinent demographic, anthropometric, and socioeconomic characteristics is unknown.

Journal

JAMA otolaryngology-- head & neck surgery

Published

2021/02/25

Authors

Isaiah A, Ernst T, Cloak CC, Clark DB, Chang L

Keywords

DOI

10.1001/jamaoto.2020.5712
Toggle Preliminary analysis of low-level alcohol use and suicidality with children in the adolescent brain and cognitive development (ABCD) baseline cohort. Psychiatry research Aguinaldo LD, Goldstone A, Hasler BP, et al. 2021
PubMed Record

Abstract

Cross-sectional analyses were conducted in the baseline cohort of the Adolescent Brain and Cognitive Development (ABCD) Study to determine if lifetime low-level alcohol use was associated with an increased likelihood of lifetime suicidality (N=10,773, ages 9-10). Among the lifetime suicide ideation and attempt groups, 37.7% and 36.2% reported lifetime low-level alcohol use, respectively; versus 22.2% in the non-suicidality group. Children reporting lifetime alcohol use (i.e., ≥ a sip) showed a nearly two-fold increase in their odds of lifetime suicidality compared to those with no previous alcohol use. Future prospective research with this cohort will continue to probe alcohol-suicidality associations.

Journal

Psychiatry research

Published

2021/02/23

Authors

Aguinaldo LD, Goldstone A, Hasler BP, Brent DA, Coronado C, Jacobus J

Keywords

Children, Substance use, Suicide prevention

DOI

10.1016/j.psychres.2021.113825
Toggle Correspondence Between Perceived Pubertal Development and Hormone Levels in 9-10 Year-Olds From the Adolescent Brain Cognitive Development Study. Frontiers in endocrinology Herting MM, Uban KA, Gonzalez MR, et al. 2021
PubMed Record

Abstract

To examine individual variability between perceived physical features and hormones of pubertal maturation in 9-10-year-old children as a function of sociodemographic characteristics.

Journal

Frontiers in endocrinology

Published

2021/02/18

Authors

Herting MM, Uban KA, Gonzalez MR, Baker FC, Kan EC, Thompson WK, Granger DA, Albaugh MD, Anokhin AP, Bagot KS, Banich MT, Barch DM, Baskin-Sommers A, Breslin FJ, Casey BJ, Chaarani B, Chang L, Clark DB, Cloak CC, Constable RT, Cottler LB, Dagher RK, Dapretto M, Dick AS, Dosenbach N, Dowling GJ, Dumas JA, Edwards S, Ernst T, Fair DA, Feldstein-Ewing SW, Freedman EG, Fuemmeler BF, Garavan H, Gee DG, Giedd JN, Glaser PEA, Goldstone A, Gray KM, Hawes SW, Heath AC, Heitzeg MM, Hewitt JK, Heyser CJ, Hoffman EA, Huber RS, Huestis MA, Hyde LW, Infante MA, Ivanova MY, Jacobus J, Jernigan TL, Karcher NR, Laird AR, LeBlanc KH, Lisdahl K, Luciana M, Luna B, Maes HH, Marshall AT, Mason MJ, McGlade EC, Morris AS, Nagel BJ, Neigh GN, Palmer CE, Paulus MP, Potter AS, Puttler LI, Rajapakse N, Rapuano K, Reeves G, Renshaw PF, Schirda C, Sher KJ, Sheth C, Shilling PD, Squeglia LM, Sutherland MT, Tapert SF, Tomko RL, Yurgelun-Todd D, Wade NE, Weiss SRB, Zucker RA, Sowell ER

Keywords

adolescent brain cognitive development, dehydroepiandrosterone, estradiol, pubertal development scale, puberty, salivary hormones, testosterone

DOI

10.3389/fendo.2020.549928
Toggle The association between child alcohol sipping and alcohol expectancies in the ABCD study. Drug and alcohol dependence Murphy MA, Dufour SC, Gray JC 2021
PubMed Record

Abstract

Underage drinking is a serious societal concern, yet relatively little is known about child sipping of alcohol and its relation to beliefs about alcohol. The current study aimed to (1) examine the contexts in which the first sip of alcohol occurs (e.g., type of alcohol, who provided sip, sip offered or taken without permission); (2) examine the association between sipping and alcohol expectancies; and (3) explore how different contexts of sipping are related to alcohol expectancies. We expected to find that children who had sipped alcohol would have increased positive expectancies and reduced negative expectancies compared to children who had never sipped alcohol.

