ABCD Study publications are authored by ABCD investigators, collaborators, and non-ABCD researchers. The analysis methodologies, findings, and interpretations expressed in these publications are those of the authors and do not constitute an endorsement by the ABCD Study®.
Please note that the publications listed here include empirical as well as non-empirical papers (e.g., focused review articles, editorials).
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Title | Journal | Authors | Year | Details |
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Toggle | Decoupling Sleep and Brain Size in Childhood: An Investigation of Genetic Covariation in the Adolescent Brain Cognitive Development Study. | Biological psychiatry global open science | Hernandez LM, Kim M, Hernandez C, et al. | 2022 | |
PubMed Record
AbstractChildhood sleep problems are common and among the most frequent and impairing comorbidities of childhood psychiatric disorders. In adults, sleep disturbances are heritable and show strong genetic associations with brain morphology; however, little is known about the genetic architecture of childhood sleep and potential etiological links between sleep, brain development, and pediatric-onset psychiatric symptoms. JournalBiological psychiatry global open sciencePublished2022/01/17AuthorsHernandez LM, Kim M, Hernandez C, Thompson W, Fan CC, Galván A, Dapretto M, Bookheimer SY, Fuligni A, Gandal MJKeywordsADHD, Brain, Childhood, Genetics, Heritability, InsomniaDOI10.1016/j.bpsgos.2021.12.011 |
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Toggle | Corrigendum to "Microstructural development from 9 to 14 years: Evidence from the ABCD Study" [Dev. Cognit. Neurosci. 53 (2022) 101044]. | Developmental cognitive neuroscience | Palmer CE, Pecheva D, Iversen JR, et al. | 2022 | |
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AbstractJournalDevelopmental cognitive neurosciencePublished2022/01/14AuthorsPalmer CE, Pecheva D, Iversen JR, Hagler DJ, Sugrue L, Nedelec P, Fan CC, Thompson WK, Jernigan TL, Dale AMKeywordsDOI10.1016/j.dcn.2022.101063 |
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Toggle | General Psychopathology, Cognition, and the Cerebral Cortex in 10-Year-Old Children: Insights From the Adolescent Brain Cognitive Development Study. | Frontiers in human neuroscience | Patel Y, Parker N, Salum GA, et al. | 2022 | |
PubMed Record
AbstractGeneral psychopathology and cognition are likely to have a bidirectional influence on each other. Yet, the relationship between brain structure, psychopathology, and cognition remains unclear. This brief report investigates the association between structural properties of the cerebral cortex [surface area, cortical thickness, intracortical myelination indexed by the T1w/T2w ratio, and neurite density assessed by restriction spectrum imaging (RSI)] with general psychopathology and cognition in a sample of children from the Adolescent Brain Cognitive Development (ABCD) study. Higher levels of psychopathology and lower levels of cognitive ability were associated with a smaller cortical surface area. Inter-regionally-across the cerebral cortex-the strength of association between an area and psychopathology is strongly correlated with the strength of association between an area and cognition. Taken together, structural deviations particularly observed in the cortical surface area influence both psychopathology and cognition. JournalFrontiers in human neurosciencePublished2022/01/13AuthorsPatel Y, Parker N, Salum GA, Pausova Z, Paus TKeywordsMRI, brain development, cerebral cortex, cohort, growthDOI10.3389/fnhum.2021.781554 |
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Toggle | Associations between cognition and polygenic liability to substance involvement in middle childhood: Results from the ABCD study. | Drug and alcohol dependence | Paul SE, Hatoum AS, Barch DM, et al. | 2022 | |
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AbstractCognition is robustly associated with substance involvement. This relationship is attributable to multiple factors, including genetics, though such contributions show inconsistent patterns in the literature. For instance, genome-wide association studies point to potential positive relationships between educational achievement and common substance use but negative relationships with heavy and/or problematic substance use. JournalDrug and alcohol dependencePublished2022/01/10AuthorsPaul SE, Hatoum AS, Barch DM, Thompson WK, Agrawal A, Bogdan R, Johnson ECKeywordsCognitive ability, Polygenic risk, Substance use, Substance use disorderDOI10.1016/j.drugalcdep.2022.109277 |
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Toggle | Brain morphometry points to emerging patterns of psychosis, depression, and anxiety vulnerability over a 2-year period in childhood. | Psychological medicine | Vargas TG, Mittal VA | 2022 | |
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AbstractGray matter morphometry studies have lent seminal insights into the etiology of mental illness. Existing research has primarily focused on adults and then, typically on a single disorder. Examining brain characteristics in late childhood, when the brain is preparing to undergo significant adolescent reorganization and various forms of serious psychopathology are just first emerging, may allow for a unique and highly important perspective of overlapping and unique pathogenesis. JournalPsychological medicinePublished2022/01/07AuthorsVargas TG, Mittal VAKeywordsAnxiety, MRI, depression, neural, neuroimaging, psychosis, schizophreniaDOI10.1017/S0033291721005304 |
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Toggle | Measurement of gender and sexuality in the Adolescent Brain Cognitive Development (ABCD) study. | Developmental cognitive neuroscience | Potter AS, Dube SL, Barrios LC, et al. | 2022 | |
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AbstractThe Adolescent Brain Cognitive Development (ABCD) study is a longitudinal study of adolescent brain development and health that includes over 11,800 youth in the United States. The ABCD study includes broad developmental domains, and gender and sexuality are two of these with noted changes across late childhood and early adolescence. The Gender Identity and Sexual Health (GISH) workgroup recommends measures of gender and sexuality for the ABCD study, prioritizing those that are developmentally sensitive, capture individual differences in the experience of gender and sexuality, and minimize participant burden. This manuscript describes the gender and sexuality measures used in ABCD and provides guidance for researchers using these data. Data showing the utility of these measures and longitudinal trends are presented. Including assessment of gender and sexuality in ABCD allows for characterization of developmental trajectories of gender and sexuality, and the broad scope of ABCD data collection allows examination of identity development in an intersectional manner. JournalDevelopmental cognitive neurosciencePublished2022/01/04AuthorsPotter AS, Dube SL, Barrios LC, Bookheimer S, Espinoza A, Feldstein Ewing SW, Freedman EG, Hoffman EA, Ivanova M, Jefferys H, McGlade EC, Tapert SF, Johns MMKeywordsABCD, Adolescent Brain Cognitive Development, Gender, SexualityDOI10.1016/j.dcn.2022.101057 |
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Toggle | Adolescent Verbal Memory as a Psychosis Endophenotype: A Genome-Wide Association Study in an Ancestrally Diverse Sample. | Genes | Wang B, Giannakopoulou O, Austin-Zimmerman I, et al. | 2022 | |
PubMed Record
AbstractVerbal memory impairment is one of the most prominent cognitive deficits in psychosis. However, few studies have investigated the genetic basis of verbal memory in a neurodevelopmental context, and most genome-wide association studies (GWASs) have been conducted in European-ancestry populations. We conducted a GWAS on verbal memory in a maximum of 11,017 participants aged 8.9 to 11.1 years in the Adolescent Brain Cognitive Development Study, recruited from a diverse population in the United States. Verbal memory was assessed by the Rey Auditory Verbal Learning Test, which included three measures of verbal memory: immediate recall, short-delay recall, and long-delay recall. We adopted a mixed-model approach to perform a joint GWAS of all participants, adjusting for ancestral background and familial relatedness. The inclusion of participants from all ancestries increased the power of the GWAS. Two novel genome-wide significant associations were found for short-delay and long-delay recall verbal memory. In particular, one locus (rs9896243) associated with long-delay recall was mapped to the NSF (N-Ethylmaleimide Sensitive Factor, Vesicle Fusing ATPase) gene, indicating the role of membrane fusion in adolescent verbal memory. Based on the GWAS in the European subset, we estimated the SNP-heritability to be 15% to 29% for the three verbal memory traits. We found that verbal memory was genetically correlated with schizophrenia, providing further evidence supporting verbal memory as an endophenotype for psychosis. JournalGenesPublished2022/01/03AuthorsWang B, Giannakopoulou O, Austin-Zimmerman I, Irizar H, Harju-Seppänen J, Zartaloudi E, Bhat A, McQuillin A, Kuchenbäcker K, Bramon EKeywordsendophenotype, genome-wide association study, neurodevelopment, psychosis, schizophrenia, verbal memoryDOI10.3390/genes13010106 |
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Toggle | Screen Time Use Among US Adolescents During the COVID-19 Pandemic: Findings From the Adolescent Brain Cognitive Development (ABCD) Study. | JAMA pediatrics | Nagata JM, Cortez CA, Cattle CJ, et al. | 2022 | |
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AbstractThis cross-sectional study reviews findings from the Adolescent Brain Cognitive Development (ABCD) Study on digital media use by US youths during the COVID-19 pandemic. JournalJAMA pediatricsPublished2022/01/01AuthorsNagata JM, Cortez CA, Cattle CJ, Ganson KT, Iyer P, Bibbins-Domingo K, Baker FCKeywordsDOI10.1001/jamapediatrics.2021.4334 |
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Toggle | Reducing the Effects of Motion Artifacts in fMRI: A Structured Matrix Completion Approach. | IEEE transactions on medical imaging | Balachandrasekaran A, Cohen AL, Afacan O, et al. | 2021 | |
PubMed Record
AbstractFunctional MRI (fMRI) is widely used to study the functional organization of normal and pathological brains. However, the fMRI signal may be contaminated by subject motion artifacts that are only partially mitigated by motion correction strategies. These artifacts lead to distance-dependent biases in the inferred signal correlations. To mitigate these spurious effects, motion-corrupted volumes are censored from fMRI time series. Censoring can result in discontinuities in the fMRI signal, which may lead to substantial alterations in functional connectivity analysis. We propose a new approach to recover the missing entries from censoring based on structured low rank matrix completion. We formulated the artifact-reduction problem as the recovery of a super-resolved matrix from unprocessed fMRI measurements. We enforced a low rank prior on a large structured matrix, formed from the samples of the time series, to recover the missing entries. The recovered time series, in addition to being motion compensated, are also slice-time corrected at a fine temporal resolution. To achieve a fast and memory-efficient solution for our proposed optimization problem, we employed a variable splitting strategy. We validated the algorithm with simulations, data acquired under different motion conditions, and datasets from the ABCD study. Functional connectivity analysis showed that the proposed reconstruction resulted in connectivity matrices with lower errors in pair-wise correlation than non-censored and censored time series based on a standard processing pipeline. In addition, seed-based correlation analyses showed improved delineation of the default mode network. These demonstrate that the method can effectively reduce the adverse effects of motion in fMRI analysis. JournalIEEE transactions on medical imagingPublished2021/12/30AuthorsBalachandrasekaran A, Cohen AL, Afacan O, Warfield SK, Gholipour AKeywordsDOI10.1109/TMI.2021.3107829 |
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Toggle | Moderate-to-vigorous intensity physical activity among adolescents in the USA during the COVID-19 pandemic. | Preventive medicine reports | Nagata JM, Cortez CA, Dooley EE, et al. | 2021 | |
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AbstractThis study aimed to evaluate adolescents’ moderate-to-vigorous intensity physical activity (MVPA) during the COVID-19 pandemic with regards to sociodemographic characteristics and determine mental health and resiliency factors associated with MVPA among a diverse national sample of adolescents ages 10-14 years. Data were collected during the pandemic in May 2020 from the Adolescent Brain Cognitive Development Study (ABCD, N = 5,153), a national prospective cohort study in the U.S. MVPA was quantified as the product of reported duration and frequency (hours per week), which was further summarized as the proportion meeting age-appropriate 2018 Physical Activity Guidelines for Americans. A similar estimate was generated using MVPA data collected prior to the pandemic. Mental health and resiliency measures were collected during the pandemic. Regression models examined associations between mental health or resiliency measures and MVPA during the pandemic. Median MVPA was 2 h per week (IQR 0, 6). Overall, the percentage of the cohort meeting MVPA guidelines decreased from 16.1% (pre-pandemic) to 8.9% (during the pandemic). Racial/ethnic minority adolescents and adolescents from lower socioeconomic backgrounds were significantly less likely to meet MVPA guidelines during the pandemic. Poorer mental health, COVID-related worry, and stress were associated with lower MVPA, while more social support and coping behaviors were associated with higher MVPA during the pandemic. In this large, national sample of adolescents, the proportion of those meeting MVPA Guidelines was lower during the COVID-19 pandemic, with significant disparities by race/ethnicity and socioeconomic status. Interventions to promote social support and coping behaviors may improve MVPA levels among adolescents during the pandemic. JournalPreventive medicine reportsPublished2021/12/27AuthorsNagata JM, Cortez CA, Dooley EE, Iyer P, Ganson KT, Pettee Gabriel KKeywordsABCD, Adolescent Brain Cognitive Development Study, Adolescents, COVID-19, Coronavirus, Exercise, HHS, U.S. Department of Health and Human Services, MVPA, moderate-to-vigorous intensity physical activity, Physical activity, RRR, Rapid Response ResearchDOI10.1016/j.pmedr.2021.101685 |
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Toggle | Genetic Association of Attention-Deficit/Hyperactivity Disorder and Major Depression With Suicidal Ideation and Attempts in Children: The Adolescent Brain Cognitive Development Study. | Biological psychiatry | Lee PH, Doyle AE, Li X, et al. | 2021 | |
PubMed Record
AbstractSuicide is among the leading causes of death in children and adolescents. There are well-known risk factors of suicide, including childhood abuse, family conflicts, social adversity, and psychopathology. While suicide risk is also known to be heritable, few studies have investigated genetic risk in younger individuals. JournalBiological psychiatryPublished2021/12/22AuthorsLee PH, Doyle AE, Li X, Silberstein M, Jung JY, Gollub RL, Nierenberg AA, Liu RT, Kessler RC, Perlis RH, Fava MKeywordsADHD, Adolescents, Children, Depression, Polygenic risk score, SuicideDOI10.1016/j.biopsych.2021.11.026 |
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Toggle | The Emotional Word-Emotional Face Stroop task in the ABCD study: Psychometric validation and associations with measures of cognition and psychopathology. | Developmental cognitive neuroscience | Smolker HR, Wang K, Luciana M, et al. | 2021 | |
PubMed Record
AbstractCharacterizing the interactions among attention, cognitive control, and emotion during adolescence may provide important insights into why this critical developmental period coincides with a dramatic increase in risk for psychopathology. However, it has proven challenging to develop a single neurobehavioral task that simultaneously engages and differentially measures these diverse domains. In the current study, we describe properties of performance on the Emotional Word-Emotional Face Stroop (EWEFS) task in the Adolescent Brain Cognitive Development (ABCD) Study, a task that allows researchers to concurrently measure processing speed/attentional vigilance (i.e., performance on congruent trials), inhibitory control (i.e., Stroop interference effect), and emotional information processing (i.e., difference in performance on trials with happy as compared to angry distracting faces). We first demonstrate that the task manipulations worked as designed and that Stroop performance is associated with multiple cognitive constructs derived from different measures at a prior time point. We then show that Stroop metrics tapping these three domains are preferentially associated with aspects of externalizing psychopathology and inattention. These results highlight the potential of the EWEFS task to help elucidate the longitudinal dynamics of attention, inhibitory control, and emotion across adolescent development, dynamics which may be altered by level of psychopathology. JournalDevelopmental cognitive neurosciencePublished2021/12/21AuthorsSmolker HR, Wang K, Luciana M, Bjork JM, Gonzalez R, Barch DM, McGlade EC, Kaiser RH, Friedman NP, Hewitt JK, Banich MTKeywordsABCD, Adolescence, Emotion, Inhibitory control, Psychopathology, StroopDOI10.1016/j.dcn.2021.101054 |
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Toggle | Functional brain network community structure in childhood: Unfinished territories and fuzzy boundaries. | NeuroImage | Tooley UA, Bassett DS, Mackey AP | 2021 | |
PubMed Record
AbstractAdult cortex is organized into distributed functional communities. Yet, little is known about community architecture of children’s brains. Here, we uncovered the community structure of cortex in childhood using fMRI data from 670 children aged 9-11 years (48% female, replication sample n=544, 56% female) from the Adolescent Brain and Cognitive Development study. We first applied a data-driven community detection approach to cluster cortical regions into communities, then employed a generative model-based approach called the weighted stochastic block model to further probe community interactions. Children showed similar community structure to adults, as defined by Yeo and colleagues in 2011, in early-developing sensory and motor communities, but differences emerged in transmodal areas. Children have more cortical territory in the limbic community, which is involved in emotion processing, than adults. Regions in association cortex interact more flexibly across communities, creating uncertainty for the model-based assignment algorithm, and perhaps reflecting cortical boundaries that are not yet solidified. Uncertainty was highest for cingulo-opercular areas involved in flexible deployment of cognitive control. Activation and deactivation patterns during a working memory task showed that both the data-driven approach and a set of adult communities statistically capture functional organization in middle childhood. Collectively, our findings suggest that community boundaries are not solidified by middle childhood. JournalNeuroImagePublished2021/12/21AuthorsTooley UA, Bassett DS, Mackey APKeywordsCommunity structure, Development, Graph theory, Network neuroscience, NetworksDOI10.1016/j.neuroimage.2021.118843 |
