ABCD Study publications are authored by ABCD investigators, collaborators, and non-ABCD researchers. The analysis methodologies, findings, and interpretations expressed in these publications are those of the authors and do not constitute an endorsement by the ABCD Study®.

Please note that the publications listed here include empirical as well as non-empirical papers (e.g., focused review articles, editorials).

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Title Journal Authors Year Details
Toggle Change in striatal functional connectivity networks across 2 years due to stimulant exposure in childhood ADHD: results from the ABCD sample. Translational psychiatry Kaminski A, Xie H, Hawkins B, et al. 2024
PubMed Record

Abstract

Widely prescribed for Attention-Deficit/Hyperactivity Disorder (ADHD), stimulants (e.g., methylphenidate) have been studied for their chronic effects on the brain in prospective designs controlling dosage and adherence. While controlled approaches are essential, they do not approximate real-world stimulant exposure contexts where medication interruptions, dosage non-compliance, and polypharmacy are common. Brain changes in real-world conditions are largely unexplored. To fill this gap, we capitalized on the observational design of the Adolescent Brain Cognitive Development (ABCD) study to examine effects of stimulants on large-scale bilateral cortical networks’ resting-state functional connectivity (rs-FC) with 6 striatal regions (left and right caudate, putamen, and nucleus accumbens) across two years in children with ADHD. Bayesian hierarchical regressions revealed associations between stimulant exposure and change in rs-FC of multiple striatal-cortical networks, affiliated with executive and visuo-motor control, which were not driven by general psychotropic medication. Of these connections, three were selective to stimulants versus stimulant naive: reduced rs-FC between caudate and frontoparietal network, and between putamen and frontoparietal and visual networks. Comparison with typically developing children in the ABCD sample revealed stronger rs-FC reduction in stimulant-exposed children for putamen and frontoparietal and visual networks, suggesting a normalizing effect of stimulants. 14% of stimulant-exposed children demonstrated reliable reduction in ADHD symptoms, and were distinguished by stronger rs-FC reduction between right putamen and visual network. Thus, stimulant exposure for a two-year period under real-world conditions modulated striatal-cortical functional networks broadly, had a normalizing effect on a subset of networks, and was associated with potential therapeutic effects involving visual attentional control.

Journal

Translational psychiatry

Published

2024/11/06

Authors

Kaminski A, Xie H, Hawkins B, Vaidya CJ

Keywords

DOI

10.1038/s41398-024-03165-7
Toggle Mobile phone ownership, social media use, and substance use at ages 11-13 in the ABCD study. Addictive behaviors Doran N, Wade NE, Courtney KE, et al. 2024
PubMed Record

Abstract

There is ongoing concern about the impact of increasing use of social media and digital devices on unhealthy behaviors such as substance use in youth. Mobile phone and social media use have been associated with substance use in adolescent and young adult samples, but few studies have evaluated these relationships in younger samples.

Journal

Addictive behaviors

Published

2024/11/06

Authors

Doran N, Wade NE, Courtney KE, Sullivan RM, Jacobus J

Keywords

Digital technology, Social media, Substance use, Youth

DOI

10.1016/j.addbeh.2024.108211
Toggle Black-White Gap Across Levels of Educational Childhood Opportunities: Findings from the ABCD Study. Open journal of educational research Assari S, Zare H 2024
PubMed Record

Abstract

This study examines racial disparities in educational outcomes-including reading proficiency, grade point average (GPA), school discrimination, and school disciplinary actions-across regions with different levels of educational childhood opportunity index (COI). Our aim is to explore how these racial gaps between Black and White students vary in areas with differing educational opportunities. We hypothesize that higher COI is associated with smaller academic achievement gaps but may also correspond with greater racial bias in unfair school treatment.

Journal

Open journal of educational research

Published

2024/11/05

Authors

Assari S, Zare H

Keywords

Academic Achievement, Black-White Achievement Gap, Childhood Opportunity Index, Educational Outcomes, Racial Disparities, School Discipline, School Discrimination

DOI

10.31586/ojer.2024.1124
Toggle Resting-state fMRI activation is associated with parent-reported phenotypic features of autism in early adolescence. Frontiers in child and adolescent psychiatry Hickson R, Hebron L, Muller-Oehring EM, et al. 2024
PubMed Record

Abstract

Autism Spectrum Disorder (ASD) is characterized by deficits in social cognition, self-referential processing, and restricted repetitive behaviors. Despite the established clinical symptoms and neurofunctional alterations in ASD, definitive biomarkers for ASD features during neurodevelopment remain unknown. In this study, we aimed to explore if activation in brain regions of the default mode network (DMN), specifically the medial prefrontal cortex (MPC), posterior cingulate cortex (PCC), superior temporal sulcus (STS), inferior frontal gyrus (IFG), angular gyrus (AG), and the temporoparietal junction (TPJ), during resting-state functional magnetic resonance imaging (rs-fMRI) is associated with possible phenotypic features of autism (PPFA) in a large, diverse youth cohort.

Journal

Frontiers in child and adolescent psychiatry

Published

2024/11/05

Authors

Hickson R, Hebron L, Muller-Oehring EM, Cheu A, Hernandez A, Kiss O, Gombert-Labedens M, Baker FC, Schulte T

Keywords

default mode network (DMN), features of autism spectrum, neuroactivation, preadolescence, rs-fMRI (resting state fMRI)

DOI

10.3389/frcha.2024.1481957
Toggle Callous-unemotional traits, cognitive functioning, and externalizing problems in a propensity-matched sample from the ABCD study. Journal of child psychology and psychiatry, and allied disciplines Murtha K, Perlstein S, Paz Y, et al. 2024
PubMed Record

Abstract

Many studies show that both callous-unemotional (CU) traits (e.g., low empathy, lack of guilt) and cognitive difficulties increase risk for externalizing psychopathology across development. However, other work suggests that some aggression (e.g., relational, proactive) may rely on intact cognitive function, which could vary based on the presence of CU traits. Moreover, no prior research has adequately accounted for common risk factors shared by CU traits, cognitive difficulties, and externalizing problems, which confounds conclusions that can be drawn about their purported relationships. The current study addressed these knowledge gaps by leveraging rigorous propensity matching methods to isolate associations between CU traits and different dimensions of cognitive function and externalizing problems.

Journal

Journal of child psychology and psychiatry, and allied disciplines

Published

2024/11/04

Authors

Murtha K, Perlstein S, Paz Y, Seidlitz J, Raine A, Hawes S, Byrd A, Waller R

Keywords

aggressive behavior, callous‐unemotional traits, cognitive function, externalizing disorders

DOI

10.1111/jcpp.14062
Toggle Cognitive and Behavioral Outcomes of Snoring Among Adolescents. JAMA network open Isaiah A, Uddin S, Ernst T, et al. 2024
PubMed Record

Abstract

Snoring is central to sleep-disordered breathing (SDB), which arises from nocturnal upper airway resistance. Habitual snoring is associated with cognitive and behavioral problems in young children, but less is known about these associations in adolescents.

Journal

JAMA network open

Published

2024/11/04

Authors

Isaiah A, Uddin S, Ernst T, Cloak C, Li D, Chang L

Keywords

DOI

10.1001/jamanetworkopen.2024.44057
Toggle Asthma and Memory Function in Children. JAMA network open Christopher-Hayes NJ, Haynes SC, Kenyon NJ, et al. 2024
PubMed Record

Abstract

Asthma is a chronic respiratory disease affecting approximately 5 million children in the US. Rodent models of asthma indicate memory deficits, but little is known about whether asthma alters children’s memory development.

Journal

JAMA network open

Published

2024/11/04

Authors

Christopher-Hayes NJ, Haynes SC, Kenyon NJ, Merchant VD, Schweitzer JB, Ghetti S

Keywords

DOI

10.1001/jamanetworkopen.2024.42803
Toggle Characterization and Mitigation of a Simultaneous Multi-Slice fMRI Artifact: Multiband Artifact Regression in Simultaneous Slices. Human brain mapping Tubiolo PN, Williams JC, Van Snellenberg JX 2024
PubMed Record

Abstract

Simultaneous multi-slice (multiband) acceleration in fMRI has become widespread, but may be affected by novel forms of signal artifact. Here, we demonstrate a previously unreported artifact manifesting as a shared signal between simultaneously acquired slices in all resting-state and task-based multiband fMRI datasets we investigated, including publicly available consortium data from the Human Connectome Project (HCP) and Adolescent Brain Cognitive Development (ABCD) Study. We propose Multiband Artifact Regression in Simultaneous Slices (MARSS), a regression-based detection and correction technique that successfully mitigates this shared signal in unprocessed data. We demonstrate that the signal isolated by MARSS correction is likely nonneural, appearing stronger in neurovasculature than gray matter. Additionally, we evaluate MARSS both against and in tandem with sICA+FIX denoising, which is implemented in HCP resting-state data, to show that MARSS mitigates residual artifact signal that is not modeled by sICA+FIX. MARSS correction leads to study-wide increases in signal-to-noise ratio, decreases in cortical coefficient of variation, and mitigation of systematic artefactual spatial patterns in participant-level task betas. Finally, MARSS correction has substantive effects on second-level t-statistics in analyses of task-evoked activation. We recommend that investigators apply MARSS to multiband fMRI datasets with moderate or higher acceleration factors, in combination with established denoising methods.

Journal

Human brain mapping

Published

2024/11/01

Authors

Tubiolo PN, Williams JC, Van Snellenberg JX

Keywords

artifact, denoising, fMRI, multiband, simultaneous multi‐slice, task‐based fMRI, working memory

DOI

10.1002/hbm.70066
Toggle A Site-Wise Reliability Analysis of the ABCD Diffusion Fractional Anisotropy and Cortical Thickness: Impact of Scanner Platforms. Human brain mapping Pan Y, Hong LE, Acheson A, et al. 2024
PubMed Record

Abstract

The Adolescent Brain and Cognitive Development (ABCD) project is the largest study of adolescent brain development. ABCD longitudinally tracks 11,868 participants aged 9-10 years from 21 sites using standardized protocols for multi-site MRI data collection and analysis. While the multi-site and multi-scanner study design enhances the robustness and generalizability of analysis results, it may also introduce nonbiological variances including scanner-related variations, subject motion, and deviations from protocols. ABCD imaging data were collected biennially within a period of ongoing maturation in cortical thickness and integrity of cerebral white matter. These changes can bias the classical test-retest methodologies, such as intraclass correlation coefficients (ICC). We developed a site-wise adaptive ICC (AICC) to evaluate the reliability of imaging-derived phenotypes while accounting for ongoing brain development. AICC iteratively estimates the population-level age-related brain development trajectory using a weighted mixed model and updates age-corrected site-wise reliability until convergence. We evaluated the test-retest reliability of regional fractional anisotropy (FA) measures from diffusion tensor imaging and cortical thickness (CT) from structural MRI data for each site. The mean AICC for 20 FA tracts across sites was 0.61 ± 0.19, lower than the mean AICC for CT in 34 regions across sites, 0.76 ± 0.12. Remarkably, sites using Siemens scanners consistently showed significantly higher AICC values compared with those using GE/Philips scanners for both FA (AICC = 0.71 ± 0.12 vs. 0.46 ± 0.17, p < 0.001) and CT (AICC = 0.80 ± 0.10 vs. 0.69 ± 0.11, p < 0.001). These findings demonstrate site-and-scanner related variations in data quality and underscore the necessity for meticulous data curation in subsequent association analyses.

Journal

Human brain mapping

Published

2024/11/01

Authors

Pan Y, Hong LE, Acheson A, Thompson PM, Jahanshad N, Zhu AH, Yu J, Chen C, Ma T, Liu HL, Veraart J, Fieremans E, Karcher NR, Kochunov P, Chen S

Keywords

brain development, diffusion tensor imaging, longitudinal, quality control, structural MRI, test–retest reliability

DOI

10.1002/hbm.70070
Toggle Early adolescents' ethnic-racial discrimination and pubertal development: Parents' ethnic-racial identities promote adolescents' resilience. The American psychologist Del Toro J, Anderson RE, Sun X, et al. 2024
PubMed Record

Abstract

Ethnically and racially underrepresented adolescents are experiencing pubertal development earlier in life than prior cohorts and their White American peers. This early onset of puberty is partly attributable to ethnic-racial discrimination. To contribute to adolescents’ resilience and posttraumatic growth in the face of ethnic-racial discrimination, parents’ ethnic-racial identities may spill over into their parenting beliefs and practices. Parents who have a sense of belonging with and commitment to their ethnic-racial identities may be aware of discrimination and actively and consistently engage in practices that build supportive home environments to support their children’s development in the context of ethnic-racial discrimination. To assess whether parents’ ethnic-racial identity commitment predicted adolescents’ resilience against ethnic-racial discrimination, we used multiple waves of survey data from adolescent siblings and their parents participating in the Adolescent Brain Cognitive Development study (N-adolescents = 1,651; N-families = 805; 35% Black, 37% Latinx, 3% Asian, 25% other ethnically and racially underrepresented youth; 49% boys, 50% girls, 1% gender nonconforming youth; Mage = 11.49, SD = 0.51). Results indicated that adolescents who experienced more frequent ethnic-racial discrimination than their siblings showed more advanced pubertal development. Parental ethnic-racial identity commitment reduced the relation between discrimination and pubertal development within a family. Results suggest that ethnic-racial identity commitment in parents can protect children when they experience ethnic-racial discrimination. Building on extant propositions related to resilience (Infurna & Luthar, 2018), the present study amplifies the depiction of resilience, yields recommendations for analysis of future research, and provides implications regarding the role of ethnicity-race in familial practices. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Journal

The American psychologist

Published

2024/11/01

Authors

Del Toro J, Anderson RE, Sun X, Lee RM

Keywords

DOI

10.1037/amp0001284
Toggle Neural mechanisms of reward processing in preadolescent irritability: Insights from the ABCD study. Journal of affective disorders Parker AJ, Walker JC, Takarae Y, et al. 2024
PubMed Record

Abstract

Elevated youth irritability is characterized by increased proneness to frustration relative to peers when rewards are blocked, and is a transdiagnostic symptom that predicts multiple forms of psychopathology and poorer socioeconomic outcomes in adulthood. Although mechanistic models propose that irritability is the result of aberrant reward-related brain function, youth irritability as it relates to multiple components of reward processes, including reward anticipation, gain, and loss, has yet to be examined in large, population-based samples. Data from the Adolescent Brain and Cognitive Development (ABCD) baseline sample (N = 5923) was used to examine associations between youth irritability (measured by parent-report) and reward-related brain activation and connectivity in a large, preadolescent sample. Preadolescents (M age = 9.96 years, SD = 0.63) performed the Monetary Incentive Delay task during functional MRI acquisition. In the task, during the anticipation period, participants were informed of the upcoming trial type (win money, lose money, no money at stake) and waited to hit a target; during the feedback period, participants were informed of their success. Whole brain and region of interest (ROI) analyses evaluated task conditions in relation to irritability level. Preadolescents with higher compared to lower levels of irritability demonstrated blunted prefrontal cortex activation in the anticipation period and exaggerated striatum-prefrontal connectivity differences among reward conditions during the feedback period. These effects persisted after adjusting for co-occurring anxiety, depression, and attention-deficit/hyperactivity disorder symptoms. These findings provide evidence for the role of reward salience in pathophysiological models of youth irritability, suggesting a mechanism that may contribute to exaggerated behavioral responses.