Journal

Drug and alcohol dependence

Published

2021/02/16

Authors

Murphy MA, Dufour SC, Gray JC

Keywords

ABCD, Alcohol, Alcohol expectancies, Alcohol use, Child alcohol sipping, Drinking

DOI

10.1016/j.drugalcdep.2021.108624
Toggle The General Factor of Psychopathology in the Adolescent Brain Cognitive Development (ABCD) Study: A Comparison of Alternative Modeling Approaches. Clinical psychological science : a journal of the Association for Psychological Science Clark DA, Hicks BM, Angstadt M, et al. 2021
PubMed Record

Abstract

Many models of psychopathology include a single general factor of psychopathology (GFP) or ” factor” to account for covariation across symptoms. The Adolescent Brain Cognitive Development (ABCD) Study provides a rich opportunity to study the development of the GFP. However, a variety of approaches for modeling the GFP have emerged, raising questions about how modeling choices impact estimated GFP scores. We used the ABCD baseline assessment (ages 9-10 years-old; =11,875) of the parent-rated Child Behavior Checklist (CBCL) to examine the implications of modeling the GFP using items versus scales; using a priori CBCL scales versus data-driven dimensions; and using bifactor, higher-order, or single-factor models. Children’s rank-ordering on the GFP was stable across models, with GFP scores similarly related to criterion variables. Results suggest that while theoretical debates about modeling the GFP continue, the practical implications of these choices for rank-ordering children and assessing external associations will often be modest.

Journal

Clinical psychological science : a journal of the Association for Psychological Science

Published

2021/02/16

Authors

Clark DA, Hicks BM, Angstadt M, Rutherford S, Taxali A, Hyde L, Weigard A, Heitzeg MM, Sripada C

Keywords

Adolescent Brain Cognitive Development Study (ABCD), Bifactor Model, Child Behavior Checklist (CBCL), General Factor of Psychopathology, p factor

DOI

10.1177/2167702620959317
Toggle Quadratic relations of BMI with depression and brain volume in children: Analysis of data from the ABCD study. Journal of psychiatric research Bohon C, Welch H 2021
PubMed Record

Abstract

Weight-related health conditions and depression peak during adolescence and show relations with brain structure. Understanding how these conditions relate to each other prior to adolescence may guide research on the co-development of unhealthy weight conditions (both underweight and overweight) and depression, with a potential brain-based link. This study examines the cross-sectional relations between body mass index (BMI), depressive symptoms, and brain volume (total and regional) to determine whether BMI has a linear or quadratic relation with depressive symptoms and brain volume and how depressive symptoms and brain volume are related.

Journal

Journal of psychiatric research

Published

2021/02/15

Authors

Bohon C, Welch H

Keywords

BMI, Brain volume, Children, Depression, Overweight, Underweight

DOI

10.1016/j.jpsychires.2021.02.038
Toggle Individual Differences in Cognitive Performance Are Better Predicted by Global Rather Than Localized BOLD Activity Patterns Across the Cortex. Cerebral cortex (New York, N.Y. : 1991) Zhao W, Palmer CE, Thompson WK, et al. 2021
PubMed Record

Abstract

Despite its central role in revealing the neurobiological mechanisms of behavior, neuroimaging research faces the challenge of producing reliable biomarkers for cognitive processes and clinical outcomes. Statistically significant brain regions, identified by mass univariate statistical models commonly used in neuroimaging studies, explain minimal phenotypic variation, limiting the translational utility of neuroimaging phenotypes. This is potentially due to the observation that behavioral traits are influenced by variations in neuroimaging phenotypes that are globally distributed across the cortex and are therefore not captured by thresholded, statistical parametric maps commonly reported in neuroimaging studies. Here, we developed a novel multivariate prediction method, the Bayesian polyvertex score, that turns a unthresholded statistical parametric map into a summary score that aggregates the many but small effects across the cortex for behavioral prediction. By explicitly assuming a globally distributed effect size pattern and operating on the mass univariate summary statistics, it was able to achieve higher out-of-sample variance explained than mass univariate and popular multivariate methods while still preserving the interpretability of a generative model. Our findings suggest that similar to the polygenicity observed in the field of genetics, the neural basis of complex behaviors may rest in the global patterning of effect size variation of neuroimaging phenotypes, rather than in localized, candidate brain regions and networks.