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Toggle | How Robust Is the p Factor? Using Multitrait-Multimethod Modeling to Inform the Meaning of General Factors of Youth Psychopathology. | Clinical psychological science : a journal of the Association for Psychological Science | Watts AL, Makol BA, Palumbo IM, et al. | 2021 | |
PubMed Record
AbstractWe used multitrait-multimethod (MTMM) modeling to examine general factors of psychopathology in three samples of youth (s = 2119, 303, 592) for whom three informants reported on the youth’s psychopathology (e.g., child, parent, teacher). Empirical support for the -factor diminished in multi-informant models compared with mono-informant models: the correlation between externalizing and internalizing factors decreased and the general factor in bifactor models essentially reflected externalizing. Widely used MTMM-informed approaches for modeling multi-informant data cannot distinguish between competing interpretations of the patterns of effects we observed, including that the -factor reflects, in part, evaluative consistency bias or that psychopathology manifests differently across contexts (e.g., home vs. school). Ultimately, support for the -factor may be stronger in mono-informant designs, although it is does not entirely vanish in multi-informant models. Instead, the general factor of psychopathology in any given mono-informant model likely reflects a complex mix of variances, some substantive and some methodological. JournalClinical psychological science : a journal of the Association for Psychological SciencePublished2021/12/17AuthorsWatts AL, Makol BA, Palumbo IM, De Los Reyes A, Olino TM, Latzman RD, DeYoung CG, Wood PK, Sher KJKeywordsgeneral factor of psychopathology, multi-informant psychopathology structures, multitrait-multimethod modeling, p-factorDOI10.1177/21677026211055170 |
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Toggle | Impact of COVID-19 on Youth With ADHD: Predictors and Moderators of Response to Pandemic Restrictions on Daily Life. | Journal of attention disorders | Rosenthal E, Franklin-Gillette S, Jung HJ, et al. | 2021 | |
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AbstractWe examined COVID-19 symptoms and infection rates, disruptions to functioning, and moderators of pandemic response for 620 youth with ADHD and 614 individually matched controls (70% male; = 12.4) participating in the Adolescent Brain and Cognitive Development study. There were no group differences in COVID-19 infection rate; however, youth with ADHD were more likely to exhibit COVID-19 symptoms ( = 0.25), greater sleep problems ( = -0.52), fear and negative emotions to infection risk ( = -0.56), trouble with remote learning ( = -0.54), rule-breaking behavior related to COVID-19 restrictions ( = -0.23), family conflict ( = -0.13), and were less prepared for the next school year ( = 0.38). Youth with ADHD were less responsive to protective environmental variables (e.g., parental monitoring, school engagement) during the pandemic and may need more specialized support with return to in-person schooling and daily activities. JournalJournal of attention disordersPublished2021/12/17AuthorsRosenthal E, Franklin-Gillette S, Jung HJ, Nelson A, Evans SW, Power TJ, Yerys BE, Dever BV, Reckner E, DuPaul GJKeywordsADD/ADHD, COVID-19, functional impairmentDOI10.1177/10870547211063641 |
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Toggle | Parent-Adolescent Discrepancies in Adolescent Recreational Screen Time Reporting During the Coronavirus Disease 2019 Pandemic. | Academic pediatrics | Nagata JM, Cortez CA, Iyer P, et al. | 2021 | |
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AbstractTo describe the relationship between parent and adolescent reports of adolescent recreational screen time and to determine sociodemographic predictors of recreational screen time reporting differences during the coronavirus disease 2019 pandemic. JournalAcademic pediatricsPublished2021/12/16AuthorsNagata JM, Cortez CA, Iyer P, Ganson KT, Chu J, Conroy AAKeywordsadolescents, coronavirus disease 2019, media use, parents, screen timeDOI10.1016/j.acap.2021.12.008 |
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Toggle | One-year predictions of delayed reward discounting in the adolescent brain cognitive development study. | Experimental and clinical psychopharmacology | Owens MM, Hahn S, Allgaier N, et al. | 2021 | |
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AbstractDelayed reward discounting (DRD) refers to the extent to which an individual devalues a reward based on a temporal delay and is known to be elevated in individuals with substance use disorders and many mental illnesses. DRD has been linked previously with both features of brain structure and function, as well as various behavioral, psychological, and life-history factors. However, there has been little work on the neurobiological and behavioral antecedents of DRD in childhood. This is an important question, as understanding the antecedents of DRD can provide signs of mechanisms in the development of psychopathology. The present study used baseline data from the Adolescent Brain Cognitive Development Study ( = 4,042) to build machine learning models to predict DRD at the first follow-up visit, 1 year later. In separate machine learning models, we tested elastic net regression, random forest regression, light gradient boosting regression, and support vector regression. In five-fold cross-validation on the training set, models using an array of questionnaire/task variables were able to predict DRD, with these findings generalizing to a held-out (i.e., “lockbox”) test set of 20% of the sample. Key predictive variables were neuropsychological test performance at baseline, socioeconomic status, screen media activity, psychopathology, parenting, and personality. However, models using magnetic resonance imaging (MRI)-derived brain variables did not reliably predict DRD in either the cross-validation or held-out test set. These results suggest a combination of questionnaire/task variables as antecedents of excessive DRD in late childhood, which may presage the development of problematic substance use in adolescence. (PsycInfo Database Record (c) 2022 APA, all rights reserved). JournalExperimental and clinical psychopharmacologyPublished2021/12/16AuthorsOwens MM, Hahn S, Allgaier N, MacKillop J, Albaugh M, Yuan D, Juliano A, Potter A, Garavan HKeywordsDOI10.1037/pha0000532 |
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Toggle | Prevalence, predictors, and treatment of eating disorders in children: a national study. | Psychological medicine | Sanzari CM, Levin RY, Liu RT | 2021 | |
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AbstractAlthough the prevalence rates of preadolescent eating disorders (EDs) are on the rise, considerably less is known about the correlates and treatment of EDs in this age group. Clarifying the epidemiology of EDs in preadolescent children is a necessary first step to understand the nature and scope of this problem in this age group. JournalPsychological medicinePublished2021/12/15AuthorsSanzari CM, Levin RY, Liu RTKeywordsABCD study, Epidemiology, eating disorders, preadolescenceDOI10.1017/S0033291721004992 |
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Toggle | Associations of circulating C-reactive proteins, APOE ε4, and brain markers for Alzheimer's disease in healthy samples across the lifespan. | Brain, behavior, and immunity | Wang Y, Grydeland H, Roe JM, et al. | 2021 | |
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AbstractThe apolipoprotein E gene ε4 allele (APOE ε4) and higher circulating level of C-reactive protein (CRP) have been extensively investigated as risk factors for Alzheimer’s disease (AD). Paradoxically, APOE ε4 has been associated with lower levels of blood CRP in middle-aged and older populations. However, few studies have investigated this intriguing relation and its impact on neurological markers for AD in younger ages, nor across the whole lifespan. Here, we examine associations of blood CRP levels, APOE ε4, and biomarkers for AD in a cognitively healthy lifespan cohort (N up to 749; 20-81 years of age) and replicate the findings in UK Biobank (N = 304 322; 37-72 years of age), the developmental ABCD study (N = 10 283; 9-11 years of age), and a middle-aged sample (N = 339; 40-65 years of age). Hippocampal volume, brain amyloid-β (Aβ) plaque levels, cerebrospinal fluid (CSF) levels of Aβ and tau species, and neurofilament protein light protein (NFL) were used as AD biomarkers in subsamples. In addition, we examined the genetic contribution to the variation of CRP levels over different CRP ranges using polygenic scores for CRP (PGS-CRP). Our results show APOE ε4 consistently associates with low blood CRP levels across all age groups (p < 0.05). Strikingly, both ε4 and PGS-CRP associated mainly with blood CRP levels within the low range (<5mg/L). We then show both APOE ε4 and high CRP levels associate with smaller hippocampus volumes across the lifespan (p < 0.025). APOE ε4 was associated with high Aβ plaque levels in the brain (FDR-corrected p = 8.69×10), low levels of CSF Aβ42 (FDR-corrected p = 6.9×10), and lower ratios of Aβ42 to Aβ40 (FDR-corrected p = 5.08×10). Blood CRP levels were weakly correlated with higher ratio of CSF Aβ42 to Aβ40 (p = 0.03, FDR-corrected p = 0.4). APOE ε4 did not correlate with blood concentrations of another 9 inflammatory cytokines, and none of these cytokines correlated with AD biomarkers. CONCLUSION: The inverse correlation between APOEε 4 and blood CRP levels existed before any pathological AD biomarker was observed, and only in the low CRP level range. Thus, we suggest to investigate whether APOEε 4 can confer risk by being associated with a lower inflammatory response to daily exposures, possibly leading to greater accumulation of low-grade inflammatory stress throughout life. A lifespan perspective is needed to understand this relationship concerning risk of developing AD. JournalBrain, behavior, and immunityPublished2021/12/14AuthorsWang Y, Grydeland H, Roe JM, Pan M, Magnussen F, Amlien IK, Watne LO, Idland AV, Bertram L, Gundersen TE, Pascual-Leone A, Cabello-Toscano M, Tormos JM, Bartres-Faz D, Drevon CA, Fjell AM, Walhovd KWKeywordsAPOE, Alzheimer’s disease, CRP, Hippocampal volume, InflammationDOI10.1016/j.bbi.2021.12.008 |
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Toggle | Transforming the Future of Adolescent Health: Opportunities From the Adolescent Brain Cognitive Development Study. | The Journal of adolescent health : official publication of the Society for Adolescent Medicine | Hoffman EA, LeBlanc K, Weiss SRB, et al. | 2021 | |
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AbstractJournalThe Journal of adolescent health : official publication of the Society for Adolescent MedicinePublished2021/12/13AuthorsHoffman EA, LeBlanc K, Weiss SRB, Dowling GJKeywordsDOI10.1016/j.jadohealth.2021.11.008 |
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Toggle | Brain network coupling associated with cognitive performance varies as a function of a child's environment in the ABCD study. | Nature communications | Ellwood-Lowe ME, Whitfield-Gabrieli S, Bunge SA | 2021 | |
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AbstractPrior research indicates that lower resting-state functional coupling between two brain networks, lateral frontoparietal network (LFPN) and default mode network (DMN), relates to cognitive test performance, for children and adults. However, most of the research that led to this conclusion has been conducted with non-representative samples of individuals from higher-income backgrounds, and so further studies including participants from a broader range of socioeconomic backgrounds are required. Here, in a pre-registered study, we analyzed resting-state fMRI from 6839 children ages 9-10 years from the ABCD dataset. For children from households defined as being above poverty (family of 4 with income > $25,000, or family of 5+ with income > $35,000), we replicated prior findings; that is, we found that better performance on cognitive tests correlated with weaker LFPN-DMN coupling. For children from households defined as being in poverty, the direction of association was reversed, on average: better performance was instead directionally related to stronger LFPN-DMN connectivity, though there was considerable variability. Among children in households below poverty, the direction of this association was predicted in part by features of their environments, such as school type and parent-reported neighborhood safety. These results highlight the importance of including representative samples in studies of child cognitive development. JournalNature communicationsPublished2021/12/10AuthorsEllwood-Lowe ME, Whitfield-Gabrieli S, Bunge SAKeywordsDOI10.1038/s41467-021-27336-y |
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Toggle | Measurement matters: An individual differences examination of family socioeconomic factors, latent dimensions of children's experiences, and resting state functional brain connectivity in the ABCD sample. | Developmental cognitive neuroscience | DeJoseph ML, Herzberg MP, Sifre RD, et al. | 2021 | |
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AbstractThe variation in experiences between high and low-socioeconomic status contexts are posited to play a crucial role in shaping the developing brain and may explain differences in child outcomes. Yet, examinations of SES and brain development have largely been limited to distal proxies of these experiences (e.g., income comparisons). The current study sought to disentangle the effects of multiple socioeconomic indices and dimensions of more proximal experiences on resting-state functional connectivity (rsFC) in a sample of 7834 youth (aged 9-10 years) from the Adolescent Brain Cognitive Development (ABCD) study. We applied moderated nonlinear factor analysis (MNLFA) to establish measurement invariance among three latent environmental dimensions of experience (material/economic deprivation, caregiver social support, and psychosocial threat). Results revealed measurement biases as a function of child age, sex, racial group, family income, and parental education, which were statistically adjusted in the final MNLFA scores. Mixed-effects models demonstrated that socioeconomic indices and psychosocial threat differentially predicted variation in frontolimbic networks, and threat statistically moderated the association between income and connectivity between the dorsal and ventral attention networks. Findings illuminate the importance of reducing measurement biases to gain a more socioculturally-valid understanding of the complex and nuanced links between socioeconomic context, children’s experiences, and neurodevelopment. JournalDevelopmental cognitive neurosciencePublished2021/12/08AuthorsDeJoseph ML, Herzberg MP, Sifre RD, Berry D, Thomas KMKeywordsAdversity, Childhood, MNLFA, Resting state functional connectivity, Socioeconomic statusDOI10.1016/j.dcn.2021.101043 |
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Toggle | Predicting multilingual effects on executive function and individual connectomes in children: An ABCD study. | Proceedings of the National Academy of Sciences of the United States of America | Kwon YH, Yoo K, Nguyen H, et al. | 2021 | |
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AbstractWhile there is a substantial amount of work studying multilingualism’s effect on cognitive functions, little is known about how the multilingual experience modulates the brain as a whole. In this study, we analyzed data of over 1,000 children from the Adolescent Brain Cognitive Development (ABCD) Study to examine whether monolinguals and multilinguals differ in executive function, functional brain connectivity, and brain-behavior associations. We observed significantly better performance from multilingual children than monolinguals in working-memory tasks. In one finding, we were able to classify multilinguals from monolinguals using only their whole-brain functional connectome at rest and during an emotional n-back task. Compared to monolinguals, the multilingual group had different functional connectivity mainly in the occipital lobe and subcortical areas during the emotional n-back task and in the occipital lobe and prefrontal cortex at rest. In contrast, we did not find any differences in behavioral performance and functional connectivity when performing a stop-signal task. As a second finding, we investigated the degree to which behavior is reflected in the brain by implementing a connectome-based behavior prediction approach. The multilingual group showed a significant correlation between observed and connectome-predicted individual working-memory performance scores, while the monolingual group did not show any correlations. Overall, our observations suggest that multilingualism enhances executive function and reliably modulates the corresponding brain functional connectome, distinguishing multilinguals from monolinguals even at the developmental stage. JournalProceedings of the National Academy of Sciences of the United States of AmericaPublished2021/12/07AuthorsKwon YH, Yoo K, Nguyen H, Jeong Y, Chun MMKeywordschildren, fMRI, functional connectivity, multilingualism, working memoryDOI10.1073/pnas.2110811118 |
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Toggle | Internalizing-externalizing comorbidity and regional brain volumes in the ABCD study. | Development and psychopathology | Schettini E, Wilson S, Beauchaine TP | 2021 | |
PubMed Record
AbstractDespite nonoverlapping diagnostic criteria, internalizing and externalizing disorders show substantial comorbidity. This comorbidity is attributable, at least in part, to transdiagnostic neuroaffective mechanisms. Both unipolar depression and externalizing disorders are characterized by structural and functional compromises in the striatum and its projections to the anterior cingulate cortex (ACC) and other frontal regions. Smaller volumes and dampened reward responding in these regions are associated with anhedonia and irritability – mood states that cut across the internalizing and externalizing spectra. In contrast, smaller amygdala volumes and dampened amygdala function differentiate externalizing disorders from internalizing disorders. Little is known, however, about associations between internalizing-externalizing comorbidity and brain volumes in these regions, or whether such patterns differ by sex. Using a transdiagnostic, research domain criteria (RDoC)-informed approach, we evaluate associations between heterotypic (Internalizing × Externalizing) symptom interactions and striatal, amygdalar, and ACC volumes among participants in the Adolescent Brain Cognitive Development study ( = 6,971, mean age 9.9 years, 51.6% female). Heterotypic symptoms were associated with ACC volumes for both sexes, over and above the main effects of internalizing and externalizing alone. However, heterotypic comorbidity was associated with larger ACC volumes for girls, but with smaller ACC volumes for boys. These findings suggest a need for further studies and transdiagnostic assessment by sex. JournalDevelopment and psychopathologyPublished2021/12/07AuthorsSchettini E, Wilson S, Beauchaine TPKeywordsRDoC, amygdala, anterior cingulate, heterotypic comorbidity, striatumDOI10.1017/s0954579421000560 |
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Toggle | Reward Processing in Children With Psychotic-Like Experiences. | Schizophrenia bulletin open | Harju-Seppänen J, Irizar H, Bramon E, et al. | 2021 | |
PubMed Record
