ABCD Study publications are authored by ABCD investigators, collaborators, and non-ABCD researchers. The analysis methodologies, findings, and interpretations expressed in these publications are those of the authors and do not constitute an endorsement by the ABCD Study®.

Please note that the publications listed here include empirical as well as non-empirical papers (e.g., focused review articles, editorials).

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Title Journal Authors Year Details
Toggle Parent versus child report of children's sexual orientation: associations with psychiatric morbidity in the Adolescent Brain Cognitive Development study. Annals of epidemiology Clark KA, Mennies RJ, Olino TM, et al. 2020
PubMed Record

Abstract

We sought to document the association between parent’s report and their child’s report of the child’s sexual orientation and associations between this agreement/disagreement and the child’s psychiatric morbidity.

Journal

Annals of epidemiology

Published

2020/04/02

Authors

Clark KA, Mennies RJ, Olino TM, Dougherty LR, Pachankis JE

Keywords

Development, Psychiatric epidemiology, Psychopathology

DOI

10.1016/j.annepidem.2020.03.009
Toggle What Is the Link Between Attention-Deficit/Hyperactivity Disorder and Sleep Disturbance? A Multimodal Examination of Longitudinal Relationships and Brain Structure Using Large-Scale Population-Based Cohorts. Biological psychiatry Shen C, Luo Q, Chamberlain SR, et al. 2020
PubMed Record

Abstract

Attention-deficit/hyperactivity disorder (ADHD) comorbid with sleep disturbances can produce profound disruption in daily life and negatively impact quality of life of both the child and the family. However, the temporal relationship between ADHD and sleep impairment is unclear, as are underlying common brain mechanisms.

Journal

Biological psychiatry

Published

2020/03/31

Authors

Shen C, Luo Q, Chamberlain SR, Morgan S, Romero-Garcia R, Du J, Zhao X, Touchette É, Montplaisir J, Vitaro F, Boivin M, Tremblay RE, Zhao XM, Robaey P, Feng J, Sahakian BJ

Keywords

ADHD, Development, Dyssomnia, Longitudinal study, Neurodevelopmental, Parasomnia

DOI

10.1016/j.biopsych.2020.03.010
Toggle Examining Specificity of Neural Correlates of Childhood Psychotic-like Experiences During an Emotional n-Back Task. Biological psychiatry. Cognitive neuroscience and neuroimaging O'Brien KJ, Barch DM, Kandala S, et al. 2020
PubMed Record

Abstract

Psychotic-like experiences (PLEs) during childhood are associated with greater risk of developing a psychotic disorder in adulthood, highlighting the importance of identifying neural correlates of childhood PLEs. Furthermore, impairment of cognitive functions, such as working memory and emotion regulation, has also been linked to psychosis risk as well as to disruptions in several brain regions. However, impairments in these domains have also been linked to other disorders, including depression. Therefore, the aim of the current study was to examine whether neural impairments in regions associated with working memory and implicit emotion regulation impairments are specific to PLEs versus depression.

Journal

Biological psychiatry. Cognitive neuroscience and neuroimaging

Published

2020/03/19

Authors

O'Brien KJ, Barch DM, Kandala S, Karcher NR

Keywords

Depression, Emotional n-back, Implicit emotion regulation, Neuroimaging, Psychotic-like experiences, Working memory

DOI

10.1016/j.bpsc.2020.02.012
Toggle Risk and protective factors for childhood suicidality: a US population-based study. The lancet. Psychiatry Janiri D, Doucet GE, Pompili M, et al. 2020
PubMed Record

Abstract

Childhood suicidal ideation and behaviours are poorly understood. We examined correlates of suicidality in a US population-based sample of children participating in the Adolescent Brain and Cognitive Development (ABCD) study. The ABCD study aims to examine trajectories of mental health from childhood to adulthood and collects information on multiple domains, including mental and physical wellbeing, brain imaging, behavioural and cognitive characteristics, and social and family environment. We sought to identify and rank risk and protective factors for childhood suicidal thoughts and behaviours across these multiple domains and evaluate their association with self-agreement and caregiver agreement in reporting suicidality.

Journal

The lancet. Psychiatry

Published

2020/03/12

Authors

Janiri D, Doucet GE, Pompili M, Sani G, Luna B, Brent DA, Frangou S

Keywords

DOI

10.1016/S2215-0366(20)30049-3
Toggle An item response theory analysis of the Prodromal Questionnaire-Brief Child Version: Developing a screening form that informs understanding of self-reported psychotic-like experiences in childhood. Journal of abnormal psychology Karcher NR, Perino MT, Barch DM 2020
PubMed Record

Abstract

The Prodromal Questionnaire-Brief Child Version (PQ-BC) has been developed as a tool for identifying psychotic-like experiences (PLEs) in school-age children. The current study examined the psychometric properties of the PQ-BC, examined how well the PQ-BC estimates the latent construct of PLEs (θ̂), and began the process of developing a screening form informed by item response theory (IRT). Utilizing the baseline ( = 11,129) sample from the Adolescent Brain Cognitive Development study, we examined which PQ-BC items provide the most information and best discriminate individuals experiencing PLEs. Using hierarchical linear models (HLMs), we found that θ̂ scores were significantly associated with several previously identified predictors of psychosis spectrum symptoms (i.e., history of psychosis, internalizing symptoms, cognitive impairments, developmental milestone delays, and resting-state functional connectivity impairments) at baseline and Year 1 ( = 5,532). Using item-level information and discrimination parameters of the PQ-BC from the baseline sample, we created a 7-item screening form. HLMs generally found significant associations between screening form scores for both baseline and Year 1 with the aforementioned predictors. The analyses provide evidence for the validity of a screening form derived from the PQ-BC using IRT-derived parameters. This screening form could prove useful when the full measure is not feasible. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Journal

Journal of abnormal psychology

Published

2020/02/27

Authors

Karcher NR, Perino MT, Barch DM

Keywords

DOI

10.1037/abn0000502
Toggle Parental and social factors in relation to child psychopathology, behavior, and cognitive function. Translational psychiatry Zhang H, Lee ZX, White T, et al. 2020
PubMed Record

Abstract

Parental and social factors have long-term impact on the neurodevelopment of offspring, but tend to highly covary with each other. Thus, it is difficult to parse out which parental and social factor contributes most to neurodevelopmental outcomes. This study aimed to assess clusters of parental and social factors associated with child psychopathology, behavioral problems, and cognition. This study employed the data of 11,875 children (9 to 11 years) from the Adolescent Brain Cognitive Development (ABCD) study. Principal component analysis (PCA) was performed on 39 environmental measures and 30 child behavior and cognitive measures separately to identify clusters of parental and social factors and clusters of child psychopathology, behaviour, and cognition. Regression analysis was used to examine independent effects of each cluster of parental and social factors on child psychopathology, behavioral problems, and cognition. Greater Parent Psychopathology cluster was associated with greater Child Psychopathology cluster. Moreover, greater Socioeconomic Status cluster was associated with greater child General Cognition and Executive Function but less Behavioral Inhibition clusters. Greater Proximal Social Environment and Interaction cluster were associated with less child Impulsive Behavior and Behavioral Inhibition, but greater Behavioral Activation cluster. The environmental clusters related to birth outcomes, maternal tobacco, and drug use were not significantly related to child psychopathology, behavior, and cognition. Our findings suggest that socioeconomic status, parental psychopathology, and social environment and interactions are the strongest risks for behavioral problems and cognitive performance in a general child population. Intervention programs should target modifiable factors within these domains.

Journal

Translational psychiatry

Published

2020/02/26

Authors

Zhang H, Lee ZX, White T, Qiu A

Keywords

DOI

10.1038/s41398-020-0761-6
Toggle Sleep Disturbance Predicts Depression Symptoms in Early Adolescence: Initial Findings From the Adolescent Brain Cognitive Development Study. The Journal of adolescent health : official publication of the Society for Adolescent Medicine Goldstone A, Javitz HS, Claudatos SA, et al. 2020
PubMed Record

Abstract

The aim of the study was to investigate associations between sleep disturbances and mental health in adolescents.

Journal

The Journal of adolescent health : official publication of the Society for Adolescent Medicine

Published

2020/02/08

Authors

Goldstone A, Javitz HS, Claudatos SA, Buysse DJ, Hasler BP, de Zambotti M, Clark DB, Franzen PL, Prouty DE, Colrain IM, Baker FC

Keywords

Adolescent, Children, Longitudinal, Mental health, Minority, Sleep duration

DOI

10.1016/j.jadohealth.2019.12.005
Toggle Prevalence and Family-Related Factors Associated With Suicidal Ideation, Suicide Attempts, and Self-injury in Children Aged 9 to 10 Years. JAMA network open DeVille DC, Whalen D, Breslin FJ, et al. 2020
PubMed Record

Abstract

Although suicide is a leading cause of death for children in the United States, and the rate of suicide in childhood has steadily increased, little is known about suicidal ideation and behaviors in children.

Journal

JAMA network open

Published

2020/02/05

Authors

DeVille DC, Whalen D, Breslin FJ, Morris AS, Khalsa SS, Paulus MP, Barch DM

Keywords

DOI

10.1001/jamanetworkopen.2019.20956
Toggle Sleep duration, brain structure, and psychiatric and cognitive problems in children. Molecular psychiatry Cheng W, Rolls E, Gong W, et al. 2020
PubMed Record

Abstract

Low sleep duration in adults is correlated with psychiatric and cognitive problems. We performed for the first time a large-scale analysis of sleep duration in children, and how this relates to psychiatric problems including depression, to cognition, and to brain structure. Structural MRI was analyzed in relation to sleep duration, and psychiatric and cognitive measures in 11,067 9-11-year-old children from the Adolescent Brain Cognitive Development (ABCD) Study, using a linear mixed model, mediation analysis, and structural equation methods in a longitudinal analysis. Dimensional psychopathology (including depression, anxiety, impulsive behavior) in the children was negatively correlated with sleep duration. Dimensional psychopathology in the parents was also correlated with short sleep duration in their children. The brain areas in which higher volume was correlated with longer sleep duration included the orbitofrontal cortex, prefrontal and temporal cortex, precuneus, and supramarginal gyrus. Longitudinal data analysis showed that the psychiatric problems, especially the depressive problems, were significantly associated with short sleep duration 1 year later. Further, mediation analysis showed that depressive problems significantly mediate the effect of these brain regions on sleep. Higher cognitive scores were associated with higher volume of the prefrontal cortex, temporal cortex, and medial orbitofrontal cortex. Public health implications are that psychopathology in the parents should be considered in relation to sleep problems in children. Moreover, we show that brain structure is associated with sleep problems in children, and that this is related to whether or not the child has depressive problems.