Journal

Cerebral cortex (New York, N.Y. : 1991)

Published

2021/02/05

Authors

Zhao W, Palmer CE, Thompson WK, Chaarani B, Garavan HP, Casey BJ, Jernigan TL, Dale AM, Fan CC

Keywords

behavioral prediction, cognition, distributed effect sizes, individual differences, neuroimaging

DOI

10.1093/cercor/bhaa290
Toggle Nonsuicidal self-injury, suicide ideation, and suicide attempts among sexual minority children. Journal of consulting and clinical psychology Blashill AJ, Fox K, Feinstein BA, et al. 2021
PubMed Record

Abstract

Sexual minority adolescents have previously been found to experience disparities in self-injurious thoughts and behaviors (SITBs) compared to heterosexual adolescents. However, there is a paucity of data on SITBs amongst children. Thus, the aim of the current study is to assess the prevalence of SITBs in a large sample of U.S. children and to test whether rates vary by sexual orientation.

Journal

Journal of consulting and clinical psychology

Published

2021/02/01

Authors

Blashill AJ, Fox K, Feinstein BA, Albright CA, Calzo JP

Keywords

DOI

10.1037/ccp0000624
Toggle A High Psychological and Somatic Symptom Profile and Family Health Factors Predict New or Persistent Pain During Early Adolescence. The Clinical journal of pain Voepel-Lewis T, Seng JS, Chen B, et al. 2021
PubMed Record

Abstract

Persistent or recurrent pain is common among adolescents and is associated with poor functioning. The purpose of this study was to determine whether preteens who present with pain, and higher, co-occurring psychological and somatic symptoms (PSS) are at higher risk for persistent pain than other children.

Journal

The Clinical journal of pain

Published

2021/02/01

Authors

Voepel-Lewis T, Seng JS, Chen B, Scott EL

Keywords

DOI

10.1097/AJP.0000000000000896
Toggle Interpreting Interaction Effects in Generalized Linear Models of Nonlinear Probabilities and Counts. Multivariate behavioral research McCabe CJ, Halvorson MA, King KM, et al. 2021
PubMed Record

Abstract

Psychology research frequently involves the study of probabilities and counts. These are typically analyzed using generalized linear models (GLMs), which can produce these quantities via nonlinear transformation of model parameters. Interactions are central within many research applications of these models. To date, typical practice in evaluating interactions for probabilities or counts extends directly from linear approaches, in which evidence of an interaction effect is supported by using the product term coefficient between variables of interest. However, unlike linear models, interaction effects in GLMs describing probabilities and counts are not equal to product terms between predictor variables. Instead, interactions may be functions of the predictors of a model, requiring nontraditional approaches for interpreting these effects accurately. Here, we define interactions as change in a marginal effect of one variable as a function of change in another variable, and describe the use of partial derivatives and discrete differences for quantifying these effects. Using guidelines and simulated examples, we then use these approaches to describe how interaction effects should be estimated and interpreted for GLMs on probability and count scales. We conclude with an example using the Adolescent Brain Cognitive Development Study demonstrating how to correctly evaluate interaction effects in a logistic model.

Journal

Multivariate behavioral research

Published

2021/02/01

Authors

McCabe CJ, Halvorson MA, King KM, Cao X, Kim DS

Keywords

Generalized linear modeling, Poisson, interaction, logistic regression, moderation

DOI

10.1080/00273171.2020.1868966
Toggle Emotional, Behavioral, and Cognitive Correlates of Attention Deficit and Hyperactive Disorder (ADHD) Screening and Diagnosis History: Sex/Gender Differences. Journal of neurology & neuromedicine Assari S 2021
PubMed Record

Abstract

While clinical studies have documented sex differences in emotional, behavioral, and cognitive function of children with Attention Deficit and Hyperactive Disorder (ADHD), it is unknown if these sex differences are due to differences in referral and diagnosis or if they can be also seen when we screen a community sample for ADHD. If these sex differences exist in populations with a diagnosis history but cannot be seen in screening, then they are unfair, preventable, and due to gender (social processes in referral and diagnosis) rather than sex.