AbstractAlterations to striatal reward pathways have been identified in individuals with psychosis. They are hypothesized to be a key mechanism that generate psychotic symptoms through the production of aberrant attribution of motivational salience and are proposed to result from accumulated childhood adversity and genetic risk, making the striatal system hyper-responsive to stress. However, few studies have examined whether children with psychotic-like experiences (PLEs) also exhibit these alterations, limiting our understanding of how differences in reward processing relate to hallucinations and delusional ideation in childhood. Consequently, we examined whether PLEs and PLE-related distress were associated with reward-related activation in the nucleus accumbens (NAcc). The sample consisted of children ( = 6718) from the Adolescent Brain Cognitive Development (ABCD) study aged 9-10 years who had participated in the Monetary Incentive Delay (MID) task in functional MRI. We used robust mixed-effects linear regression models to investigate the relationship between PLEs and NAcc activation during the reward anticipation and reward outcome stages of the MID task. Analyses were adjusted for gender, household income, ethnicity, depressive symptoms, movement in the scanner, pubertal development, scanner ID, subject and family ID. There was no reliable association between PLEs and alterations to anticipation- or outcome-related striatal reward processing. We discuss the implications for developmental models of psychosis and suggest a developmental delay model of how PLEs may arise at this stage of development. JournalSchizophrenia bulletin openPublished2021/12/04AuthorsHarju-Seppänen J, Irizar H, Bramon E, Blakemore SJ, Mason L, Bell VKeywordschildhood, fMRI, psychotic-like experiencesDOI10.1093/schizbullopen/sgab054 |
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Toggle | Associations Between Traumatic Stress, Brain Volumes and Post-traumatic Stress Disorder Symptoms in Children: Data from the ABCD Study. | Behavior genetics | Bustamante D, Amstadter AB, Pritikin JN, et al. | 2021 | |
PubMed Record
AbstractReduced volumes in brain regions of interest (ROIs), primarily from adult samples, are associated with posttraumatic stress disorder (PTSD). We extended this work to children using data from the Adolescent Brain Cognitive Development (ABCD) Study® (N = 11,848; M = 9.92). Structural equation modeling and an elastic-net (EN) machine-learning approach were used to identify potential effects of traumatic events (TEs) on PTSD symptoms (PTSDsx) directly, and indirectly via the volumes 300 subcortical and cortical ROIs. We then estimated the genetic and environmental variation in the phenotypes. TEs were directly associated with PTSDsx (r = 0.92) in children, but their indirect effects (r < 0.0004)-via the volumes of EN-identified subcortical and cortical ROIs-were negligible at this age. Additive genetic factors explained a modest proportion of the variance in TEs (23.4%) and PTSDsx (21.3%), and accounted for most of the variance of EN-identified volumes of four of the five subcortical (52.4-61.8%) three of the nine cortical ROIs (46.4-53.3%) and cerebral white matter in the left hemisphere (57.4%). Environmental factors explained most of the variance in TEs (C = 61.6%, E = 15.1%), PTSDsx (residual-C = 18.4%, residual-E = 21.8%), right lateral ventricle (C = 15.2%, E = 43.1%) and six of the nine EN-identified cortical ROIs (C = 4.0-13.6%, E = 56.7-74.8%). There is negligible evidence that the volumes of brain ROIs are associated with the indirect effects of TEs on PTSDsx at this age. Overall, environmental factors accounted for more of the variation in TEs and PTSDsx. Whereas additive genetic factors accounted for most of the variability in the volumes of a minority of cortical and in most of subcortical ROIs. JournalBehavior geneticsPublished2021/12/03AuthorsBustamante D, Amstadter AB, Pritikin JN, Brick TR, Neale MCKeywordsBrain, Children, Environment, Genetic, MRI, PTSD, RegularizationDOI10.1007/s10519-021-10092-6 |
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Toggle | Microstructural development from 9 to 14 years: Evidence from the ABCD Study. | Developmental cognitive neuroscience | Palmer CE, Pecheva D, Iversen JR, et al. | 2021 | |
PubMed Record
AbstractDuring late childhood behavioral changes, such as increased risk-taking and emotional reactivity, have been associated with the maturation of cortico-cortico and cortico-subcortical circuits. Understanding microstructural changes in both white matter and subcortical regions may aid our understanding of how individual differences in these behaviors emerge. Restriction spectrum imaging (RSI) is a framework for modelling diffusion-weighted imaging that decomposes the diffusion signal from a voxel into hindered, restricted, and free compartments. This yields greater specificity than conventional methods of characterizing diffusion. Using RSI, we quantified voxelwise restricted diffusion across the brain and measured age associations in a large sample (n = 8086) from the Adolescent Brain and Cognitive Development (ABCD) study aged 9-14 years. Older participants showed a higher restricted signal fraction across the brain, with the largest associations in subcortical regions, particularly the basal ganglia and ventral diencephalon. Importantly, age associations varied with respect to the cytoarchitecture within white matter fiber tracts and subcortical structures, for example age associations differed across thalamic nuclei. This suggests that age-related changes may map onto specific cell populations or circuits and highlights the utility of voxelwise compared to ROI-wise analyses. Future analyses will aim to understand the relevance of this microstructural developmental for behavioral outcomes. JournalDevelopmental cognitive neurosciencePublished2021/12/03AuthorsPalmer CE, Pecheva D, Iversen JR, Hagler DJ, Sugrue L, Nedelec P, Fan CC, Thompson WK, Jernigan TL, Dale AMKeywordsAdolescence, Development, Diffusion, Microstructure, Neuroimaging, SubcorticalDOI10.1016/j.dcn.2021.101044 |
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Toggle | Psychotic-Like Experiences Associated with Sleep Disturbance and Brain Volumes in Youth: Findings from the Adolescent Brain Cognitive Development Study. | JCPP advances | Lunsford-Avery JR, Damme KSF, Vargas T, et al. | 2021 | |
PubMed Record
AbstractSleep disturbance is characteristic of schizophrenia and at-risk populations, suggesting a possible etiological role in psychosis. Biological mechanisms underlying associations between sleep and psychosis vulnerability are unclear, although reduced sleep-regulatory brain structure volumes are a proposed contributor. This study is the first to examine relationships between psychotic-like experiences (PLEs; subclinical symptoms reflecting psychosis vulnerability/risk), sleep, and brain volumes in youth. JournalJCPP advancesPublished2021/12/02AuthorsLunsford-Avery JR, Damme KSF, Vargas T, Sweitzer MM, Mittal VAKeywordsbrain volumes, psychosis, psychotic-like experiences, sleep, structural MRI, thalamusDOI10.1002/jcv2.12055 |
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Toggle | Association of Outdoor Ambient Fine Particulate Matter With Intracellular White Matter Microstructural Properties Among Children. | JAMA network open | Burnor E, Cserbik D, Cotter DL, et al. | 2021 | |
PubMed Record
AbstractOutdoor particulate matter 2.5 μm or less in diameter (PM2.5) is a ubiquitous environmental neurotoxicant that may affect the developing brain. Little is known about associations between PM2.5 and white matter connectivity. JournalJAMA network openPublished2021/12/01AuthorsBurnor E, Cserbik D, Cotter DL, Palmer CE, Ahmadi H, Eckel SP, Berhane K, McConnell R, Chen JC, Schwartz J, Jackson R, Herting MMKeywordsDOI10.1001/jamanetworkopen.2021.38300 |
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Toggle | Parental Education and Children's Sleep Disturbance: Minorities' Diminished Returns. | International journal of epidemiologic research | Assari S | 2021 | |
PubMed Record
AbstractWhile increased parental education reduces children’s sleep problems, less is known about racial variation in such protection. According to Minorities’ Diminished Returns (MDRs) theory, economic resources such as parental education show weaker health effects for minority groups such as Blacks and Latinos than non-Latino Whites, which is due to racism and social stratification. In this study, we investigated the association between parental education and children’s sleep problems, as a proxy of sleep problems, by race. JournalInternational journal of epidemiologic researchPublished2021/12/01AuthorsAssari SKeywordsChildren, Parental education, Sleep problemsDOI10.34172/ijer.2021.06 |
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Toggle | Testing whether implicit emotion regulation mediates the association between discrimination and symptoms of psychopathology in late childhood: An RDoC perspective. | Development and psychopathology | Vargas TG, Mittal VA | 2021 | |
PubMed Record
AbstractDiscrimination has been associated with adverse mental health outcomes, though it is unclear how early in life this association becomes apparent. Implicit emotion regulation, developing during childhood, is a foundational skill tied to a range of outcomes. Implicit emotion regulation has yet to be tested as an associated process for mental illness symptoms that can often emerge during this sensitive developmental period. Youth aged 9-11 were recruited for the Adolescent Brain Cognitive Development (ABCD) study. Associations between psychotic-like experiences, depressive symptoms, and total discrimination (due to race, ethnicity, nationality, weight, or sexual minority status) were tested, as well as associations with implicit emotion regulation measures (emotional updating working memory and inhibitory control). Analyses examined whether associations with symptoms were mediated by implicit emotion regulation. Discrimination related to decreased implicit emotion regulation performance, and increased endorsement of depressive symptoms and psychotic-like experiences. Emotional updating working memory performance partially mediated the association between discrimination and psychotic-like experiences, while emotional inhibitory control did not. Discrimination and implicit emotion regulation could serve as putative transdiagnostic markers of vulnerability. Results support the utility of using multiple units of analysis to improve understanding of complex emerging neurocognitive functions and developmentally sensitive periods. JournalDevelopment and psychopathologyPublished2021/12/01AuthorsVargas TG, Mittal VAKeywordsdepression, discrimination, emotion, emotion regulation, psychosis, systemicDOI10.1017/S0954579421000638 |
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Toggle | Comparison of European, African, Asian, and Other/Mixed Race American Children for the Association Between Household Income and Perceived Discrimination. | International journal of travel medicine and global health | Assari S, Ayoubian A, Caldwell CH | 2021 | |
PubMed Record
AbstractPerceived discrimination is one of the reasons behind racial/ethnic health disparities. However, less is known about racial and ethnic groups differ in social determinants of discrimination. This study aimed to compare the association between household income and perceived discrimination among American children of different racial/ethnic groups. JournalInternational journal of travel medicine and global healthPublished2021/12/01AuthorsAssari S, Ayoubian A, Caldwell CHKeywordsDiscrimination, Education, Health, Income, Racism, Socioeconomic StatusDOI10.34172/ijtmgh.2021.06 |
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Toggle | Multimodal Ensemble Deep Learning to Predict Disruptive Behavior Disorders in Children. | Frontiers in neuroinformatics | Menon SS, Krishnamurthy K | 2021 | |
PubMed Record
AbstractOppositional defiant disorder and conduct disorder, collectively referred to as disruptive behavior disorders (DBDs), are prevalent psychiatric disorders in children. Early diagnosis of DBDs is crucial because they can increase the risks of other mental health and substance use disorders without appropriate psychosocial interventions and treatment. However, diagnosing DBDs is challenging as they are often comorbid with other disorders, such as attention-deficit/hyperactivity disorder, anxiety, and depression. In this study, a multimodal ensemble three-dimensional convolutional neural network (3D CNN) deep learning model was used to classify children with DBDs and typically developing children. The study participants included 419 females and 681 males, aged 108-131 months who were enrolled in the Adolescent Brain Cognitive Development Study. Children were grouped based on the presence of DBDs ( = 550) and typically developing ( = 550); assessments were based on the scores from the Child Behavior Checklist and on the Schedule for Affective Disorders and Schizophrenia for School-age Children-Present and Lifetime version for DSM-5. The diffusion, structural, and resting-state functional magnetic resonance imaging (rs-fMRI) data were used as input data to the 3D CNN. The model achieved 72% accuracy in classifying children with DBDs with 70% sensitivity, 72% specificity, and an F1-score of 70. In addition, the discriminative power of the classifier was investigated by identifying the cortical and subcortical regions primarily involved in the prediction of DBDs using a gradient-weighted class activation mapping method. The classification results were compared with those obtained using the three neuroimaging modalities individually, and a connectome-based graph CNN and a multi-scale recurrent neural network using only the rs-fMRI data. JournalFrontiers in neuroinformaticsPublished2021/11/24AuthorsMenon SS, Krishnamurthy KKeywords3D CNN, deep learning, disruptive behavior disorders, multimodal ensemble learning, neuroimagingDOI10.3389/fninf.2021.742807 |
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Toggle | Graph auto-encoding brain networks with applications to analyzing large-scale brain imaging datasets. | NeuroImage | Liu M, Zhang Z, Dunson DB | 2021 | |
PubMed Record
AbstractThere has been a huge interest in studying human brain connectomes inferred from different imaging modalities and exploring their relationships with human traits, such as cognition. Brain connectomes are usually represented as networks, with nodes corresponding to different regions of interest (ROIs) and edges to connection strengths between ROIs. Due to the high-dimensionality and non-Euclidean nature of networks, it is challenging to depict their population distribution and relate them to human traits. Current approaches focus on summarizing the network using either pre-specified topological features or principal components analysis (PCA). In this paper, building on recent advances in deep learning, we develop a nonlinear latent factor model to characterize the population distribution of brain graphs and infer their relationships to human traits. We refer to our method as Graph AuTo-Encoding (GATE). We applied GATE to two large-scale brain imaging datasets, the Adolescent Brain Cognitive Development (ABCD) study and the Human Connectome Project (HCP) for adults, to study the structural brain connectome and its relationship with cognition. Numerical results demonstrate huge advantages of GATE over competitors in terms of prediction accuracy, statistical inference, and computing efficiency. We found that the structural connectome has a stronger association with a wide range of human cognitive traits than was apparent using previous approaches. JournalNeuroImagePublished2021/11/22AuthorsLiu M, Zhang Z, Dunson DBKeywordsBrain networks, Graph CNN, Non-linear factor analysis, Replicated networks, Variational auto-encoderDOI10.1016/j.neuroimage.2021.118750 |
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Toggle | Brain structural associations with depression in a large early adolescent sample (the ABCD study®). | EClinicalMedicine | Shen X, MacSweeney N, Chan SWY, et al. | 2021 | |
PubMed Record
AbstractDepression is the leading cause of disability worldwide with > 50% of cases emerging before the age of 25 years. Large-scale neuroimaging studies in depression implicate robust structural brain differences in the disorder. However, most studies have been conducted in adults and therefore, the temporal origins of depression-related imaging features remain largely unknown. This has important implications for understanding aetiology and informing timings of potential intervention. JournalEClinicalMedicinePublished2021/11/20AuthorsShen X, MacSweeney N, Chan SWY, Barbu MC, Adams MJ, Lawrie SM, Romaniuk L, McIntosh AM, Whalley HCKeywordsAdolescent Brain and Cognitive Development Study, Adolescent depression, Big data, Brain structureDOI10.1016/j.eclinm.2021.101204 |
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Toggle | Minding the Gap: Adolescent and Parent/Caregiver Reporter Discrepancies on Symptom Presence, Impact of Covariates, and Clinical Implications. | Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners | Ford SH, McCoy TP | 2021 | |
PubMed Record
AbstractPrimary care practitioners (PCPs) provide care to adolescents in the context of their families. Supporting parent/caregiver knowledge of symptoms can create opportunities for better recognition of symptoms that can then lead to early identification, intervention, and prevention of poor outcomes. JournalJournal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & PractitionersPublished2021/11/19AuthorsFord SH, McCoy TPKeywordsAdolescent health, advocacy, anhedonia, communication, depressed mood, family-centered careDOI10.1016/j.pedhc.2021.09.010 |
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Toggle | Brain signatures in children who contemplate suicide: learning from the large-scale ABCD study. | Psychological medicine | Wiglesworth A, Falke CA, Fiecas M, et al. | 2021 | |
PubMed Record
AbstractSuicide is the second-leading cause of death in youth. Understanding the neural correlates of suicide ideation (SI) in children is crucial to ongoing efforts to understand and prevent youth suicide. This study characterized key neural networks during rest and emotion task conditions in an epidemiologically informed sample of children who report current, past, or no SI. JournalPsychological medicinePublished2021/11/17AuthorsWiglesworth A, Falke CA, Fiecas M, Luciana M, Cullen KR, Klimes-Dougan BKeywordsChildren, default mode network, fMRI, salience network, suicideDOI10.1017/S0033291721004074 |
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Toggle | Persistent and distressing psychotic-like experiences using adolescent brain cognitive development℠ study data. | Molecular psychiatry | Karcher NR, Loewy RL, Savill M, et al. | 2021 | |
PubMed Record
AbstractChildhood psychotic-like experiences (PLEs) are associated with a range of impairments; a subset of children experiencing PLEs will develop psychiatric disorders, including psychotic disorders. A potential distinguishing factor between benign PLEs versus PLEs that are clinically relevant is whether PLEs are distressing and/or persistent. The current study used three waves of Adolescent Brain Cognitive Development℠ (ABCD) study PLEs assessments to examine the extent to which persistent and/or distressing PLEs were associated with relevant baseline risk factors (e.g., cognition) and functioning/mental health service utilization domains. Four groups varying in PLE persistence and distress endorsement were created based on all available data in ABCD Release 3.0, with group membership not contingent on complete data: persistent distressing PLEs (n = 272), transient distressing PLEs (n = 298), persistent non-distressing PLEs (n = 221), and transient non-distressing PLEs (n = 536) groups. Using hierarchical linear models, results indicated youth with distressing PLEs, whether transient or persistent, showed delayed developmental milestones (β = 0.074, 95%CI:0.013,0.134) and altered structural MRI metrics (β = -0.0525, 95%CI:-0.100,-0.005). Importantly, distress interacted with PLEs persistence for the domains of functioning/mental health service utilization (β = 0.079, 95%CI:0.016,0.141), other reported psychopathology (β = 0.101, 95%CI:0.030,0.170), cognition (β = -0.052, 95%CI:0.-0.099,-0.002), and environmental adversity (β = 0.045, 95%CI:0.003,0.0.86; although no family history effects), with the interaction characterized by greatest impairment in the persistent distressing PLEs group. These results have implications for disentangling the importance of distress and persistence for PLEs with regards to impairments, including functional, pathophysiological, and environmental outcomes. These novel longitudinal data underscore that it is often only in the context of distress that persistent PLEs were related to impairments. JournalMolecular psychiatryPublished2021/11/16AuthorsKarcher NR, Loewy RL, Savill M, Avenevoli S, Huber RS, Makowski C, Sher KJ, Barch DMKeywordsDOI10.1038/s41380-021-01373-x |