Journal

Journal of affective disorders

Published

2024/10/31

Authors

Parker AJ, Walker JC, Takarae Y, Dougherty LR, Wiggins JL

Keywords

Brain, Irritability, Preadolescence, Psychopathology, Reward

DOI

10.1016/j.jad.2024.10.124
Toggle State-level variation in the prevalence of child psychopathology symptoms in the US: Results from the ABCD study SSM - Mental Health Keyes KM, Kreski NT, Weissman D, et al. 2024
Link to publication

Abstract

Objective
To estimate the prevalence of clinically meaningful youth mood, anxiety, behavioral, and attention symptoms across US states.

Method

Data are drawn from the Adolescent Brain Cognitive Development (ABCD) study baseline wave, which included 11,876 children ages 9–10. Statistical weighting strategies generated projected state-specific prevalence estimates for the 17 states where ABCD collected data based on state socio-demographics. Twenty dimensions of mental health were assessed with the Child Behavior Checklist using recommended cut-scores to assess clinical and sub-threshold symptoms.

Results

Psychopathology symptom prevalence varied by state and outcome. Projected prevalence of internalizing problems ranged from 11.0% [95% CI: 9.8%, 12.2%; Oklahoma] to 7.9% [95% CI: 6.9%, 9.0%; Maryland] across states. Projected prevalence of externalizing problems ranged from 6.9% [95% CI: 6.1%, 7.8%; South Carolina] to 4.5% [95% CI: 3.7%, 5.4%; California]. Regions with high symptoms included sections of the South (e.g., Oklahoma, South Carolina) and Vermont. Conduct problems had the most variability across states (i.e., greatest state-level prevalence 91% higher than the lowest). Attention problems had the least variability across states (greatest state-level prevalence 26% higher than the lowest).

Conclusions

Clinically meaningful psychopathology symptoms are common in children across the US, with substantial state-level variability in prevalence. Understanding variability in the prevalence of psychopathology symptoms across the US can help to inform resource allocation to increase the availability of youth mental health services.

Journal

SSM - Mental Health

Published

2024/10/31

Authors

Keyes KM, Kreski NT, Weissman D, & McLaughlin KA

Keywords

DOI

https://doi.org/10.1016/j.ssmmh.2024.100361
Toggle An investigation of multimodal predictors of adolescent alcohol initiation. Drug and alcohol dependence Moore A, Lewis B, Elton A, et al. 2024
PubMed Record

Abstract

Early alcohol initiation is associated with negative, alcohol-related outcomes. While previous work identifies numerous risk factors for early use, the relative contributions of known predictors remains understudied. The current project addresses this gap by 1) prospectively predicting early alcohol initiation using measures of inhibition control, reward sensitivity, and contextual risk factors and 2) interrogating the relative importance of each domain.

Journal

Drug and alcohol dependence

Published

2024/10/31

Authors

Moore A, Lewis B, Elton A, Squeglia LM, Nixon SJ

Keywords

ABCD Study®, Adolescence, Alcohol, Initiation

DOI

10.1016/j.drugalcdep.2024.112491
Toggle Linking neuroimaging and mental health data from the ABCD Study to UrbanSat measurements of macro environmental factors Nature Mental Health Goldblatt R, Holz N, Tate GW, et al. 2024
Link to publication

Abstract

Although numerous studies over the past decade have highlighted the influence of environmental factors on mental health, globally applicable data on physical surroundings such as land cover and urbanicity are still limited. The urban environment is complex and composed of many interacting factors. To understand how urban living affects mental health, simultaneous measures of multiple environmental factors need to be related to symptoms of mental illness, while considering the underlying brain structure and function. So far, most studies have assessed individual urban environmental factors, such as greenness, in isolation and related them to individual symptoms of mental illness. We have refined the satellite-based ‘Urban Satellite’ (UrbanSat) measures, consisting of 11 satellite-data-derived environmental indicators, and linked them through residential addresses with participants of the Adolescent Brain Cognitive Development (ABCD) Study. The ABCD Study is the largest ongoing longitudinal and observational study exploring brain development and child health, involving 11,800 children, assessed at 9–16 years of age, from 21 sites across the USA. Here we describe linking of the ABCD Study data with UrbanSat variables, including each subject’s residential address at their baseline visit, including land cover and land use, nighttime lights and population characteristics. We also highlight and discuss important links of the satellite-data variables to the default mode network clustering coefficient and cognition. This comprehensive dataset provides an important tool for advancing neurobehavioral research on urbanicity during the critical developmental periods of childhood and adolescence.

Journal

Nature Mental Health

Published

2024/10/30

Authors

Goldblatt R, Holz N, Tate GW, Sherman K, Ghebremicael S, Bhuyan SS, Al-Ajlouni YA, Santillanes S, Araya G, Abad S, Herting MM, Thompson WK, Thapaliya B, Sapkota R, Xu J, Liu J, The environMENTAL consortium, Schumann G, & Calhoun VD

Keywords

DOI

https://doi.org/10.1038/s44220-024-00318-x
Toggle Associations between Fine Particulate Matter Components, Their Sources, and Cognitive Outcomes in Children Ages 9-10 Years Old from the United States. Environmental health perspectives Sukumaran K, Botternhorn KL, Schwartz J, et al. 2024
PubMed Record

Abstract

Emerging literature suggests that fine particulate matter [with aerodynamic diameter ()] air pollution and its components are linked to various neurodevelopmental outcomes. However, few studies have evaluated how component mixtures from distinct sources relate to cognitive outcomes in children.

Journal

Environmental health perspectives

Published

2024/10/30

Authors

Sukumaran K, Botternhorn KL, Schwartz J, Gauderman J, Cardenas-Iniguez C, McConnell R, Hackman DA, Berhane K, Ahmadi H, Abad S, Habre R, Herting MM

Keywords

DOI

10.1289/EHP14418
Toggle Association between gender diversity and substance use experimentation in early adolescents. Drug and alcohol dependence Shao IY, Low P, Sui S, et al. 2024
PubMed Record

Abstract

Gender diversity, encompassing gender identity beyond traditional binary frameworks, has been associated with substance use during adolescence. However, there is a paucity of studies that consider different dimensions of gender diversity. This study investigates associations between multiple dimensions of gender diversity and substance experimentation in early adolescents.

Journal

Drug and alcohol dependence

Published

2024/10/29

Authors

Shao IY, Low P, Sui S, Otmar CD, Ganson KT, Testa A, Santos GM, He J, Baker FC, Nagata JM

Keywords

Adolescent, Alcohol, Cannabis, Gender, Gender diverse, Marijuana, Nicotine, Smoking, Substance use, Transgender

DOI

10.1016/j.drugalcdep.2024.112473
Toggle Attention-mediated genetic influences on psychotic symptomatology in adolescence Nature Mental Health Chang SE, Hughes DE, Zhu J, et al. 2024
Link to publication

Abstract

Attention problems are among the earliest precursors of schizophrenia. In this longitudinal cohort study, we examine relationships between cognitive and neuropsychiatric polygenic scores (PGSs), psychosis-spectrum symptoms and attention-related phenotypes in adolescence (ABCD; n = 11,855; mean baseline age 9.93 ± 0.6). Across three biennial visits, greater attentional variability and altered functional connectivity were associated with severity of psychotic-like experiences (PLEs). In European-ancestry youth, neuropsychiatric and cognitive PGSs were associated with greater PLE severity (R2 = 0.026–0.035) and greater attentional variability (R2 = 0.100–0.109). Notably, the effect of broad neurodevelopmental PGS on PLEs weakened over time, whereas schizophrenia PGS did not. Attentional variability partially mediated relationships between multiple PGSs and PLEs, explaining 4–16% of these associations. Finally, PGSs parsed by developmental coexpression modules were significantly associated with PLE severity, though effect sizes were larger for genome-wide PGSs. Findings implicate broad neurodevelopmental liability in the pathophysiology of psychosis-spectrum symptomatology in adolescence; attentional variability may link risk variants to symptoms.

Journal

Nature Mental Health

Published

2024/10/28

Authors

Chang SE, Hughes DE, Zhu J, Hyat M, Salone SD, Goodman ZT, Roffman JL, Karcher NR, Hernandez LM, Forsyth JK, & Bearden CE

Keywords

DOI

https://doi.org/10.1038/s44220-024-00338-7
Toggle Functional brain connectivity predictors of prospective substance use initiation and their environmental correlates. Biological psychiatry. Cognitive neuroscience and neuroimaging Kardan O, Weigard A, Cope L, et al. 2024
PubMed Record

Abstract

Early substance use initiation (SUI) places youth at substantially higher risk for later substance use disorders. Furthermore, adolescence is a critical period for the maturation of brain networks, the pace and magnitude of which are susceptible to environmental influences and may shape risk for SUI.

Journal

Biological psychiatry. Cognitive neuroscience and neuroimaging

Published

2024/10/25

Authors

Kardan O, Weigard A, Cope L, Martz M, Angstadt M, McCurry KL, Michael C, Hardee J, Hyde LW, Sripada C, Heitzeg MM

Keywords

Adolescence, Brain development, Environmental factors, Functional brain connectivity, Substance use initiation

DOI

10.1016/j.bpsc.2024.10.002
Toggle Traumatic and Adverse Childhood Experiences and Developmental Differences in Psychiatric Risk. JAMA psychiatry Russell JD, Heyn SA, Peverill M, et al. 2024
PubMed Record

Abstract

While adverse childhood experiences (ACEs) are known to impart significant risk for negative mental health and cognitive outcomes in youth, translation of ACE scores into clinical intervention is limited by poor specificity in predicting negative outcomes. This work expands on the ACE framework using a data-driven approach to identify 8 different forms of traumatic and adverse childhood experiences (TRACEs) and reveal their differential associations with psychiatric risk and cognition across development.

Journal

JAMA psychiatry

Published

2024/10/23

Authors

Russell JD, Heyn SA, Peverill M, DiMaio S, Herringa RJ

Keywords

DOI

10.1001/jamapsychiatry.2024.3231
Toggle Associations between polygenic scores for cognitive and non-cognitive factors of educational attainment and measures of behavior, psychopathology, and neuroimaging in the adolescent brain cognitive development study. Psychological medicine Gorelik AJ, Paul SE, Miller AP, et al. 2024
PubMed Record

Abstract

Educational attainment (EduA) is correlated with life outcomes, and EduA itself is influenced by both cognitive and non-cognitive factors. A recent study performed a ‘genome-wide association study (GWAS) by subtraction,’ subtracting genetic effects for cognitive performance from an educational attainment GWAS to create orthogonal ‘cognitive’ and ‘non-cognitive’ factors. These cognitive and non-cognitive factors showed associations with behavioral health outcomes in adults; however, whether these correlations are present during childhood is unclear.

Journal

Psychological medicine

Published

2024/10/23

Authors

Gorelik AJ, Paul SE, Miller AP, Baranger DAA, Lin S, Zhang W, Elsayed NM, Modi H, Addala P, Bijsterbosch J, Barch DM, Karcher NR, Hatoum AS, Agrawal A, Bogdan R, Johnson EC

Keywords

academic achievement, cognitive performance, educational attainment, genetics, late childhood, middle childhood, neuroimaging, polygenic scores

DOI

10.1017/S0033291724002174
Toggle Discrimination and manic symptoms in early adolescence: A prospective cohort study. Journal of affective disorders Nagata JM, Wong J, Zamora G, et al. 2024
PubMed Record

Abstract

This study aims to investigate the prospective associations between four types of perceived discrimination (country of origin, race and ethnicity, sexual orientation, and weight) and the development of manic symptoms in a diverse, nationwide sample of adolescents aged 9-14 years in the U.S.

Journal

Journal of affective disorders

Published

2024/10/22

Authors

Nagata JM, Wong J, Zamora G, Al-Shoaibi AAA, Low P, Ganson KT, Testa A, He J, Lavender JM, Baker FC

Keywords

Adolescence, Bipolar disorder, Discrimination, Mania

DOI

10.1016/j.jad.2024.10.078
Toggle Working memory related brain-behavior associations in the context of socioeconomic and psychosocial deprivation. Cortex; a journal devoted to the study of the nervous system and behavior Cui Z, Sweet L, M Kogan S, et al. 2024
PubMed Record

Abstract

Burgeoning neuroimaging research documents the associations between working memory (WM)-associated neural and behavioral responses. However, these associations have yielded small and inconsistent effect sizes. We hypothesize that one reason for the weakened brain-behavior associations stems from different environmental contexts. Specifically, little research has examined how exposure to adverse rearing environments accounts for variability in brain-behavior relations. Deprivation, characterized by an absence of cognitive and positive social stimulation, has been shown to compromise children’s neurocognitive development. Hence, informed by an ecological approach to developmental neuroscience, the present study aims to investigate if psychosocial and socioeconomic deprivation serves as moderators in the associations between neural responses and behaviors during a WM task. Using data from the Adolescent Brain Cognitive Development study (N = 11, 878, M = 9.48, 47.8% female, 52.0% White), we found that psychosocial, but not socioeconomic deprivation, significantly attenuated the positive association between WM-related neural activation within the frontoparietal network and attendant behavioral performance. Specifically, children exposed to higher levels of psychosocial deprivation exhibited weaker brain-behavior relations during a WM task. This finding suggests that a certain level of neural response during cognitive tasks may correspond to different levels of behavioral performance depending on children’s rearing environment, highlighting the importance of contextual factors in understanding the brain and cognitive development.

Journal

Cortex; a journal devoted to the study of the nervous system and behavior

Published

2024/10/22

Authors

Cui Z, Sweet L, M Kogan S, Oshri A

Keywords

Brain-behavior relations, Early life stress, Psychosocial deprivation, Socioeconomic deprivation, Working memory

DOI

10.1016/j.cortex.2024.09.013
Toggle Lifetime History of Head or Traumatic Brain Injury Before Age 9 and School Outcomes: Results From the Adolescent Brain Cognitive Development Study. The Journal of school health Waltzman D, Haarbauer-Krupa J, Daugherty J, et al. 2024
PubMed Record

Abstract

Limited information about school outcomes among children (especially early childhood) with lifetime history of head injury, including traumatic brain injury (TBI), may inhibit efforts to support their academics and physical and mental health.

Journal

The Journal of school health

Published

2024/10/21

Authors

Waltzman D, Haarbauer-Krupa J, Daugherty J, Sarmiento K, Yurgelun-Todd DA, McGlade EC

Keywords

Child and adolescent health, injury prevention, public health

DOI

10.1111/josh.13508
Toggle Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries. Nature genetics García-Marín LM, Campos AI, Diaz-Torres S, et al. 2024
PubMed Record

Abstract

Subcortical brain structures are involved in developmental, psychiatric and neurological disorders. Here we performed genome-wide association studies meta-analyses of intracranial and nine subcortical brain volumes (brainstem, caudate nucleus, putamen, hippocampus, globus pallidus, thalamus, nucleus accumbens, amygdala and the ventral diencephalon) in 74,898 participants of European ancestry. We identified 254 independent loci associated with these brain volumes, explaining up to 35% of phenotypic variance. We observed gene expression in specific neural cell types across differentiation time points, including genes involved in intracellular signaling and brain aging-related processes. Polygenic scores for brain volumes showed predictive ability when applied to individuals of diverse ancestries. We observed causal genetic effects of brain volumes with Parkinson’s disease and attention-deficit/hyperactivity disorder. Findings implicate specific gene expression patterns in brain development and genetic variants in comorbid neuropsychiatric disorders, which could point to a brain substrate and region of action for risk genes implicated in brain diseases.