Journal

Journal of neurology & neuromedicine

Published

2021/02/01

Authors

Assari S

Keywords

DOI

10.29245/2572.942x/2021/1.1278
Toggle Caffeine exposure in utero is associated with structural brain alterations and deleterious neurocognitive outcomes in 9-10 year old children. Neuropharmacology Christensen ZP, Freedman EG, Foxe JJ 2021
PubMed Record

Abstract

Caffeine, a very widely used and potent neuromodulator, easily crosses the placental barrier, but relatively little is known about the long-term impact of gestational caffeine exposure (GCE) on neurodevelopment. Here, we leverage magnetic resonance imaging (MRI) data, collected from a very large sample of 9157 children, aged 9-10 years, as part of the Adolescent Brain and Cognitive Development (ABCD ®) study, to investigate brain structural outcomes at 27 major fiber tracts as a function of GCE. Significant relationships between GCE and fractional anisotropy (FA) measures in the inferior fronto-occipito fasciculus and corticospinal tract of the left hemisphere (IFOF-LH; CST-LH) were detected via mixed effects binomial regression. We further investigated the interaction between these fiber tracts, GCE, cognitive measures (working memory, task efficiency), and psychopathology measures (externalization, internalization, somatization, and neurodevelopment). GCE was associated with poorer outcomes on all measures of psychopathology but had negligible effect on cognitive measures. Higher FA values in both fiber tracts were associated with decreased neurodevelopmental problems and improved performance on both cognitive tasks. We also identified a decreased association between FA in the CST-LH and task efficiency in the GCE group. These findings suggest that GCE can lead to future neurodevelopmental complications and that this occurs, in part, through alteration of the microstructure of critical fiber tracts such as the IFOF-LH and CST-LH. These data suggest that current guidelines regarding limiting caffeine intake during pregnancy may require some recalibration.

Journal

Neuropharmacology

Published

2021/01/30

Authors

Christensen ZP, Freedman EG, Foxe JJ

Keywords

Brain development, Caffeine, Children and adolescents, Diffusion tensor imaging, White matter

DOI

10.1016/j.neuropharm.2021.108479
Toggle Decomposing complex links between the childhood environment and brain structure in school-aged youth. Developmental cognitive neuroscience Hong SJ, Sisk LM, Caballero C, et al. 2021
PubMed Record

Abstract

Childhood experiences play a profound role in conferring risk and resilience for brain and behavioral development. However, how different facets of the environment shape neurodevelopment remains largely unknown. Here we sought to decompose heterogeneous relationships between environmental factors and brain structure in 989 school-aged children from the Adolescent Brain Cognitive Development Study. We applied a cross-modal integration and clustering approach called ‘Similarity Network Fusion’, which combined two brain morphometrics (i.e., cortical thickness and myelin-surrogate markers), and key environmental factors (i.e., trauma exposure, neighborhood safety, school environment, and family environment) to identify homogeneous subtypes. Depending on the subtyping resolution, results identified two or five subgroups, each characterized by distinct brain structure-environment profiles. Notably, more supportive caregiving and school environments were associated with greater myelination, whereas less supportive caregiving, higher family conflict and psychopathology, and higher perceived neighborhood safety were observed with greater cortical thickness. These subtypes were highly reproducible and predicted externalizing symptoms and overall mental health problems. Our findings support the theory that distinct environmental exposures are differentially associated with alterations in structural neurodevelopment. Delineating more precise associations between risk factors, protective factors, and brain development may inform approaches to enhance risk identification and optimize interventions targeting specific experiences.

Journal

Developmental cognitive neuroscience

Published

2021/01/22

Authors

Hong SJ, Sisk LM, Caballero C, Mekhanik A, Roy AK, Milham MP, Gee DG

Keywords

Adversity, Brain development, Childhood, Environment, Neuroanatomy, Subtyping

DOI

10.1016/j.dcn.2021.100919
Toggle Multimodal Neuroimaging of Suicidal Thoughts and Behaviors in a U.S. Population-Based Sample of School-Age Children. The American journal of psychiatry Vidal-Ribas P, Janiri D, Doucet GE, et al. 2021
PubMed Record

Abstract

Suicide deaths and suicidal thoughts and behaviors are considered a public health emergency, yet their underpinnings in the brain remain elusive. The authors examined the classification accuracy of individual, environmental, and clinical characteristics, as well as multimodal brain imaging correlates, of suicidal thoughts and behaviors in a U.S. population-based sample of school-age children.