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Toggle | Neural vulnerability and hurricane-related media are associated with post-traumatic stress in youth. | Nature human behaviour | Dick AS, Silva K, Gonzalez R, et al. | 2021 | |
PubMed Record
AbstractThe human toll of disasters extends beyond death, injury and loss. Post-traumatic stress (PTS) can be common among directly exposed individuals, and children are particularly vulnerable. Even children far removed from harm’s way report PTS, and media-based exposure may partially account for this phenomenon. In this study, we examine this issue using data from nearly 400 9- to 11-year-old children collected before and after Hurricane Irma, evaluating whether pre-existing neural patterns moderate associations between hurricane experiences and later PTS. The ‘dose’ of both self-reported objective exposure and media exposure predicted PTS, the latter even among children far from the hurricane. Furthermore, neural responses in brain regions associated with anxiety and stress conferred particular vulnerability. For example, heightened amygdala reactivity to fearful stimuli moderated the association between self-reported media exposure and PTS. Collectively, these findings show that for some youth with measurable vulnerability, consuming extensive disaster-related media may offer an alternative pathway to disaster exposure that transcends geography and objective risk. JournalNature human behaviourPublished2021/11/15AuthorsDick AS, Silva K, Gonzalez R, Sutherland MT, Laird AR, Thompson WK, Tapert SF, Squeglia LM, Gray KM, Nixon SJ, Cottler LB, La Greca AM, Gurwitch RH, Comer JSKeywordsDOI10.1038/s41562-021-01216-3 |
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Toggle | Mapping Complex Brain Torque Components and Their Genetic Architecture and Phenomic Associations in 24,112 Individuals. | Biological psychiatry | Zhao L, Matloff W, Shi Y, et al. | 2021 | |
PubMed Record
AbstractThe functional significance and mechanisms determining the development and individual variability of structural brain asymmetry remain unclear. Here, we systematically analyzed all relevant components of the most prominent structural asymmetry, brain torque (BT), and their relationships with potential genetic and nongenetic modifiers in a sample comprising 24,112 individuals from six cohorts. JournalBiological psychiatryPublished2021/11/10AuthorsZhao L, Matloff W, Shi Y, Cabeen RP, Toga AWKeywordsAge, Big data discovery, Brain asymmetry, Handedness, Heritability, SexDOI10.1016/j.biopsych.2021.11.002 |
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Toggle | Widespread attenuating changes in brain connectivity associated with the general factor of psychopathology in 9- and 10-year olds. | Translational psychiatry | Sripada C, Angstadt M, Taxali A, et al. | 2021 | |
PubMed Record
AbstractConvergent research identifies a general factor (“P factor”) that confers transdiagnostic risk for psychopathology. Large-scale networks are key organizational units of the human brain. However, studies of altered network connectivity patterns associated with the P factor are limited, especially in early adolescence when most mental disorders are first emerging. We studied 11,875 9- and 10-year olds from the Adolescent Brain and Cognitive Development (ABCD) study, of whom 6593 had high-quality resting-state scans. Network contingency analysis was used to identify altered interconnections associated with the P factor among 16 large-scale networks. These connectivity changes were then further characterized with quadrant analysis that quantified the directionality of P factor effects in relation to neurotypical patterns of positive versus negative connectivity across connections. The results showed that the P factor was associated with altered connectivity across 28 network cells (i.e., sets of connections linking pairs of networks); p values < 0.05 FDR-corrected for multiple comparisons. Higher P factor scores were associated with hypoconnectivity within default network and hyperconnectivity between default network and multiple control networks. Among connections within these 28 significant cells, the P factor was predominantly associated with “attenuating” effects (67%; p < 0.0002), i.e., reduced connectivity at neurotypically positive connections and increased connectivity at neurotypically negative connections. These results demonstrate that the general factor of psychopathology produces attenuating changes across multiple networks including default network, involved in spontaneous responses, and control networks involved in cognitive control. Moreover, they clarify mechanisms of transdiagnostic risk for psychopathology and invite further research into developmental causes of distributed attenuated connectivity. JournalTranslational psychiatryPublished2021/11/09AuthorsSripada C, Angstadt M, Taxali A, Kessler D, Greathouse T, Rutherford S, Clark DA, Hyde LW, Weigard A, Brislin SJ, Hicks B, Heitzeg MKeywordsDOI10.1038/s41398-021-01708-w |
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Toggle | Racism May Interrupt Age-related Brain Growth of African American Children in the United States. | Journal of pediatrics & child health care | Assari S, Mincy R | 2021 | |
PubMed Record
AbstractConsiderable research has documented age-related growth in brain size as a marker of normal brain development. This is particularly important because brain volume has a significant role in overall cognitive performance. However, less research is done on whether age-related changes in the global brain volume differ across diverse racial and ethnic groups. We hypothesized that age-related growth in brain size would be disrupted in African American children who are historically affected by racism. JournalJournal of pediatrics & child health carePublished2021/11/09AuthorsAssari S, Mincy RKeywordsMRI, age, brain development, global brain volume, racism, social determinants, structural MRIDOI10.26420/jpediatrchildhealthcare.2021.1047 |
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Toggle | Brain-wide functional connectivity patterns support general cognitive ability and mediate effects of socioeconomic status in youth. | Translational psychiatry | Sripada C, Angstadt M, Taxali A, et al. | 2021 | |
PubMed Record
AbstractGeneral cognitive ability (GCA) is an individual difference dimension linked to important academic, occupational, and health-related outcomes and its development is strongly linked to differences in socioeconomic status (SES). Complex abilities of the human brain are realized through interconnections among distributed brain regions, but brain-wide connectivity patterns associated with GCA in youth, and the influence of SES on these connectivity patterns, are poorly understood. The present study examined functional connectomes from 5937 9- and 10-year-olds in the Adolescent Brain Cognitive Development (ABCD) multi-site study. Using multivariate predictive modeling methods, we identified whole-brain functional connectivity patterns linked to GCA. In leave-one-site-out cross-validation, we found these connectivity patterns exhibited strong and statistically reliable generalization at 19 out of 19 held-out sites accounting for 18.0% of the variance in GCA scores (cross-validated partial η). GCA-related connections were remarkably dispersed across brain networks: across 120 sets of connections linking pairs of large-scale networks, significantly elevated GCA-related connectivity was found in 110 of them, and differences in levels of GCA-related connectivity across brain networks were notably modest. Consistent with prior work, socioeconomic status was a strong predictor of GCA in this sample, and we found that distributed GCA-related brain connectivity patterns significantly statistically mediated this relationship (mean proportion mediated: 15.6%, p < 2 × 10). These results demonstrate that socioeconomic status and GCA are related to broad and diffuse differences in functional connectivity architecture during early adolescence, potentially suggesting a mechanism through which socioeconomic status influences cognitive development. JournalTranslational psychiatryPublished2021/11/08AuthorsSripada C, Angstadt M, Taxali A, Clark DA, Greathouse T, Rutherford S, Dickens JR, Shedden K, Gard AM, Hyde LW, Weigard A, Heitzeg MKeywordsDOI10.1038/s41398-021-01704-0 |
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Toggle | Adolescent Brain Cognitive Development (ABCD) study Linked External Data (LED): Protocol and practices for geocoding and assignment of environmental data. | Developmental cognitive neuroscience | Fan CC, Marshall A, Smolker H, et al. | 2021 | |
PubMed Record
AbstractOur brain is constantly shaped by our immediate environments, and while some effects are transient, some have long-term consequences. Therefore, it is critical to identify which environmental risks have evident and long-term impact on brain development. To expand our understanding of the environmental context of each child, the Adolescent Brain Cognitive Development (ABCD) Study® incorporates the use of geospatial location data to capture a range of individual, neighborhood, and state level data based on the child’s residential location in order to elucidate the physical environmental contexts in which today’s youth are growing up. We review the major considerations and types of geocoded information incorporated by the Linked External Data Environmental (LED) workgroup to expand on the built and natural environmental constructs in the existing and future ABCD Study data releases. Understanding the environmental context of each youth furthers the consortium’s mission to understand factors that may influence individual differences in brain development, providing the opportunity to inform public policy and health organization guidelines for child and adolescent health. JournalDevelopmental cognitive neurosciencePublished2021/11/08AuthorsFan CC, Marshall A, Smolker H, Gonzalez MR, Tapert SF, Barch DM, Sowell E, Dowling GJ, Cardenas-Iniguez C, Ross J, Thompson WK, Herting MMKeywordsBuilt environment, Environmental health, Environmental neuroscience, Natural environment, NeighborhoodDOI10.1016/j.dcn.2021.101030 |
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Toggle | Pubertal timing and functional neurodevelopmental alterations independently mediate the effect of family conflict on adolescent psychopathology. | Developmental cognitive neuroscience | Petrican R, Miles S, Rudd L, et al. | 2021 | |
PubMed Record
AbstractThis study tested the hypothesis that early life adversity (ELA) heightens psychopathology risk by concurrently altering pubertal and neurodevelopmental timing, and associated gene transcription signatures. Analyses focused on threat- (family conflict/neighbourhood crime) and deprivation-related ELAs (parental inattentiveness/unmet material needs), using longitudinal data from 1514 biologically unrelated youths in the Adolescent Brain and Cognitive Development (ABCD) study. Typical developmental changes in white matter microstructure corresponded to widespread BOLD signal variability (BOLD increases (linked to cell communication and biosynthesis genes) and region-specific task-related BOLD increases/decreases (linked to signal transduction, immune and external environmental response genes). Increasing resting-state (RS), but decreasing task-related BOLD predicted normative functional network segregation. Family conflict was the strongest concurrent and prospective contributor to psychopathology, while material deprivation constituted an additive risk factor. ELA-linked psychopathology was predicted by higher Time 1 threat-evoked BOLD (associated with axonal development, myelination, cell differentiation and signal transduction genes), reduced Time 2 RS BOLD (associated with cell metabolism and attention genes) and greater Time 1 to Time 2 control/attention network segregation. Earlier pubertal timing and neurodevelopmental alterations independently mediated ELA effects on psychopathology. Our results underscore the differential roles of the immediate and wider external environment(s) in concurrent and longer-term ELA consequences. JournalDevelopmental cognitive neurosciencePublished2021/11/06AuthorsPetrican R, Miles S, Rudd L, Wasiewska W, Graham KS, Lawrence ADKeywordsBOLD variability, Early life adversity, Externalizing problems, Functional brain networks, Neurodevelopment, Structure-function coupling, TranscriptomicsDOI10.1016/j.dcn.2021.101032 |
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Toggle | Concussion Among Children in the United States General Population: Incidence and Risk Factors. | Frontiers in neurology | Cook NE, Iverson GL | 2021 | |
PubMed Record
AbstractThe objective of this study was to examine the incidence of concussion and risk factors for sustaining concussion among children from the United States general population. This prospective cohort study used data from the Adolescent Brain Cognitive Development (ABCD) Study. Children were recruited from schools across the US, sampled to reflect the sociodemographic variation of the US population. The current sample includes 11,013 children aged 9 to 10 years old (47.6% girls; 65.5% White) who were prospectively followed for an average of 1 year (mean = 367.9 days, SD = 40.8, range 249-601). The primary outcome was caregiver-reported concussion during a 1 year follow-up period. Logistic regression was used to determine which potential clinical, health history, and behavioral characteristics (assessed at baseline) were prospectively associated with concussion. In the 1 year follow-up period between ages 10 and 11, 1 in 100 children ( = 123, 1.1%) sustained a concussion. In univariate models, three baseline predictors (ADHD, prior concussion, and accident proneness) were significantly associated with sustaining a concussion. In a multivariate model, controlling for all other predictors, only prior concussion remained significantly associated with the occurrence of a concussion during the observation period (Odds Ratio = 5.49, 95% CI: 3.40-8.87). The most robust and only independent prospective predictor of sustaining a concussion was history of a prior concussion. History of concussion is associated with 5.5 times greater odds of sustaining concussion between ages 10 and 11 among children from the general US population. JournalFrontiers in neurologyPublished2021/11/01AuthorsCook NE, Iverson GLKeywordsepidemiology, head trauma, mild traumatic brain injury, pediatric, traumatic injuryDOI10.3389/fneur.2021.773927 |
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Toggle | Greater radiologic evidence of hypothalamic gliosis predicts adiposity gain in children at risk for obesity. | Obesity (Silver Spring, Md.) | Sewaybricker LE, Kee S, Melhorn SJ, et al. | 2021 | |
PubMed Record
AbstractThis study investigated, in a large pediatric population, whether magnetic resonance imaging (MRI) evidence of mediobasal hypothalamic (MBH) gliosis is associated with baseline or change over 1 year in body adiposity. JournalObesity (Silver Spring, Md.)Published2021/11/01AuthorsSewaybricker LE, Kee S, Melhorn SJ, Schur EAKeywordsDOI10.1002/oby.23286 |
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Toggle | History of Depression, Elevated Body Mass Index, and Waist-to-Height Ratio in Preadolescent Children. | Psychosomatic medicine | Lewis-de Los Angeles WW, Liu RT | 2021 | |
PubMed Record
AbstractThis study aimed to evaluate whether a history of depression or self-injurious thoughts and behaviors predict elevated body mass index (BMI) and elevated waist-to-height ratio in preadolescents. JournalPsychosomatic medicinePublished2021/11/01AuthorsLewis-de Los Angeles WW, Liu RTKeywordsDOI10.1097/PSY.0000000000000982 |
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Toggle | Demographic and mental health assessments in the adolescent brain and cognitive development study: Updates and age-related trajectories. | Developmental cognitive neuroscience | Barch DM, Albaugh MD, Baskin-Sommers A, et al. | 2021 | |
PubMed Record
AbstractThe Adolescent Brain Cognitive Development (ABCD) Study of 11,880 youth incorporates a comprehensive range of measures assessing predictors and outcomes related to mental health across childhood and adolescence in participating youth, as well as information about family mental health history. We have previously described the logic and content of the mental health assessment battery at Baseline and 1-year follow-up. Here, we describe changes to that battery and issues and clarifications that have emerged, as well as additions to the mental health battery at the 2-, 3-, 4-, and 5-year follow-ups. We capitalize on the recent release of longitudinal data for caregiver and youth report of mental health data to evaluate trajectories of dimensions of psychopathology as a function of demographic factors. For both caregiver and self-reported mental health symptoms, males showed age-related decreases in internalizing and externalizing symptoms, while females showed an increase in internalizing symptoms with age. Multiple indicators of socioeconomic status (caregiver education, family income, financial adversity, neighborhood poverty) accounted for unique variance in both caregiver and youth-reported externalizing and internalizing symptoms. These data highlight the importance of examining developmental trajectories of mental health as a function of key factors such as sex and socioeconomic environment. JournalDevelopmental cognitive neurosciencePublished2021/10/29AuthorsBarch DM, Albaugh MD, Baskin-Sommers A, Bryant BE, Clark DB, Dick AS, Feczko E, Foxe JJ, Gee DG, Giedd J, Glantz MD, Hudziak JJ, Karcher NR, LeBlanc K, Maddox M, McGlade EC, Mulford C, Nagel BJ, Neigh G, Palmer CE, Potter AS, Sher KJ, Tapert SF, Thompson WK, Xie LKeywordsAssessment, Longitudinal assessment, Mental health, PsychopathologyDOI10.1016/j.dcn.2021.101031 |
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Toggle | Contributions of PTSD polygenic risk and environmental stress to suicidality in preadolescents. | Neurobiology of stress | Daskalakis NP, Schultz LM, Visoki E, et al. | 2021 | |
PubMed Record