Journal

Molecular psychiatry

Published

2020/02/03

Authors

Cheng W, Rolls E, Gong W, Du J, Zhang J, Zhang XY, Li F, Feng J

Keywords

DOI

10.1038/s41380-020-0663-2
Toggle Associations Among Body Mass Index, Cortical Thickness, and Executive Function in Children. JAMA pediatrics Laurent JS, Watts R, Adise S, et al. 2020
PubMed Record

Abstract

A total of 25.7 million children in the United States are classified as overweight or obese. Obesity is associated with deficits in executive function, which may contribute to poor dietary decision-making. Less is known about the associations between being overweight or obese and brain development.

Journal

JAMA pediatrics

Published

2020/02/01

Authors

Laurent JS, Watts R, Adise S, Allgaier N, Chaarani B, Garavan H, Potter A, Mackey S

Keywords

DOI

10.1001/jamapediatrics.2019.4708
Toggle White Matter Tract Integrity, Involvement in Sports, and Depressive Symptoms in Children. Child psychiatry and human development Gorham LS, Barch DM 2020
PubMed Record

Abstract

White matter tract integrity, measured via fractional anisotropy (FA), may serve as a mediating variable between exercise and depression. To study this, we examined data from 3973 children participating in the ABCD study. Parents of children completed the Sports and Activities questionnaire and the Child Behavior Checklist, and children completed a diffusion MRI scan, providing information about the FA of the parahippocampal cingulum and fornix. Results showed that involvement in sports was associated with reduced depression in boys. The number of activities and sports that a child was involved in was negatively related to FA of the left fornix but was unrelated to FA of other tracts. FA of these white matter tracts was also unrelated to depressive symptoms. This suggests that while white matter tract integrity is associated with exercise, it may not be part of a pathway linking exercise to depression levels in preadolescent boys.

Journal

Child psychiatry and human development

Published

2020/01/25

Authors

Gorham LS, Barch DM

Keywords

Children, Depression, Diffusion MRI, Exercise, White matter tract integrity

DOI

10.1007/s10578-020-00960-3
Toggle Disruptive Behavior Problems, Callous-Unemotional Traits, and Regional Gray Matter Volume in the Adolescent Brain and Cognitive Development Study. Biological psychiatry. Cognitive neuroscience and neuroimaging Waller R, Hawes SW, Byrd AL, et al. 2020
PubMed Record

Abstract

Neurobiological differences linked to socioemotional and cognitive processing are well documented in youths with disruptive behavior disorders (DBDs), especially youths with callous-unemotional (CU) traits. The current study expanded this literature by examining gray matter volume (GMV) differences among youths with DBD with CU traits (DBDCU+), youths with DBD without CU traits (DBD-only), and youths that were typically developing (TD).

Journal

Biological psychiatry. Cognitive neuroscience and neuroimaging

Published

2020/01/22

Authors

Waller R, Hawes SW, Byrd AL, Dick AS, Sutherland MT, Riedel MC, Tobia MJ, Bottenhorn KL, Laird AR, Gonzalez R

Keywords

ABCD, Amygdala, Antisocial behavior, Callous-unemotional traits, Gray matter volume, Hippocampus

DOI

10.1016/j.bpsc.2020.01.002
Toggle Association of lead-exposure risk and family income with childhood brain outcomes. Nature medicine Marshall AT, Betts S, Kan EC, et al. 2020
PubMed Record

Abstract

Socioeconomic factors influence brain development and structure, but most studies have overlooked neurotoxic insults that impair development, such as lead exposure. Childhood lead exposure affects cognitive development at the lowest measurable concentrations, but little is known about its impact on brain development during childhood. We examined cross-sectional associations among brain structure, cognition, geocoded measures of the risk of lead exposure and sociodemographic characteristics in 9,712 9- and 10-year-old children. Here we show stronger negative associations of living in high-lead-risk census tracts in children from lower- versus higher-income families. With increasing risk of exposure, children from lower-income families exhibited lower cognitive test scores, smaller cortical volume and smaller cortical surface area. Reducing environmental insults associated with lead-exposure risk might confer greater benefit to children experiencing more environmental adversity, and further understanding of the factors associated with high lead-exposure risk will be critical for improving such outcomes in children.

Journal

Nature medicine

Published

2020/01/13

Authors

Marshall AT, Betts S, Kan EC, McConnell R, Lanphear BP, Sowell ER

Keywords

DOI

10.1038/s41591-019-0713-y
Toggle Editorial: Family History of Depression and Child Striatal Volumes in the ABCD Study: Promise and Perils of Neuroimaging Research With Large Samples. Journal of the American Academy of Child and Adolescent Psychiatry Beauchaine TP 2020
PubMed Record

Abstract

Every generation of psychopathologists is confronted with critical issues that, if left unaddressed, impede progress in both science and practice. As just one example, progress in psychiatry was hindered for many years by problems with diagnostic validity. Surmounting these problems required painstaking efforts to operationalize diagnostic criteria and to formulate effective structured interviews. More recently, critical issues facing psychiatry include tackling the so-called replication crisis, and mapping the overwhelming etiological complexity of psychopathology-two interrelated challenges. Many highly cited findings from past decades have failed to replicate, have not been subjected to replication, or have overestimated effect sizes considerably. Such findings apply to virtually all areas of psychiatric research, spanning genetics, central and peripheral biomarkers, and interventions..

Journal

Journal of the American Academy of Child and Adolescent Psychiatry

Published

2020/01/10

Authors

Beauchaine TP

Keywords

DOI

10.1016/j.jaac.2020.01.002
Toggle Factor structure, measurement and structural invariance, and external validity of an abbreviated youth version of the UPPS-P Impulsive Behavior Scale. Psychological assessment Watts AL, Smith GT, Barch DM, et al. 2019
PubMed Record

Abstract

The current study examines the measurement properties and validity of a novel, abbreviated youth version of the UPPS-P Impulsive Behavior Scale that was developed to maintain measurement consistency with the existing adult short form. Specifically, we examined this scale’s (a) factor structure; (b) measurement and structural invariance across four demographic characteristics: gender, ethnicity, household income, and parental education; and (c) correlates using a subset of 4,521 preadolescent (9- and 10-year old) children (53% male) from the baseline wave of the Adolescent Brain and Cognitive Development (ABCD) study, a large, community-based sample. Our findings supported a correlated 5-factor model, as well as a hierarchical model that recaptured the covariation among these 5 lower-order factors in three higher-order factors. Both of these models are consistent with the commonly observed structure of the UPPS-P among adults. We established measurement invariance across all demographic characteristics. Finally, our UPPS-P scales evidenced good convergent and discriminant validity with a broad swath of theoretically relevant external criteria, including self- and parent-reported personality and psychopathology, as well as lab-based neurocognitive tasks. Our findings indicate that we can assess multidimensional impulsivity in children reliably and validly by means of self-report, allowing assessment of this critical domain at early stages of development. We hope that this measure will facilitate the study of impulsivity in large-scale samples to begin to understand the evolution and long-term consequences of impulsivity. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Journal

Psychological assessment

Published

2019/12/16

Authors

Watts AL, Smith GT, Barch DM, Sher KJ

Keywords

DOI

10.1037/pas0000791
Toggle Differential Relationships of Child Anxiety and Depression to Child Report and Parent Report of Electronic Media Use. Child psychiatry and human development Fors PQ, Barch DM 2019
PubMed Record

Abstract

Child depression and anxiety have been associated with electronic media use, but the comorbidity between the two has rarely been accounted for in analyses. We examined both child and parent reports of electronic media use in relation to parent-reported child depression and anxiety. Using survey and interview data collected for 9- to 11-year-olds from the 21-site adolescent brain cognitive development study, we conducted generalized linear mixed models. Our results demonstrated that electronic media use was more strongly associated with depression than anxiety, and that accounting for depression significantly reduced the relationship between electronic media use and anxiety. Different categories of electronic media showed differential relationships to anxiety and depression, with video gaming and video chatting related to anxiety, but video watching related to depression. These findings provide important data to ground theories of the mechanisms that contribute to these associations.

Journal

Child psychiatry and human development

Published

2019/12/01

Authors

Fors PQ, Barch DM

Keywords

Anxiety, Children, Depression, Electronic media use, Technology

DOI

10.1007/s10578-019-00892-7
Toggle Correction of respiratory artifacts in MRI head motion estimates. NeuroImage Fair DA, Miranda-Dominguez O, Snyder AZ, et al. 2019
PubMed Record

Abstract

Head motion represents one of the greatest technical obstacles in magnetic resonance imaging (MRI) of the human brain. Accurate detection of artifacts induced by head motion requires precise estimation of movement. However, head motion estimates may be corrupted by artifacts due to magnetic main field fluctuations generated by body motion. In the current report, we examine head motion estimation in multiband resting state functional connectivity MRI (rs-fcMRI) data from the Adolescent Brain and Cognitive Development (ABCD) Study and comparison ‘single-shot’ datasets. We show that respirations contaminate movement estimates in functional MRI and that respiration generates apparent head motion not associated with functional MRI quality reductions. We have developed a novel approach using a band-stop filter that accurately removes these respiratory effects from motion estimates. Subsequently, we demonstrate that utilizing a band-stop filter improves post-processing fMRI data quality. Lastly, we demonstrate the real-time implementation of motion estimate filtering in our FIRMM (Framewise Integrated Real-Time MRI Monitoring) software package.