Journal

The American journal of psychiatry

Published

2021/01/21

Authors

Vidal-Ribas P, Janiri D, Doucet GE, Pornpattananangkul N, Nielson DM, Frangou S, Stringaris A

Keywords

Children, Neuroimaging, Risk Factors, Suicide

DOI

10.1176/appi.ajp.2020.20020120
Toggle Association of gray matter volumes with general and specific dimensions of psychopathology in children. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Durham EL, Jeong HJ, Moore TM, et al. 2021
PubMed Record

Abstract

Childhood is an important time for the manifestation of psychopathology. Psychopathology is characterized by considerable comorbidity which is mirrored in the underlying neural correlates of psychopathology. Both common and dissociable variations in brain volume have been found across multiple mental disorders in adult and youth samples. However, the majority of these studies used samples with broad age ranges which may obscure developmental differences. The current study examines associations between regional gray matter volumes (GMV) and psychopathology in a large sample of children with a narrowly defined age range. We used data from 9607 children 9-10 years of age collected as part of the Adolescent Brain Cognitive Development Study (ABCD Study). A bifactor model identified a general psychopathology factor that reflects common variance across disorders and specific factors representing internalizing symptoms, ADHD symptoms, and conduct problems. Brain volume was acquired using 3T MRI. After correction for multiple testing, structural equation modeling revealed nearly global inverse associations between regional GMVs and general psychopathology and conduct problems, with associations also found for ADHD symptoms (p-values ≤ 0.048). Age, sex, and race were included as covariates. Sensitivity analyses including total GMV or intracranial volume (ICV) as covariates support this global association, as a large majority of region-specific results became nonsignificant. Sensitivity analyses including income, parental education, and medication use as additional covariates demonstrate largely convergent results. These findings suggest that globally smaller GMVs are a nonspecific risk factor for general psychopathology, and possibly for conduct problems and ADHD as well.

Journal

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Published

2021/01/21

Authors

Durham EL, Jeong HJ, Moore TM, Dupont RM, Cardenas-Iniguez C, Cui Z, Stone FE, Berman MG, Lahey BB, Kaczkurkin AN

Keywords

DOI

10.1038/s41386-020-00952-w
Toggle Multimethod investigation of the neurobiological basis of ADHD symptomatology in children aged 9-10: baseline data from the ABCD study. Translational psychiatry Owens MM, Allgaier N, Hahn S, et al. 2021
PubMed Record

Abstract

Attention deficit/hyperactivity disorder is associated with numerous neurocognitive deficits, including poor working memory and difficulty inhibiting undesirable behaviors that cause academic and behavioral problems in children. Prior work has attempted to determine how these differences are instantiated in the structure and function of the brain, but much of that work has been done in small samples, focused on older adolescents or adults, and used statistical approaches that were not robust to model overfitting. The current study used cross-validated elastic net regression to predict a continuous measure of ADHD symptomatology using brain morphometry and activation during tasks of working memory, inhibitory control, and reward processing, with separate models for each MRI measure. The best model using activation during the working memory task to predict ADHD symptomatology had an out-of-sample R = 2% and was robust to residualizing the effects of age, sex, race, parental income and education, handedness, pubertal status, and internalizing symptoms from ADHD symptomatology. This model used reduced activation in task positive regions and reduced deactivation in task negative regions to predict ADHD symptomatology. The best model with morphometry alone predicted ADHD symptomatology with an R = 1% but this effect dissipated when including covariates. The inhibitory control and reward tasks did not yield generalizable models. In summary, these analyses show, with a large and well-characterized sample, that the brain correlates of ADHD symptomatology are modest in effect size and captured best by brain morphometry and activation during a working memory task.

Journal

Translational psychiatry

Published

2021/01/18

Authors

Owens MM, Allgaier N, Hahn S, Yuan D, Albaugh M, Adise S, Chaarani B, Ortigara J, Juliano A, Potter A, Garavan H

Keywords

DOI

10.1038/s41398-020-01192-8
Toggle Retaining Adolescent and Young Adult Participants in Research During a Pandemic: Best Practices From Two Large-Scale Developmental Neuroimaging Studies (NCANDA and ABCD). Frontiers in behavioral neuroscience Nooner KB, Chung T, Feldstein Ewing SW, et al. 2021
PubMed Record

Abstract

The novel coronavirus pandemic that emerged in late 2019 (COVID-19) has created challenges not previously experienced in human research. This paper discusses two large-scale NIH-funded multi-site longitudinal studies of adolescents and young adults – the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) and the Adolescent Brain Cognitive Development (ABCD) Study – and valuable approaches to learn about adaptive processes for conducting developmentally sensitive research with neuroimaging and neurocognitive testing across consortia during a global pandemic. We focus on challenges experienced during the pandemic and modifications that may guide other projects, such as implementing adapted protocols that protect the safety of participants and research staff, and addressing assessment challenges through the use of strategies such as remote and mobile assessments. Given the pandemic’s disproportionate impacts on participants typically underrepresented in research, we describe efforts to retain these individuals. The pandemic provides an opportunity to develop adaptive processes that can facilitate future studies’ ability to mobilize effectively and rapidly.