AbstractSuicidal ideation and attempts (i.e., suicidality) are complex behaviors driven by environmental stress, genetic susceptibility, and their interaction. Preadolescent suicidality is a major health problem with rising rates, yet its underlying biology is understudied. Here we studied effects of genetic stress susceptibility, approximated by the polygenic risk score (PRS) for post-traumatic-stress-disorder (PTSD), on preadolescent suicidality in participants from the Adolescent Brain Cognitive Development (ABCD) Study®. We further evaluated PTSD-PRS effects on suicidality in the presence of environmental stressors that are established suicide risk factors. Analyses included both European and African ancestry participants using PRS calculated based on summary statistics from ancestry-specific genome-wide association studies. In European ancestry participants (N = 4,619, n = 378 suicidal), PTSD-PRS was associated with preadolescent suicidality (odds ratio [OR] = 1.12, 95%CI 1-1.25, p = 0.038). Results in African ancestry participants (N = 1,334, n = 130 suicidal) showed a similar direction but were not statistically significant (OR = 1.21, 95%CI 0.93-1.57, p = 0.153). Sensitivity analyses using non-psychiatric polygenic score for height and using cross-ancestry PTSD-PRS did not reveal any association with suicidality, supporting the specificity of the association of ancestry-specific PTSD-PRS with suicidality. Environmental stressors were robustly associated with suicidality across ancestries with moderate effect size for negative life events and family conflict (OR 1.27-1.6); and with large effect size (OR ∼ 4) for sexual-orientation discrimination. When combined with environmental factors, PTSD-PRS showed marginal additive effects in explaining variability in suicidality, with no evidence for G × E interaction. Results support use of cross-phenotype PRS, specifically stress-susceptibility, as a genetic marker for suicidality risk early in the lifespan. JournalNeurobiology of stressPublished2021/10/27AuthorsDaskalakis NP, Schultz LM, Visoki E, Moore TM, Argabright ST, Harnett NG, DiDomenico GE, Warrier V, Almasy L, Barzilay RKeywordsChild psychiatry, PTSD, Polygenic risk score, Stress, SuicideDOI10.1016/j.ynstr.2021.100411 |
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Toggle | Shorter Duration and Lower Quality Sleep Have Widespread Detrimental Effects on Developing Functional Brain Networks in Early Adolescence. | Cerebral cortex communications | Brooks SJ, Katz ES, Stamoulis C | 2021 | |
PubMed Record
AbstractSleep is critical for cognitive health, especially during complex developmental periods such as adolescence. However, its effects on maturating brain networks that support cognitive function are only partially understood. We investigated the impact of shorter duration and reduced quality sleep, common stressors during development, on functional network properties in early adolescence-a period of significant neural maturation, using resting-state functional magnetic resonance imaging from 5566 children (median age = 120.0 months; 52.1% females) in the Adolescent Brain Cognitive Development cohort. Decreased sleep duration, increased sleep latency, frequent waking up at night, and sleep-disordered breathing symptoms were associated with lower topological efficiency, flexibility, and robustness of visual, sensorimotor, attention, fronto-parietal control, default-mode and/or limbic networks, and with aberrant changes in the thalamus, basal ganglia, hippocampus, and cerebellum ( < 0.05). These widespread effects, many of which were body mass index-independent, suggest that unhealthy sleep in early adolescence may impair neural information processing and integration across incompletely developed networks, potentially leading to deficits in their cognitive correlates, including attention, reward, emotion processing and regulation, memory, and executive control. Shorter sleep duration, frequent snoring, difficulty waking up, and daytime sleepiness had additional detrimental network effects in nonwhite participants, indicating racial disparities in the influence of sleep metrics. JournalCerebral cortex communicationsPublished2021/10/26AuthorsBrooks SJ, Katz ES, Stamoulis CKeywordsadolescence, brain, connectome, sleep duration, sleep qualityDOI10.1093/texcom/tgab062 |
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Toggle | Large-scale functional brain networks of maladaptive childhood aggression identified by connectome-based predictive modeling. | Molecular psychiatry | Ibrahim K, Noble S, He G, et al. | 2021 | |
PubMed Record
AbstractDisruptions in frontoparietal networks supporting emotion regulation have been long implicated in maladaptive childhood aggression. However, the association of connectivity between large-scale functional networks with aggressive behavior has not been tested. The present study examined whether the functional organization of the connectome predicts severity of aggression in children. This cross-sectional study included a transdiagnostic sample of 100 children with aggressive behavior (27 females) and 29 healthy controls without aggression or psychiatric disorders (13 females). Severity of aggression was indexed by the total score on the parent-rated Reactive-Proactive Aggression Questionnaire. During fMRI, participants completed a face emotion perception task of fearful and calm faces. Connectome-based predictive modeling with internal cross-validation was conducted to identify brain networks that predicted aggression severity. The replication and generalizability of the aggression predictive model was then tested in an independent sample of children from the Adolescent Brain Cognitive Development (ABCD) study. Connectivity predictive of aggression was identified within and between networks implicated in cognitive control (medial-frontal, frontoparietal), social functioning (default mode, salience), and emotion processing (subcortical, sensorimotor) (r = 0.31, RMSE = 9.05, p = 0.005). Out-of-sample replication (p < 0.002) and generalization (p = 0.007) of findings predicting aggression from the functional connectome was demonstrated in an independent sample of children from the ABCD study (n = 1791; n = 1701). Individual differences in large-scale functional networks contribute to variability in maladaptive aggression in children with psychiatric disorders. Linking these individual differences in the connectome to variation in behavioral phenotypes will advance identification of neural biomarkers of maladaptive childhood aggression to inform targeted treatments. JournalMolecular psychiatryPublished2021/10/25AuthorsIbrahim K, Noble S, He G, Lacadie C, Crowley MJ, McCarthy G, Scheinost D, Sukhodolsky DGKeywordsDOI10.1038/s41380-021-01317-5 |
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Toggle | Editorial: Polygenic Risk Scores in Child Psychiatry, Research Promise, and Potential Clinical Pitfalls. | Journal of the American Academy of Child and Adolescent Psychiatry | Shaw P | 2021 | |
PubMed Record
AbstractPolygenic risk scores (PRSs) for mental disorders have become a major player in child psychiatry research. PRSs quantify a child’s risk for childhood psychiatric disorders by summing the effects of a multitude of common risk genetic variants across the entire genome. Each genetic variant in isolation contributes a minuscule amount to the disorder, but their combined effect can be substantial. The study by Pat et al. illustrates how PRSs can be used as a starting point to examine the mechanisms that might link common genetic variant risk with symptoms. In their exploration of how genes, cognition, and psychopathology may be tied together, the authors apply meticulous analytic techniques to a rich, open dataset (the Adolescent Brain Cognitive Development [ABCD] cohort) and report fascinating results. JournalJournal of the American Academy of Child and Adolescent PsychiatryPublished2021/10/23AuthorsShaw PKeywordsDOI10.1016/j.jaac.2021.10.010 |
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Toggle | Investigating the Link Between Depression, Cognition, and Motivation in Late Childhood. | Child psychiatry and human development | Steinberger DC, Barch DM | 2021 | |
PubMed Record
AbstractResearch has revealed broad cognitive deficits (e.g., memory, learning) in depression, and that motivation may account for this link. We tested the state (i.e., only present during depression), trait (i.e., underlying vulnerability) and scar (i.e., lasting corollary) hypotheses of cognitive dysfunction in depression. We additionally tested subjective motivation as a mediator of the concurrent depression-cognition link. In a longitudinal sample of 11,878 children ages 9-11, we found no evidence of a concurrent state or longitudinal trait or scar relationship between depression and cognition. The pattern of depression-cognition relationships-which precluded a mediator analysis-in our childhood sample is a departure from previous studies. Our findings indicate that cognitive deficits are not strongly associated with depression in childhood, in contrast with the impairment commonly seen in older individuals with depression. JournalChild psychiatry and human developmentPublished2021/10/22AuthorsSteinberger DC, Barch DMKeywordsChildren, Cognitive function, Depression, Longitudinal analysis, MotivationDOI10.1007/s10578-021-01267-7 |
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Toggle | Passive Sensing of Preteens' Smartphone Use: An Adolescent Brain Cognitive Development (ABCD) Cohort Substudy. | JMIR mental health | Wade NE, Ortigara JM, Sullivan RM, et al. | 2021 | |
PubMed Record
AbstractConcerns abound regarding childhood smartphone use, but studies to date have largely relied on self-reported screen use. Self-reporting of screen use is known to be misreported by pediatric samples and their parents, limiting the accurate determination of the impact of screen use on social, emotional, and cognitive development. Thus, a more passive, objective measurement of smartphone screen use among children is needed. JournalJMIR mental healthPublished2021/10/18AuthorsWade NE, Ortigara JM, Sullivan RM, Tomko RL, Breslin FJ, Baker FC, Fuemmeler BF, Delrahim Howlett K, Lisdahl KM, Marshall AT, Mason MJ, Neale MC, Squeglia LM, Wolff-Hughes DL, Tapert SF, Bagot KSKeywordsmobile phone, passive sensing, preadolescents, screen time, screen use, smartphone useDOI10.2196/29426 |
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Toggle | Associations among negative life events, changes in cortico-limbic connectivity, and psychopathology in the ABCD Study. | Developmental cognitive neuroscience | Brieant AE, Sisk LM, Gee DG | 2021 | |
PubMed Record
AbstractAdversity exposure is a risk factor for psychopathology, which most frequently onsets during adolescence, and prior research has demonstrated that alterations in cortico-limbic connectivity may account in part for this association. In a sample of youth from the Adolescent Brain Cognitive Development (ABCD) Study (N = 4006), we tested a longitudinal structural equation model to examine the indirect effect of adversity exposure (negative life events) on later psychopathology via changes in cortico-limbic resting-state functional connectivity (rsFC). We also examined the potential protective effects of parental acceptance. Generally, cortico-limbic connectivity became more strongly negative between baseline and year 2 follow-up, suggesting that stronger negative correlations within these cortico-limbic networks may reflect a more mature phenotype. Exposure to a greater number of negative life events was associated with stronger negative cortico-limbic rsFC which, in turn, was associated with lower internalizing (but not externalizing) symptoms. The indirect effect of negative life events on internalizing symptoms via cortico-limbic rsFC was significant. Parental acceptance did not moderate the association between negative life events and rsFC. Our findings highlight how stressful childhood experiences may accelerate neurobiological maturation in specific cortico-limbic connections, potentially reflecting an adaptive process that protects against internalizing problems in the context of adversity. JournalDevelopmental cognitive neurosciencePublished2021/10/16AuthorsBrieant AE, Sisk LM, Gee DGKeywordsAdversity, Cortico-limbic, Psychopathology, Resting-state fMRIDOI10.1016/j.dcn.2021.101022 |
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Toggle | An update on the assessment of culture and environment in the ABCD Study®: Emerging literature and protocol updates over three measurement waves. | Developmental cognitive neuroscience | Gonzalez R, Thompson EL, Sanchez M, et al. | 2021 | |
PubMed Record
AbstractAdvances in our understanding of risk and resilience factors in adolescent brain health and development increasingly demand a broad set of assessment tools that consider a youth’s peer, family, school, neighborhood, and cultural contexts in addition to neurobiological, genetic, and biomedical information. The Culture and Environment (CE) Workgroup (WG) of the Adolescent Brain Cognitive Development (ABCD) Study curates these important components of the protocol throughout ten years of planned data collection. In this report, the CE WG presents an update on the evolution of the ABCD Study® CE protocol since study inception (Zucker et al., 2018), as well as emerging findings that include CE measures. Background and measurement characteristics of instruments present in the study since baseline have already been described in our 2018 report, and therefore are only briefly described here. New measures introduced since baseline are described in more detail. Descriptive statistics on all measures are presented based on a total sample of 11,000+ youth and their caregivers assessed at baseline and the following two years. Psychometric properties of the measures, including longitudinal aspects of the data, are reported, along with considerations for future measurement waves. The CE WG ABCD® components are an essential part of the overall protocol that permits characterization of the unique cultural and social environment within which each developing brain is transactionally embedded. JournalDevelopmental cognitive neurosciencePublished2021/10/16AuthorsGonzalez R, Thompson EL, Sanchez M, Morris A, Gonzalez MR, Feldstein Ewing SW, Mason MJ, Arroyo J, Howlett K, Tapert SF, Zucker RAKeywordsDevelopment, acculturation, cultural identity, family effects, social interactions, substance useDOI10.1016/j.dcn.2021.101021 |
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Toggle | Risk of lead exposure, subcortical brain structure, and cognition in a large cohort of 9- to 10-year-old children. | PloS one | Marshall AT, McConnell R, Lanphear BP, et al. | 2021 | |
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AbstractLead, a toxic metal, affects cognitive development at the lowest measurable concentrations found in children, but little is known about its direct impact on brain development. Recently, we reported widespread decreases in cortical surface area and volume with increased risks of lead exposure, primarily in children of low-income families. JournalPloS onePublished2021/10/14AuthorsMarshall AT, McConnell R, Lanphear BP, Thompson WK, Herting MM, Sowell ERKeywordsDOI10.1371/journal.pone.0258469 |
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Toggle | Association between parental age, brain structure, and behavioral and cognitive problems in children. | Molecular psychiatry | Du J, Rolls ET, Gong W, et al. | 2021 | |
PubMed Record
AbstractTo investigate the relation between parental age, and behavioral, cognitive and brain differences in the children. JournalMolecular psychiatryPublished2021/10/14AuthorsDu J, Rolls ET, Gong W, Cao M, Vatansever D, Zhang J, Kang J, Cheng W, Feng JKeywordsDOI10.1038/s41380-021-01325-5 |
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Toggle | Adolescent civic engagement: Lessons from Black Lives Matter. | Proceedings of the National Academy of Sciences of the United States of America | Baskin-Sommers A, Simmons C, Conley M, et al. | 2021 | |
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AbstractIn 2020, individuals of all ages engaged in demonstrations condemning police brutality and supporting the Black Lives Matter (BLM) movement. Research that used parent reports and trends commented on in popular media suggested that adolescents under 18 had become increasingly involved in this movement. In the first large-scale quantitative survey of adolescents’ exposure to BLM demonstrations, 4,970 youth (mean = 12.88 y) across the United States highlighted that they were highly engaged, particularly with media, and experienced positive emotions when exposed to the BLM movement. In addition to reporting strong engagement and positive emotions related to BLM demonstrations, Black adolescents in particular reported higher negative emotions when engaging with different types of media and more exposure to violence during in-person BLM demonstrations. Appreciating youth civic engagement, while also providing support for processing complex experiences and feelings, is important for the health and welfare of young people and society. JournalProceedings of the National Academy of Sciences of the United States of AmericaPublished2021/10/12AuthorsBaskin-Sommers A, Simmons C, Conley M, Chang SA, Estrada S, Collins M, Pelham W, Beckford E, Mitchell-Adams H, Berrian N, Tapert SF, Gee DG, Casey BJKeywordsBlack Lives Matter, adolescents, demonstrations, raceDOI10.1073/pnas.2109860118 |
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Toggle | A Comprehensive Overview of the Physical Health of the Adolescent Brain Cognitive Development Study Cohort at Baseline. | Frontiers in pediatrics | Palmer CE, Sheth C, Marshall AT, et al. | 2021 | |
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AbstractPhysical health in childhood is crucial for neurobiological as well as overall development, and can shape long-term outcomes into adulthood. The landmark, longitudinal Adolescent Brain Cognitive Development Study (ABCD study), was designed to investigate brain development and health in almost 12,000 youth who were recruited when they were 9-10 years old and will be followed through adolescence and early adulthood. The overall goal of this paper is to provide descriptive analyses of physical health measures in the ABCD study at baseline, including but not limited to sleep, physical activity and sports involvement, and body mass index. Further this summary will describe how physical health measures collected from the ABCD cohort compare with current normative data and clinical guidelines. We propose this data set has the potential to facilitate clinical recommendations and inform national standards of physical health in this age group. This manuscript will also provide important information for ABCD users and help guide analyses investigating physical health including new avenues for health disparity research as it pertains to adolescent and young adult development. JournalFrontiers in pediatricsPublished2021/10/05AuthorsPalmer CE, Sheth C, Marshall AT, Adise S, Baker FC, Chang L, Clark DB, Coronado C, Dagher RK, Diaz V, Dowling GJ, Gonzalez MR, Haist F, Herting MM, Huber RS, Jernigan TL, LeBlanc K, Lee K, Lisdahl KM, Neigh G, Patterson MW, Renshaw P, Rhee KE, Tapert S, Thompson WK, Uban K, Sowell ER, Yurgelun-Todd DKeywordsdevelopmental milestones, middle childhood, physical activity, physical health, puberty, sleep, sociodemographicsDOI10.3389/fped.2021.734184 |
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Toggle | Heritability Analysis in Twins Indicates a Genetic Basis for Velopharyngeal Morphology. | The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association | Lee MK, Liu C, Leslie EJ, et al. | 2021 | |
PubMed Record
AbstractThe velopharyngeal mechanism is comprised of several muscular components that act in a coordinated manner to control airflow through the nose and mouth. Proper velopharyngeal function is essential for normal speech, swallowing, and breathing. The genetic basis of normal-range velopharyngeal morphology is poorly understood. The purpose of this study was to estimate the heritability of velopharyngeal dimensions. We measured five velopharyngeal variables (velar length, velar thickness, effective velar length, levator muscle length and pharyngeal depth) from MRIs of 155 monozygotic and 208 dizygotic twin pairs and then calculated heritability for these traits using a structural equation modeling approach. The heritability estimates were statistically significant (95% confidence intervals excluded zero) and ranged from 0.19 to 0.46. There was also evidence of significant genetic correlations between pairs of traits, pointing to the influence of common genetic effects. These results indicate that genetic factors influence variation in clinically relevant velopharyngeal structures. JournalThe Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationPublished2021/10/04AuthorsLee MK, Liu C, Leslie EJ, Shaffer JR, Perry JL, Weinberg SMKeywordsgenetics, mRI, soft palate, structural equation modeling, uvulaDOI10.1177/10556656211045530 |