Journal

NeuroImage

Published

2019/11/25

Authors

Fair DA, Miranda-Dominguez O, Snyder AZ, Perrone A, Earl EA, Van AN, Koller JM, Feczko E, Tisdall MD, van der Kouwe A, Klein RL, Mirro AE, Hampton JM, Adeyemo B, Laumann TO, Gratton C, Greene DJ, Schlaggar BL, Hagler DJ, Watts R, Garavan H, Barch DM, Nigg JT, Petersen SE, Dale AM, Feldstein-Ewing SW, Nagel BJ, Dosenbach NUF

Keywords

DOI

10.1016/j.neuroimage.2019.116400
Toggle Screen time and problem behaviors in children: exploring the mediating role of sleep duration. The international journal of behavioral nutrition and physical activity Guerrero MD, Barnes JD, Chaput JP, et al. 2019
PubMed Record

Abstract

Previous research examining the relationship between screen time (ST) and psychological health outcomes have primarily focused on one type of ST (i.e., television), while little research has considered other types of screens (e.g., videos, movies, social media), screen content (e.g., violent video games), or potential mediating variables. Therefore, the purpose of the present study was to assess ST types and content and their association with problem behaviors, and to determine whether these relationships were mediated by sleep duration.

Journal

The international journal of behavioral nutrition and physical activity

Published

2019/11/14

Authors

Guerrero MD, Barnes JD, Chaput JP, Tremblay MS

Keywords

Aggressive behavior, Mature-rated video games, Negative binomial structural equation modeling, Rule-breaking behavior, Television/movies, Video games

DOI

10.1186/s12966-019-0862-x
Toggle Prevalence and correlates of maladaptive guilt in middle childhood. Journal of affective disorders Donohue MR, Tillman R, Perino MT, et al. 2019
PubMed Record

Abstract

Maladaptive guilt can develop by age three and is associated with severe affective psychopathology in adolescents and adults. Yet, little is known about its prevalence prior to adolescence, or which children are at greatest risk of developing this symptom. This study examined the prevalence and correlates of maladaptive guilt in middle childhood.

Journal

Journal of affective disorders

Published

2019/11/13

Authors

Donohue MR, Tillman R, Perino MT, Whalen DJ, Luby J, Barch DM

Keywords

Family conflict, Maladaptive guilt, Maternal depression, Negative parenting, Prevalence

DOI

10.1016/j.jad.2019.11.075
Toggle Brain Volume Abnormalities in Youth at High Risk for Depression: Adolescent Brain and Cognitive Development Study. Journal of the American Academy of Child and Adolescent Psychiatry Pagliaccio D, Alqueza KL, Marsh R, et al. 2019
PubMed Record

Abstract

Children of parents with depression are two to three times more likely to develop major depressive disorder than children without parental history; however, subcortical brain volume abnormalities characterizing major depressive disorder risk remain unclear. The Adolescent Brain and Cognitive Development (ABCD) Study provides an opportunity to identify subcortical differences associated with parental depressive history.

Journal

Journal of the American Academy of Child and Adolescent Psychiatry

Published

2019/10/18

Authors

Pagliaccio D, Alqueza KL, Marsh R, Auerbach RP

Keywords

ABCD, adolescent depression, dorsal striatum, subcortical brain volume, ventral striatum

DOI

10.1016/j.jaac.2019.09.032
Toggle Delineating and validating higher-order dimensions of psychopathology in the Adolescent Brain Cognitive Development (ABCD) study. Translational psychiatry Michelini G, Barch DM, Tian Y, et al. 2019
PubMed Record

Abstract

Hierarchical dimensional systems of psychopathology promise more informative descriptions for understanding risk and predicting outcome than traditional diagnostic systems, but it is unclear how many major dimensions they should include. We delineated the hierarchy of childhood and adult psychopathology and validated it against clinically relevant measures. Participants were 9987 9- and 10-year-old children and their parents from the Adolescent Brain Cognitive Development (ABCD) study. Factor analyses of items from the Child Behavior Checklist and Adult Self-Report were run to delineate hierarchies of dimensions. We examined the familial aggregation of the psychopathology dimensions, and the ability of different factor solutions to account for risk factors, real-world functioning, cognitive functioning, and physical and mental health service utilization. A hierarchical structure with a general psychopathology (‘p’) factor at the apex and five specific factors (internalizing, somatoform, detachment, neurodevelopmental, and externalizing) emerged in children. Five similar dimensions emerged also in the parents. Child and parent p-factors correlated highly (r = 0.61, p < 0.001), and smaller but significant correlations emerged for convergent dimensions between parents and children after controlling for p-factors (r = 0.09-0.21, p < 0.001). A model with child p-factor alone explained mental health service utilization (R = 0.23, p < 0.001), but up to five dimensions provided incremental validity to account for developmental risk and current functioning in children (R = 0.03-0.19, p < 0.001). In this first investigation comprehensively mapping the psychopathology hierarchy in children and adults, we delineated a hierarchy of higher-order dimensions associated with a range of clinically relevant validators. These findings hold important implications for psychiatric nosology and future research in this sample.

Journal

Translational psychiatry

Published

2019/10/17

Authors

Michelini G, Barch DM, Tian Y, Watson D, Klein DN, Kotov R

Keywords

DOI

10.1038/s41398-019-0593-4
Toggle Author Correction: No evidence for a bilingual executive function advantage in the ABCD study. Nature human behaviour Dick AS, Garcia NL, Pruden SM, et al. 2019
PubMed Record

Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Journal

Nature human behaviour

Published

2019/10/01

Authors

Dick AS, Garcia NL, Pruden SM, Thompson WK, Hawes SW, Sutherland MT, Riedel MC, Laird AR, Gonzalez R

Keywords

DOI

10.1038/s41562-019-0756-6
Toggle Identifying reproducible individual differences in childhood functional brain networks: An ABCD study. Developmental cognitive neuroscience Marek S, Tervo-Clemmens B, Nielsen AN, et al. 2019
PubMed Record

Abstract

The 21-site Adolescent Brain Cognitive Development (ABCD) study provides an unparalleled opportunity to characterize functional brain development via resting-state functional connectivity (RSFC) and to quantify relationships between RSFC and behavior. This multi-site data set includes potentially confounding sources of variance, such as differences between data collection sites and/or scanner manufacturers, in addition to those inherent to RSFC (e.g., head motion). The ABCD project provides a framework for characterizing and reproducing RSFC and RSFC-behavior associations, while quantifying the extent to which sources of variability bias RSFC estimates. We quantified RSFC and functional network architecture in 2,188 9-10-year old children from the ABCD study, segregated into demographically-matched discovery (N = 1,166) and replication datasets (N = 1,022). We found RSFC and network architecture to be highly reproducible across children. We did not observe strong effects of site; however, scanner manufacturer effects were large, reproducible, and followed a “short-to-long” association with distance between regions. Accounting for potential confounding variables, we replicated that RSFC between several higher-order networks was related to general cognition. In sum, we provide a framework for how to characterize RSFC-behavior relationships in a rigorous and reproducible manner using the ABCD dataset and other large multi-site projects.

Journal

Developmental cognitive neuroscience

Published

2019/09/19

Authors

Marek S, Tervo-Clemmens B, Nielsen AN, Wheelock MD, Miller RL, Laumann TO, Earl E, Foran WW, Cordova M, Doyle O, Perrone A, Miranda-Dominguez O, Feczko E, Sturgeon D, Graham A, Hermosillo R, Snider K, Galassi A, Nagel BJ, Ewing SWF, Eggebrecht AT, Garavan H, Dale AM, Greene DJ, Barch DM, Fair DA, Luna B, Dosenbach NUF

Keywords

ABCD, Cognitive ability, Development, Functional connectivity, Reproducibility, Resting state fMRI

DOI

10.1016/j.dcn.2019.100706
Toggle Ensuring the Best Use of Data: The Adolescent Brain Cognitive Development Study. JAMA pediatrics Compton WM, Dowling GJ, Garavan H 2019
PubMed Record

Abstract

Journal

JAMA pediatrics

Published

2019/09/01

Authors

Compton WM, Dowling GJ, Garavan H

Keywords

DOI

10.1001/jamapediatrics.2019.2081
Toggle Author Correction: No evidence for a bilingual executive function advantage in the nationally representative ABCD study. Nature human behaviour Dick AS, Garcia NL, Pruden SM, et al. 2019
PubMed Record

Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Journal

Nature human behaviour

Published

2019/09/01

Authors

Dick AS, Garcia NL, Pruden SM, Thompson WK, Hawes SW, Sutherland MT, Riedel MC, Laird AR, Gonzalez R

Keywords

DOI

10.1038/s41562-019-0709-0
Toggle Prediction of neurocognition in youth from resting state fMRI. Molecular psychiatry Sripada C, Rutherford S, Angstadt M, et al. 2019
PubMed Record

Abstract

Difficulties with higher-order cognitive functions in youth are a potentially important vulnerability factor for the emergence of problematic behaviors and a range of psychopathologies. This study examined 2013 9-10 year olds in the first data release from the Adolescent Brain Cognitive Development 21-site consortium study in order to identify resting state functional connectivity patterns that predict individual-differences in three domains of higher-order cognitive functions: General Ability, Speed/Flexibility, and Learning/Memory. For General Ability scores in particular, we observed consistent cross-site generalizability, with statistically significant predictions in 14 out of 15 held-out sites. These results survived several tests for robustness including replication in split-half analysis and in a low head motion subsample. We additionally found that connectivity patterns involving task control networks and default mode network were prominently implicated in predicting differences in General Ability across participants. These findings demonstrate that resting state connectivity can be leveraged to produce generalizable markers of neurocognitive functioning. Additionally, they highlight the importance of task control-default mode network interconnections as a major locus of individual differences in cognitive functioning in early adolescence.