Journal

Frontiers in behavioral neuroscience

Published

2021/01/18

Authors

Nooner KB, Chung T, Feldstein Ewing SW, Brumback T, Arwood Z, Tapert SF, Brown SA, Cottler L

Keywords

adolescent, developmental, longitudinal, neuroimaging, pandemic, retention, young adult

DOI

10.3389/fnbeh.2020.597902
Toggle Typologies of Family Functioning and 24-h Movement Behaviors. International journal of environmental research and public health Guerrero MD, Barnes JD, Tremblay MS, et al. 2021
PubMed Record

Abstract

Research on the importance of the family environment on children’s health behaviors is ubiquitous, yet critical gaps in the literature exist. Many studies have focused on one family characteristic and have relied on variable-centered approaches as opposed to person-centered approaches (e.g., latent profile analysis). The purpose of the current study was to use latent profile analysis to identify family typologies characterized by parental acceptance, parental monitoring, and family conflict, and to examine whether such typologies are associated with the number of movement behavior recommendations (i.e., physical activity, screen time, and sleep) met by children. Data for this cross-sectional observational study were part of the baseline data from the Adolescent Brain Cognitive Development (ABCD) study. Data were collected across 21 study sites in the United States. Participants included 10,712 children (female = 5143, males = 5578) aged 9 and 10 years (M = 9.91, SD = 0.62). Results showed that children were meaningfully classified into one of five family typologies. Children from families with and (P2; OR = 0.54; 95% CI, 0.39-0.76); , , and (P3; OR = 0.28; 95% CI, 0.20, 0.40); , , and (P4; OR = 0.24; 95% CI, 0.16, 0.36); and , , and (P5; OR = 0.19; 95% CI, 0.12-0.29) were less likely to meet all three movement behavior recommendations compared to children from families with , , and (P1). These findings highlight the importance of the family environment for promoting healthy movement behaviors among children.

Journal

International journal of environmental research and public health

Published

2021/01/15

Authors

Guerrero MD, Barnes JD, Tremblay MS, Pulkki-Råback L

Keywords

children, family environment, latent profile analysis, physical activity, screen time, sleep

DOI

10.3390/ijerph18020699
Toggle Differentiated nomological networks of internalizing, externalizing, and the general factor of psychopathology (' factor') in emerging adolescence in the ABCD study. Psychological medicine Brislin SJ, Martz ME, Joshi S, et al. 2021
PubMed Record

Abstract

Structural models of psychopathology consistently identify internalizing (INT) and externalizing (EXT) specific factors as well as a superordinate factor that captures their shared variance, the factor. Questions remain, however, about the meaning of these data-driven dimensions and the interpretability and distinguishability of the larger nomological networks in which they are embedded.

Journal

Psychological medicine

Published

2021/01/14

Authors

Brislin SJ, Martz ME, Joshi S, Duval ER, Gard A, Clark DA, Hyde LW, Hicks BM, Taxali A, Angstadt M, Rutherford S, Heitzeg MM, Sripada C

Keywords

ABCD study, emerging adolescence, externalizing, general factor of psychopathology, internalizing, p factor

DOI

10.1017/S0033291720005103
Toggle Risk factors associated with curiosity about alcohol use in the ABCD cohort. Alcohol (Fayetteville, N.Y.) Wade NE, Palmer CE, Gonzalez MR, et al. 2021
PubMed Record