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Toggle | Incipient alcohol use in childhood: Early alcohol sipping and its relations with psychopathology and personality. | Development and psychopathology | Watts AL, Wood PK, Jackson KM, et al. | 2021 | |
PubMed Record
AbstractPrior research has shown that sipping of alcohol begins to emerge during childhood and is potentially etiologically significant for later substance use problems. Using a large, community sample of 9- and 10-year-olds (N = 11,872; 53% female), we examined individual differences in precocious alcohol use in the form of alcohol sipping. We focused explicitly on features that are robust and well-demonstrated correlates of, and antecedents to, alcohol excess and related problems later in the lifespan, including youth- and parent-reported externalizing traits (i.e., impulsivity, behavioral inhibition and activation) and psychopathology. Seventeen percent of the sample reported sipping alcohol outside of a religiously sanctioned activity by age 9 or 10. Several aspects of psychopathology and personality emerged as small but reliable correlates of sipping. Nonreligious sipping was related to youth-reported impulsigenic traits, aspects of behavioral activation, prodromal psychotic-like symptoms, and mood disorder diagnoses, as well as parent-reported externalizing disorder diagnoses. Religious sipping was unexpectedly associated with certain aspects of impulsivity. Together, our findings point to the potential importance of impulsivity and other transdiagnostic indicators of psychopathology (e.g., emotion dysregulation, novelty seeking) in the earliest forms of drinking behavior. JournalDevelopment and psychopathologyPublished2021/10/01AuthorsWatts AL, Wood PK, Jackson KM, Lisdahl KM, Heitzeg MM, Gonzalez R, Tapert SF, Barch DM, Sher KJKeywordsalcohol sipping, novelty seeking, personality, precocious alcohol use, psychopathologyDOI10.1017/S0954579420000541 |
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Toggle | Callous-unemotional traits and reduced default mode network connectivity within a community sample of children. | Development and psychopathology | Umbach RH, Tottenham N | 2021 | |
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AbstractCallous-unemotional (CU) traits characterize a subset of youth at risk for persistent and serious antisocial behavior. Differences in resting state connectivity in the default mode network (DMN) have been associated with CU traits in forensic and clinical samples of adolescents and with deficient interpersonal/affective traits (often operationalized as Factor 1 psychopathy traits) in adults. It is unclear whether these brain-behavior associations extend to community-based children. Using mixed model analyses, we tested the associations between CU traits and within-network resting-state connectivity of seven task-activated networks and the DMN using data from 9,636 9-11-year-olds in the Adolescent Brain Cognitive Development (ABCD) study. Even after accounting for comorbid externalizing problems, higher levels of CU traits were associated with reduced connectivity within the DMN. This finding is consistent with prior literature surrounding psychopathy and CU traits in clinically and forensically based populations, suggesting the correlation likely exists on a spectrum, can be detected in childhood, and is not restricted to children with significant antisocial behavior. JournalDevelopment and psychopathologyPublished2021/10/01AuthorsUmbach RH, Tottenham NKeywordsbrain imaging developmental, callous-unemotional, resting stateDOI10.1017/S0954579420000401 |
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Toggle | Cortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group. | Translational psychiatry | Harrewijn A, Cardinale EM, Groenewold NA, et al. | 2021 | |
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AbstractThe goal of this study was to compare brain structure between individuals with generalized anxiety disorder (GAD) and healthy controls. Previous studies have generated inconsistent findings, possibly due to small sample sizes, or clinical/analytic heterogeneity. To address these concerns, we combined data from 28 research sites worldwide through the ENIGMA-Anxiety Working Group, using a single, pre-registered mega-analysis. Structural magnetic resonance imaging data from children and adults (5-90 years) were processed using FreeSurfer. The main analysis included the regional and vertex-wise cortical thickness, cortical surface area, and subcortical volume as dependent variables, and GAD, age, age-squared, sex, and their interactions as independent variables. Nuisance variables included IQ, years of education, medication use, comorbidities, and global brain measures. The main analysis (1020 individuals with GAD and 2999 healthy controls) included random slopes per site and random intercepts per scanner. A secondary analysis (1112 individuals with GAD and 3282 healthy controls) included fixed slopes and random intercepts per scanner with the same variables. The main analysis showed no effect of GAD on brain structure, nor interactions involving GAD, age, or sex. The secondary analysis showed increased volume in the right ventral diencephalon in male individuals with GAD compared to male healthy controls, whereas female individuals with GAD did not differ from female healthy controls. This mega-analysis combining worldwide data showed that differences in brain structure related to GAD are small, possibly reflecting heterogeneity or those structural alterations are not a major component of its pathophysiology. JournalTranslational psychiatryPublished2021/10/01AuthorsHarrewijn A, Cardinale EM, Groenewold NA, Bas-Hoogendam JM, Aghajani M, Hilbert K, Cardoner N, Porta-Casteràs D, Gosnell S, Salas R, Jackowski AP, Pan PM, Salum GA, Blair KS, Blair JR, Hammoud MZ, Milad MR, Burkhouse KL, Phan KL, Schroeder HK, Strawn JR, Beesdo-Baum K, Jahanshad N, Thomopoulos SI, Buckner R, Nielsen JA, Smoller JW, Soares JC, Mwangi B, Wu MJ, Zunta-Soares GB, Assaf M, Diefenbach GJ, Brambilla P, Maggioni E, Hofmann D, Straube T, Andreescu C, Berta R, Tamburo E, Price RB, Manfro GG, Agosta F, Canu E, Cividini C, Filippi M, Kostić M, Munjiza Jovanovic A, Alberton BAV, Benson B, Freitag GF, Filippi CA, Gold AL, Leibenluft E, Ringlein GV, Werwath KE, Zwiebel H, Zugman A, Grabe HJ, Van der Auwera S, Wittfeld K, Völzke H, Bülow R, Balderston NL, Ernst M, Grillon C, Mujica-Parodi LR, van Nieuwenhuizen H, Critchley HD, Makovac E, Mancini M, Meeten F, Ottaviani C, Ball TM, Fonzo GA, Paulus MP, Stein MB, Gur RE, Gur RC, Kaczkurkin AN, Larsen B, Satterthwaite TD, Harper J, Myers M, Perino MT, Sylvester CM, Yu Q, Lueken U, Veltman DJ, Thompson PM, Stein DJ, Van der Wee NJA, Winkler AM, Pine DSKeywordsDOI10.1038/s41398-021-01622-1 |
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Toggle | Longitudinal Impact of Childhood Adversity on Early Adolescent Mental Health During the COVID-19 Pandemic in the ABCD Study Cohort: Does Race or Ethnicity Moderate Findings? | Biological psychiatry global open science | Stinson EA, Sullivan RM, Peteet BJ, et al. | 2021 | |
PubMed Record
AbstractDuring the COVID-19 pandemic in the United States, mental health among youth has been negatively affected. Youth with a history of adverse childhood experiences (ACEs), as well as youth from minoritized racial-ethnic backgrounds, may be especially vulnerable to experiencing COVID-19-related distress. The aims of this study are to examine whether exposure to pre-pandemic ACEs predicts mental health during the COVID-19 pandemic in youth and whether racial-ethnic background moderates these effects. JournalBiological psychiatry global open sciencePublished2021/09/29AuthorsStinson EA, Sullivan RM, Peteet BJ, Tapert SF, Baker FC, Breslin FJ, Dick AS, Gonzalez MR, Guillaume M, Marshall AT, McCabe CJ, Pelham WE, Van Rinsveld A, Sheth CS, Sowell ER, Wade NE, Wallace AL, Lisdahl KMKeywordsAdolescence, Adverse childhood experiences, COVID-19, Health disparities, Mental health, PandemicDOI10.1016/j.bpsgos.2021.08.007 |
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Toggle | Recalibrating expectations about effect size: A multi-method survey of effect sizes in the ABCD study. | PloS one | Owens MM, Potter A, Hyatt CS, et al. | 2021 | |
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AbstractEffect sizes are commonly interpreted using heuristics established by Cohen (e.g., small: r = .1, medium r = .3, large r = .5), despite mounting evidence that these guidelines are mis-calibrated to the effects typically found in psychological research. This study’s aims were to 1) describe the distribution of effect sizes across multiple instruments, 2) consider factors qualifying the effect size distribution, and 3) identify examples as benchmarks for various effect sizes. For aim one, effect size distributions were illustrated from a large, diverse sample of 9/10-year-old children. This was done by conducting Pearson’s correlations among 161 variables representing constructs from all questionnaires and tasks from the Adolescent Brain and Cognitive Development Study® baseline data. To achieve aim two, factors qualifying this distribution were tested by comparing the distributions of effect size among various modifications of the aim one analyses. These modified analytic strategies included comparisons of effect size distributions for different types of variables, for analyses using statistical thresholds, and for analyses using several covariate strategies. In aim one analyses, the median in-sample effect size was .03, and values at the first and third quartiles were .01 and .07. In aim two analyses, effects were smaller for associations across instruments, content domains, and reporters, as well as when covarying for sociodemographic factors. Effect sizes were larger when thresholding for statistical significance. In analyses intended to mimic conditions used in “real-world” analysis of ABCD data, the median in-sample effect size was .05, and values at the first and third quartiles were .03 and .09. To achieve aim three, examples for varying effect sizes are reported from the ABCD dataset as benchmarks for future work in the dataset. In summary, this report finds that empirically determined effect sizes from a notably large dataset are smaller than would be expected based on existing heuristics. JournalPloS onePublished2021/09/23AuthorsOwens MM, Potter A, Hyatt CS, Albaugh M, Thompson WK, Jernigan T, Yuan D, Hahn S, Allgaier N, Garavan HKeywordsDOI10.1371/journal.pone.0257535 |
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Toggle | Prevalence and correlates of suicidal ideation and suicide attempts in preadolescent children: A US population-based study. | Translational psychiatry | Lawrence HR, Burke TA, Sheehan AE, et al. | 2021 | |
PubMed Record
AbstractThe present study evaluated sociodemographic and diagnostic predictors of suicidal ideation and attempts in a nationally representative sample of preadolescent youth enrolled in the Adolescent Brain Cognitive Development Study. Rates and predictors of psychiatric treatment utilization among suicidal youth also were examined. Eleven thousand eight hundred and seventy-five 9- and 10-year-old children residing in the United States were assessed. Children and their parents/guardians provided reports of children’s lifetime history of suicidal ideation, suicide attempts, and psychiatric disorders. Parents also reported on sociodemographic characteristics and mental health service utilization. Multivariate logistic regression analyses were employed to evaluate sociodemographic and diagnostic correlates of suicidal ideation, suicide attempts among youth with suicidal ideation, and treatment utilization among youth with suicidal ideation and suicide attempts. Lifetime prevalence rates were 14.33% for suicidal ideation and 1.26% for suicide attempts. Youth who identified as male, a sexual minority, or multiracial had greater odds of suicidal ideation, and sexual minority youth and youth with a low family income had greater odds of suicide attempts. Comorbid psychopathology was associated with higher odds of both suicidal ideation and suicide attempts. In youth, 34.59% who have suicidal ideation and 54.82% who had attempted suicide received psychiatric treatment. Treatment utilization among suicidal youth was lower among those who identified as female, Black, and Hispanic. Suicidal ideation and attempts among preadolescent children are concerningly high and targeted assessment and preventative efforts are needed, especially for males, racial, ethnic, and sexual minority youth, and those youth experiencing comorbidity. JournalTranslational psychiatryPublished2021/09/22AuthorsLawrence HR, Burke TA, Sheehan AE, Pastro B, Levin RY, Walsh RFL, Bettis AH, Liu RTKeywordsDOI10.1038/s41398-021-01593-3 |
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Toggle | Vertex-wise multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology. | NeuroImage | Shadrin AA, Kaufmann T, van der Meer D, et al. | 2021 | |
PubMed Record
AbstractBrain morphology has been shown to be highly heritable, yet only a small portion of the heritability is explained by the genetic variants discovered so far. Here we extended the Multivariate Omnibus Statistical Test (MOSTest) and applied it to genome-wide association studies (GWAS) of vertex-wise structural magnetic resonance imaging (MRI) cortical measures from N=35,657 participants in the UK Biobank. We identified 695 loci for cortical surface area and 539 for cortical thickness, in total 780 unique genetic loci associated with cortical morphology robustly replicated in 8,060 children of mixed ethnicity from the Adolescent Brain Cognitive Development (ABCD) Study®. This reflects more than 8-fold increase in genetic discovery at no cost to generalizability compared to the commonly used univariate GWAS methods applied to region of interest (ROI) data. Functional follow up including gene-based analyses implicated 10% of all protein-coding genes and pointed towards pathways involved in neurogenesis and cell differentiation. Power analysis indicated that applying the MOSTest to vertex-wise structural MRI data triples the effective sample size compared to conventional univariate GWAS approaches. The large boost in power obtained with the vertex-wise MOSTest together with pronounced replication rates and highlighted biologically meaningful pathways underscores the advantage of multivariate approaches in the context of highly distributed polygenic architecture of the human brain. JournalNeuroImagePublished2021/09/21AuthorsShadrin AA, Kaufmann T, van der Meer D, Palmer CE, Makowski C, Loughnan R, Jernigan TL, Seibert TM, Hagler DJ, Smeland OB, Motazedi E, Chu Y, Lin A, Cheng W, Hindley G, Thompson WK, Fan CC, Holland D, Westlye LT, Frei O, Andreassen OA, Dale AMKeywordsCortical surface area, Cortical thickness, Distributed polygenic architecture, Genome-wide association study, Multivariate vertex-wise analysisDOI10.1016/j.neuroimage.2021.118603 |
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Toggle | Covariate Correcting Networks for Identifying Associations Between Socioeconomic Factors and Brain Outcomes in Children | Medical Image Computing and Computer Assisted Intervention – MICCAI 2021 | Cho H, Park G, Isaiah A, et al. | 2021 | |
Link to Publication
AbstractBrain development in adolescence is synthetically influenced by various factors such as age, education, and socioeconomic conditions. To identify an independent effect from a variable of interest (e.g., socioeconomic conditions), statistical models such as General Linear Model (GLM) are typically adopted to account for covariates (e.g., age and gender). However, statistical models may be vulnerable with insufficient sample size and outliers, and multiple tests for a whole brain analysis lead to inevitable false-positives without sufficient sensitivity. Hence, it is necessary to develop a unified framework for multiple tests that robustly fits the observation and increases sensitivity. We therefore propose a unified flexible neural network that optimizes on the contribution from the main variable of interest as introduced in original GLM, which leads to improved statistical outcomes. The results on group analysis with fractional anisotropy (FA) from Diffusion Tensor Images from Adolescent Brain Cognitive Development (ABCD) study demonstrate that the proposed method provides much more selective and meaningful detection of ROIs related to socioeconomic status over conventional methods. JournalMedical Image Computing and Computer Assisted Intervention – MICCAI 2021Published2021/09/21AuthorsCho H, Park G, Isaiah A, et al.KeywordsDOIhttps://doi.org/10.1007/978-3-030-87234-2_40 |
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Toggle | Sleep Disturbances, Obesity, and Cognitive Function in Childhood: A Mediation Analysis. | Current developments in nutrition | Mattey-Mora PP, Nelson EJ | 2021 | |
PubMed Record
AbstractChildhood cognitive development is influenced by biological and environmental factors. One such factor, obesity, impairs cognitive development and is associated with sleep disturbances. JournalCurrent developments in nutritionPublished2021/09/15AuthorsMattey-Mora PP, Nelson EJKeywordsBMI, childhood, cognitive function, crystallized cognition, fluid cognition, mediation analysis, obesity, sleep disturbancesDOI10.1093/cdn/nzab119 |
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Toggle | Identifying profiles of brain structure and associations with current and future psychopathology in youth. | Developmental cognitive neuroscience | Mattoni M, Wilson S, Olino TM | 2021 | |
PubMed Record
AbstractBrain structure is often studied as a marker of youth psychopathology by examining associations between volume or thickness of individual regions and specific diagnoses. However, these univariate approaches do not address whether the effect of a particular region may depend on the structure of other regions. Here, we identified subgroups of individuals with distinct profiles of brain structure and examined how these profiles were associated with concurrent and future youth psychopathology. We used latent profile analysis to identify distinct neuroanatomical profiles of subcortical region volume and orbitofrontal cortical thickness in the ABCD study (N = 9376, mean age = 9.91, SD = 0.62). We identified a five-profile solution consisting of a reduced subcortical volume profile, a reduced orbitofrontal thickness profile, a reduced limbic and elevated striatal volume profile, an elevated orbitofrontal thickness and reduced striatal volume profile, and an elevated orbitofrontal thickness and subcortical volume profile. While controlling for age, sex, and intracranial volume, profiles exhibited differences in concurrent psychopathology measured dimensionally and categorically and in psychopathology at 1-year follow-up measured dimensionally. Results show that profiles of brain structure have incremental validity for associations with youth psychopathology beyond intracranial volume. JournalDevelopmental cognitive neurosciencePublished2021/09/14AuthorsMattoni M, Wilson S, Olino TMKeywordsABCD study, Brain profile, Brain structure, Latent profile analysis, Youth psychopathologyDOI10.1016/j.dcn.2021.101013 |
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Toggle | Multimodal MR Images-Based Diagnosis of Early Adolescent Attention-Deficit/Hyperactivity Disorder Using Multiple Kernel Learning. | Frontiers in neuroscience | Zhou X, Lin Q, Gui Y, et al. | 2021 | |
PubMed Record