Journal

Molecular psychiatry

Published

2019/08/19

Authors

Sripada C, Rutherford S, Angstadt M, Thompson WK, Luciana M, Weigard A, Hyde LH, Heitzeg M

Keywords

DOI

10.1038/s41380-019-0481-6
Toggle 24-Hour Movement Behaviors and Impulsivity. Pediatrics Guerrero MD, Barnes JD, Walsh JJ, et al. 2019
PubMed Record

Abstract

The objective of this study was to examine individual and concurrent associations between meeting the Canadian 24-Hour Movement Guidelines for Children and Youth (9-11 hours of sleep per night, ≤2 hours of recreational screen time (ST) per day, and at least 60 minutes of moderate to vigorous physical activity per day) and dimensions of impulsivity.

Journal

Pediatrics

Published

2019/08/14

Authors

Guerrero MD, Barnes JD, Walsh JJ, Chaput JP, Tremblay MS, Goldfield GS

Keywords

DOI

10.1542/peds.2019-0187
Toggle Image processing and analysis methods for the Adolescent Brain Cognitive Development Study. NeuroImage Hagler DJ, Hatton S, Cornejo MD, et al. 2019
PubMed Record

Abstract

The Adolescent Brain Cognitive Development (ABCD) Study is an ongoing, nationwide study of the effects of environmental influences on behavioral and brain development in adolescents. The main objective of the study is to recruit and assess over eleven thousand 9-10-year-olds and follow them over the course of 10 years to characterize normative brain and cognitive development, the many factors that influence brain development, and the effects of those factors on mental health and other outcomes. The study employs state-of-the-art multimodal brain imaging, cognitive and clinical assessments, bioassays, and careful assessment of substance use, environment, psychopathological symptoms, and social functioning. The data is a resource of unprecedented scale and depth for studying typical and atypical development. The aim of this manuscript is to describe the baseline neuroimaging processing and subject-level analysis methods used by ABCD. Processing and analyses include modality-specific corrections for distortions and motion, brain segmentation and cortical surface reconstruction derived from structural magnetic resonance imaging (sMRI), analysis of brain microstructure using diffusion MRI (dMRI), task-related analysis of functional MRI (fMRI), and functional connectivity analysis of resting-state fMRI. This manuscript serves as a methodological reference for users of publicly shared neuroimaging data from the ABCD Study.

Journal

NeuroImage

Published

2019/08/12

Authors

Hagler DJ, Hatton S, Cornejo MD, Makowski C, Fair DA, Dick AS, Sutherland MT, Casey BJ, Barch DM, Harms MP, Watts R, Bjork JM, Garavan HP, Hilmer L, Pung CJ, Sicat CS, Kuperman J, Bartsch H, Xue F, Heitzeg MM, Laird AR, Trinh TT, Gonzalez R, Tapert SF, Riedel MC, Squeglia LM, Hyde LW, Rosenberg MD, Earl EA, Howlett KD, Baker FC, Soules M, Diaz J, de Leon OR, Thompson WK, Neale MC, Herting M, Sowell ER, Alvarez RP, Hawes SW, Sanchez M, Bodurka J, Breslin FJ, Morris AS, Paulus MP, Simmons WK, Polimeni JR, van der Kouwe A, Nencka AS, Gray KM, Pierpaoli C, Matochik JA, Noronha A, Aklin WM, Conway K, Glantz M, Hoffman E, Little R, Lopez M, Pariyadath V, Weiss SR, Wolff-Hughes DL, DelCarmen-Wiggins R, Feldstein Ewing SW, Miranda-Dominguez O, Nagel BJ, Perrone AJ, Sturgeon DT, Goldstone A, Pfefferbaum A, Pohl KM, Prouty D, Uban K, Bookheimer SY, Dapretto M, Galvan A, Bagot K, Giedd J, Infante MA, Jacobus J, Patrick K, Shilling PD, Desikan R, Li Y, Sugrue L, Banich MT, Friedman N, Hewitt JK, Hopfer C, Sakai J, Tanabe J, Cottler LB, Nixon SJ, Chang L, Cloak C, Ernst T, Reeves G, Kennedy DN, Heeringa S, Peltier S, Schulenberg J, Sripada C, Zucker RA, Iacono WG, Luciana M, Calabro FJ, Clark DB, Lewis DA, Luna B, Schirda C, Brima T, Foxe JJ, Freedman EG, Mruzek DW, Mason MJ, Huber R, McGlade E, Prescot A, Renshaw PF, Yurgelun-Todd DA, Allgaier NA, Dumas JA, Ivanova M, Potter A, Florsheim P, Larson C, Lisdahl K, Charness ME, Fuemmeler B, Hettema JM, Maes HH, Steinberg J, Anokhin AP, Glaser P, Heath AC, Madden PA, Baskin-Sommers A, Constable RT, Grant SJ, Dowling GJ, Brown SA, Jernigan TL, Dale AM

Keywords

ABCD, Adolescent, Data sharing, Magnetic resonance imaging, Processing pipeline

DOI

10.1016/j.neuroimage.2019.116091
Toggle Demographic, psychological, behavioral, and cognitive correlates of BMI in youth: Findings from the Adolescent Brain Cognitive Development (ABCD) study. Psychological medicine Gray JC, Schvey NA, Tanofsky-Kraff M 2019
PubMed Record

Abstract

Previous research has implicated demographic, psychological, behavioral, and cognitive variables in the onset and maintenance of pediatric overweight/obesity. No adequately-powered study has simultaneously modeled these variables to assess their relative associations with body mass index (BMI; kg/m2) in a nationally representative sample of youth.

Journal

Psychological medicine

Published

2019/07/10

Authors

Gray JC, Schvey NA, Tanofsky-Kraff M

Keywords

Adolescent, BMI, obesity, pediatric, youth

DOI

10.1017/S0033291719001545
Toggle Association of Prenatal Cannabis Exposure With Psychosis Proneness Among Children in the Adolescent Brain Cognitive Development (ABCD) Study. JAMA psychiatry Fine JD, Moreau AL, Karcher NR, et al. 2019
PubMed Record

Abstract

This cohort study uses data from the ongoing Adolescent Brain Cognitive Development (ABCD) study to assess the association of maternal use of cannabis before and after knowledge of pregnancy with psychosis proneness in children.

Journal

JAMA psychiatry

Published

2019/07/01

Authors

Fine JD, Moreau AL, Karcher NR, Agrawal A, Rogers CE, Barch DM, Bogdan R

Keywords

DOI

10.1001/jamapsychiatry.2019.0076
Toggle Association Between Childhood Anhedonia and Alterations in Large-scale Resting-State Networks and Task-Evoked Activation. JAMA psychiatry Pornpattananangkul N, Leibenluft E, Pine DS, et al. 2019
PubMed Record

Abstract

Anhedonia can present in children and predict detrimental clinical outcomes.

Journal

JAMA psychiatry

Published

2019/06/01

Authors

Pornpattananangkul N, Leibenluft E, Pine DS, Stringaris A

Keywords

DOI

10.1001/jamapsychiatry.2019.0020
Toggle No evidence for a bilingual executive function advantage in the nationally representative ABCD study. Nature human behaviour Dick AS, Garcia NL, Pruden SM, et al. 2019
PubMed Record

Abstract

Learning a second language in childhood is inherently advantageous for communication. However, parents, educators and scientists have been interested in determining whether there are additional cognitive advantages. One of the most exciting yet controversial findings about bilinguals is a reported advantage for executive function. That is, several studies suggest that bilinguals perform better than monolinguals on tasks assessing cognitive abilities that are central to the voluntary control of thoughts and behaviours-the so-called ‘executive functions’ (for example, attention, inhibitory control, task switching and resolving conflict). Although a number of small- and large-sample studies have reported a bilingual executive function advantage (see refs. for a review), there have been several failures to replicate these findings, and recent meta-analyses have called into question the reliability of the original empirical claims. Here we show, in a very large, demographically representative sample (n = 4,524) of 9- to 10-year-olds across the United States, that there is little evidence for a bilingual advantage for inhibitory control, attention and task switching, or cognitive flexibility, which are key aspects of executive function. We also replicate previously reported disadvantages in English vocabulary in bilinguals. However, these English vocabulary differences are substantially mitigated when we account for individual differences in socioeconomic status or intelligence. In summary, notwithstanding the inherently positive benefits of learning a second language in childhood, we found little evidence that it engenders additional benefits to executive function development.

Journal

Nature human behaviour

Published

2019/05/20

Authors

Dick AS, Garcia NL, Pruden SM, Thompson WK, Hawes SW, Sutherland MT, Riedel MC, Laird AR, Gonzalez R

Keywords

DOI

10.1038/s41562-019-0609-3
Toggle Cerebral circulation time derived from fMRI signals in large blood vessels. Journal of magnetic resonance imaging : JMRI Yao JF, Wang JH, Yang HS, et al. 2019
PubMed Record

Abstract

The systemic low-frequency oscillation (sLFO) functional (f)MRI signals extracted from the internal carotid artery (ICA) and the superior sagittal sinus (SSS) are found to have valuable physiological information.