Journal

Nature genetics

Published

2024/10/21

Authors

García-Marín LM, Campos AI, Diaz-Torres S, Rabinowitz JA, Ceja Z, Mitchell BL, Grasby KL, Thorp JG, Agartz I, Alhusaini S, Ames D, Amouyel P, Andreassen OA, Arfanakis K, Arias-Vasquez A, Armstrong NJ, Athanasiu L, Bastin ME, Beiser AS, Bennett DA, Bis JC, Boks MPM, Boomsma DI, Brodaty H, Brouwer RM, Buitelaar JK, Burkhardt R, Cahn W, Calhoun VD, Carmichael OT, Chakravarty M, Chen Q, Ching CRK, Cichon S, Crespo-Facorro B, Crivello F, Dale AM, Smith GD, de Geus EJC, De Jager PL, de Zubicaray GI, Debette S, DeCarli C, Depondt C, Desrivières S, Djurovic S, Ehrlich S, Erk S, Espeseth T, Fernández G, Filippi I, Fisher SE, Fleischman DA, Fletcher E, Fornage M, Forstner AJ, Francks C, Franke B, Ge T, Goldman AL, Grabe HJ, Green RC, Grimm O, Groenewold NA, Gruber O, Gudnason V, Håberg AK, Haukvik UK, Heinz A, Hibar DP, Hilal S, Himali JJ, Ho BC, Hoehn DF, Hoekstra PJ, Hofer E, Hoffmann W, Holmes AJ, Homuth G, Hosten N, Ikram MK, Ipser JC, Jack CR, Jahanshad N, Jönsson EG, Kahn RS, Kanai R, Klein M, Knol MJ, Launer LJ, Lawrie SM, Hellard SL, Lee PH, Lemaître H, Li S, Liewald DCM, Lin H, Longstreth WT, Lopez OL, Luciano M, Maillard P, Marquand AF, Martin NG, Martinot JL, Mather KA, Mattay VS, McMahon KL, Mecocci P, Melle I, Meyer-Lindenberg A, Mirza-Schreiber N, Milaneschi Y, Mosley TH, Mühleisen TW, Müller-Myhsok B, Maniega SM, Nauck M, Nho K, Niessen WJ, Nöthen MM, Nyquist PA, Oosterlaan J, Pandolfo M, Paus T, Pausova Z, Penninx BWJH, Pike GB, Psaty BM, Pütz B, Reppermund S, Rietschel MD, Risacher SL, Romanczuk-Seiferth N, Romero-Garcia R, Roshchupkin GV, Rotter JI, Sachdev PS, Sämann PG, Saremi A, Sargurupremraj M, Saykin AJ, Schmaal L, Schmidt H, Schmidt R, Schofield PR, Scholz M, Schumann G, Schwarz E, Shen L, Shin J, Sisodiya SM, Smith AV, Smoller JW, Soininen HS, Steen VM, Stein DJ, Stein JL, Thomopoulos SI, Toga AW, Tordesillas-Gutiérrez D, Trollor JN, Valdes-Hernandez MC, van T Ent D, van Bokhoven H, van der Meer D, van der Wee NJA, Vázquez-Bourgon J, Veltman DJ, Vernooij MW, Villringer A, Vinke LN, Völzke H, Walter H, Wardlaw JM, Weinberger DR, Weiner MW, Wen W, Westlye LT, Westman E, White T, Witte AV, Wolf C, Yang J, Zwiers MP, Ikram MA, Seshadri S, Thompson PM, Satizabal CL, Medland SE, Rentería ME

Keywords

DOI

10.1038/s41588-024-01951-z
Toggle Responsible use of population neuroscience data: Towards standards of accountability and integrity. Developmental cognitive neuroscience Brown SA, Garavan H, Jernigan TL, et al. 2024
PubMed Record

Abstract

This editorial focuses on the issue of data misuse which is increasingly evidenced in social media as well as some premiere scientific journals. This issue is of critical importance to open science projects in general, and ABCD in particular, given the broad array of biological, behavioral and environmental information collected on this American sample of 12.000 youth and parents. ABCD data are already widely used with over 1000 publications and twice as many citations per year as expected (relative citation index based on year, field and journal). However, the adverse consequences of misuse of data, and inaccurate interpretation of emergent findings from this precedent setting study may have profound impact on disadvantaged populations and perpetuate biases and societal injustices.

Journal

Developmental cognitive neuroscience

Published

2024/10/18

Authors

Brown SA, Garavan H, Jernigan TL, Tapert SF, Huber RS, Lopez D, Murray T, Dowling G, Hoffman EA, Uddin LQ

Keywords

Ancestry, Genetic, Health equity, Inclusivity, Population descriptors, Population neuroscience, Race, Responsible data use

DOI

10.1016/j.dcn.2024.101466
Toggle Heritability and Genetic Contribution Analysis of Structural-Functional Coupling in Human Brain. Imaging Neuroscience Dai W, Zhang Z, Song P, et al. 2024
Link to publication

Abstract

The flow of functional connectivity (FC) is thought to be supported by white matter structural connectivity (SC). While research on the correlations between SC and FC (SC-FC coupling) has progressed, the genetic implications of SC-FC coupling have not been thoroughly examined. Traditionally, SC-FC coupling investigations utilize predefined atlases. Here, we adopted an atlas-free SC-FC coupling built on the high-resolution white surface (the interface of white matter and gray matter) to uncover common genetic variations. Leveraging data from the Human Connectome Project, we demonstrated considerable heritability in areas within the early and intermediate visual cortex and across dorsal-attention, language, and somatomotor functional networks. We detected 334 genetic loci (spanning 234 cytogenetic bands) linked to SC-FC coupling (P < 1.26 × 10−11), notably in cingulo-opercular, somatomotor, and default mode networks. Using an external dataset from the Adolescent Brain Cognitive Development study, we confirmed 187 cytogenetic bands associated with SC-FC coupling across 22 brain regions (P < 1× 10-5). Genetic correlation analyses revealed high genetic interrelatedness for SC-FC coupling in neighboring regions. Furthermore, it showed genetic correlations with a spectrum of complex traits, encompassing various neurological and psychiatric conditions. In essence, our study paves the way towards deciphering the genetic interplay between structural and functional connectivity of the brain.

Journal

Imaging Neuroscience

Published

2024/10/16

Authors

Dai W, Zhang Z, Song P, Zhang H, & Zhao Y

Keywords

DOI

https://doi.org/10.1162/imag_a_00346
Toggle Functional network disruptions in youth with concussion using the Adolescent Brain Cognitive Development study. Brain injury Sheldrake E, Nishat E, Wheeler AL, et al. 2024
PubMed Record

Abstract

This study aimed to compare psychosocial outcomes and functional neuroimaging among youth with concussion, youth with anxiety, and age- and sex-matched controls.

Journal

Brain injury

Published

2024/10/16

Authors

Sheldrake E, Nishat E, Wheeler AL, Goldstein BI, Reed N, Scratch SE

Keywords

Concussion, MRI, fMRI, mental health, pediatric

DOI

10.1080/02699052.2024.2416545
Toggle Social cognitive influences associated with susceptibility to nicotine and tobacco use in youth in the ABCD Study. Journal of studies on alcohol and drugs Doran N, Gonzalez MR, Courtney KE, et al. 2024
PubMed Record

Abstract

Chronic use of nicotine and tobacco products (NTP) continues to be a leading cause of morbidity and mortality. Uptake is most common among youth and young adults but knowledge about effective prevention and intervention approaches is insufficient. The goal of the present study was to examine the impact of social cognitive factors on NTP risk over time among youth in the national ABCD cohort.

Journal

Journal of studies on alcohol and drugs

Published

2024/10/15

Authors

Doran N, Gonzalez MR, Courtney KE, Wade NE, Pelham W, Patel H, Roesch S, Jacobus J

Keywords

DOI

10.15288/jsad.24-00041
Toggle The ABCD and HBCD Studies: Longitudinal Studies to Inform Prevention Science. Focus (American Psychiatric Publishing) Dowling GJ, Hoffman EA, Cole KM, et al. 2024
PubMed Record

Abstract

Increasing rates of overdose among U.S. adolescents and young adults, along with rising rates of emotional distress in these groups, are renewing the urgency for developmentally targeted and personalized substance use and other mental health prevention interventions. Most prevention programs recognize the unique vulnerability of childhood and adolescence and target parents and youths, addressing modifiable environmental risk and protective factors that affect behavior during periods when the brain is most susceptible to change. Until recently, a scarcity of comprehensive studies has limited a full understanding of the complexity of factors that may affect neurodevelopment, including substance exposure in pregnancy and/or subsequent substance use in adolescence, alongside their dynamic interactions with environmental factors and genetics. Two large longitudinal cohort studies funded by National Institutes of Health-the Adolescent Brain Cognitive Development (ABCD) Study and the HEALthy Brain and Child Development (HBCD) Study-are collecting data on neurodevelopment and a wide range of environmental and biological factors across the first two decades of life to build databases that will allow researchers to study how individual neurodevelopmental trajectories are influenced by drugs, adverse childhood experiences, and genetics, among other factors. These studies are already deepening the understanding of risk and resilience factors that prevention programs could target and will identify critical windows where interventions can have the most impact on an individual’s neurodevelopmental trajectory. This article describes what is being learned from ABCD and expected from HBCD and how these studies might inform prevention as these children grow and more data are gathered.

Journal

Focus (American Psychiatric Publishing)

Published

2024/10/15

Authors

Dowling GJ, Hoffman EA, Cole KM, Wargo EM, Volkow N

Keywords

Brain Development, Child/Adolescent Psychiatry, Neurocognition, Prenatal Substance Exposure, Prevention, Substance Use

DOI

10.1176/appi.focus.20240016
Toggle Adolescent resilience in the face of COVID-19 stressors: the role of trauma and protective factors. Psychological medicine Zhang L, Cropley VL, Whittle S, et al. 2024
PubMed Record

Abstract

The COVID-19 pandemic introduced unique stressors that posed significant threats to adolescent mental health. However, limited research has examined the impact of trauma exposure on vulnerability to subsequent stressor-related mental health outcomes in adolescents. Furthermore, it is unclear whether there are protective factors that promote resilience against the negative impacts of COVID-19 stressors in adolescents with prior trauma exposure. This preregistered study aimed to investigate the impact of trauma on COVID-19 stressor-related mental health difficulties in adolescents, in addition to the role of protective factors.

Journal

Psychological medicine

Published

2024/10/14

Authors

Zhang L, Cropley VL, Whittle S, Rakesh D

Keywords

COVID-19 pandemic, adolescent mental health, protective factors, stressors, trauma

DOI

10.1017/S0033291724001806
Toggle A phenome-wide association study of cross-disorder genetic liability in youth genetically similar to individuals from European reference populations Nature Mental Health Paul SE, Colbert SMC, Gorelik AJ, et al. 2024
Link to Publication

Abstract

Etiologic insights into psychopathology may be gained by using hypothesis-free methods to identify associations between genetic risk for broad psychopathology and phenotypes measured during adolescence, including both markers of child psychopathology and intermediate phenotypes such as neural structure that may link genetic risk with outcomes. Here we conducted an exploratory phenome-wide association study (phenotype n = 1,271–1,697) of polygenic risk scores (PRS) for broad-spectrum psychopathology (that is, compulsive, psychotic, neurodevelopmental and internalizing) in youth most genetically similar to individuals from European reference populations (n = 5,556; ages 9–13) who completed the baseline and/or 2-year follow-up of the ongoing Adolescent Brain Cognitive Development Study. We found that neurodevelopmental and internalizing PRS were significantly associated with phenotypes across multiple domains (neurodevelopmental, 190 and 214 (147 and 165 after pruning correlated phenotypes at an r2 of 0.6); internalizing, 124 and 183 (93 and 131 after pruning) phenotypes at baseline and 2-year follow-up, respectively), whereas compulsive and psychotic PRS showed zero and two significant associations, respectively, after Bonferroni correction. Compulsive, psychotic and neurodevelopmental PRS were further associated with brain structure metrics, with minimal evidence that brain structure indirectly linked PRS to 2-year follow-up outcomes. Genetic variation influencing risk to psychopathology manifests broadly as behaviors, psychopathology symptoms and related risk factors in middle childhood and early adolescence.

Journal

Nature Mental Health

Published

2024/10/14

Authors

Paul SE, Colbert SMC, Gorelik AJ, Johnson EC, Hatoum AS, Baranger DAA, Hansen IS, Nagella I, Blaydon L, Hornstein A, Elsayed NM, Barch DM, Bogdan R, & Karcher NR

Keywords

DOI

https://doi.org/10.1038/s44220-024-00313-2
Toggle Resting-State Functional Connectivity Predicts Attention Problems in Children: Evidence from the ABCD Study. NeuroSci Duffy KA, Helwig NE 2024
PubMed Record

Abstract

Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, and numerous functional and structural differences have been identified in the brains of individuals with ADHD compared to controls. This study uses data from the baseline sample of the large, epidemiologically informed Adolescent Brain Cognitive Development Study of children aged 9-10 years old ( = 7979). Cross-validated Poisson elastic net regression models were used to predict a dimensional measure of ADHD symptomatology from within- and between-network resting-state correlations and several known risk factors, such as biological sex, socioeconomic status, and parental history of problematic alcohol and drug use. We found parental history of drug use and biological sex to be the most important predictors of attention problems. The connection between the default mode network and the dorsal attention network was the only brain network identified as important for predicting attention problems. Specifically, we found that reduced magnitudes of the anticorrelation between the default mode and dorsal attention networks relate to increased attention problems in children. Our findings complement and extend recent studies that have connected individual differences in structural and task-based fMRI to ADHD symptomatology and individual differences in resting-state fMRI to ADHD diagnoses.

Journal

NeuroSci

Published

2024/10/12

Authors

Duffy KA, Helwig NE

Keywords

Poisson regression, adolescent brain cognitive development (ABCD), attention-deficit/hyperactivity disorder (ADHD), functional magnetic resonance imaging (fMRI), group elastic net

DOI

10.3390/neurosci5040033
Toggle Neuroimaging in psychiatry: toward mechanistic insights and clinical utility. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Barch D, Liston C 2024
PubMed Record

Abstract

Journal

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Published

2024/10/11

Authors

Barch D, Liston C

Keywords

DOI

10.1038/s41386-024-01984-2
Toggle Prospective associations between Sleep, Sensation-Seeking and Mature Screen Usage in Early Adolescents: Findings from the Adolescent Brain Cognitive Development (ABCD) Study. Sleep Zhang L, Oshri A, Carvalho C, et al. 2024
PubMed Record

Abstract

Early exposure to mature content is linked to high-risk behaviors. This study aims to prospectively investigate how sleep and sensation-seeking behaviors influence the consumption of mature video games and R-rated movies in early adolescents. A secondary analysis examines the bidirectional relationships between sleep patterns and mature screen usage.

Journal

Sleep

Published

2024/10/11

Authors

Zhang L, Oshri A, Carvalho C, Uddin LQ, Geier C, Nagata JM, Cummins K, Hoffman EA, Tomko RL, Chaarani B, Squeglia LM, Wing D, Mason MJ, Fuemmeler B, Lisdahl K, Tapert SF, Baker FC, Kiss O

Keywords

ABCD study, R-rated movies, screen time, sensation seeking, sleep, variability

DOI

10.1093/sleep/zsae234
Toggle Distinct functional connectivity phenotypes in preadolescent children with binge eating disorder by BMI status Obesity Steward T, Jann K, & Murray SB 2024
PubMed Record

Abstract

Objective: The neurobiological mechanisms underpinning binge eating disorder (BED) in children remain largely unclear, as the alterations that have been identified to date may be attributable to BED, obesity, or compound effects. This study aimed to delineate functional connectivity (FC) patterns in inhibitory control and reward networks in preadolescent children with and without BED from the Adolescent Brain Cognitive Development (ABCD) Study according to BMI.