Abstract

Curiosity and intent to use alcohol in pre-adolescence is a risk factor for later experimentation and use, yet we know little of how curiosity about use develops. Here, we examine factors that may influence curiosity about alcohol use, as it may be an important predictor of later drinking behavior. Cross-sectional data on youth ages 10-11 from the ongoing Adolescent Brain Cognitive Development℠ (ABCD) Study Year 1 follow-up were used (n = 2,334; NDA 2.0.1). All participants were substance-naïve at time of assessment. Group factor analysis identified latent factors across common indicators of risk for early substance use (i.e., psychopathology and trait characteristics; substance use attitudes/behaviors; neurocognition; family and environment). Logistic mixed-effect models tested associations between latent factors of risk for early substance use and curiosity about alcohol use, controlling for demographics and study site. Two multidimensional factors were significantly inversely and positively associated with greater curiosity about alcohol use, respectively: 1) low internalizing and externalizing symptomatology coupled with low impulsivity, perceived neighborhood safety, negative parental history of alcohol use problems, and fewer adverse life experiences and family conflict; and 2) low perceived risk of alcohol use coupled with lack of peer disapproval of use. When assessing all risk factors in an overall regression, lack of perceived harm from trying alcohol once or twice was associated with greater likelihood of alcohol curiosity. Taken together, perceptions that alcohol use causes little harm and having peers with similar beliefs is related to curiosity about alcohol use among substance-naïve 10-11-year-olds. General mental health and environmental risk factors similarly increase the odds of curiosity for alcohol. Identification of multidimensional risk factors for early alcohol use may point to novel prevention and early intervention targets. Future longitudinal investigations in the ABCD cohort will determine the extent to which these factors and curiosity predict alcohol use among youth.

Journal

Alcohol (Fayetteville, N.Y.)

Published

2021/01/09

Authors

Wade NE, Palmer CE, Gonzalez MR, Wallace AL, Infante MA, Tapert SF, Jacobus J, Bagot KS

Keywords

alcohol, alcohol curiosity, children, intent to use, pre-adolescent

DOI

10.1016/j.alcohol.2021.01.002
Toggle Powering and Structuring Intersectionality: Beyond Main and Interactive Associations. Research on child and adolescent psychopathology Del Río-González AM, Holt SL, Bowleg L 2021
PubMed Record

Abstract

It is exciting to watch intersectionality travel from its roots in Black feminist activism and critical legal studies to increasingly more mainstream research domains such as psychology and psychopathology. We commend Mennies et al. (Journal of Abnormal Child Psychology, 2020) for their application of the intersectionality framework to the study of psychopathology and treatment utilization in youth in the ABCD study. We argue, however, that this application falls short of its intersectional promise. We discuss some conceptual and methodological/analytical issues that evidence the focal article’s lack of alignment with intersectionality’s core tenets, particularly regarding the central role of power and social-structural factors as drivers of inequities across intersectional positions. Specifically, we discuss our concerns with the testing and flattening of intersectionality, the selection and operationalization of intersectional positions, and the use of conventional regression models as quantitative analytical approach. We end by suggesting ways that intersectionality can help reduce the inequities in psychopathology and treatment utilization identified by Mennies et al. (Journal of Abnormal Child Psychology, 2020).

Journal

Research on child and adolescent psychopathology

Published

2021/01/06

Authors

Del Río-González AM, Holt SL, Bowleg L

Keywords

Interactive effects models, Intersectionality, Multiple main effects models, Quantitative intersectionality

DOI

10.1007/s10802-020-00720-w
Toggle Family Processes and Child Psychopathology: A Between- and Within-Family/Child Analysis. Research on child and adolescent psychopathology Lin SY, Schleider JL, Eaton NR 2021
PubMed Record

Abstract

A vast array of family processes is linked to child mental development, among which (1) low parental acceptance and (2) high family conflict are known as transdiagnostic risk factors for child internalizing and externalizing psychopathology. In contrast to most prior research adopting cross-sectional or lagged designs, the current study applied fine-grained multilevel modeling to elucidate the complex relationships among parental acceptance, family conflict, and child psychopathology, considering the nesting structure of children within families and longitudinal changes within children. We focused on preadolescents from the two-wave Adolescent Brain Cognitive Development Study (N = 4,953; aged 9-12) and accounted for parental psychopathology and sex differences. Our findings suggest that consistent between-family and between-child differences in parental acceptance play a transdiagnostic role for both child internalizing and externalizing psychopathology, whereas family conflict is only significantly associated with externalizing psychopathology. Additionally, short-term within-family and within-child improvements in parental acceptance and family conflict across one year were associated with decreased externalizing, but not internalizing, psychopathology. These findings support the potential importance and feasibility of targeting these family process factors for child externalizing problems outside of an intensive treatment setting. We further discussed how such findings serve as a foundation for future research on family processes and child internalizing problems. The varying results across different grouping levels highlight the importance of decomposing within- from between-family/child effects in future studies on family processes and child psychopathology.