Journal

Journal of magnetic resonance imaging : JMRI

Published

2019/04/29

Authors

Yao JF, Wang JH, Yang HS, Liang Z, Cohen-Gadol AA, Rayz VL, Tong Y

Keywords

BOLD signal, cerebral circulation time, fMRI signal, internal carotid artery, low-frequency oscillations, superior sagittal sinus

DOI

10.1002/jmri.26765
Toggle Stress exposures, neurodevelopment and health measures in the ABCD study. Neurobiology of stress Hoffman EA, Clark DB, Orendain N, et al. 2019
PubMed Record

Abstract

The Adolescent Brain Cognitive Development (ABCD) Study, a large, longitudinal study of brain development and child health, is uniquely positioned to explore relationships among stress, neurodevelopment, and psychiatric symptomatology, including substance use and addiction. There is much we do not know about how adverse experiences affect the developing brain and cognitive, social, emotional, and academic outcomes. The data collected by the ABCD Study will allow the examination of the relationships among these variables in adolescence, including the effects of stressors (e.g., abuse, neglect, household challenges, parental substance use) on psychological adjustment and other stress responses. A comprehensive protocol that includes physical and mental health, substance use, culture and environment, neurocognitive assessments, biospecimen analyses, and structural and functional neuroimaging will provide opportunities for learning about the impacts of stressors on health and other outcomes in the context of adolescent development. This knowledge could lead to the development of interventions that reduce or even reverse the impacts of stressors.

Journal

Neurobiology of stress

Published

2019/03/19

Authors

Hoffman EA, Clark DB, Orendain N, Hudziak J, Squeglia LM, Dowling GJ

Keywords

Adolescent, Development, Stress

DOI

10.1016/j.ynstr.2019.100157
Toggle Assessing callous-unemotional traits: development of a brief, reliable measure in a large and diverse sample of preadolescent youth. Psychological medicine Hawes SW, Waller R, Thompson WK, et al. 2019
PubMed Record

Abstract

Callous-unemotional (CU) traits are critical to developmental, diagnostic, and clinical models of antisocial behaviors (AB). However, assessments of CU traits within large-scale longitudinal and neurobiologically focused investigations remain remarkably sparse. We sought to develop a brief measure of CU traits using items from widely administered instruments that could be linked to neuroimaging, genetic, and environmental data within already existing datasets and future studies.

Journal

Psychological medicine

Published

2019/03/08

Authors

Hawes SW, Waller R, Thompson WK, Hyde LW, Byrd AL, Burt SA, Klump KL, Gonzalez R

Keywords

Antisocial behaviors, callous-unemotional traits, conduct disorder

DOI

10.1017/S0033291719000278
Toggle Involvement in Sports, Hippocampal Volume, and Depressive Symptoms in Children. Biological psychiatry. Cognitive neuroscience and neuroimaging Gorham LS, Jernigan T, Hudziak J, et al. 2019
PubMed Record

Abstract

Recent studies have found that higher levels of exercise are associated with fewer symptoms of depression among young people. In addition, research suggests that exercise may modify hippocampal volume, a brain region that has been found to show reduced volume in depression. However, it is not clear whether this relationship emerges as early as preadolescence.

Journal

Biological psychiatry. Cognitive neuroscience and neuroimaging

Published

2019/02/04

Authors

Gorham LS, Jernigan T, Hudziak J, Barch DM

Keywords

Children, Depression, Exercise, Hippocampus, Neuroimaging, Structural

DOI

10.1016/j.bpsc.2019.01.011
Toggle Resting-State Functional Connectivity and Psychotic-like Experiences in Childhood: Results From the Adolescent Brain Cognitive Development Study. Biological psychiatry Karcher NR, O'Brien KJ, Kandala S, et al. 2019
PubMed Record

Abstract

Psychotic-like experiences (PLEs) during childhood are associated with greater risk of developing a psychotic disorder (and other mental disorders), highlighting the importance of identifying neural correlates of childhood PLEs. Three major cortical networks-the cingulo-opercular network (CON), default mode network (DMN), and frontoparietal network-are consistently implicated in psychosis and PLEs in adults. However, it is unclear whether variation in functional connectivity is associated with PLEs in school-aged children.

Journal

Biological psychiatry

Published

2019/01/26

Authors

Karcher NR, O'Brien KJ, Kandala S, Barch DM

Keywords

Delusional ideation, Perceptual distortions, Psychotic-like experiences, Resting-state functional connectivity, Subcortical connectivity, Within-network connectivity

DOI

10.1016/j.biopsych.2019.01.013
Toggle Prevalence of Eating Disorders Among US Children Aged 9 to 10 Years: Data From the Adolescent Brain Cognitive Development (ABCD) Study. JAMA pediatrics Rozzell K, Moon DY, Klimek P, et al. 2019
PubMed Record

Abstract

This study extrapolates data from the Adolescent Brain Cognitive Development (ABCD) study to estimate the prevalence of eating disorders in US preadolescent children.

Journal

JAMA pediatrics

Published

2019/01/01

Authors

Rozzell K, Moon DY, Klimek P, Brown T, Blashill AJ

Keywords

DOI

10.1001/jamapediatrics.2018.3678
Toggle Sexual minority children: Mood disorders and suicidality disparities. Journal of affective disorders Blashill AJ, Calzo JP 2018
PubMed Record

Abstract

Sexual minority (gay, lesbian, and bisexual) individuals experience elevated mood disorders and suicidality compared to their heterosexual counterparts. However, to date, these sexual orientation disparities have yet to be examined among middle childhood-aged participants.

Journal

Journal of affective disorders

Published

2018/12/17

Authors

Blashill AJ, Calzo JP

Keywords

Children, Mood disorders, Sexual minority, Sexual orientation, Suicide

DOI

10.1016/j.jad.2018.12.040
Toggle The structure of cognition in 9 and 10 year-old children and associations with problem behaviors: Findings from the ABCD study's baseline neurocognitive battery. Developmental cognitive neuroscience Thompson WK, Barch DM, Bjork JM, et al. 2018
PubMed Record

Abstract

The Adolescent Brain Cognitive Development (ABCD) study is poised to be the largest single-cohort long-term longitudinal study of neurodevelopment and child health in the United States. Baseline data on N= 4521 children aged 9-10 were released for public access on November 2, 2018. In this paper we performed principal component analyses of the neurocognitive assessments administered to the baseline sample. The neurocognitive battery included seven measures from the NIH Toolbox as well as five other tasks. We implemented a Bayesian Probabilistic Principal Components Analysis (BPPCA) model that incorporated nesting of subjects within families and within data collection sites. We extracted varimax-rotated component scores from a three-component model and associated these scores with parent-rated Child Behavior Checklist (CBCL) internalizing, externalizing, and stress reactivity. We found evidence for three broad components that encompass general cognitive ability, executive function, and learning/memory. These were significantly associated with CBCL scores in a differential manner but with small effect sizes. These findings set the stage for longitudinal analysis of neurocognitive and psychopathological data from the ABCD cohort as they age into the period of maximal adolescent risk-taking.

Journal

Developmental cognitive neuroscience

Published

2018/12/13

Authors

Thompson WK, Barch DM, Bjork JM, Gonzalez R, Nagel BJ, Nixon SJ, Luciana M

Keywords

Adolescence, Child behavior checklist, Externalizing, Internalizing, NIH toolbox, Neurocognition, Principal components analysis, Stress reactivity

DOI

10.1016/j.dcn.2018.12.004
Toggle Child Sexual Orientation and Gender Identity in the Adolescent Brain Cognitive Development Cohort Study. JAMA pediatrics Calzo JP, Blashill AJ 2018
PubMed Record

Abstract

This survey study queried children and parents on the child’s sexual orientation and gender identity.

Journal

JAMA pediatrics

Published

2018/11/01

Authors

Calzo JP, Blashill AJ

Keywords

DOI

10.1001/jamapediatrics.2018.2496
Toggle Screen media activity and brain structure in youth: Evidence for diverse structural correlation networks from the ABCD study. NeuroImage Paulus MP, Squeglia LM, Bagot K, et al. 2018
PubMed Record

Abstract

The adolescent brain undergoes profound structural changes which is influenced by many factors. Screen media activity (SMA; e.g., watching television or videos, playing video games, or using social media) is a common recreational activity in children and adolescents; however, its effect on brain structure is not well understood. A multivariate approach with the first cross-sectional data release from the Adolescent Brain Cognitive Development (ABCD) study was used to test the maturational coupling hypothesis, i.e. the notion that coordinated patterns of structural change related to specific behaviors. Moreover, the utility of this approach was tested by determining the association between these structural correlation networks and psychopathology or cognition. ABCD participants with usable structural imaging and SMA data (N = 4277 of 4524) were subjected to a Group Factor Analysis (GFA) to identify latent variables that relate SMA to cortical thickness, sulcal depth, and gray matter volume. Subject scores from these latent variables were used in generalized linear mixed-effect models to investigate associations between SMA and internalizing and externalizing psychopathology, as well as fluid and crystalized intelligence. Four SMA-related GFAs explained 37% of the variance between SMA and structural brain indices. SMA-related GFAs correlated with brain areas that support homologous functions. Some but not all SMA-related factors corresponded with higher externalizing (Cohen’s d effect size (ES) 0.06-0.1) but not internalizing psychopathology and lower crystalized (ES: 0.08-0.1) and fluid intelligence (ES: 0.04-0.09). Taken together, these findings support the notion of SMA related maturational coupling or structural correlation networks in the brain and provides evidence that individual differences of these networks have mixed consequences for psychopathology and cognitive performance.

Journal

NeuroImage

Published

2018/10/16

Authors

Paulus MP, Squeglia LM, Bagot K, Jacobus J, Kuplicki R, Breslin FJ, Bodurka J, Morris AS, Thompson WK, Bartsch H, Tapert SF

Keywords

DOI

10.1016/j.neuroimage.2018.10.040
Toggle Associations between 24 hour movement behaviours and global cognition in US children: a cross-sectional observational study. The Lancet. Child & adolescent health Walsh JJ, Barnes JD, Cameron JD, et al. 2018
PubMed Record

Abstract

Childhood and adolescence are crucial periods for brain development, and the behaviours during a typical 24 h period contribute to cognitive performance. The Canadian 24-Hour Movement Guidelines for Children and Youth recommend at least 60 min physical activity per day, 2 h or less recreational screen time per day, and 9-11 h sleep per night in children aged 8-11 years. We investigated the relationship between adherence to these recommendations and global cognition.