Methods: Resting-state FC was examined in the inhibitory control network by using seeds in the dorsolateral prefrontal cortex, the anterior cingulate cortex, and the posterior cingulate cortex, whereas the reward network included seeds in the orbitofrontal cortex, nucleus accumbens, and amygdala. Seed-to-voxel analyses characterized FC differences between preadolescent children with BED with a high BMI and those with BED with a low BMI.

Results: We identified that BED was characterized by reduced connectivity between the reward network and regions in the default mode network, irrespective of weight status. Participants with BED also presented with hypoconnectivity in fronto-amygdalar circuits, which has been consistently associated with impaired emotion regulation capacity.

Conclusions: Our findings support that FC alterations between the reward network and the default mode network may be specifically impacted by the presence of BED as opposed to weight status.

Journal

Obesity

Published

2024/10/10

Authors

Steward T, Jann K, & Murray SB

Keywords

DOI

DOI: 10.1002/oby.24145
Toggle Longitudinal panel networks of risk and protective factors for early adolescent suicidality in the ABCD sample. Development and psychopathology Wallace GT, Conner BT 2024
PubMed Record

Abstract

Rates of youth suicidal thoughts and behaviors (STBs) are rising, and younger age at onset increases vulnerability to negative outcomes. However, few studies have investigated STBs in early adolescence (ages 10-13), and accurate prediction of youth STBs remains poor. Network analyses that can examine pairwise associations between many theoretically relevant variables may identify complex pathways of risk for early adolescent STBs. The present study applied longitudinal network analysis to examine interrelations between STBs and several previously identified risk and protective factors. Data came from 9,854 youth in the Adolescent Brain Cognitive Development Study cohort ( = 9.90 ± .62 years, 63% white, 53% female at baseline). Youth and their caregivers completed an annual measurement battery between ages 9-10 through 11-12 years. Panel Graphical Vector Autoregressive models evaluated associations between STBs and several mental health symptoms, socioenvironmental factors, life stressors, and substance use. In the contemporaneous and between-subjects networks, direct associations were observed between STBs and internalizing symptoms, substance use, family conflict, lower parental monitoring, and lower school protective factors. Potential indirect pathways of risk for STBs were also observed. Age-specific interventions may benefit from prioritizing internalizing symptoms and early substance use, as well as promoting positive school and family support.

Journal

Development and psychopathology

Published

2024/10/10

Authors

Wallace GT, Conner BT

Keywords

early adolescent, family conflict, internalizing, network analysis, suicidal thoughts and behaviors

DOI

10.1017/S0954579424001597
Toggle Functional imaging derived ADHD biotypes based on deep clustering: a study on personalized medication therapy guidance. EClinicalMedicine Feng A, Zhi D, Feng Y, et al. 2024
PubMed Record

Abstract

Attention deficit hyperactivity disorder (ADHD) is one prevalent neurodevelopmental disorder with childhood onset, however, there is no clear correspondence established between clinical ADHD subtypes and primary medications. Identifying objective and reliable neuroimaging markers for categorizing ADHD biotypes may lead to more individualized, biotype-guided treatment.

Journal

EClinicalMedicine

Published

2024/10/10

Authors

Feng A, Zhi D, Feng Y, Jiang R, Fu Z, Xu M, Zhao M, Yu S, Stevens M, Sun L, Calhoun V, Sui J

Keywords

Adolescent brain and cognitive development (ABCD) study, Attention deficit hyperactivity disorder (ADHD), Biological subtype detection, Deep clustering, Graph convolutional network (GCN)

DOI

10.1016/j.eclinm.2024.102876
Toggle Dimensions of experienced gender and prospective self-injurious thoughts and behaviors in preadolescent children: A national study. Journal of affective disorders Hull S, Origlio J, Noyola N, et al. 2024
PubMed Record

Abstract

Gender diverse youth face higher risk of engaging in self-injurious thoughts and behaviors (SITBs) compared to cisgender youth. Limitations in past research include a focus on older adolescents, an emphasis on specific gender identity labels that may not be inclusive of the range of youth gender experiences, and reliance on cross-sectional data. Thus, the current study prospectively evaluated dimensions of experienced gender in relation to first-onset SITBs among preadolescents.

Journal

Journal of affective disorders

Published

2024/10/09

Authors

Hull S, Origlio J, Noyola N, Henin A, Liu RT

Keywords

Gender diversity, Preadolescence, Self-injury, Suicide

DOI

10.1016/j.jad.2024.10.033
Toggle Investigating cross-sectional and longitudinal relationships between brain structure and distinct dimensions of externalizing psychopathology in the ABCD sample. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Nakua H, Propp L, Bedard AV, et al. 2024
PubMed Record

Abstract

Externalizing psychopathology in childhood is a predictor of poor outcomes across the lifespan. Children exhibiting elevated externalizing symptoms also commonly show emotion dysregulation and callous-unemotional (CU) traits. Examining cross-sectional and longitudinal neural correlates across dimensions linked to externalizing psychopathology during childhood may clarify shared or distinct neurobiological vulnerability for psychopathological impairment later in life. We used tabulated brain structure and behavioural data from baseline, year 1, and year 2 timepoints of the Adolescent Brain Cognitive Development Study (ABCD; baseline n = 10,534). We fit separate linear mixed effect models to examine whether baseline brain structures in frontolimbic and striatal regions (cortical thickness or subcortical volume) were associated with externalizing symptoms, emotion dysregulation, and/or CU traits at baseline and over a two-year period. The most robust relationships found at the cross-sectional level was between cortical thickness in the right rostral middle frontal gyrus and bilateral pars orbitalis was positively associated with CU traits (β = |0.027-0.033|, p = 0.009-0.03). Over the two-year follow-up period, higher baseline cortical thickness in the left pars triangularis and rostral middle frontal gyrus predicted greater decreases in externalizing symptoms ((F = 6.33-6.94, p = 0.014). The results of the current study suggest that unique regions within frontolimbic and striatal networks may be more strongly associated with different dimensions of externalizing psychopathology. The longitudinal findings indicate that brain structure in early childhood may provide insight into structural features that influence behaviour over time.

Journal

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Published

2024/10/09

Authors

Nakua H, Propp L, Bedard AV, Sanches M, Ameis SH, Andrade BF

Keywords

DOI

10.1038/s41386-024-02000-3
Toggle Risk and resilience profiles and their transition pathways in the ABCD Study. Development and psychopathology Yang R, Tuy S, Dougherty LR, et al. 2024
PubMed Record

Abstract

The transition from childhood to adolescence presents elevated risks for the onset of psychopathology in youth. Given the multilayered nature of development, the present study leverages the longitudinal, population-based Adolescent Brain Cognitive Development Study to derive ecologically informed risk/resilience profiles based on multilevel influences (e.g., neighborhood and family socioeconomic resources, parenting, school characteristics) and their transition pathways and examine their associations with psychopathology. Latent profile analysis characterized risk/resilience profiles at each time point (i.e., baseline, Year-1, Year-2); latent transition analysis estimated the most likely transition pathway for each individual. Analysis of covariance was used to examine associations between profile membership at baseline (i.e., ages 9-11) and psychopathology, both concurrently and at Year-2 follow-up. Further, we examined the associations between profile transition pathways and Year-2 psychopathology. Four distinct profiles emerged across time – High-SES High-Protective, High-SES Low-Protective, Low-SES High-Family-Risk, and Low-SES High-Protective. Despite reasonably high stability, significant transition over time among profiles was detected. Profile membership at baseline significantly correlated with concurrent psychopathology and predicted psychopathology 2 years later. Additionally, profile transition pathways significantly predicted Year-2 psychopathology, exemplifying equifinality and multifinality. Characterizing and tracing shifts in ecologically informed risk/resilience influences, our findings have the potential to inform more precise intervention efforts in youth.

Journal

Development and psychopathology

Published

2024/10/09

Authors

Yang R, Tuy S, Dougherty LR, Wiggins JL

Keywords

Developmental psychopathology, person-centered approach, risk and resilience

DOI

10.1017/S0954579424001603
Toggle Disordered Eating in Early Adolescence: Disparities Among Minoritised Youth Daniel B, Suissa A, Liu J, et al. 2024
PubMed Record

Abstract

Background: Disordered eating in early adolescence impacts development, with long-term health implications. Minoritised adolescents might be at higher risk of disordered eating due to minority stress, but most research has focused on White, heterosexual, cisgender individuals; less is known about disordered eating among minoritised adolescents. We examined sexual, gender, racial, and ethnic identities in relation to disordered eating in early adolescence.

Method: Using 2-year follow-up data from adolescents ages 10-14 in the Adolescent Brain Cognitive Development Study (N = 9385), we examined associations between sexual, gender, racial, and ethnic identities and past-2 week disordered eating (preoccupation with weight, weight control behaviors, and binge eating).

Results: Compared to heterosexual peers, gay/bisexual adolescents had higher odds of all three outcomes (AOR 1.90-3.32); those “questioning” their sexual identity had higher odds of preoccupation with weight (AOR 1.82) and binge eating (AOR 2.53). Compared to cisgender adolescents, transgender adolescents had higher odds of binge eating (AOR 2.62); those “questioning” their gender identity had higher odds of preoccupation with weight (AOR 2.45). Adolescents whose racial identity was categorised as “Another” had higher odds of preoccupation with weight (AOR 1.46) and weight control behaviors (AOR 1.58) compared to White adolescents. Finally, Hispanic adolescents had higher odds of all disordered eating outcomes than non-Hispanic adolescents (AOR 1.25-1.59).

Discussion: This study is among the first to reveal disparities in disordered eating among minoritised early adolescents. Further examination of these disparities can inform future interventions. Healthcare providers are encouraged to screen for disordered eating, recognising that minoritised early adolescents may be at risk.

Journal

Published

2024/10/09

Authors

Daniel B, Suissa A, Liu J, Bruzzese J-M, Jackman KB, & Leonard S

Keywords

disordered eating; ethnic minority; gender minority; health disparities; racial minority; sexual minority.

DOI

DOI: 10.1111/jan.16526
Toggle Screen time and mental health: a prospective analysis of the Adolescent Brain Cognitive Development (ABCD) Study. BMC public health Nagata JM, Al-Shoaibi AAA, Leong AW, et al. 2024
PubMed Record

Abstract

Despite the ubiquity of adolescent screen use, there are limited longitudinal studies that examine the prospective relationships between screen time and child behavioral problems in a large, diverse nationwide sample of adolescents in the United States, which was the objective of the current study.

Journal

BMC public health

Published

2024/10/07

Authors

Nagata JM, Al-Shoaibi AAA, Leong AW, Zamora G, Testa A, Ganson KT, Baker FC

Keywords

ADHD, Adolescents, Anxiety, Conduct disorder, Depression, Digital media, Digital technology, Oppositional defiant disorder, Screen time, Social media, Somatic, Television, Video games

DOI

10.1186/s12889-024-20102-x
Toggle Associations of adverse childhood experiences with blood pressure among early adolescents in the United States. American journal of preventive cardiology Al-Shoaibi AAA, Lee CM, Raney JH, et al. 2024
PubMed Record

Abstract

The associations of adverse childhood experiences (ACEs) with blood pressure in adulthood are inconclusive. Similarly, the association between ACEs and blood pressure earlier in the life course is understudied. This study aims to assess the associations of ACEs with blood pressure among early adolescents. We utilized data collected at baseline (age: 9-10 years) and Year 2 follow-up from 4077 participants in the Adolescent Brain Cognitive Development (ABCD) Study. We used adjusted multiple linear regression models to estimate the associations of ACEs (cumulative score and subtypes) at baseline with systolic blood pressure (SBP) and diastolic blood pressure (DBP) at year 2 of follow-up. Experiencing ≥4 ACEs (compared to 0) was significantly associated with higher SBP ( = 3.31, 95 % CI 0.03, 6.57, = 0.048). Of the ACEs subtypes, household substance use ( = 2.28, 95 % CI 0.28, 4.28, = 0.028) and divorce or separation ( = 2.08, 95 % CI 0.01, 4.15, = 0.048) were both significantly associated with a higher SBP while household mental illness ( = 2.57, 95 % CI 1.32, 3.81, < 0.001) was significantly associated with a higher DBP. Our findings suggest that exposure to multiple ACEs is associated with higher blood pressure in adolescence.

Journal

American journal of preventive cardiology

Published

2024/10/04

Authors

Al-Shoaibi AAA, Lee CM, Raney JH, Ganson KT, Testa A, Dooley EE, Gooding HC, Gabriel KP, Baker FC, Nagata JM

Keywords

Adolescents, Adverse childhood experiences, Diastolic blood pressure, Systolic blood pressure

DOI

10.1016/j.ajpc.2024.100883
Toggle Bayesian inference for group-level cortical surface image-on-scalar regression with Gaussian process priors. Biometrics Whiteman AS, Johnson TD, Kang J 2024
PubMed Record

Abstract

In regression-based analyses of group-level neuroimage data, researchers typically fit a series of marginal general linear models to image outcomes at each spatially referenced pixel. Spatial regularization of effects of interest is usually induced indirectly by applying spatial smoothing to the data during preprocessing. While this procedure often works well, the resulting inference can be poorly calibrated. Spatial modeling of effects of interest leads to more powerful analyses; however, the number of locations in a typical neuroimage can preclude standard computing methods in this setting. Here, we contribute a Bayesian spatial regression model for group-level neuroimaging analyses. We induce regularization of spatially varying regression coefficient functions through Gaussian process priors. When combined with a simple non-stationary model for the error process, our prior hierarchy can lead to more data-adaptive smoothing than standard methods. We achieve computational tractability through a Vecchia-type approximation of our prior that retains full spatial rank and can be constructed for a wide class of spatial correlation functions. We outline several ways to work with our model in practice and compare performance against standard vertex-wise analyses and several alternatives. Finally, we illustrate our methods in an analysis of cortical surface functional magnetic resonance imaging task contrast data from a large cohort of children enrolled in the adolescent brain cognitive development study.

Journal

Biometrics

Published

2024/10/03

Authors

Whiteman AS, Johnson TD, Kang J

Keywords

Gaussian processes, neuroimaging, spatially varying coefficient model

DOI

10.1093/biomtc/ujae116
Toggle Exploring the intersection of polygenic risk scores and prenatal alcohol exposure: Unraveling the mental health equation. Alcohol, clinical & experimental research Gerlikhman L, Sarkar DK 2024
PubMed Record

Abstract

Prenatal alcohol exposure poses significant risks to offspring mental health. However, the interplay between genetic predispositions to mental health disorders and prenatal alcohol exposure remains incompletely understood, limiting our ability to develop effective interventions for these conditions.