Journal

Research on child and adolescent psychopathology

Published

2021/01/06

Authors

Lin SY, Schleider JL, Eaton NR

Keywords

Externalizing psychopathology, Family process, Internalizing, Parenting, Preadolescent

DOI

10.1007/s10802-020-00749-x
Toggle Cingulo-opercular and Cingulo-parietal Brain Networks Functional Connectivity in Pre-adolescents: Multiplicative Effects of Race, Ethnicity, and Parental Education. Research in health science Assari S 2021
PubMed Record

Abstract

A growing body of research has shown a diminished association between socioeconomic status (SES) indicators and a wide range of neuroimaging indicators for racial and ethnic minorities compared to majority groups. However, less is known about these effects for resting-state functional connectivity between various brain networks.

Journal

Research in health science

Published

2021/01/01

Authors

Assari S

Keywords

MRI, brain development, functional MRI, functional connectivity, parental education, pre-adolescents, socioeconomic status, youth

DOI

10.22158/rhs.v6n2p76
Toggle The Main and Interactive Associations between Demographic Factors and Psychopathology and Treatment Utilization in Youth: A Test of Intersectionality in the ABCD Study. Research on child and adolescent psychopathology Mennies RJ, Birk SL, Norris LA, et al. 2021
PubMed Record

Abstract

Demographic factors may be associated with youth psychopathology due to social-contextual factors that may also pose barriers to intervention. Further, in line with intersectionality theory, youth with multiple non-dominant identities may be most likely to experience psychopathology and face barriers to care. This study examined rates of parent-reported psychopathology and mental health treatment utilization as a function of several demographic characteristics (in isolation and in concert) in a population-based, demographically diverse sample of 11,875 9- to 10-year-old youth. Results indicated most consistently that lower SES was associated with greater rates of psychopathology and greater likelihood of treatment utilization; that Asian American youth (relative to all other racial groups) and Hispanic/Latinx (relative to non-Hispanic/Latinx) youth were less likely to have a history of psychopathology or to have utilized treatment; and that male youth had greater rates of lifetime Obsessive Compulsive Disorder (OCD) and Oppositional Defiant Disorder (ODD) and were more likely to have utilized treatment. There was more modest support for interactive effects between demographic factors on psychopathology, which are discussed. The present study provides some support for differential rates of parent-reported psychopathology and treatment utilization as a function of demographic identities in youth. Potential explanations for these differences (e.g., cultural differences in symptom presentation; underreporting of symptoms) are discussed.

Journal

Research on child and adolescent psychopathology

Published

2021/01/01

Authors

Mennies RJ, Birk SL, Norris LA, Olino TM

Keywords

Adolescent, Epidemiology, Ethnicity, Psychopathology, Race, SES

DOI

10.1007/s10802-020-00687-8
Toggle Associations Between Prenatal Cannabis Exposure and Childhood Outcomes: Results From the ABCD Study. JAMA psychiatry Paul SE, Hatoum AS, Fine JD, et al. 2021
PubMed Record

Abstract

In light of increasing cannabis use among pregnant women, the US Surgeon General recently issued an advisory against the use of marijuana during pregnancy.

Journal

JAMA psychiatry

Published

2021/01/01

Authors

Paul SE, Hatoum AS, Fine JD, Johnson EC, Hansen I, Karcher NR, Moreau AL, Bondy E, Qu Y, Carter EB, Rogers CE, Agrawal A, Barch DM, Bogdan R

Keywords

DOI

10.1001/jamapsychiatry.2020.2902
Toggle Parental Education or Household Income? Which Socioeconomic Status Indicator Can Better Reduce Body Mass Index Disparities among Latino Children? Journal of economics and public finance Assari S, Malek-Ahmadi MR, Caldwell CH 2021
PubMed Record

Abstract

We compared the effects of parental education and household income on children’s body mass index (BMI) in Hispanic White (HW) and non-Hispanic White (NHW) families.

Journal

Journal of economics and public finance

Published

2021/01/01

Authors

Assari S, Malek-Ahmadi MR, Caldwell CH

Keywords

body mass index (BMI), children, ethnicity, obesity, socioeconomic status

DOI

10.22158/jepf.v7n1p19