Journal

The Lancet. Child & adolescent health

Published

2018/09/27

Authors

Walsh JJ, Barnes JD, Cameron JD, Goldfield GS, Chaput JP, Gunnell KE, Ledoux AA, Zemek RL, Tremblay MS

Keywords

DOI

10.1016/S2352-4642(18)30278-5
Toggle Convergent influences of lifestyle behaviour on neurocognitive development in children. The Lancet. Child & adolescent health Bustamante EE 2018
PubMed Record

Abstract

Journal

The Lancet. Child & adolescent health

Published

2018/09/27

Authors

Bustamante EE

Keywords

DOI

10.1016/S2352-4642(18)30305-5
Toggle Assessment of the Prodromal Questionnaire-Brief Child Version for Measurement of Self-reported Psychoticlike Experiences in Childhood. JAMA psychiatry Karcher NR, Barch DM, Avenevoli S, et al. 2018
PubMed Record

Abstract

Childhood psychoticlike experiences (PLEs) are associated with greater odds of a diagnosis of a psychotic disorder during adulthood. However, no known, well-validated self-report tools have been designed to measure childhood PLEs.

Journal

JAMA psychiatry

Published

2018/08/01

Authors

Karcher NR, Barch DM, Avenevoli S, Savill M, Huber RS, Simon TJ, Leckliter IN, Sher KJ, Loewy RL

Keywords

DOI

10.1001/jamapsychiatry.2018.1334
Toggle Implications of the ABCD study for developmental neuroscience. Developmental cognitive neuroscience Feldstein Ewing SW, Bjork JM, Luciana M 2018
PubMed Record

Abstract

The Adolescent Brain Cognitive Development Study (ABCD) will capture a breadth of multi-faceted biobehavioral, environmental, familial, and genetic longitudinal developmental open-access data from over 11,000 9-10 year olds throughout the United States of America (USA) for an envisioned ten-year span. This will subsequently represent the largest study ever attempted with this level of brain phenotypic detail. This study holds the opportunity for exciting advances in the understanding of typical adolescent neurodevelopment, discovery of neurodevelopmental underpinnings of mental illness, as well as the neurodevelopmental influences of (and on) social factors, substance use, and critically – their interaction. This project will certainly take unprecedented steps in informing the nature of adolescence and the developing brain. The scale and open-access features of ABCD also necessarily entail areas for consideration to enhance the integrity of the ABCD study, and protect against potential misuse and misinterpretation of ABCD data. Ultimately, with the open-source data, all scientists in the broader community have as much responsibility as the investigators within the Consortium to treat these data with care. It will be fascinating to see what dynamic data these paths generate. ABCD is poised to exemplify how large-scale longitudinal developmental neuroscientific studies can be designed and efficiently conducted.

Journal

Developmental cognitive neuroscience

Published

2018/08/01

Authors

Feldstein Ewing SW, Bjork JM, Luciana M

Keywords

DOI

10.1016/j.dcn.2018.05.003
Toggle Outreach and innovation: Communication strategies for the ABCD Study. Developmental cognitive neuroscience Hoffman EA, Howlett KD, Breslin F, et al. 2018
PubMed Record

Abstract

The Adolescent Brain Cognitive Development (ABCD) Study, a large, longitudinal study of brain development and child health, relies on the engagement of communities, educators, and families to ensure its success. To that end, community and partner relationships, development of targeted messages and materials for specific audiences (educators, families, youth, scientists), and continued and consistent outreach must be an integral part of the Consortium activities. The ABCD Consortium has made these efforts a priority and developed a framework to raise awareness about the study and promote sustained broad-base support from diverse stakeholders.

Journal

Developmental cognitive neuroscience

Published

2018/04/16

Authors

Hoffman EA, Howlett KD, Breslin F, Dowling GJ

Keywords

Adolescent, Communication, Development, Engagement, Outreach

DOI

10.1016/j.dcn.2018.04.001
Toggle Recruiting the ABCD sample: Design considerations and procedures. Developmental cognitive neuroscience Garavan H, Bartsch H, Conway K, et al. 2018
PubMed Record

Abstract

The ABCD study is a new and ongoing project of very substantial size and scale involving 21 data acquisition sites. It aims to recruit 11,500 children and follow them for ten years with extensive assessments at multiple timepoints. To deliver on its potential to adequately describe adolescent development, it is essential that it adopt recruitment procedures that are efficient and effective and will yield a sample that reflects the nation’s diversity in an epidemiologically informed manner. Here, we describe the sampling plans and recruitment procedures of this study. Participants are largely recruited through the school systems with school selection informed by gender, race and ethnicity, socioeconomic status, and urbanicity. Procedures for school selection designed to mitigate selection biases, dynamic monitoring of the accumulating sample to correct deviations from recruitment targets, and a description of the recruitment procedures designed to foster a collaborative attitude between the researchers, the schools and the local communities, are provided.

Journal

Developmental cognitive neuroscience

Published

2018/04/16

Authors

Garavan H, Bartsch H, Conway K, Decastro A, Goldstein RZ, Heeringa S, Jernigan T, Potter A, Thompson W, Zahs D

Keywords

Adolescence, Adolescent Brain Cognitive Development, Recruitment, Study design

DOI

10.1016/j.dcn.2018.04.004
Toggle A description of the ABCD organizational structure and communication framework. Developmental cognitive neuroscience Auchter AM, Hernandez Mejia M, Heyser CJ, et al. 2018
PubMed Record

Abstract

The Adolescent Brain Cognitive Development (ABCD) study is designed to be the largest study of brain development and child health in the United States, performing comprehensive assessments of 11,500 children repeatedly for 10 years. An endeavor of this magnitude requires an organized framework of governance and communication that promotes collaborative decision-making and dissemination of information. The ABCD consortium structure, built upon the Matrix Management approach of organizational theory, facilitates the integration of input from all institutions, numerous internal workgroups and committees, federal partners, and external advisory groups to make use of a broad range of expertise to ensure the study’s success.

Journal

Developmental cognitive neuroscience

Published

2018/04/16

Authors

Auchter AM, Hernandez Mejia M, Heyser CJ, Shilling PD, Jernigan TL, Brown SA, Tapert SF, Dowling GJ

Keywords

Adolescence, Development, Governance, Longitudinal, Neuroimaging, Organizational framework

DOI

10.1016/j.dcn.2018.04.003
Toggle A brief validated screen to identify boys and girls at risk for early marijuana use. Developmental cognitive neuroscience Loeber R, Clark DB, Ahonen L, et al. 2018
PubMed Record

Abstract

To guide recruitment, the ABCD Study requires a method for identifying children at high risk for early-onset substance use that may be utilized during the recruitment process. This study was undertaken to inform the development of a brief screen for identifying youths’ risk of early-onset substance use and other adverse outcomes. To be acceptable by participants in this context, consideration of potential items was limited to child characteristics previously determined to be potentially pertinent and parental cigarette smoking. To focus the analyses on a single target substance use outcome pertinent to the stated goals of the ABCD Study, early-onset marijuana use was selected. Utilizing data collected prior to the initiation of the ABCD Study, four longitudinal data sets were used in nine secondary data analyses to test, replicate and validate a brief screening assessment for boys and girls to identify those at risk for early-onset marijuana use by ages 14-15. The combination of child externalizing problems reported by the parent (4 items: destroys things belonging to his/her family or others; disobedience at school; lying or cheating; steals outside the home) and parent smoking (1 item) proved to be the optimal screen. This was largely replicated across the four data sets. Indicators of predictive efficiency were modest in magnitude and statistically significant in 8 out of the 9 analyses. The results informed the screen’s optimal threshold for identifying children at risk for early-onset marijuana use. The addition of child internalizing problems did not improve these predictions. Further analyses showed the predictive utility of the screen for several other substance use outcomes at ages 15 to 18, including alcohol and nicotine use. The results support the use of a short screening assessment to identify youth at risk for early-onset substance use in the ABCD Study and other research.

Journal

Developmental cognitive neuroscience

Published

2018/04/07

Authors

Loeber R, Clark DB, Ahonen L, FitzGerald D, Trucco EM, Zucker RA

Keywords

Adolescence, Marijuana use, Risk screening

DOI

10.1016/j.dcn.2018.03.011
Toggle Current, future and potential use of mobile and wearable technologies and social media data in the ABCD study to increase understanding of contributors to child health. Developmental cognitive neuroscience Bagot KS, Matthews SA, Mason M, et al. 2018
PubMed Record

Abstract

Mobile and wearable technologies and novel methods of data collection are innovating health-related research. These technologies and methods allow for multi-system level capture of data across environmental, physiological, behavioral, and psychological domains. In the Adolescent Brain Cognitive Development (ABCD) Study, there is great potential for harnessing the acceptability, accessibility, and functionality of mobile and social technologies for in-vivo data capture to precisely measure factors, and interactions between factors, that contribute to childhood and adolescent neurodevelopment and psychosocial and health outcomes. Here we discuss advances in mobile and wearable technologies and methods of analysis of geospatial, ecologic, social network and behavioral data. Incorporating these technologies into the ABCD study will allow for interdisciplinary research on the effects of place, social interactions, environment, and substance use on health and developmental outcomes in children and adolescents.