Journal

Alcohol, clinical & experimental research

Published

2024/09/29

Authors

Gerlikhman L, Sarkar DK

Keywords

genetic predispositions, mental health, offspring, polygenic risk scores, prenatal alcohol exposure

DOI

10.1111/acer.15456
Toggle The moderating role of reward/punishment sensitivity in the relationship between intelligence and prosocial behavior in children Current Psychology Yu M, Xu H, Long Y, et al. 2024
Link to publication

Abstract

Can the relationship between intelligence and prosocial behavior in children be moderated by the personality trait of reward/punishment sensitivity? To answer the question, we utilized data from the ABCD study, which included a total of 10,606 children aged 9 to 11 years. Prosocial behavior was assessed using a shortened subscale of the Strengths and Difficulties Questionnaire. Fluid and crystallized intelligence were evaluated using the National Institutes of Health (NIH) Toolbox, which includes seven tests designed to measure different cognitive aspects. Reward sensitivity and punishment sensitivity were assessed by the Behavioral Inhibition System/Behavioral Activation System (BIS/BAS) scale. Through moderation analysis, we discovered significant interactions between fluid intelligence and reward sensitivity, between crystallized intelligence and reward sensitivity, as well as between crystallized intelligence and punishment sensitivity, in relation to children’s prosocial behavior. Specifically, at low level of reward sensitivity, high level of fluid or crystallized intelligence was associated with a greater likelihood of engaging in prosocial behavior compared to low level. However, when reward sensitivity or punishment sensitivity was at high level, high level of crystallized intelligence was related to decreased prosocial behavior. These findings indicated that the relationship between children’s intelligence and prosocial behavior could be influenced by reward sensitivity or punishment sensitivity.

Journal

Current Psychology

Published

2024/09/28

Authors

Yu M, Xu H, Long Y, Zhang Y, Jia L, Qu D, & Chen R

Keywords

DOI

https://doi.org/10.1007/s12144-024-06703-0
Toggle Association Between Extreme Heat and Externalizing Symptoms in Pre- and Early Adolescence: Findings From the ABCD Study JAACAP Open Briker S, Tran KT, Visoki E, et al. 2024
Link to publication

Abstract

Objective
Considering the growing threat of climate change and the current youth mental health crisis, data is needed on the relationship between climate and youth mental health. Hot weather contributes to the mental health burden, specifically aggression. We studied associations between extreme heat and externalizing symptoms or suicidal behavior among US preadolescents.

Method
We analyzed data from the Adolescent Brain Cognitive Development (ABCD) Study. Participants (N= 8,120, mean age 9.89 years at baseline, 48.40% female, 23.81% Black, 18.17% Hispanic) were assessed longitudinally between 2016-2020 across 21 sites. We estimated exposure to extreme heat (measured around the study site) as the number of days in the month of study visit with a maximum temperature ≥ 90°F (32.2°C) based on National Centers for Environmental Information data. We characterized exposure to extreme heat across race/ethnic groups. We used mixed-effects regression models to test associations of extreme heat with externalizing symptoms (parent-report) and suicide attempts (self-report), assessed in a validated clinical interview. Models adjusted for demographics (age, sex, race, ethnicity, household income) and neighborhood characteristics (gross residential density, population density, national walkability index, and fraction of grass, forest and built land use).

Results
Exposure to extreme heat was less prevalent among non-Hispanic White participants (5.2 days/month) compared to non-Hispanic Black and to Hispanic youth (7.2 and 7.4 days/month, respectively). Extreme heat showed a small but significant association with externalizing symptoms (Incidence Rate Ratio [IRR]=1.06, 95%CI = [1.04-1.08], P< .001). The association did not change when adjusting for demographics and remained similar when further adjusting for neighborhood characteristics (IRR=1.05, 95%CI = [1.00-1.12], P=.04). Sensitivity analyses using extreme heat at the participants’ home address-level in the 6-days prior to study visit, available only for ABCD baseline assessment, revealed similar findings. Extreme heat was not associated with suicide attempts (OR=0.94, 95% CI = 0.77-1.14, P=.52).

Conclusion
Our findings add to the literature on the association between extreme heat and externalizing symptoms and suggest that this association already exists in preadolescence. Future studies are warranted to better understand the mechanisms linking hot weather and mental health and its related racial/ethnic disparities.

Journal

JAACAP Open

Published

2024/09/27

Authors

Briker S, Tran KT, Visoki E, Gordon JH, Hoffman KW, & Barzilay R

Keywords

extreme heat; adolescents; mental health; climate change; ABCD Study

DOI

https://doi.org/10.1016/j.jaacop.2024.09.009
Toggle Puberty interacts with sleep and brain network organization to predict mental health. Frontiers in human neuroscience Mitchell ME, Nugiel T 2024
PubMed Record

Abstract

Along with pubertal development, the transition to adolescence brings about increased risk for sleep disturbances and mental health problems. Functional connectivity of overlapping large-scale brain networks, such as increased connectivity between the default mode and dorsal attention networks, has been reported to relate to both sleep and mental health problems. Clarifying whether pubertal development interacts with sleep disturbances and functional brain networks to predict mental health may provide information to improve the timing and design of interventions targeting sleep disturbances in adolescents.

Journal

Frontiers in human neuroscience

Published

2024/09/27

Authors

Mitchell ME, Nugiel T

Keywords

brain network organization, externalizing, internalizing, puberty, sleep

DOI

10.3389/fnhum.2024.1379945
Toggle Autism is associated with in vivo changes in gray matter neurite architecture. Autism research : official journal of the International Society for Autism Research Christensen ZP, Freedman EG, Foxe JJ 2024
PubMed Record

Abstract

Postmortem investigations in autism have identified anomalies in neural cytoarchitecture across limbic, cerebellar, and neocortical networks. These anomalies include narrow cell mini-columns and variable neuron density. However, difficulty obtaining sufficient post-mortem samples has often prevented investigations from converging on reproducible measures. Recent advances in processing magnetic resonance diffusion weighted images (DWI) make in vivo characterization of neuronal cytoarchitecture a potential alternative to post-mortem studies. Using extensive DWI data from the Adolescent Brain Cognitive Development (ABCD®) study 142 individuals with an autism diagnosis were compared with 8971 controls using a restriction spectrum imaging (RSI) framework that characterized total neurite density (TND), its component restricted normalized directional diffusion (RND), and restricted normalized isotropic diffusion (RNI). A significant decrease in TND was observed in autism in the right cerebellar cortex (β = -0.005, SE =0.0015, p = 0.0267), with significant decreases in RNI and significant increases in RND found diffusely throughout posterior and anterior aspects of the brain, respectively. Furthermore, these regions remained significant in post-hoc analysis when the autism sample was compared against a subset of 1404 individuals with other psychiatric conditions (pulled from the original 8971). These findings highlight the importance of characterizing neuron cytoarchitecture in autism and the significance of their incorporation as physiological covariates in future studies.

Journal

Autism research : official journal of the International Society for Autism Research

Published

2024/09/26

Authors

Christensen ZP, Freedman EG, Foxe JJ

Keywords

DWI, autism, cerebellum, children and adolescents, cytoarchitecture, gray matter, neurodevelopment

DOI

10.1002/aur.3239
Toggle Pubertal timing mediates the association between threat adversity and psychopathology. Psychological medicine Shaul M, Whittle S, Silk TJ, et al. 2024
PubMed Record

Abstract

Exposure to adversity in childhood is a risk factor for lifetime mental health problems. Altered pace of biological aging, as measured through pubertal timing, is one potential explanatory pathway for this risk. This study examined whether pubertal timing mediated the association between adversity (threat and deprivation) and adolescent mental health problems (internalizing and externalizing), and whether this was moderated by sex.

Journal

Psychological medicine

Published

2024/09/26

Authors

Shaul M, Whittle S, Silk TJ, Vijayakumar N

Keywords

adverse childhood experiences, childhood trauma, developmental psychology, puberty

DOI

10.1017/S003329172400179X
Toggle Childhood Prevalence and Latent Classes of Behavioral Issues in the Adolescent Brain Cognitive Development-Social Development Dataset Crime & Delinquency Wojciechowski T, Ahonen L, & McCoy 2024
Link to publication

Abstract

This study sought to identify latent classes of early-life behavioral issues among a sample of youth and compare to previous results obtained from a justice-involved youth sample. The first wave of the Adolescent Brain Cognitive Development-Social Development Study was analyzed. Latent class analysis was used to identify within-person latent clusters of behavioral issues (violence, stealing, substance use, being disruptive, cheating). A three-class model best fit the data. These three classes were characterized by low prevalence of all behaviors (Low), high prevalence of stealing (Stealing Only), and high prevalence of cheating and violence (Cheating and Violence). This finding demonstrated some similarities to classes identified in a justice-involved youth sample, but also some distinct differences.

Journal

Crime & Delinquency

Published

2024/09/26

Authors

Wojciechowski T, Ahonen L, & McCoy

Keywords

DOI

https://doi.org/10.1177/00111287241285582
Toggle Unsupervised machine learning for identifying attention-deficit/hyperactivity disorder subtypes based on cognitive function and their implications for brain structure. Psychological medicine Yamashita M, Shou Q, Mizuno Y 2024
PubMed Record

Abstract

Structural anomalies in the frontal lobe and basal ganglia have been reported in patients with attention-deficit/hyperactivity disorder (ADHD). However, these findings have been not always consistent because of ADHD diversity. This study aimed to identify ADHD subtypes based on cognitive function and find their distinct brain structural characteristics.

Journal

Psychological medicine

Published

2024/09/26

Authors

Yamashita M, Shou Q, Mizuno Y

Keywords

attention-deficit/hyperactivity disorder, brain structure, cognitive function, heterogeneity, unsupervised machine learning

DOI

10.1017/S0033291724002368
Toggle Effect of comorbid psychologic and somatic symptom trajectories on early onset substance use among U.S. youth in the ABCD study. Addictive behaviors Voepel-Lewis T, Stoddard SA, Ploutz-Snyder RJ, et al. 2024
PubMed Record

Abstract

Adolescent substance use (SU) is often motivated by a desire to alleviate undesirable symptoms. To test the self-medication hypothesis, we examined associations between comorbid psychologic and somatic symptom trajectories across early adolescence and early onset SU.

Journal

Addictive behaviors

Published

2024/09/25

Authors

Voepel-Lewis T, Stoddard SA, Ploutz-Snyder RJ, Chen B, Boyd CJ

Keywords

Adolescence, Adolescent substance use, Comorbid symptoms, Early onset substance use, Symptom trajectories

DOI

10.1016/j.addbeh.2024.108181
Toggle Brain structures with stronger genetic associations are not less associated with family- and state-level economic contexts. Developmental cognitive neuroscience Williams CM, Weissman DG, Mallard TT, et al. 2024
PubMed Record

Abstract

We investigate whether neural, cognitive, and psychopathology phenotypes that are more strongly related to genetic differences are less strongly associated with family- and state-level economic contexts (N = 5374 individuals with 1KG-EUR-like genotypes with 870 twins, from the Adolescent Behavior and Cognitive Development study). We estimated the twin- and SNP-based heritability of each phenotype, as well as its association with an educational attainment polygenic index (EA PGI). We further examined associations with family socioeconomic status (SES) and tested whether SES-related differences were moderated by state cost of living and social safety net programs (Medicaid expansion and cash assistance). SES was broadly associated with cognition, psychopathology, brain volumes, and cortical surface areas, even after controlling for the EA PGI. Brain phenotypes that were more heritable or more strongly associated with the EA PGI were not, overall, less related to SES, nor were SES-related differences in these phenotypes less moderated by macroeconomic context and policy. Informing a long-running theoretical debate, and contra to widespread lay beliefs, results suggest that aspects of child brain development that are more strongly related to genetic differences are not, in general, less associated with socioeconomic contexts and policies.

Journal

Developmental cognitive neuroscience

Published

2024/09/24

Authors

Williams CM, Weissman DG, Mallard TT, McLaughlin KA, Harden KP

Keywords

Brain structure, Educational attainment polygenic index, Heritability, Policy, Socioeconomic status

DOI

10.1016/j.dcn.2024.101455
Toggle Negative and positive urgency as pathways in the intergenerational transmission of suicide risk in childhood. Frontiers in psychiatry Ortin-Peralta A, Schiffman A, Malik J, et al. 2024
PubMed Record

Abstract

Parental suicide attempts and suicide death increase suicide risk in their offspring. High levels of impulsivity have been observed in families at high risk for suicide. Impulsivity, a highly heritable trait that is especially elevated in childhood, is frequently measured with the UPPS-P Impulsive Behavior Scale, which includes negative urgency, positive urgency, sensation seeking, premeditation, and perseverance. Our study examined the association between the UPPS-P facets and suicide ideation (without suicide attempts) and suicide attempts at baseline and first-time endorsement within the next two years in childhood. We also examined how the UPPS-P facets mediated the association between parental suicide attempts and suicide death and offspring first-time suicide ideation and attempts at follow-up.

Journal

Frontiers in psychiatry

Published

2024/09/23

Authors

Ortin-Peralta A, Schiffman A, Malik J, Polanco-Roman L, Hennefield L, Luking K

Keywords

UPPS-P, childhood, familial transmission, impulsivity, suicidal ideation, suicide attempts

DOI

10.3389/fpsyt.2024.1417991
Toggle The developmental and dynamic relationship between psychopathology and psychotic-like experiences trajectories in children and adolescents. Journal of affective disorders Jia L, Wei Z, Liu B, et al. 2024
PubMed Record

Abstract

The previous cross-sectional and prospective studies have reported that psychopathology was associated with the occurrence of psychotic-like experiences (PLEs). However, few of these studies have examined this longitudinal association considering the different developmental trajectories of PLEs, as well as the growth or changes of psychopathology over time.

Journal

Journal of affective disorders

Published

2024/09/19

Authors

Jia L, Wei Z, Liu B, Yu M, Zhang X, He X, Xi Y, Chen R, Zhang X

Keywords

Children and adolescents, Developmental and dynamic, Psychopathology, Psychotic-like experiences

DOI

10.1016/j.jad.2024.09.100
Toggle Prevalence and sociodemographic associations with weight discrimination in early adolescents. Preventive medicine reports Nagata JM, Helmer CK, Wong JH, et al. 2024
PubMed Record

Abstract

To evaluate the prevalence of weight discrimination (the perception of being treated unfairly based on weight) and its sociodemographic associations among early adolescents aged 10 to 13 in the United States.

Journal

Preventive medicine reports

Published

2024/09/19

Authors

Nagata JM, Helmer CK, Wong JH, Domingue SK, Shim JE, Al-Shoaibi AAA

Keywords

Adolescent, Cohort, Discrimination, Epidemiology, LGBTQ, Sexual minority, Weight discrimination, Weight stigma

DOI

10.1016/j.pmedr.2024.102892
Toggle Socioeconomic resources in youth are linked to divergent patterns of network integration/segregation across the brain's transmodal axis. PNAS nexus Michael C, Taxali A, Angstadt M, et al. 2024
PubMed Record

Abstract

Socioeconomic resources (SER) calibrate the developing brain to the current context, which can confer or attenuate risk for psychopathology across the lifespan. Recent multivariate work indicates that SER levels powerfully relate to intrinsic functional connectivity patterns across the entire brain. Nevertheless, the neuroscientific meaning of these widespread neural differences remains poorly understood, despite its translational promise for early risk identification, targeted intervention, and policy reform. In the present study, we leverage graph theory to precisely characterize multivariate and univariate associations between SER across household and neighborhood contexts and the intrinsic functional architecture of brain regions in 5,821 youth (9-10 years) from the Adolescent Brain Cognitive Development Study. First, we establish that decomposing the brain into profiles of integration and segregation captures more than half of the multivariate association between SER and functional connectivity with greater parsimony (100-fold reduction in number of features) and interpretability. Second, we show that the topological effects of SER are not uniform across the brain; rather, higher SER levels are associated with greater integration of somatomotor and subcortical systems, but greater segregation of default mode, orbitofrontal, and cerebellar systems. Finally, we demonstrate that topological associations with SER are spatially patterned along the unimodal-transmodal gradient of brain organization. These findings provide critical interpretive context for the established and widespread associations between SER and brain organization. This study highlights both higher-order and somatomotor networks that are differentially implicated in environmental stress, disadvantage, and opportunity in youth.