AbstractAttention-deficit/hyperactivity disorder (ADHD) is one of the most common brain diseases among children. The current criteria of ADHD diagnosis mainly depend on behavior analysis, which is subjective and inconsistent, especially for children. The development of neuroimaging technologies, such as magnetic resonance imaging (MRI), drives the discovery of brain abnormalities in structure and function by analyzing multimodal neuroimages for computer-aided diagnosis of brain diseases. This paper proposes a multimodal machine learning framework that combines the Boruta based feature selection and Multiple Kernel Learning (MKL) to integrate the multimodal features of structural and functional MRIs and Diffusion Tensor Images (DTI) for the diagnosis of early adolescent ADHD. The rich and complementary information of the macrostructural features, microstructural properties, and functional connectivities are integrated at the kernel level, followed by a support vector machine classifier for discriminating ADHD from healthy children. Our experiments were conducted on the comorbidity-free ADHD subjects and covariable-matched healthy children aged 9-10 chosen from the Adolescent Brain and Cognitive Development (ABCD) study. This paper is the first work to combine structural and functional MRIs with DTI for early adolescents of the ABCD study. The results indicate that the kernel-level fusion of multimodal features achieves 0.698 of AUC (area under the receiver operating characteristic curves) and 64.3% of classification accuracy for ADHD diagnosis, showing a significant improvement over the early feature fusion and unimodal features. The abnormal functional connectivity predictors, involving default mode network, attention network, auditory network, and sensorimotor mouth network, thalamus, and cerebellum, as well as the anatomical regions in basal ganglia, are found to encode the most discriminative information, which collaborates with macrostructure and diffusion alterations to boost the performances of disorder diagnosis. JournalFrontiers in neurosciencePublished2021/09/14AuthorsZhou X, Lin Q, Gui Y, Wang Z, Liu M, Lu HKeywordsDTI, attention-deficit/hyperactivity disorder, disorder diagnosis, early adolescent, multimodal MR images, multiple kernel learning, resting-state functional MRI, structural MRIDOI10.3389/fnins.2021.710133 |
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Toggle | General . specific vulnerabilities: polygenic risk scores and higher-order psychopathology dimensions in the Adolescent Brain Cognitive Development (ABCD) Study. | Psychological medicine | Waszczuk MA, Miao J, Docherty AR, et al. | 2021 | |
PubMed Record
AbstractPolygenic risk scores (PRSs) capture genetic vulnerability to psychiatric conditions. However, PRSs are often associated with multiple mental health problems in children, complicating their use in research and clinical practice. The current study is the first to systematically test which PRSs associate broadly with all forms of childhood psychopathology, and which PRSs are more specific to one or a handful of forms of psychopathology. JournalPsychological medicinePublished2021/09/14AuthorsWaszczuk MA, Miao J, Docherty AR, Shabalin AA, Jonas KG, Michelini G, Kotov RKeywordsChild Behavior Checklist, childhood psychopathology, general factor, genetic, polygenicDOI10.1017/S0033291721003639 |
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Toggle | Screen time and early adolescent mental health, academic, and social outcomes in 9- and 10- year old children: Utilizing the Adolescent Brain Cognitive Development ℠ (ABCD) Study. | PloS one | Paulich KN, Ross JM, Lessem JM, et al. | 2021 | |
PubMed Record
AbstractIn a technology-driven society, screens are being used more than ever. The high rate of electronic media use among children and adolescents begs the question: is screen time harming our youth? The current study draws from a nationwide sample of 11,875 participants in the United States, aged 9 to 10 years, from the Adolescent Brain Cognitive Development Study (ABCD Study®). We investigate relationships between screen time and mental health, behavioral problems, academic performance, sleep habits, and peer relationships by conducting a series of correlation and regression analyses, controlling for SES and race/ethnicity. We find that more screen time is moderately associated with worse mental health, increased behavioral problems, decreased academic performance, and poorer sleep, but heightened quality of peer relationships. However, effect sizes associated with screen time and the various outcomes were modest; SES was more strongly associated with each outcome measure. Our analyses do not establish causality and the small effect sizes observed suggest that increased screen time is unlikely to be directly harmful to 9-and-10-year-old children. JournalPloS onePublished2021/09/08AuthorsPaulich KN, Ross JM, Lessem JM, Hewitt JKKeywordsDOI10.1371/journal.pone.0256591 |
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Toggle | Genetic variation in endocannabinoid signaling is associated with differential network-level functional connectivity in youth. | Journal of neuroscience research | Sisk LM, Rapuano KM, Conley MI, et al. | 2021 | |
PubMed Record
AbstractThe endocannabinoid system is an important regulator of emotional responses such as fear, and a number of studies have implicated endocannabinoid signaling in anxiety. The fatty acid amide hydrolase (FAAH) C385A polymorphism, which is associated with enhanced endocannabinoid signaling in the brain, has been identified across species as a potential protective factor from anxiety. In particular, adults with the variant FAAH 385A allele have greater fronto-amygdala connectivity and lower anxiety symptoms. Whether broader network-level differences in connectivity exist, and when during development this neural phenotype emerges, remains unknown and represents an important next step in understanding how the FAAH C385A polymorphism impacts neurodevelopment and risk for anxiety disorders. Here, we leveraged data from 3,109 participants in the nationwide Adolescent Brain Cognitive Development Study℠ (10.04 ± 0.62 years old; 44.23% female, 55.77% male) and a cross-validated, data-driven approach to examine associations between genetic variation and large-scale resting-state brain networks. Our findings revealed a distributed brain network, comprising functional connections that were both significantly greater (95% CI for p values = [<0.001, <0.001]) and lesser (95% CI for p values = [0.006, <0.001]) in A-allele carriers relative to non-carriers. Furthermore, there was a significant interaction between genotype and the summarized connectivity of functional connections that were greater in A-allele carriers, such that non-carriers with connectivity more similar to A-allele carriers (i.e., greater connectivity) had lower anxiety symptoms (β = -0.041, p = 0.030). These findings provide novel evidence of network-level changes in neural connectivity associated with genetic variation in endocannabinoid signaling and suggest that genotype-associated neural differences may emerge at a younger age than genotype-associated differences in anxiety. JournalJournal of neuroscience researchPublished2021/09/08AuthorsSisk LM, Rapuano KM, Conley MI, Greene AS, Horien C, Rosenberg MD, Scheinost D, Constable RT, Glatt CE, Casey BJ, Gee DGKeywordsanxiety, brain development, brain networks, endocannabinoid signaling, functional connectivityDOI10.1002/jnr.24946 |
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Toggle | Cortical Thickness in bilingual and monolingual children: Relationships to language use and language skill. | NeuroImage | Vaughn KA, Nguyen MVH, Ronderos J, et al. | 2021 | |
PubMed Record
AbstractThere is a growing body of evidence based on adult neuroimaging that suggests that the brain adapts to bilingual experiences to support language proficiency. The Adolescent Brain Cognitive Development (ABCD) Study is a useful source of data for evaluating this claim during childhood, as it involves data from a large sample of American children. Using the baseline ABCD Study data collected at ages nine and ten, the goal of this study was to identify differences in cortical thickness between bilinguals and monolinguals and to evaluate how variability in English vocabulary and English use within bilinguals might explain these group differences. We identified bilingual participants as children who spoke a non-English language and were exposed to the non-English language at home. We then identified a matched sample of English monolingual participants based on age, sex, pubertal status, parent education, household income, non-verbal IQ, and handedness. Bilinguals had thinner cortex than monolinguals in widespread cortical regions. Within bilinguals, more English use was associated with greater frontal and parietal cortical thickness; greater English vocabulary was associated with greater frontal and temporal cortical thickness. These findings replicate and extend previous research with bilingual children and highlight unexplained cortical thickness differences between bilinguals and monolinguals. JournalNeuroImagePublished2021/09/07AuthorsVaughn KA, Nguyen MVH, Ronderos J, Hernandez AEKeywordsBilingual, Child, Cortical Thickness, MRIDOI10.1016/j.neuroimage.2021.118560 |
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Toggle | Motivation and Cognitive Abilities as Mediators Between Polygenic Scores and Psychopathology in Children. | Journal of the American Academy of Child and Adolescent Psychiatry | Pat N, Riglin L, Anney R, et al. | 2021 | |
PubMed Record
AbstractFundamental questions in biological psychiatry concern the mechanisms that mediate between genetic liability and psychiatric symptoms. Genetic liability for many common psychiatric disorders often confers transdiagnostic risk to develop a wide variety of psychopathological symptoms through yet unknown pathways. This study examined the psychological and cognitive pathways that might mediate the relationship between genetic liability (indexed by polygenic scores; PS) and broad psychopathology (indexed by p factor and its underlying dimensions). JournalJournal of the American Academy of Child and Adolescent PsychiatryPublished2021/09/07AuthorsPat N, Riglin L, Anney R, Wang Y, Barch DM, Thapar A, Stringaris AKeywordsADHD, Adolescent Brain Cognitive Development, MDD, polygenic score, transdiagnostic psychopathologyDOI10.1016/j.jaac.2021.08.019 |
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Toggle | Children's Knowledge of Cannabis and Other Substances in States with Different Cannabis Use Regulations. | Substance use & misuse | Ross JM, Rieselbach MM, Hewitt JK, et al. | 2021 | |
PubMed Record
Abstract: Public acceptance of cannabis continues to increase across the US, yet there has been little research on how cannabis legalization affects young children. The present study compared knowledge of cannabis and other substances among children living in states with different cannabis laws and examined whether the association between such substance knowledge and externalizing behavior varies by state cannabis regulations. : Participants were from the Adolescent Brain Cognitive Development Study (ABCD Study®) at the baseline assessment ( = 11,875, ages 9-11, collected from 2016 to 2018). Chi-square difference tests were used to compare nested models testing group differences in knowledge of substances and the association between externalizing disorder/behavior and substance knowledge as a function of state legality of cannabis use (recreational, medical, low THC/CBD, none). : Children living in states with more permissive cannabis laws had a greater knowledge of cannabis and reported more alcohol experimentation. In contrast, knowledge regarding alcohol, tobacco, and other illicit drugs was not greater in children from states with more permissive cannabis laws. Externalizing disorder/behavior was not significantly associated with cannabis knowledge in any group and not significantly different across groups. The association between externalizing disorder/behavior and illicit drug knowledge was significant only in states with the recreational and medical use laws but did not differ significantly across groups. : Children living in environments with more permissive cannabis regulations have greater knowledge of cannabis, but not other substances, and report more experimentation with alcohol. JournalSubstance use & misusePublished2021/09/05AuthorsRoss JM, Rieselbach MM, Hewitt JK, Banich MT, Rhee SHKeywordsCannabis, children, policiesDOI10.1080/10826084.2021.1972316 |
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Toggle | Sociodemographic Correlates of Contemporary Screen Time Use among 9- and 10-Year-Old Children. | The Journal of pediatrics | Nagata JM, Ganson KT, Iyer P, et al. | 2021 | |
PubMed Record
AbstractTo determine sociodemographic correlates of contemporary screen time use among a diverse population-based sample of 9- and 10-year-old children. JournalThe Journal of pediatricsPublished2021/09/02AuthorsNagata JM, Ganson KT, Iyer P, Chu J, Baker FC, Pettee Gabriel K, Garber AK, Murray SB, Bibbins-Domingo KKeywordsadolescents, pediatrics, screen time, smart phone, social media, televisionDOI10.1016/j.jpeds.2021.08.077 |
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Toggle | Smaller Hippocampal Volume Among Black and Latinx Youth Living in High-Stigma Contexts. | Journal of the American Academy of Child and Adolescent Psychiatry | Hatzenbuehler ML, Weissman DG, McKetta S, et al. | 2021 | |
PubMed Record
AbstractTo determine whether structural and individual forms of stigma are associated with neurodevelopment in children. JournalJournal of the American Academy of Child and Adolescent PsychiatryPublished2021/09/02AuthorsHatzenbuehler ML, Weissman DG, McKetta S, Lattanner MR, Ford JV, Barch DM, McLaughlin KAKeywordshippocampal volume, neurodevelopment, population neuroscience, stigmaDOI10.1016/j.jaac.2021.08.017 |
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Toggle | Early Adolescent Substance Use Before and During the COVID-19 Pandemic: A Longitudinal Survey in the ABCD Study Cohort. | The Journal of adolescent health : official publication of the Society for Adolescent Medicine | Pelham WE, Tapert SF, Gonzalez MR, et al. | 2021 | |
PubMed Record
AbstractEvaluate changes in early adolescent substance use during the coronavirus disease 2019 (COVID-19) pandemic using a prospective, longitudinal, nationwide cohort. JournalThe Journal of adolescent health : official publication of the Society for Adolescent MedicinePublished2021/09/01AuthorsPelham WE, Tapert SF, Gonzalez MR, McCabe CJ, Lisdahl KM, Alzueta E, Baker FC, Breslin FJ, Dick AS, Dowling GJ, Guillaume M, Hoffman EA, Marshall AT, McCandliss BD, Sheth CS, Sowell ER, Thompson WK, Van Rinsveld AM, Wade NE, Brown SAKeywordsAnxiety, COVID-19, Depression, Drinking, Drug use, StressDOI10.1016/j.jadohealth.2021.06.015 |
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Toggle | Predicting fluid intelligence in adolescence from structural MRI with deep learning methods | Intelligence | Saha S, Pagnozzi A, Bradford D, et al. | 2021 | |
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AbstractBackground Methods Results Conclusion JournalIntelligencePublished2021/09/01AuthorsSaha S, Pagnozzi A, Bradford D, et al.KeywordsDOIhttps://doi.org/10.1016/j.intell.2021.101568 |
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Toggle | The relationship between brain structure and general psychopathology in preadolescents. | Journal of child psychology and psychiatry, and allied disciplines | Mewton L, Lees B, Squeglia LM, et al. | 2021 | |
PubMed Record
AbstractAn emerging body of literature has indicated that broad, transdiagnostic dimensions of psychopathology are associated with alterations in brain structure across the life span. The current study aimed to investigate the relationship between brain structure and broad dimensions of psychopathology in the critical preadolescent period when psychopathology is emerging. JournalJournal of child psychology and psychiatry, and allied disciplinesPublished2021/09/01AuthorsMewton L, Lees B, Squeglia LM, Forbes MK, Sunderland M, Krueger R, Koch FC, Baillie A, Slade T, Hoy N, Teesson MKeywordsGeneralized psychopathology, brain structure, externalizing, internalizing, preadolescenceDOI10.1111/jcpp.13513 |
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Toggle | Neural response to monetary loss among youth with disruptive behavior disorders and callous-unemotional traits in the ABCD study. | NeuroImage. Clinical | Byrd AL, Hawes SW, Waller R, et al. | 2021 | |
PubMed Record
AbstractEtiological models highlight reduced punishment sensitivity as a core risk factor for disruptive behavior disorders (DBD) and callous-unemotional (CU) traits. The current study examined neural sensitivity to the anticipation and receipt of loss, one key aspect of punishment sensitivity, among youth with DBD, comparing those with and without CU traits. Data were obtained from the Adolescent Brain and Cognitive Development (ABCD) Study (N = 11,874; Mage = 9.51; 48% female). Loss-related fMRI activity during the monetary incentive delay task was examined across 16 empirically-derived a priori brain regions (e.g., striatum, amygdala, insula, anterior cingulate cortex, medial prefrontal cortex) and compared across the following groups: (1) typically developing (n = 693); (2) DBD (n = 995), subdivided into those (3) with CU traits (DBD + CU, n = 198), and (4) without CU traits (DBD-only, n = 276). Latent variable modeling was also employed to examine network-level activity. There were no significant between-group differences in brain activity to loss anticipation or receipt. Null findings were confirmed with and without covariates, using alternative grouping approaches, and in dimensional models. Network-level analyses also demonstrated comparable activity across groups during loss anticipation and receipt. Findings suggest that differences in punishment sensitivity among youth with DBD are unrelated to loss anticipation or receipt. More precise characterizations of other aspects punishment sensitivity are needed to understand risk for DBD and CU traits. JournalNeuroImage. ClinicalPublished2021/09/01AuthorsByrd AL, Hawes SW, Waller R, Delgado MR, Sutherland MT, Dick AS, Trucco EM, Riedel MC, Pacheco-Colón I, Laird AR, Gonzalez RKeywordsABCD, Antisocial behavior, Callous-unemotional, Conduct problems, Imaging, Punishment sensitivity, fMRIDOI10.1016/j.nicl.2021.102810 |
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Toggle | Widespread Positive Direct and Indirect Effects of Regular Physical Activity on the Developing Functional Connectome in Early Adolescence. | Cerebral cortex (New York, N.Y. : 1991) | Brooks SJ, Parks SM, Stamoulis C | 2021 | |
PubMed Record
AbstractAdolescence is a period of profound but incompletely understood changes in the brain’s neural circuitry (the connectome), which is vulnerable to risk factors such as unhealthy weight, but may be protected by positive factors such as regular physical activity. In 5955 children (median age = 120 months; 50.86% females) from the Adolescent Brain Cognitive Development (ABCD) cohort, we investigated direct and indirect (through impact on body mass index [BMI]) effects of physical activity on resting-state networks, the backbone of the functional connectome that ubiquitously affects cognitive function. We estimated significant positive effects of regular physical activity on network connectivity, efficiency, robustness and stability (P ≤ 0.01), and on local topologies of attention, somatomotor, frontoparietal, limbic, and default-mode networks (P < 0.05), which support extensive processes, from memory and executive control to emotional processing. In contrast, we estimated widespread negative BMI effects in the same network properties and brain regions (P < 0.05). Additional mediation analyses suggested that physical activity could also modulate network topologies leading to better control of food intake, appetite and satiety, and ultimately lower BMI. Thus, regular physical activity may have extensive positive effects on the development of the functional connectome, and may be critical for improving the detrimental effects of unhealthy weight on cognitive health. JournalCerebral cortex (New York, N.Y. : 1991)Published2021/08/26AuthorsBrooks SJ, Parks SM, Stamoulis CKeywordsBMI, adolescence, brain networks, functional connectome, physical activityDOI10.1093/cercor/bhab126 |