Journal

Developmental cognitive neuroscience

Published

2018/03/28

Authors

Bagot KS, Matthews SA, Mason M, Squeglia LM, Fowler J, Gray K, Herting M, May A, Colrain I, Godino J, Tapert S, Brown S, Patrick K

Keywords

ABCD, Child development, Child health, Mobile technology, Social media, Wearable sensors

DOI

10.1016/j.dcn.2018.03.008
Toggle Assessment of culture and environment in the Adolescent Brain and Cognitive Development Study: Rationale, description of measures, and early data. Developmental cognitive neuroscience Zucker RA, Gonzalez R, Feldstein Ewing SW, et al. 2018
PubMed Record

Abstract

Neurodevelopmental maturation takes place in a social environment in addition to a neurobiological one. Characterization of social environmental factors that influence this process is therefore an essential component in developing an accurate model of adolescent brain and neurocognitive development, as well as susceptibility to change with the use of marijuana and other drugs. The creation of the Culture and Environment (CE) measurement component of the ABCD protocol was guided by this understanding. Three areas were identified by the CE Work Group as central to this process: influences relating to CE Group membership, influences created by the proximal social environment, influences stemming from social interactions. Eleven measures assess these influences, and by time of publication, will have been administered to well over 7,000 9-10 year-old children and one of their parents. Our report presents baseline data on psychometric characteristics (mean, standard deviation, range, skewness, coefficient alpha) of all measures within the battery. Effectiveness of the battery in differentiating 9-10 year olds who were classified as at higher and lower risk for marijuana use in adolescence was also evaluated. Psychometric characteristics on all measures were good to excellent; higher vs. lower risk contrasts were significant in areas where risk differentiation would be anticipated.

Journal

Developmental cognitive neuroscience

Published

2018/03/17

Authors

Zucker RA, Gonzalez R, Feldstein Ewing SW, Paulus MP, Arroyo J, Fuligni A, Morris AS, Sanchez M, Wills T

Keywords

Acculturation, Cultural identity, Family effects, Social interaction, Substance use

DOI

10.1016/j.dcn.2018.03.004
Toggle Biospecimens and the ABCD study: Rationale, methods of collection, measurement and early data. Developmental cognitive neuroscience Uban KA, Horton MK, Jacobus J, et al. 2018
PubMed Record

Abstract

Biospecimen collection in the Adolescent Brain Cognitive Development (ABCD) study – of hair samples, shed deciduous (baby) teeth, and body fluids – will serve dual functions of screening for study eligibility, and providing measures of biological processes thought to predict or correlate with key study outcomes on brain and cognitive development. Biosamples are being collected annually to screen for recency of drug use prior to the neuroimaging or cognitive testing visit, and to store for the following future studies: (1) on the effects of exposure to illicit and recreational drugs (including alcohol and nicotine); (2) of pubertal hormones on brain and cognitive developmental trajectories; (3) on the contribution of genomics and epigenomics to child and adolescent development and behavioral outcomes; and (4) with pre- and post-natal exposure to environmental neurotoxicants and drugs of abuse measured from novel tooth analyses. The present manuscript describes the rationales for inclusion and selection of the specific biospecimens, methodological considerations for each measure, future plans for assessment of biospecimens during follow-up visits, and preliminary ABCD data to illustrate methodological considerations.

Journal

Developmental cognitive neuroscience

Published

2018/03/16

Authors

Uban KA, Horton MK, Jacobus J, Heyser C, Thompson WK, Tapert SF, Madden PAF, Sowell ER

Keywords

ABCD study, Biospecimens, Environmental exposures, Genetics, Gonadal hormones, Substance use

DOI

10.1016/j.dcn.2018.03.005
Toggle The Adolescent Brain Cognitive Development (ABCD) study: Imaging acquisition across 21 sites. Developmental cognitive neuroscience Casey BJ, Cannonier T, Conley MI, et al. 2018
PubMed Record

Abstract

The ABCD study is recruiting and following the brain development and health of over 10,000 9-10 year olds through adolescence. The imaging component of the study was developed by the ABCD Data Analysis and Informatics Center (DAIC) and the ABCD Imaging Acquisition Workgroup. Imaging methods and assessments were selected, optimized and harmonized across all 21 sites to measure brain structure and function relevant to adolescent development and addiction. This article provides an overview of the imaging procedures of the ABCD study, the basis for their selection and preliminary quality assurance and results that provide evidence for the feasibility and age-appropriateness of procedures and generalizability of findings to the existent literature.

Journal

Developmental cognitive neuroscience

Published

2018/03/14

Authors

Casey BJ, Cannonier T, Conley MI, Cohen AO, Barch DM, Heitzeg MM, Soules ME, Teslovich T, Dellarco DV, Garavan H, Orr CA, Wager TD, Banich MT, Speer NK, Sutherland MT, Riedel MC, Dick AS, Bjork JM, Thomas KM, Chaarani B, Mejia MH, Hagler DJ, Daniela Cornejo M, Sicat CS, Harms MP, Dosenbach NUF, Rosenberg M, Earl E, Bartsch H, Watts R, Polimeni JR, Kuperman JM, Fair DA, Dale AM

Keywords

Addiction, Adolescence, Development, Impulsivity, Memory, Reward

DOI

10.1016/j.dcn.2018.03.001
Toggle Adolescent Brain Development: Implications for Understanding Risk and Resilience Processes Through Neuroimaging Research. Journal of research on adolescence : the official journal of the Society for Research on Adolescence Morris AS, Squeglia LM, Jacobus J, et al. 2018
PubMed Record

Abstract

This special section focuses on research that utilizes neuroimaging methods to examine the impact of social relationships and socioemotional development on adolescent brain function. Studies include novel neuroimaging methods that further our understanding of adolescent brain development. This special section has a particular focus on how study findings add to our understanding of risk and resilience. In this introduction to the special section, we discuss the role of neuroimaging in developmental science and provide a brief review of neuroimaging methods. We present key themes that are covered in the special section articles including: (1) emerging methods in developmental neuroscience, (2) emotion-cognition interaction, and (3) the role of social relationships in brain function. We conclude our introduction with future directions for integrating developmental neuroscience into the study of adolescence, and highlight key points from the special section’s commentaries which include information on the landmark Adolescent Brain Cognitive Development (ABCD) study.

Journal

Journal of research on adolescence : the official journal of the Society for Research on Adolescence

Published

2018/03/01

Authors

Morris AS, Squeglia LM, Jacobus J, Silk JS

Keywords

DOI

10.1111/jora.12379
Toggle The Adolescent Brain Cognitive Development Study. Journal of research on adolescence : the official journal of the Society for Research on Adolescence Jernigan TL, Brown SA, Dowling GJ 2018
PubMed Record

Abstract

Journal

Journal of research on adolescence : the official journal of the Society for Research on Adolescence

Published

2018/03/01

Authors

Jernigan TL, Brown SA, Dowling GJ

Keywords

DOI

10.1111/jora.12374
Toggle Adolescent neurocognitive development and impacts of substance use: Overview of the adolescent brain cognitive development (ABCD) baseline neurocognition battery. Developmental cognitive neuroscience Luciana M, Bjork JM, Nagel BJ, et al. 2018
PubMed Record

Abstract

Adolescence is characterized by numerous social, hormonal and physical changes, as well as a marked increase in risk-taking behaviors. Dual systems models attribute adolescent risk-taking to tensions between developing capacities for cognitive control and motivational strivings, which may peak at this time. A comprehensive understanding of neurocognitive development during the adolescent period is necessary to permit the distinction between premorbid vulnerabilities and consequences of behaviors such as substance use. Thus, the prospective assessment of cognitive development is fundamental to the aims of the newly launched Adolescent Brain and Cognitive Development (ABCD) Consortium. This paper details the rationale for ABC’lected measures of neurocognition, presents preliminary descriptive data on an initial sample of 2299 participants, and provides a context for how this large-scale project can inform our understanding of adolescent neurodevelopment.

Journal

Developmental cognitive neuroscience

Published

2018/02/21

Authors

Luciana M, Bjork JM, Nagel BJ, Barch DM, Gonzalez R, Nixon SJ, Banich MT

Keywords

Adolescence, Longitudinal, NIH Toolbox, Neurocognition, Substance use

DOI

10.1016/j.dcn.2018.02.006
Toggle Adolescent brain cognitive development (ABCD) study: Overview of substance use assessment methods. Developmental cognitive neuroscience Lisdahl KM, Sher KJ, Conway KP, et al. 2018
PubMed Record

Abstract

One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States.

Journal

Developmental cognitive neuroscience

Published

2018/02/21

Authors

Lisdahl KM, Sher KJ, Conway KP, Gonzalez R, Feldstein Ewing SW, Nixon SJ, Tapert S, Bartsch H, Goldstein RZ, Heitzeg M

Keywords

Adolescent, Adolescent Brain Cognitive Development Study, Alcohol, Assessment, Cannabis, Child, Drug use, Inhalants, Longitudinal, Marijuana, Methods, Nicotine, Prescription drug use, Substance use

DOI

10.1016/j.dcn.2018.02.007
Toggle Introduction. Developmental cognitive neuroscience Jernigan TL, Brown SA 2018
PubMed Record

Abstract

The Adolescent Brain Cognitive Development (ABCD) Study is a longitudinal, observational study of over 10,000 youth recruited at 21 sites throughout the United States. Comprehensive biennial assessments and more limited interim assessments measure health, mental health, neurocognition, family, cultural and environmental variables, substance use, genetic and other biomarkers, and structural and functional brain development. Within this Special Issue, readers will find much information about the rationale and objectives of the study, the broad ranging assessment protocols and new as well as traditional methodologies applied at baseline, the recruitment and retention strategies, and the anticipated final composition of the cohort. Information is also provided about how the study is coordinated and conducted, how decisions are made, how data quality is monitored, and how ethical standards are protected. In this introduction we will focus instead on the position of the ABCD Study in the changing landscape of biomedical research.