Journal

PNAS nexus

Published

2024/09/18

Authors

Michael C, Taxali A, Angstadt M, Kardan O, Weigard A, Molloy MF, McCurry KL, Hyde LW, Heitzeg MM, Sripada C

Keywords

brain development, graph theory, multivariate predictive modeling, socioeconomic resources, transmodal gradient

DOI

10.1093/pnasnexus/pgae412
Toggle Delay discounting and nucleus accumbens functional connectivity are related to weight status in adolescents from the ABCD study. Pediatric obesity Overholtzer LN, Ahmadi H, Bottenhorn K, et al. 2024
PubMed Record

Abstract

Despite the growing epidemic of paediatric obesity, questions remain regarding potential neural mechanisms for individual risk. Delay discounting is a cognitive process of comparison of valuation between immediate and delayed reward, which has been inconsistently linked to weight status. Moreover, central to the brain’s reward system is the nucleus accumbens, a region structurally and functionally altered in obesity.

Journal

Pediatric obesity

Published

2024/09/17

Authors

Overholtzer LN, Ahmadi H, Bottenhorn K, Hsu E, Herting MM

Keywords

childhood obesity, nucleus accumbens, resting state, reward sensitivity

DOI

10.1111/ijpo.13173
Toggle The impact of breastfeeding on facial appearance in adolescent children. PloS one Goovaerts S, El Sergani AM, Lee MK, et al. 2024
PubMed Record

Abstract

Evidence that breastfeeding impacts the facial features of children is conflicting. Most studies to date have focused on dental and skeletal malocclusion. It currently remains unclear whether such effects are of sufficient magnitude to be detectable on outward facial appearance. Here, we evaluate the extent to which maternally reported breastfeeding is associated with 3D facial shape in a large adolescent cohort. After extracting 3D facial surfaces from MR scans in 2275 9- and 10-year-old children and aligning the surfaces in dense correspondence, we analyzed the effect of breastfeeding on shape as a dichotomous (no/yes) and semi-quantitative (to assess duration in months) variable using partial least squares regression. Our results showed no effect (p = 0.532) when breastfeeding was dichotomized. However, when treated as a semi-quantitative variable, breastfeeding duration was associated with statistically significant changes in shape (p = 3.61x 10-4). The most prominent facial changes included relative retrusion of the central midface, zygomatic arches, and orbital regions along with relative protrusion of forehead, cheek, and mandible. The net effect was that as breastfeeding duration increased, the facial profile in children became flatter (less convex). The observed effects on the face, however, were subtle and likely not conspicuous enough to be noticed by most observers. This was true even when comparing the faces of children breastfed for 19-24 months to children with no reported breastfeeding. Thus, breastfeeding does appear to have detectable effect on outward facial appearance in adolescent children, but its practical impact appears to be minimal.

Journal

PloS one

Published

2024/09/17

Authors

Goovaerts S, El Sergani AM, Lee MK, Shaffer JR, Claes P, Weinberg SM

Keywords

DOI

10.1371/journal.pone.0310538
Toggle Integrating Diet and Health Care in Child Health Research-Reply. JAMA pediatrics Li ZA, Ray MK, Hershey T 2024
PubMed Record

Abstract

Journal

JAMA pediatrics

Published

2024/09/16

Authors

Li ZA, Ray MK, Hershey T

Keywords

DOI

10.1001/jamapediatrics.2024.3578
Toggle Impact of Pre-Adolescent Substance Familiarity on Subsequent Use: Longitudinal Analysis of Risk by Latent Classes in the Adolescent Brain Cognitive Development Sample. Substance use & misuse Moore A, Lewis B, Farrior H, et al. 2024
PubMed Record

Abstract

Predicting substance use in adolescence is a difficult yet important task in developing effective prevention. We aim to extend previous findings on the linear associations between familiarity with (knowledge of) substances in childhood and subsequent substance use in adolescence through a latent class analysis (LCA) to create risk profiles based on substance familiarity.

Journal

Substance use & misuse

Published

2024/09/15

Authors

Moore A, Lewis B, Farrior H, Hinckley J, Nixon SJ, Bhatia D

Keywords

Adolescent risk factor familiarity longitudinal cohort

DOI

10.1080/10826084.2024.2403109
Toggle From individual motivation to substance use initiation: A longitudinal cohort study assessing the associations between reward sensitivity and subsequent risk of substance use initiation among US adolescents. Addictive behaviors Shao IY, Al-Shoaibi AAA, Ganson KT, et al. 2024
PubMed Record

Abstract

Substance use in youth remains a pressing problem in the United States. Existing studies have shown the importance of neuropathways responsible for affective response and reward motivation in adolescents’ substance use initiation and maintenance. However, limited observational studies have explored the relationship between aspects of behavioral motivation traits and the likelihood of substance use initiation in adolescents. In this prospective cohort study, we assessed the associations between behavioral motivation traits based on the Behavioral Inhibition and Approach Systems (BIS-BAS) Scale and substance use initiation using data from the Adolescent Brain Cognitive Development (ABCD) study.

Journal

Addictive behaviors

Published

2024/09/12

Authors

Shao IY, Al-Shoaibi AAA, Ganson KT, Testa A, Kiss O, He J, Baker FC, Nagata JM

Keywords

Adolescent health, Behavioral motivation, Reward sensitivity, Substance use

DOI

10.1016/j.addbeh.2024.108162
Toggle Association of birth weight with neuropsychological functioning in early adolescence: A retrospective cohort study. Psychiatry research Zhou Q, Zhao X, Chen J, et al. 2024
PubMed Record

Abstract

This study aimed to compare the neuropsychological function in early adolescence between children born small for gestational age (SGA) or large for gestational age (LGA) and those born appropriate for gestational age (AGA).

Journal

Psychiatry research

Published

2024/09/11

Authors

Zhou Q, Zhao X, Chen J, Yang A, Zhao XM, Li X

Keywords

Birth weight, Early adolescence, Large for gestational age, Magnetic resonance imaging, Small for gestational age

DOI

10.1016/j.psychres.2024.116183
Toggle Gender Identity Disparities in Early Adolescent Sleep: Findings from the Adolescent Brain Cognitive Development Study. LGBT health Ricklefs C, Balasubramanian P, Ganson KT, et al. 2024
PubMed Record

Abstract

Our aim was to examine associations between transgender identity and sleep disturbance in a demographically diverse, national sample of U.S. early adolescents. We conducted a cross-sectional analysis of the Adolescent Brain Cognitive Development Study from Year 3 (2019-2021, = 10,277, 12-13 years) to investigate the association between transgender identity and caregiver-reported measures of their adolescent’s sleep, assessed by the Sleep Disturbance Scale for Children. Transgender adolescents had a higher risk of overall sleep disturbance and symptoms of insomnia and excessive sleepiness. Furthermore, per caregiver report, transgender adolescents were more likely to have shorter sleep duration categories; particularly concerning is the significant risk of <5 hours of sleep for transgender adolescents compared with their cisgender peers. These findings indicate that transgender adolescents had worse caregiver-reported sleep outcomes compared to cisgender peers. This study highlights the need for screenings and interventions targeted at improving sleep among transgender adolescents.

Journal

LGBT health

Published

2024/09/10

Authors

Ricklefs C, Balasubramanian P, Ganson KT, Testa A, Kiss O, Baker FC, Nagata JM

Keywords

adolescence, gender minority, sleep, sleep disparities, transgender

DOI

10.1089/lgbt.2023.0431
Toggle Efficient federated learning for distributed neuroimaging data. Frontiers in neuroinformatics Thapaliya B, Ohib R, Geenjaar E, et al. 2024
PubMed Record

Abstract

Recent advancements in neuroimaging have led to greater data sharing among the scientific community. However, institutions frequently maintain control over their data, citing concerns related to research culture, privacy, and accountability. This creates a demand for innovative tools capable of analyzing amalgamated datasets without the need to transfer actual data between entities. To address this challenge, we propose a decentralized sparse federated learning (FL) strategy. This approach emphasizes local training of sparse models to facilitate efficient communication within such frameworks. By capitalizing on model sparsity and selectively sharing parameters between client sites during the training phase, our method significantly lowers communication overheads. This advantage becomes increasingly pronounced when dealing with larger models and accommodating the diverse resource capabilities of various sites. We demonstrate the effectiveness of our approach through the application to the Adolescent Brain Cognitive Development (ABCD) dataset.

Journal

Frontiers in neuroinformatics

Published

2024/09/09

Authors

Thapaliya B, Ohib R, Geenjaar E, Liu J, Calhoun V, Plis SM

Keywords

communication efficiency, efficient federated learning, neuroimaging, sparse models, sparsity

DOI

10.3389/fninf.2024.1430987
Toggle Optimization of self- or parent-reported psychiatric phenotypes in longitudinal studies. Journal of child psychology and psychiatry, and allied disciplines Ivankovic F, Johnson S, Shen J, et al. 2024
PubMed Record

Abstract

The Adolescent Brain Cognitive Development (ABCD) study is a longitudinal study of US adolescents with a wide breadth of psychiatric, neuroimaging and genetic data that can be leveraged to better understand psychiatric diseases. The reliability and validity of the psychiatric data collected have not yet been examined. This study aims to explore and optimize the reliability/validity of psychiatric diagnostic constructs in the ABCD study.

Journal

Journal of child psychology and psychiatry, and allied disciplines

Published

2024/09/09

Authors

Ivankovic F, Johnson S, Shen J, Scharf JM, Mathews CA

Keywords

Phenotype, adolescence, diagnosis, epidemiology, genetics

DOI

10.1111/jcpp.14054
Toggle Neurodevelopmental imprints of sociomarkers in adolescent brain connectomes. Scientific reports Kang E, Yun B, Cha J, et al. 2024
PubMed Record

Abstract

Neural consequences of social disparities are not yet rigorously investigated. How socioeconomic conditions influence children’s connectome development remains unknown. This paper endeavors to gauge how precisely the connectome structure of the brain can predict an individual’s social environment, thereby inversely assessing how social influences are engraved in the neural development of the Adolescent brain. Utilizing Adolescent Brain and Cognition Development (ABCD) data (9099 children residing in the United States), we found that social conditions both at the household and neighborhood levels are significantly associated with specific neural connections. Solely with brain connectome data, we train a linear support vector machine (SVM) to predict socio-economic conditions of those adolescents. The classification performance generally improves when the thresholds of the advantageous and disadvantageous environments compartmentalize the extreme cases. Among the tested thresholds, the 20th and 80th percentile thresholds using the dual combination of household income and neighborhood education yielded the highest Area Under the Precision-Recall Curve (AUPRC) of 0.8224. We identified 8 significant connections that critically contribute to predicting social environments in the parietal lobe and frontal lobe. Insights into social factors that contribute to early brain connectome development is critical to mitigate the disadvantages of children growing up in unfavorable neighborhoods.

Journal

Scientific reports

Published

2024/09/09

Authors

Kang E, Yun B, Cha J, Suk HI, Shin EK

Keywords

Adolesecent brain, Connectomes, Neurodevelopmental imprints, Sociomarkers

DOI

10.1038/s41598-024-71309-2
Toggle The impact of sleep problems during late childhood on internalizing problems in early-mid adolescence. Behavioral sleep medicine Santos JPL, Versace A, Ladouceur CD, et al. 2024
PubMed Record

Abstract

Sleep and internalizing problems escalate during adolescence and can negatively impact long-term health. However, the directionality of this risk-relationship remains poorly understood within a developmental context. The current study aimed to determine the directionality of this relationship in adolescents with no history of psychiatric disorder and whether sex at birth played a role in this relationship.

Journal

Behavioral sleep medicine

Published

2024/09/08

Authors

Santos JPL, Versace A, Ladouceur CD, Soehner AM

Keywords

DOI

10.1080/15402002.2024.2401471
Toggle Neurodevelopmental Subtypes of Functional Brain Organization in the ABCD Study Using a Rigorous Analytic Framework. NeuroImage DeRosa J, Friedman NP, Calhoun V, et al. 2024
PubMed Record

Abstract

The current study demonstrates that an individual’s resting-state functional connectivity (RSFC) is a dependable biomarker for identifying differential patterns of cognitive and emotional functioning during late childhood. Using baseline RSFC data from the Adolescent Brain Cognitive Development (ABCD) study, which includes children aged 9-11, we identified four distinct RSFC subtypes. We introduce an integrated methodological pipeline for testing the reliability and importance of these subtypes. In the Identification phase, Leiden Community Detection defined RSFC subtypes, with their reproducibility confirmed through a split-sample technique in the Validation stage. The Evaluation phase showed that distinct cognitive and mental health profiles are associated with each subtype, with the Predictive phase indicating that subtypes better predict various cognitive and mental health characteristics than individual RSFC connections. The Replication stage employed bootstrapping and down-sampling methods to substantiate the reproducibility of these subtypes further. This work allows future explorations of developmental trajectories of these RSFC subtypes.

Journal

NeuroImage

Published

2024/09/06

Authors

DeRosa J, Friedman NP, Calhoun V, Banich MT

Keywords

Adolescent Brain Cognitive Development Study, Biomarker, Machine Learning, Resting-State Functional Connectivity

DOI

10.1016/j.neuroimage.2024.120827
Toggle Cognitive processing speed and accuracy are intrinsically different in genetic architecture and brain phenotypes. Nature communications Li M, Dang X, Chen Y, et al. 2024
PubMed Record

Abstract

Since the birth of cognitive science, researchers have used reaction time and accuracy to measure cognitive ability. Although recognition of these two measures is often based on empirical observations, the underlying consensus is that most cognitive behaviors may be along two fundamental dimensions: cognitive processing speed (CPS) and cognitive processing accuracy (CPA). In this study, we used genomic-wide association studies (GWAS) data from 14 cognitive traits to show the presence of those two factors and revealed the specific neurobiological basis underlying them. We identified that CPS and CPA had distinct brain phenotypes (e.g. white matter microstructure), neurobiological bases (e.g. postsynaptic membrane), and developmental periods (i.e. late infancy). Moreover, those two factors showed differential associations with other health-related traits such as screen exposure and sleep status, and a significant causal relationship with psychiatric disorders such as major depressive disorder and schizophrenia. Utilizing an independent cohort from the Adolescent Brain Cognitive Development (ABCD) study, we also uncovered the distinct contributions of those two factors on the cognitive development of young adolescents. These findings reveal two fundamental factors underlying various cognitive abilities, elucidate the distinct brain structural fingerprint and genetic architecture of CPS and CPA, and hint at the complex interrelationship between cognitive ability, lifestyle, and mental health.