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Toggle | Association Between Discrimination Stress and Suicidality in Preadolescent Children. | Journal of the American Academy of Child and Adolescent Psychiatry | Argabright ST, Visoki E, Moore TM, et al. | 2021 | |
PubMed Record
AbstractYouth suicide rates in the United States have been increasing in recent years, especially in Black Americans, the reasons for which are unclear. Environmental adversity is key in youth suicidality; hence there is a need to study stressors that have a disproportionate impact on Black youths. We aimed to disentangle the unique contribution of racial/ethnic discrimination from other adversities associated with childhood suicidal ideation and attempts (suicidality). JournalJournal of the American Academy of Child and Adolescent PsychiatryPublished2021/08/20AuthorsArgabright ST, Visoki E, Moore TM, Ryan DT, DiDomenico GE, Njoroge WFM, Taylor JH, Guloksuz S, Gur RC, Gur RE, Benton TD, Barzilay RKeywordschild psychiatry, discrimination, exposome, race, suicideDOI10.1016/j.jaac.2021.08.011 |
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Toggle | Similar but distinct - Effects of different socioeconomic indicators on resting state functional connectivity: Findings from the Adolescent Brain Cognitive Development (ABCD) Study®. | Developmental cognitive neuroscience | Rakesh D, Zalesky A, Whittle S | 2021 | |
PubMed Record
AbstractEarly socioeconomic status (SES) has consistently been associated with child health and cognitive outcomes, in addition to alterations in brain function and connectivity. The goal of the present study was to probe the effects of different facets of SES (parent education, income, and neighborhood disadvantage), that likely represent varying aspects of the environment, on resting state functional connectivity (rsFC). We investigated this question in a large sample of 9475 children (aged 9-10 years) from the Adolescent Brain Cognitive Development (ABCD) Study. Specifically, we analyzed the association between household SES (parent education, income-to-needs ratio) and neighborhood disadvantage, and system-level rsFC using within-sample split-half replication. We then tested whether the associations were unique to each SES measure, and whether household SES and neighborhood disadvantage had interactive effects on rsFC. SES measures had both common and distinct effects on rsFC, with sensory-motor systems (e.g., sensorimotor network) and cognitive networks (e.g., front-parietal network) particularly implicated. Further, the association between neighborhood disadvantage and sensorimotor network connectivity was less pronounced in the presence of high income-to-needs. Findings demonstrate that different facets of SES have distinct and interacting effects on rsFC, highlighting the importance of considering different indicators when studying the effects of SES on the brain. JournalDevelopmental cognitive neurosciencePublished2021/08/14AuthorsRakesh D, Zalesky A, Whittle SKeywordsABCD study, Adolescence, Disadvantage, Education, Income, Neighborhood socioeconomic status, Resting state functional connectivity, Socioeconomic status, fMRIDOI10.1016/j.dcn.2021.101005 |
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Toggle | Issues in Estimating Interpretable Lower Order Factors in Second-Order Hierarchical Models: Commentary on Clark et al. (2021). | Clinical psychological science : a journal of the Association for Psychological Science | Moore TM, Lahey BB | 2021 | |
PubMed Record
AbstractClark and colleagues asserted that lower-order factors in second-order models are comparable to specific factors in bifactor models when residualized on the general factor (Clark et al., 2021). Modeling simulated data demonstrated that residualized lower-order factors are correlated with bifactor specific factors only to the extent that factor loadings are proportional. Modeling actual data with violations of proportionality showed that specific and residualized lower-order factors are not always highly correlated and have differential correlations with criterion variables, even when both models fit acceptably. Because proportionality constraints limit only second-order models, bifactor models should be the first option for hierarchical modeling. JournalClinical psychological science : a journal of the Association for Psychological SciencePublished2021/08/09AuthorsMoore TM, Lahey BBKeywordsDOI10.1177/21677026211035114 |
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Toggle | Relationships between apparent cortical thickness and working memory across the lifespan - Effects of genetics and socioeconomic status. | Developmental cognitive neuroscience | Krogsrud SK, Mowinckel AM, Sederevicius D, et al. | 2021 | |
PubMed Record
AbstractWorking memory (WM) supports several higher-level cognitive abilities, yet we know less about factors associated with development and decline in WM compared to other cognitive processes. Here, we investigated lifespan changes in WM capacity and their structural brain correlates, using a longitudinal sample including 2358 magnetic resonance imaging (MRI) scans and WM scores from 1656 participants (4.4-86.4 years, mean follow-up interval 4.3 years). 8764 participants (9.0-10.9 years) with MRI, WM scores and genetic information from the Adolescent Brain Cognitive Development study were used for follow-up analyses. Results showed that both the information manipulation component and the storage component of WM improved during childhood and adolescence, but the age-decline could be fully explained by reductions in passive storage capacity alone. Greater WM function in development was related to apparent thinner cortex in both samples, also when general cognitive function was accounted for. The same WM-apparent thickness relationship was found for young adults. The WM-thickness relationships could not be explained by SNP-based co-heritability or by socioeconomic status. A larger sample with genetic information may be necessary to disentangle the true gene-environment effects. In conclusion, WM capacity changes greatly through life and has anatomically extended rather than function-specific structural cortical correlates. JournalDevelopmental cognitive neurosciencePublished2021/08/08AuthorsKrogsrud SK, Mowinckel AM, Sederevicius D, Vidal-Piñeiro D, Amlien IK, Wang Y, Sørensen Ø, Walhovd KB, Fjell AMKeywordsCortical thickness, Development, Digit span, Heritability, Lifespan, Working memoryDOI10.1016/j.dcn.2021.100997 |
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Toggle | Association of Local Variation in Neighborhood Disadvantage in Metropolitan Areas With Youth Neurocognition and Brain Structure. | JAMA pediatrics | Hackman DA, Cserbik D, Chen JC, et al. | 2021 | |
PubMed Record
AbstractNeighborhood disadvantage is an important social determinant of health in childhood and adolescence. Less is known about the association of neighborhood disadvantage with youth neurocognition and brain structure, and particularly whether associations are similar across metropolitan areas and are attributed to local differences in disadvantage. JournalJAMA pediatricsPublished2021/08/02AuthorsHackman DA, Cserbik D, Chen JC, Berhane K, Minaravesh B, McConnell R, Herting MMKeywordsDOI10.1001/jamapediatrics.2021.0426 |
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Toggle | Prevalence of Perceived Racism and Discrimination Among US Children Aged 10 and 11 Years: The Adolescent Brain Cognitive Development (ABCD) Study. | JAMA pediatrics | Nagata JM, Ganson KT, Sajjad OM, et al. | 2021 | |
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AbstractThis cross-sectional study uses data from the Adolescent Brain Cognitive Development Study to assess the prevalence of perceived racism and discrimination among US children aged 10 through 11 years. JournalJAMA pediatricsPublished2021/08/01AuthorsNagata JM, Ganson KT, Sajjad OM, Benabou SE, Bibbins-Domingo KKeywordsDOI10.1001/jamapediatrics.2021.1022 |
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Toggle | Genetic and environmental influences on executive functions and intelligence in middle childhood. | Developmental science | Freis SM, Morrison CL, Lessem JM, et al. | 2021 | |
PubMed Record
AbstractExecutive functions (EFs) and intelligence (IQ) are phenotypically correlated. In twin studies, latent variables for EFs and IQ display moderate to high heritability estimates; however, they show variable genetic correlations in twin studies spanning childhood to middle age. We analyzed data from over 11,000 children (9- to 10-year-olds, including 749 twin pairs) in the Adolescent Brain Cognitive Development (ABCD) Study to examine the phenotypic and genetic relations between EFs and IQ in childhood. We identified two EF factors-Common EF and Updating-Specific-which were both related to IQ (rs = 0.64-0.81). Common EF and IQ were heritable (53%-67%), and their genetic correlation (rG = 0.86) was not significantly different than 1. These results suggest that EFs and IQ are phenotypically but not genetically separable in middle childhood, meaning that this phenotypic separability may be influenced by environmental factors. JournalDevelopmental sciencePublished2021/07/29AuthorsFreis SM, Morrison CL, Lessem JM, Hewitt JK, Friedman NPKeywordscognitive control, executive control, general cognitive ability, heritability, inhibition, working memoryDOI10.1111/desc.13150 |
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Toggle | Substance use patterns in 9-10 year olds: Baseline findings from the adolescent brain cognitive development (ABCD) study. | Drug and alcohol dependence | Lisdahl KM, Tapert S, Sher KJ, et al. | 2021 | |
PubMed Record
AbstractThe Adolescent Brain Cognitive Development ™ Study (ABCD Study®) is an open-science, multi-site, prospective, longitudinal study following over 11,800 9- and 10-year-old youth into early adulthood. The ABCD Study aims to prospectively examine the impact of substance use (SU) on neurocognitive and health outcomes. Although SU initiation typically occurs during teen years, relatively little is known about patterns of SU in children younger than 12. JournalDrug and alcohol dependencePublished2021/07/29AuthorsLisdahl KM, Tapert S, Sher KJ, Gonzalez R, Nixon SJ, Feldstein Ewing SW, Conway KP, Wallace A, Sullivan R, Hatcher K, Kaiver C, Thompson W, Reuter C, Bartsch H, Wade NE, Jacobus J, Albaugh MD, Allgaier N, Anokhin AP, Bagot K, Baker FC, Banich MT, Barch DM, Baskin-Sommers A, Breslin FJ, Brown SA, Calhoun V, Casey BJ, Chaarani B, Chang L, Clark DB, Cloak C, Constable RT, Cottler LB, Dagher RK, Dapretto M, Dick A, Do EK, Dosenbach NUF, Dowling GJ, Fair DA, Florsheim P, Foxe JJ, Freedman EG, Friedman NP, Garavan HP, Gee DG, Glantz MD, Glaser P, Gonzalez MR, Gray KM, Grant S, Haist F, Hawes S, Heeringa SG, Hermosillo R, Herting MM, Hettema JM, Hewitt JK, Heyser C, Hoffman EA, Howlett KD, Huber RS, Huestis MA, Hyde LW, Iacono WG, Isaiah A, Ivanova MY, James RS, Jernigan TL, Karcher NR, Kuperman JM, Laird AR, Larson CL, LeBlanc KH, Lopez MF, Luciana M, Luna B, Maes HH, Marshall AT, Mason MJ, McGlade E, Morris AS, Mulford C, Nagel BJ, Neigh G, Palmer CE, Paulus MP, Pecheva D, Prouty D, Potter A, Puttler LI, Rajapakse N, Ross JM, Sanchez M, Schirda C, Schulenberg J, Sheth C, Shilling PD, Sowell ER, Speer N, Squeglia L, Sripada C, Steinberg J, Sutherland MT, Tomko R, Uban K, Vrieze S, Weiss SRB, Wing D, Yurgelun-Todd DA, Zucker RA, Heitzeg MMKeywordsABCD study, Alcohol, Alcohol sipping, Caffeine, Cannabis, Children, Externalizing behaviors, NicotineDOI10.1016/j.drugalcdep.2021.108946 |
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Toggle | Prenatal caffeine exposure: association with neurodevelopmental outcomes in 9- to 11-year-old children. | Journal of child psychology and psychiatry, and allied disciplines | Zhang R, Manza P, Volkow ND | 2021 | |
PubMed Record
AbstractDespite the widespread use of caffeine including consumption during pregnancy, the effect of prenatal caffeine exposure on child brain development and behavior is unclear. JournalJournal of child psychology and psychiatry, and allied disciplinesPublished2021/07/27AuthorsZhang R, Manza P, Volkow NDKeywordsABCD study, Prenatal caffeine exposure, brain structural development, childhood obesity, childhood outcomes, psychopathologyDOI10.1111/jcpp.13495 |
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Toggle | Is executive dysfunction a risk marker or consequence of psychopathology? A test of executive function as a prospective predictor and outcome of general psychopathology in the adolescent brain cognitive development study®. | Developmental cognitive neuroscience | Romer AL, Pizzagalli DA | 2021 | |
PubMed Record
AbstractA general psychopathology (‘p’) factor captures shared variation across mental disorders. One hypothesis is that poor executive function (EF) contributes to p. Although EF is related to p concurrently, it is unclear whether EF predicts or is a consequence of p. For the first time, we examined prospective relations between EF and p in 9845 preadolescents (aged 9-12) from the Adolescent Brain Cognitive Development Study® longitudinally over two years. We identified higher-order factor models of psychopathology at baseline and one- and two-year follow-up waves. Consistent with previous research, a cross-sectional inverse relationship between EF and p emerged. Using residualized-change models, baseline EF prospectively predicted p factor scores two years later, controlling for prior p, sex, age, race/ethnicity, parental education, and family income. Baseline p factor scores also prospectively predicted change in EF two years later. Tests of specificity revealed that bi-directional prospective relations between EF and p were largely generalizable across externalizing, internalizing, neurodevelopmental, somatization, and detachment symptoms. EF consistently predicted change in externalizing and neurodevelopmental symptoms. These novel results suggest that executive dysfunction is both a risk marker and consequence of general psychopathology. EF may be a promising transdiagnostic intervention target to prevent the onset and maintenance of psychopathology. JournalDevelopmental cognitive neurosciencePublished2021/07/22AuthorsRomer AL, Pizzagalli DAKeywordsExecutive function, General psychopathology, Longitudinal, Risk factor, Transdiagnostic, p FactorDOI10.1016/j.dcn.2021.100994 |
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Toggle | Heterogeneity Within Youth With Childhood-Onset Conduct Disorder in the ABCD Study. | Frontiers in psychiatry | Brislin SJ, Martz ME, Cope LM, et al. | 2021 | |
PubMed Record
AbstractThe purpose of this study was to examine if personality traits can be used to characterize subgroups of youth diagnosed with childhood-onset conduct disorder (CD). Participants were 11,552 youth from the Adolescent Brain Cognitive Development study. Data used in this report came from doi: 10.15154/1504041 ( age 9.92; 45.3% female, 49.6% white, 19.0% Hispanic). A subset of this sample ( = 365) met criteria for CD. Latent profile analyses (LPA) were performed on this subgroup ( = 365) to define profiles of individuals with CD based on self-report measures of impulsivity, punishment sensitivity, reward response, and callous-unemotional traits. Follow up analyses determined if these groups differed on clinically relevant variables including psychopathology, environmental risk factors, social risk factors, and neurocognitive functioning. Participants with a CD diagnosis scored significantly higher on psychological, environmental, social, and neurocognitive risk factors. The LPA revealed three unique profiles, which differed significantly on liability for broad psychopathology and domain-specific liability for externalizing psychopathology but were largely matched on environmental and social risk factors. These unique configurations provide a useful way to further parse clinically relevant subgroups within youth who meet criteria for childhood-onset CD, setting the stage for prospective longitudinal research using these latent profiles to better understand the development of youth with childhood-onset CD. JournalFrontiers in psychiatryPublished2021/07/16AuthorsBrislin SJ, Martz ME, Cope LM, Hardee JE, Weigard A, Heitzeg MMKeywordsBIS/BAS, CU traits, UPPS-P impulsive behavior scale, conduct disorder, impulsivity, latent profile analysisDOI10.3389/fpsyt.2021.701199 |
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Toggle | Psychotic-like Experiences and Polygenic Liability in the Adolescent Brain Cognitive Development Study. | Biological psychiatry. Cognitive neuroscience and neuroimaging | Karcher NR, Paul SE, Johnson EC, et al. | 2021 | |
PubMed Record
AbstractChildhood psychotic-like experiences (PLEs) often precede the development of later severe psychopathology. This study examined whether childhood PLEs are associated with several psychopathology-related polygenic scores (PGSs) and additionally examined possible neural and behavioral mechanisms. JournalBiological psychiatry. Cognitive neuroscience and neuroimagingPublished2021/07/13AuthorsKarcher NR, Paul SE, Johnson EC, Hatoum AS, Baranger DAA, Agrawal A, Thompson WK, Barch DM, Bogdan RKeywordsEducational attainment, MRI, Polygenic, Psychopathology, Psychotic-like experiences, SchizophreniaDOI10.1016/j.bpsc.2021.06.012 |
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Toggle | Imaging and health metrics in incidental cerebellar tonsillar ectopia: findings from the Adolescent Brain Cognitive Development Study (ABCD). | Neuroradiology | Nwotchouang BST, Ibrahimy A, Loth DM, et al. | 2021 | |
PubMed Record
AbstractIncidental cerebellar tonsillar ectopia (ICTE) that meets the radiographic criterion for Chiari malformation type I (CMI) is an increasingly common finding in the clinical setting, but its significance is unclear. The present study examined posterior cranial fossa (PCF) morphometrics and a broad range of health instruments of pediatric ICTE cases and matched controls extracted from the Adolescent Brain Cognitive Development (ABCD) dataset. JournalNeuroradiologyPublished2021/07/11AuthorsNwotchouang BST, Ibrahimy A, Loth DM, Labuda E, Labuda N, Eppleheimer M, Labuda R, Bapuraj JR, Allen PA, Klinge P, Loth FKeywordsAdolescent Brain Cognitive Development (ABCD) pediatric study, Brain morphometrics, Chiari malformation type I, Incidental cerebellar tonsillar ectopia, Magnetic resonance imagingDOI10.1007/s00234-021-02759-y |
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Toggle | Psychiatric comorbidity of eating disorders in children between the ages of 9 and 10. | Journal of child psychology and psychiatry, and allied disciplines | Convertino AD, Blashill AJ | 2021 | |
PubMed Record
AbstractEating disorders exhibit high comorbidity with other psychiatric disorders, most notably mood, substance use, and anxiety disorders. However, most studies examining psychiatric comorbidity are conducted in adolescents and adults. Therefore, the comorbidity among children living with eating disorders is unknown. The aim of this study was to characterize co-occurring psychiatric disorders with eating disorders in a US sample of children aged 9-10 years old utilizing the Adolescent Brain Cognitive Development study. JournalJournal of child psychology and psychiatry, and allied disciplinesPublished2021/07/05AuthorsConvertino AD, Blashill AJKeywordsEating disorder, anorexia nervosa, binge eating, bulimia nervosaDOI10.1111/jcpp.13484 |