Journal

Developmental cognitive neuroscience

Published

2018/02/15

Authors

Jernigan TL, Brown SA

Keywords

DOI

10.1016/j.dcn.2018.02.002
Toggle The adolescent brain cognitive development study external advisory board. Developmental cognitive neuroscience Charness ME 2017
PubMed Record

Abstract

Journal

Developmental cognitive neuroscience

Published

2017/12/28

Authors

Charness ME

Keywords

DOI

10.1016/j.dcn.2017.12.007
Toggle Approaching Retention within the ABCD Study. Developmental cognitive neuroscience Feldstein Ewing SW, Chang L, Cottler LB, et al. 2017
PubMed Record

Abstract

Retention efforts are critical to maintain relationships with research participants over time. This is especially important for the Adolescent Brain Cognitive Development (ABCD) study, where families are asked to stay engaged with the study throughout the course of 10 years. This high-degree of involvement is essential to longitudinally track child and adolescent development. At a minimum, we will connect with families every 6 months by telephone, and every year in person, with closer contact with the youth directly as they transition into adolescence. Differential retention, when related to non-random issues pertaining to demographic or risk features, can negatively impact the generalizability of study outcomes. Thus, to ensure high rates of retention for all participants, the ABCD study employs a number of efforts to support youth and families. This overview details the framework and concrete steps for retention.

Journal

Developmental cognitive neuroscience

Published

2017/11/11

Authors

Feldstein Ewing SW, Chang L, Cottler LB, Tapert SF, Dowling GJ, Brown SA

Keywords

ABCD study, Adolescents, Longitudinal, Multi-site, Retention

DOI

10.1016/j.dcn.2017.11.004
Toggle Demographic, physical and mental health assessments in the adolescent brain and cognitive development study: Rationale and description. Developmental cognitive neuroscience Barch DM, Albaugh MD, Avenevoli S, et al. 2017
PubMed Record

Abstract

The Adolescent Brain and Cognitive Development (ABCD) Study incorporates a comprehensive range of measures assessing predictors and outcomes related to both mental and physical health across childhood and adolescence. The workgroup developed a battery that would assess a comprehensive range of domains that address study aims while minimizing participant and family burden. We review the major considerations that went into deciding what constructs to cover in the demographics, physical health and mental health domains, as well as the process of selecting measures, piloting and refining the originally proposed battery. We present a description of the baseline battery, as well as the six-month interim assessments and the one-year follow-up assessments. This battery includes assessments from the perspectives of both the parent and the target youth, as well as teacher reports. This battery will provide a foundational baseline assessment of the youth’s current function so as to permit characterization of stability and change in key domains over time. The findings from this battery will also be utilized to identify both resilience markers that predict healthy development and risk factors for later adverse outcomes in physical health, mental health, and substance use and abuse.

Journal

Developmental cognitive neuroscience

Published

2017/11/03

Authors

Barch DM, Albaugh MD, Avenevoli S, Chang L, Clark DB, Glantz MD, Hudziak JJ, Jernigan TL, Tapert SF, Yurgelun-Todd D, Alia-Klein N, Potter AS, Paulus MP, Prouty D, Zucker RA, Sher KJ

Keywords

Assessment, Mental health, Physical health, Psychopathology

DOI

10.1016/j.dcn.2017.10.010
Toggle The conception of the ABCD study: From substance use to a broad NIH collaboration. Developmental cognitive neuroscience Volkow ND, Koob GF, Croyle RT, et al. 2017
PubMed Record

Abstract

Adolescence is a time of dramatic changes in brain structure and function, and the adolescent brain is highly susceptible to being altered by experiences like substance use. However, there is much we have yet to learn about how these experiences influence brain development, how they promote or interfere with later health outcomes, or even what healthy brain development looks like. A large longitudinal study beginning in early adolescence could help us understand the normal variability in adolescent brain and cognitive development and tease apart the many factors that influence it. Recent advances in neuroimaging, informatics, and genetics technologies have made it feasible to conduct a study of sufficient size and scope to answer many outstanding questions. At the same time, several Institutes across the NIH recognized the value of collaborating in such a project because of its ability to address the role of biological, environmental, and behavioral factors like gender, pubertal hormones, sports participation, and social/economic disparities on brain development as well as their association with the emergence and progression of substance use and mental illness including suicide risk. Thus, the Adolescent Brain Cognitive Development study was created to answer the most pressing public health questions of our day.

Journal

Developmental cognitive neuroscience

Published

2017/10/10

Authors

Volkow ND, Koob GF, Croyle RT, Bianchi DW, Gordon JA, Koroshetz WJ, Pérez-Stable EJ, Riley WT, Bloch MH, Conway K, Deeds BG, Dowling GJ, Grant S, Howlett KD, Matochik JA, Morgan GD, Murray MM, Noronha A, Spong CY, Wargo EM, Warren KR, Weiss SRB

Keywords

Adolescent, Brain development, Longitudinal, Mental health, Neuroimaging, Substance use

DOI

10.1016/j.dcn.2017.10.002
Toggle The utility of twins in developmental cognitive neuroscience research: How twins strengthen the ABCD research design. Developmental cognitive neuroscience Iacono WG, Heath AC, Hewitt JK, et al. 2017
PubMed Record

Abstract

The ABCD twin study will elucidate the genetic and environmental contributions to a wide range of mental and physical health outcomes in children, including substance use, brain and behavioral development, and their interrelationship. Comparisons within and between monozygotic and dizygotic twin pairs, further powered by multiple assessments, provide information about genetic and environmental contributions to developmental associations, and enable stronger tests of causal hypotheses, than do comparisons involving unrelated children. Thus a sub-study of 800 pairs of same-sex twins was embedded within the overall Adolescent Brain and Cognitive Development (ABCD) design. The ABCD Twin Hub comprises four leading centers for twin research in Minnesota, Colorado, Virginia, and Missouri. Each site is enrolling 200 twin pairs, as well as singletons. The twins are recruited from registries of all twin births in each State during 2006-2008. Singletons at each site are recruited following the same school-based procedures as the rest of the ABCD study. This paper describes the background and rationale for the ABCD twin study, the ascertainment of twin pairs and implementation strategy at each site, and the details of the proposed analytic strategies to quantify genetic and environmental influences and test hypotheses critical to the aims of the ABCD study.

Journal

Developmental cognitive neuroscience

Published

2017/09/12

Authors

Iacono WG, Heath AC, Hewitt JK, Neale MC, Banich MT, Luciana MM, Madden PA, Barch DM, Bjork JM

Keywords

Brain function, Brain structure, Environment, Heritability, Substance use, Twins

DOI

10.1016/j.dcn.2017.09.001
Toggle Biomedical ethics and clinical oversight in multisite observational neuroimaging studies with children and adolescents: The ABCD experience. Developmental cognitive neuroscience Clark DB, Fisher CB, Bookheimer S, et al. 2017
PubMed Record

Abstract

Observational neuroimaging studies with children and adolescents may identify neurological anomalies and other clinically relevant findings. Planning for the management of this information involves ethical considerations that may influence informed consent, confidentiality, and communication with participants about assessment results. Biomedical ethics principles include respect for autonomy, beneficence, non-maleficence, and justice. Each project presents unique challenges. The Adolescent Brain and Cognitive Development study (ABCD) collaborators have systematically developed recommendations with written guidelines for identifying and responding to potential risks that adhere to biomedical ethics principles. To illustrate, we will review the ABCD approach to three areas: (1) hazardous substance use; (2) neurological anomalies; and (3) imminent potential for self-harm or harm to others. Each ABCD site is responsible for implementing procedures consistent with these guidelines in accordance with their Institutional Review Board approved protocols, state regulations, and local resources. To assure that each site has related plans and resources in place, site emergency procedures manuals have been developed, documented and reviewed for adherence to ABCD guidelines. This article will describe the principles and process used to develop these ABCD bioethics and medical oversight guidelines, the concerns and options considered, and the resulting approaches advised to sites.

Journal

Developmental cognitive neuroscience

Published

2017/06/28

Authors

Clark DB, Fisher CB, Bookheimer S, Brown SA, Evans JH, Hopfer C, Hudziak J, Montoya I, Murray M, Pfefferbaum A, Yurgelun-Todd D

Keywords

Adolescence, Clinical oversight, Ethics, Magnetic resonance imaging, Substance use

DOI

10.1016/j.dcn.2017.06.005
Toggle The ABCD study of neurodevelopment: Identifying neurocircuit targets for prevention and treatment of adolescent substance abuse. Current treatment options in psychiatry Bjork JM, Straub LK, Provost RG, et al. 2017
PubMed Record

Abstract

Substance use disorders (SUD) can be considered developmental disorders in light of their frequent origins in substance initiation during adolescence. Cross-sectional functional magnetic resonance imaging (fMRI) studies of adolescent substance users or adolescents with SUD have indicated aberrations in brain structures or circuits implicated in motivation, self-control, and mood-regulation. However, attributing these differences to the neurotoxicological effects of chronic substance use has been problematic in that these circuits are also aberrant in at-risk children, such as those with prenatal substance exposure, externalizing disorders (such as conduct disorder), or prodromal internalizing disorders such as depression. To better isolate the effects of substance exposure on the adolescent brain, the newly-launched Adolescent Brain Cognitive Development (ABCD) study, funded by the National Institutes of Health, will follow the neurodevelopmental trajectories of over 11,000 American 9/10-year-olds for 10 years, into emerging adulthood. This study will provide a rich open-access dataset on longitudinal interactions of neurodevelopment, environmental exposures, and childhood psychopathology that confer addiction risk. The ABCD twin study will further clarify genetic versus experiential influences (e.g., substance use) on neurodevelopmental and psychosocial outcomes. Neurocircuitry thought to regulate mood and behavior has been directly normalized by administration of psychoactive medications and by cognitive therapies in adults. Because of this, we contend that ABCD project data will be a crucial resource for prevention and treatment of SUD in adolescence because its cutting-edge neuroimaging and childhood assessments hold potential for discovery of additional targetable brain differences earlier in development that are prognostic of (or aberrant in) SUD. The ABCD sample size will also have the power to illuminate how sex differences, environmental interactions and other individual differences interact with neurodevelopment to inform treatment in different groups of adolescents.

Journal

Current treatment options in psychiatry

Published

2017/04/20

Authors

Bjork JM, Straub LK, Provost RG, Neale MC

Keywords

Addiction, Adolescence, Depression, Development, Impulsivity, Neuroimaging

DOI

10.1007/s40501-017-0108-y