Journal

Nature communications

Published

2024/09/06

Authors

Li M, Dang X, Chen Y, Chen Z, Xu X, Zhao Z, Wu D

Keywords

DOI

10.1038/s41467-024-52222-8
Toggle Happy children! A network of psychological and environmental factors associated with the development of positive affect in 9-13 children. PloS one Feraco T, Cona G 2024
PubMed Record

Abstract

To deepen the development of positive affect during early adolescence and shed new light on its predictors, this study adopts an exploratory network approach to first identify the main domains that describe the variability of children’s psychological, environmental, and behavioral characteristics, and then use these domains to longitudinally predict positive affect and its development within a latent growth framework. To this aim, we considered 10,904 US participants (9 years old at baseline; 13 years old 42 months later), six measurement occasions of positive affect, and 46 baseline indicators from the ABCD study. Our results not only confirm that positive affect declines between 9 and 13 years old, but also show that among the five domains identified (behavioral dysregulation, cognitive functioning, psychological problems, supportive social environment, and extracurricular activities), only a supportive social environment consistently predicts positive affect. This is crucial for practitioners and policymakers, as it can help them focus on the elements within our complex network of psychological, social, and environmental variability.

Journal

PloS one

Published

2024/09/06

Authors

Feraco T, Cona G

Keywords

DOI

10.1371/journal.pone.0307560
Toggle Are factors that predict conversion to psychosis associated with initial transition to a high risk state? An adolescent brain cognitive development study analysis. Schizophrenia research Smucny J, Wood A, Davidson IN, et al. 2024
PubMed Record

Abstract

Previous work suggests that cognitive and environmental risk factors may predict conversion to psychosis in individuals at clinical high risk (CHRs) for the disorder. Less clear, however, is whether these same factors are also associated with the initial emergence of the high risk state in individuals who do not meet current threshold criteria for being considered high risk.

Journal

Schizophrenia research

Published

2024/09/05

Authors

Smucny J, Wood A, Davidson IN, Carter CS

Keywords

ABCD, Clinical high risk, PQ-BC, Prodrome, Psychosis, Schizophrenia

DOI

10.1016/j.schres.2024.08.022
Toggle A multi-level examination of impulsivity and links to suicide ideation among Native American youth. Journal of affective disorders Wiglesworth A, White E, Bendezu JJ, et al. 2024
PubMed Record

Abstract

Despite preliminary evidence that links impulsivity to suicide risk among Native American youth, impulsivity has not been directly studied in relation to suicide ideation (SI) or behaviors in this population. We examined indexes of rapid-response impulsivity (RRI) across multiple levels of analysis (self-report, behavioral, neurobiological) and associations with SI among Native American youth ages 9-10 in the Adolescent Brain Cognitive Development Study.

Journal

Journal of affective disorders

Published

2024/09/05

Authors

Wiglesworth A, White E, Bendezu JJ, Roediger DJ, Weiss H, Luciana M, Fiecas MB, Cullen KR, Klimes-Dougan B

Keywords

ABCD study, Developmental Psychopathology, Impulsivity, Native American, Suicide ideation, Youth

DOI

10.1016/j.jad.2024.08.225
Toggle Neural response to monetary incentives in acquired adolescent depression after mild traumatic brain injury: Stage 2 Registered Report. Brain communications Hogeveen J, Campbell EM, Mullins TS, et al. 2024
PubMed Record

Abstract

Depression is a common consequence of traumatic brain injury. Separately, spontaneous depression-arising without brain injury-has been linked to abnormal responses in motivational neural circuitry to the anticipation or receipt of rewards. It is unknown if post-injury and spontaneously occurring depression share similar phenotypic profiles. This issue is compounded by the fact that nearly all examinations of these psychiatric sequelae are : there are rarely any prospective assessments of mood and neural functioning before and after a brain injury. In this Stage 2 Registered Report, we used the Adolescent Brain Cognitive Development Consortium dataset to examine if a disruption in functional neural responses to rewards is present in patients with depression after a mild traumatic brain injury. Notably, this study provides an unparalleled opportunity to examine the trajectory of neuropsychiatric symptoms longitudinally within-subjects. This allowed us to isolate mild traumatic brain injury-specific variance independent from pre-existing functioning. Here, we focus on a case-control comparison between 43 youth who experienced a mild traumatic brain injury between MRI visits, and 43 well-matched controls. Contrary to pre-registered predictions (https://osf.io/h5uba/), there was no statistically credible increase in depression in mild traumatic brain injury cases relative to controls. Mild traumatic brain injury was associated with subtle changes in motivational neural circuit recruitment during the anticipation of incentives on the Monetary Incentive Delay paradigm. Specifically, changes in neural recruitment appeared to reflect a failure to deactivate ‘task-negative’ brain regions (ventromedial prefrontal cortex), alongside blunted recruitment of ‘task-positive’ regions (anterior cingulate, anterior insula and caudate), during the anticipation of reward and loss in adolescents following mild brain injuries. Critically, these changes in brain activity were not correlated with depressive symptoms at either visit or depression change scores before and after the brain injury. Increased time since injury was associated with a recovery of cognitive functioning-driven primarily by processing speed differences-but depression did not scale with time since injury. These cognitive changes were also uncorrelated with neural changes after mild traumatic brain injury. This report provides evidence that acquired depression may not be observed as commonly after a mild traumatic brain injury in late childhood and early adolescence, relative to findings in adult cases. Several reasons for these differing findings are considered, including sampling enrichment in retrospective cohort studies, under-reporting of depressive symptoms in parent-report data, and neuroprotective factors in childhood and adolescence.

Journal

Brain communications

Published

2024/09/04

Authors

Hogeveen J, Campbell EM, Mullins TS, Robertson-Benta CR, Quinn DK, Mayer AR, Cavanagh JF

Keywords

TBI, adolescence, depression, fMRI, reward

DOI

10.1093/braincomms/fcae250
Toggle Social Epidemiology of Early Initiation of Electronic and Conventional Cigarette Use in Early to Middle Adolescents. Journal of biomedical and life sciences Assari S, Zare H, Sheikhattari P 2024
PubMed Record

Abstract

Early initiation of tobacco use among adolescents is a significant public health concern. While there is extensive research on overall tobacco use, much of it focuses on initiation in late adolescence, uses cross-sectional designs, and lacks specific exploration of electronic versus conventional cigarette use. This study aims to investigate social determinants influencing the early initiation of electronic and conventional cigarette use among U.S. adolescents.

Journal

Journal of biomedical and life sciences

Published

2024/09/04

Authors

Assari S, Zare H, Sheikhattari P

Keywords

Adolescents, Combustible Tobacco, Electronic Cigarette, Social Determinants, Tobacco, Youth

DOI

10.31586/jbls.2024.1038
Toggle Cognitive and Psychological Mediators of the Social Gradient in Tobacco Use Initiation Among Adolescents: Evidence from the ABCD Study. Journal of biomedical and life sciences Assari S, Zare H 2024
PubMed Record

Abstract

Tobacco use among adolescents is a significant public health concern, with early initiation leading to long-term health risks. Understanding the factors that contribute to the initiation of tobacco use is crucial for developing effective prevention strategies. This study investigates the roles of substance use harm knowledge and tobacco susceptibility in mediating the relationship between social gradients (race, ethnicity, and socioeconomic status) and tobacco use initiation among adolescents.

Journal

Journal of biomedical and life sciences

Published

2024/09/04

Authors

Assari S, Zare H

Keywords

ABCD study, Adolescents, Health disparities, Social gradients, Socioeconomic status, Substance use harm knowledge, Tobacco susceptibility, Tobacco use

DOI

10.31586/jbls.2024.1035
Toggle Frontostriatal salience network expansion in individuals in depression. Nature Lynch CJ, Elbau IG, Ng T, et al. 2024
PubMed Record

Abstract

Decades of neuroimaging studies have shown modest differences in brain structure and connectivity in depression, hindering mechanistic insights or the identification of risk factors for disease onset. Furthermore, whereas depression is episodic, few longitudinal neuroimaging studies exist, limiting understanding of mechanisms that drive mood-state transitions. The emerging field of precision functional mapping has used densely sampled longitudinal neuroimaging data to show behaviourally meaningful differences in brain network topography and connectivity between and in healthy individuals, but this approach has not been applied in depression. Here, using precision functional mapping and several samples of deeply sampled individuals, we found that the frontostriatal salience network is expanded nearly twofold in the cortex of most individuals with depression. This effect was replicable in several samples and caused primarily by network border shifts, with three distinct modes of encroachment occurring in different individuals. Salience network expansion was stable over time, unaffected by mood state and detectable in children before the onset of depression later in adolescence. Longitudinal analyses of individuals scanned up to 62 times over 1.5 years identified connectivity changes in frontostriatal circuits that tracked fluctuations in specific symptoms and predicted future anhedonia symptoms. Together, these findings identify a trait-like brain network topology that may confer risk for depression and mood-state-dependent connectivity changes in frontostriatal circuits that predict the emergence and remission of depressive symptoms over time.

Journal

Nature

Published

2024/09/04

Authors

Lynch CJ, Elbau IG, Ng T, Ayaz A, Zhu S, Wolk D, Manfredi N, Johnson M, Chang M, Chou J, Summerville I, Ho C, Lueckel M, Bukhari H, Buchanan D, Victoria LW, Solomonov N, Goldwaser E, Moia S, Caballero-Gaudes C, Downar J, Vila-Rodriguez F, Daskalakis ZJ, Blumberger DM, Kay K, Aloysi A, Gordon EM, Bhati MT, Williams N, Power JD, Zebley B, Grosenick L, Gunning FM, Liston C

Keywords

DOI

10.1038/s41586-024-07805-2
Toggle Screen time, problematic screen use, and eating disorder symptoms among early adolescents: findings from the Adolescent Brain Cognitive Development (ABCD) Study. Eating and weight disorders : EWD Chu J, Ganson KT, Testa A, et al. 2024
PubMed Record

Abstract

Emerging research evidence suggests positive relationships between higher screen time and eating disorders. However, few studies have examined the prospective associations between screen use and eating disorder symptoms in early adolescents and how problematic screen use may contribute to symptom development.

Journal

Eating and weight disorders : EWD

Published

2024/09/04

Authors

Chu J, Ganson KT, Testa A, Al-Shoaibi AAA, Jackson DB, Rodgers RF, He J, Baker FC, Nagata JM

Keywords

Adolescent health, Eating disorders, Problematic screen use, Screen time

DOI

10.1007/s40519-024-01685-1
Toggle Sleep Disturbance and Subsequent Suicidal Behaviors in Preadolescence. JAMA network open Gowin JL, Stoddard J, Doykos TK, et al. 2024
PubMed Record

Abstract

Suicide is a leading cause of death among adolescents, who demonstrate high rates of sleep disturbance. Poor sleep appears to confer risk for suicide, but longitudinal investigation of suicidal behaviors remains rare, particularly in the transition from childhood to early adolescence.

Journal

JAMA network open

Published

2024/09/03

Authors

Gowin JL, Stoddard J, Doykos TK, Sammel MD, Bernert RA

Keywords

DOI

10.1001/jamanetworkopen.2024.33734
Toggle Assessing a prediction model for depression risk using an early adolescent sample with self-reported depression JCPP Advances Xu EY, MacSweeney N, Thng G, et al. 2024
Link to publication

Abstract

Background
Major depressive disorder (MDD) in adolescence is a risk factor for poor physical and psychiatric outcomes in adulthood, with earlier age of onset associated with poorer outcomes. Identifying Depression Early in Adolescence Risk Score (IDEA-RS) is a model for predicting MDD in youth aged >15 years, but replication in younger samples (<15 years) is lacking. Here, we tested IDEA-RS in a younger sample (9–11 years) to assess whether IDEA-RS could be applied to earlier onset depression.

Methods
We applied IDEA-RS predictor weights to 9854 adolescents (9–11 years) from the Adolescent Brain Cognitive Development (ABCD) Study, United States. We derived incident depression outcomes from self-reported data at 2-year follow-up (11–13 years): incident MDD and increase in depression symptoms (DS). Sensitivity analyses were conducted using parent-reported data. We assessed accuracy and calibration in predicting self-reported incident depression and compared this to a refitted model with predictor weights derived in ABCD. Lastly, we tested associations between IDEA-RS predictors and self-reported incident depression.

Results
External replication yielded better-than-chance discriminative capacity for self-reported incident depression (MDD: AUC = 61.4%, 95% CI = 53.5%–69.4%; DS: AUC = 57.9%, 95% CI = 54.6%–61.3%) but showed poor calibration with overly extreme risk estimates. Re-estimating predictor weights improved discriminative capacity (MDD: AUC = 75.9%, 95% CI = 70.3%–81.4%; DS: AUC = 64.8%, 95% CI = 61.9%–67.7%) and calibration. IDEA-RS predictors ‘poorest level of relationship with the primary caregiver’ (OR = 4.25, 95% CI = 1.73–10.41) and ‘high/highest levels of family conflict’ (OR = 3.36 [95% CI = 1.34–8.43] and OR = 3.76 [95% CI = 1.50–9.38], respectively) showed greatest associations with self-reported incident MDD.

Conclusions
While IDEA-RS yields better-than-chance predictions on external replication, accuracy is improved when differences between samples, such as case-control mix, are adjusted for. IDEA-RS may be more suited to research settings with sufficient data for refitting. Altogether, we find that IDEA-RS can be generalisable to early adolescents after refitting and that family dysfunction may be especially impactful for this period of development.

Journal

JCPP Advances

Published

2024/09/03

Authors

Xu EY, MacSweeney N, Thng G, Barbu MC, Shen X, Kwong ASF, Romaniuk L, McIntosh A, Lawrie SM, & Whalley HC

Keywords

DOI

https://doi.org/10.1002/jcv2.12276
Toggle Neural and Behavioral Correlates of Binge Eating in 9- to 10-Year-Old Children. Journal of the American Academy of Child and Adolescent Psychiatry Smith KE, Hsu E, Mason TB, et al. 2024
PubMed Record

Abstract

This observational study compared children with and without binge eating (BE) on biobehavioral measures of reward responsiveness, inhibitory control, and emotion processes, while accounting for the impact of weight.

Journal

Journal of the American Academy of Child and Adolescent Psychiatry

Published

2024/09/03

Authors

Smith KE, Hsu E, Mason TB, Luo S

Keywords

binge eating, children, eating disorders, neuroimaging, obesity

DOI

10.1016/j.jaac.2024.07.925
Toggle Depressive symptoms during the transition to adolescence: Left hippocampal volume as a marker of social context sensitivity. Proceedings of the National Academy of Sciences of the United States of America Martinez M, Cai T, Yang B, et al. 2024
PubMed Record

Abstract

The transition to adolescence is a critical period for mental health development. Socio-experiential environments play an important role in the emergence of depressive symptoms with some adolescents showing more sensitivity to social contexts than others. Drawing on recent developmental neuroscience advances, we examined whether hippocampal volume amplifies social context effects in the transition to adolescence. We analyzed 2-y longitudinal data from the Adolescent Brain Cognitive Development (ABCD) study in a diverse sample of 11,832 youth (mean age: 9.914 y; range: 8.917 to 11.083 y; 47.8% girls) from 21 sites across the United States. Socio-experiential environments (i.e., family conflict, primary caregiver’s depressive symptoms, parental warmth, peer victimization, and prosocial school environment), hippocampal volume, and a wide range of demographic characteristics were measured at baseline. Youth’s symptoms of major depressive disorder were assessed at both baseline and 2 y later. Multilevel mixed-effects linear regression analyses showed that negative social environments (i.e., family conflict, primary caregiver’s depressive symptoms, and peer victimization) and the absence of positive social environments (i.e., parental warmth and prosocial school environment) predicted greater increases in youth’s depressive symptoms over 2 y. Importantly, left hippocampal volume amplified social context effects such that youth with larger left hippocampal volume experienced greater increases in depressive symptoms in more negative and less positive social environments. Consistent with brain-environment interaction models of mental health, these findings underscore the importance of families, peers, and schools in the development of depression during the transition to adolescence and show how neural structure amplifies social context sensitivity.

Journal

Proceedings of the National Academy of Sciences of the United States of America

Published

2024/09/03

Authors

Martinez M, Cai T, Yang B, Zhou Z, Shankman SA, Mittal VA, Haase CM, Qu Y

Keywords

developmental neuroscience, hippocampus, mental health, neurobiological susceptibility, social sensitivity

DOI

10.1073/pnas.2321965121
Toggle Breastfeeding has long-term impacts on the brain and body, but where do we go from here? (Commentary on 'Breastfeeding duration and brain-body development in 9-10-year-olds: modulating effect of socioeconomic levels'). Pediatric research Howell BR 2024
PubMed Record

Abstract

Journal

Pediatric research

Published

2024/09/02

Authors

Howell BR

Keywords

DOI

10.1038/s41390-024-03533-5
Toggle Longitudinal associations between youth prosocial behavior and dimensions of psychopathology JCPP Advances Reimann GE, Lahey BB, Jeong HJ, et al. 2024
Link to Publication

Abstract

Background
Studies suggest that prosocial behavior, having high empathy and engaging in behaviors intended to benefit others, may predict mental health or vice versa; however, these findings have been mixed. The purpose of the current study was to examine the bidirectional relationships between prosocial behavior and dimensions of psychopathology in children.

Methods
The relationships between prosocial behavior and four dimensions of psychopathology (general psychopathology, internalizing symptoms, conduct problems, and attention-deficit/hyperactivity disorder symptoms) were examined longitudinally in children 9–12 years of age from the Adolescent Brain Cognitive Development Study (N = 9122). We used a random intercept cross-lagged panel model to distinguish between stable, trait-like (between-person) and time-dependent (within-person) fluctuations across a 24-month period.

Results
Between-person results revealed that prosocial behavior was negatively associated with general psychopathology and conduct problems while being positively associated with internalizing symptoms. Within-person results demonstrated that, out of four possible directional paths tested, one was significant. This path showed that greater general psychopathology and conduct problems at the first-year follow-up predicted fewer prosocial behaviors at the second-year follow-up, although the effect size was small. In contrast, prosocial behavior did not predict psychopathology dimensions for any year.

Conclusions
The results of this study suggest that prosocial behaviors have stable associations with psychopathology across preadolescence; however, evidence of a directional association in which psychopathology predicts fewer prosocial behaviors in the future was only modest.

Journal

JCPP Advances

Published

2024/08/31

Authors

Reimann GE, Lahey BB, Jeong HJ, Durham EL, Archer C, Cardenas-Iniguez C, Berman MG, Moore TM, Applegate B, Kaczkurkin AN

Keywords

DOI

https://doi.org/10.1002/jcv2.12282
Toggle Replicability and generalizability in population psychiatric neuroimaging. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Marek S, Laumann TO 2024
PubMed Record

Abstract

Studies linking mental health with brain function in cross-sectional population-based association studies have historically relied on small, underpowered samples. Given the small effect sizes typical of such brain-wide associations, studies require samples into the thousands to achieve the statistical power necessary for replicability. Here, we detail how small sample sizes have hampered replicability and provide sample size targets given established association strength benchmarks. Critically, while replicability will improve with larger samples, it is not guaranteed that observed effects will meaningfully apply to target populations of interest (i.e., be generalizable). We discuss important considerations related to generalizability in psychiatric neuroimaging and provide an example of generalizability failure due to “shortcut learning” in brain-based predictions of mental health phenotypes. Shortcut learning is a phenomenon whereby machine learning models learn an association between the brain and an unmeasured construct (the shortcut), rather than the intended target of mental health. Given the complex nature of brain-behavior interactions, the future of epidemiological approaches to brain-based studies of mental health will require large, diverse samples with comprehensive assessment.

Journal

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Published

2024/08/30

Authors

Marek S, Laumann TO

Keywords

DOI

10.1038/s41386-024-01960-w
Toggle Adversities Mediate Social Determinants of Youth Tobacco Use Initiation. Journal of biomedical and life sciences Assari S, Sheikhattari P, Zare H 2024
PubMed Record

Abstract

Social determinants of health (SDOH) significantly influence health behaviors, including tobacco use among youth. Adversities such as perceived discrimination, perceived neighborhood stress, life trauma, and financial strain are stressors that may mediate the relationship between various SDOH and youth tobacco use. This study aims to investigate whether multidimensional adversities mediate the effects of SDOH on tobacco use among youth.

Journal

Journal of biomedical and life sciences

Published

2024/08/29

Authors

Assari S, Sheikhattari P, Zare H

Keywords

Adversities, Family Structure, Financial Strain, Household Income, Life Trauma, Mediation, Neighborhood Income, Parental Education, Perceived Discrimination, Social Determinants of Health, Youth Tobacco Use

DOI

10.31586/jbls.2024.1039
Toggle Predicting adolescent psychopathology from early life factors: A machine learning tutorial. Global epidemiology Siddique F, Lee BK 2024
PubMed Record

Abstract

The successful implementation and interpretation of machine learning (ML) models in epidemiological studies can be challenging without an extensive programming background. We provide a didactic example of machine learning for risk prediction in this study by determining whether early life factors could be useful for predicting adolescent psychopathology.

Journal

Global epidemiology

Published

2024/08/29

Authors

Siddique F, Lee BK

Keywords

Adolescent, Child, Machine learning, Mental disorders, Pregnancy, Risk prediction

DOI

10.1016/j.gloepi.2024.100161
Toggle Psychiatric Symptoms, Cognition, and Symptom Severity in Children. JAMA psychiatry Pines A, Tozzi L, Bertrand C, et al. 2024
PubMed Record

Abstract

Mental illnesses are a leading cause of disability globally, and functional disability is often in part caused by cognitive impairments across psychiatric disorders. However, studies have consistently reported seemingly opposite findings regarding the association between cognition and psychiatric symptoms.

Journal

JAMA psychiatry

Published

2024/08/28

Authors

Pines A, Tozzi L, Bertrand C, Keller AS, Zhang X, Whitfield-Gabrieli S, Hastie T, Larsen B, Leikauf J, Williams LM

Keywords

DOI

10.1001/jamapsychiatry.2024.2399
Toggle Tobacco Susceptibility Explains Diminished Returns of Family Income on Black Adolescents' Tobacco Initiation. Open journal of psychology Assari S, Sheikhattari P 2024
PubMed Record

Abstract

Minorities’ Diminished Returns (MDRs) theory posits that socioeconomic resources have weaker protective effects on health and behavior for racial and ethnic minorities compared to Whites. This study examines whether tobacco susceptibility, defined as curiosity, intention, and openness to future tobacco use, mediates the diminished returns of family income on tobacco initiation among Black adolescents.

Journal

Open journal of psychology

Published

2024/08/27

Authors

Assari S, Sheikhattari P

Keywords

ABCD Study, Black Adolescents, Family Income, Health Disparities, Tobacco Initiation, Tobacco Susceptibility

DOI

10.31586/ojp.2024.1037
Toggle Role of Impulsivity in Explaining Social Gradient in Youth Tobacco Use Initiation: Does Race Matter? Open journal of neuroscience Assari S, Sheikhattari P 2024
PubMed Record

Abstract

Socioeconomic status (SES) is traditionally viewed as a protective factor against impulsivity and subsequent tobacco use in youth. The prevailing model suggests that higher SES is associated with lower impulsivity, which in turn reduces the likelihood of future tobacco use. However, this pathway may not hold uniformly across racial groups due to differences in impulsivity and the phenomenon of Minorities’ Diminished Returns (MDRs), where the protective effects of SES, such as educational attainment, tend to be weaker or even reversed for Black youth compared to their White counterparts.

Journal

Open journal of neuroscience

Published

2024/08/27

Authors

Assari S, Sheikhattari P

Keywords

Impulsivity, Racial Disparities, Socioeconomic Status (SES), Substance Use, Tobacco Use, Youth Health Disparities

DOI

10.31586/ojn.2024.1052
Toggle Anxiety and Depression Symptoms, Adverse Childhood Experiences, and Persistent/Recurrent Pain Across Early Adolescence. Academic pediatrics Senger-Carpenter T, Zhang A, Ordway M, et al. 2024
PubMed Record

Abstract

To determine whether anxiety and depression symptoms are mechanisms through which adverse childhood experiences (ACEs) contribute toward persistent/recurrent pain (PRP) across early adolescence.

Journal

Academic pediatrics

Published

2024/08/26

Authors

Senger-Carpenter T, Zhang A, Ordway M, Stoddard SA, Voepel-Lewis T

Keywords

adolescence, adverse childhood experiences, anxiety, depression, pain

DOI

10.1016/j.acap.2024.08.013
Toggle Higher Neighborhood Crime Rates Don't Always Predict Early Initiation of Tobacco, Marijuana, and Alcohol. Journal of social mathematical & human engineering sciences Assari S, Sheikhattari P 2024
PubMed Record

Abstract

The initiation of substance use during adolescence is a significant public health concern with long-term implications. Structural and environmental factors, such as community-level crime statistics related to drug offenses, are often assumed to influence the likelihood of substance use among youth. However, the relationship between these environmental crime indicators and early substance use initiation in adolescents is not well understood.

Journal

Journal of social mathematical & human engineering sciences

Published

2024/08/24

Authors

Assari S, Sheikhattari P

Keywords

Adolescent Substance Use, Alcohol Use, Drug-Related Crime, Environmental Crime Statistics, Marijuana Use, Tobacco Use

DOI

10.31586/jsmhes.2024.1049
Toggle Ventral attention network connectivity is linked to cortical maturation and cognitive ability in childhood. Nature neuroscience Dong HM, Zhang XH, Labache L, et al. 2024
PubMed Record

Abstract

The human brain experiences functional changes through childhood and adolescence, shifting from an organizational framework anchored within sensorimotor and visual regions into one that is balanced through interactions with later-maturing aspects of association cortex. Here, we link this profile of functional reorganization to the development of ventral attention network connectivity across independent datasets. We demonstrate that maturational changes in cortical organization link preferentially to within-network connectivity and heightened degree centrality in the ventral attention network, whereas connectivity within network-linked vertices predicts cognitive ability. This connectivity is associated closely with maturational refinement of cortical organization. Children with low ventral attention network connectivity exhibit adolescent-like topographical profiles, suggesting that attentional systems may be relevant in understanding how brain functions are refined across development. These data suggest a role for attention networks in supporting age-dependent shifts in cortical organization and cognition across childhood and adolescence.

Journal

Nature neuroscience

Published

2024/08/23

Authors

Dong HM, Zhang XH, Labache L, Zhang S, Ooi LQR, Yeo BTT, Margulies DS, Holmes AJ, Zuo XN

Keywords

DOI

10.1038/s41593-024-01736-x
Toggle Empirical examination of working memory performance and its neural correlates in relation to delay discounting in two large samples. Behavioural brain research Elsayed M, Owens MM, Balodis I, et al. 2024
PubMed Record

Abstract

The neurobiological basis of working memory and delay discounting are theorized to overlap, but few studies have empirically examined these relations in large samples. To address this, we investigated the association of neural activation during an fMRI N-Back working memory task with delay discounting area, as well as in- and out-of-scanner working memory measures. These analyses were conducted in two large task fMRI datasets, the Human Connectome Project and the Adolescent Brain Cognitive Development Study. Although in- and out-of-scanner working memory performance were significantly associated with N-back task brain activation regions, contrary to our hypotheses, there were no significant associations between working memory task activation and delay discounting scores. These findings call into question the extent of the neural overlap in delay discounting and working memory and highlight the need for more investigations directly interrogating overlapping and distinct brain regions across cognitive neuroscience tasks.

Journal

Behavioural brain research

Published

2024/08/22

Authors

Elsayed M, Owens MM, Balodis I, MacKillop J

Keywords

delay discounting, functional magnetic resonance imaging, impulsivity, n-back, working memory

DOI

10.1016/j.bbr.2024.115217
Toggle Associations Between Genetic Risk, Physical Activities, and Distressing Psychotic-like Experiences. Schizophrenia bulletin Ku BS, Yuan Q, Arias-Magnasco A, et al. 2024
PubMed Record

Abstract

Persistent distressing psychotic-like experiences (PLE) are associated with impaired functioning and future psychopathology. Prior research suggests that physical activities may be protective against psychopathology. However, it is unclear whether physical activities may interact with genetics in the development of psychosis.

Journal

Schizophrenia bulletin

Published

2024/08/22

Authors

Ku BS, Yuan Q, Arias-Magnasco A, Lin BD, Walker EF, Druss BG, Ren J, van Os J, Guloksuz S

Keywords

gene-environment interaction, physical activities, polygenic risk score, psychotic-like experiences, schizophrenia, team sports

DOI

10.1093/schbul/sbae141
Toggle Interactive roles of preterm-birth and socioeconomic status in cortical thickness of language-related brain structures: Findings from the Adolescent Brain Cognitive Development (ABCD) study. Cortex; a journal devoted to the study of the nervous system and behavior Nolte C, Michalska KJ, Nelson PM, et al. 2024
PubMed Record

Abstract

Preterm-born (PTB) children are at an elevated risk for neurocognitive difficulties in general and language difficulties more specifically. Environmental factors such as socio-economic status (SES) play a key role for Term children’s language development. SES has been shown to predict PTB children’s behavioral developmental trajectories, sometimes surpassing its role for Term children. However, the role of SES in the neurocognitive basis of PTB children’s language development remains uncharted. Here, we aimed to evaluate the role of SES in the neural basis of PTB children’s language performance. Leveraging the Adolescent Brain Cognitive Development (ABCD) Study, the largest longitudinal study of adolescent brain development and behavior to date, we showed that prematurity status (PTB versus Term) and multiple aspects of SES additively predict variability in cortical thickness, which is in turn related to children’s receptive vocabulary performance. We did not find evidence to support the differential role of environmental factors for PTB versus Term children, underscoring that environmental factors are significant contributors to development of both Term and PTB children. Taken together, our results suggest that the environmental factors influencing language development might exhibit similarities across the full spectrum of gestational age.

Journal

Cortex; a journal devoted to the study of the nervous system and behavior

Published

2024/08/22

Authors

Nolte C, Michalska KJ, Nelson PM, Demir-Lira ӦE

Keywords

Cortical thickness, Language, Preterm-birth, Socio-economic status

DOI

10.1016/j.cortex.2024.05.024
Toggle Characterizing Long COVID in Children and Adolescents. JAMA Gross RS, Thaweethai T, Kleinman LC, et al. 2024
PubMed Record

Abstract

Most research to understand postacute sequelae of SARS-CoV-2 infection (PASC), or long COVID, has focused on adults, with less known about this complex condition in children. Research is needed to characterize pediatric PASC to enable studies of underlying mechanisms that will guide future treatment.

Journal

JAMA

Published

2024/08/21

Authors

Gross RS, Thaweethai T, Kleinman LC, Snowden JN, Rosenzweig EB, Milner JD, Tantisira KG, Rhee KE, Jernigan TL, Kinser PA, Salisbury AL, Warburton D, Mohandas S, Wood JC, Newburger JW, Truong DT, Flaherman VJ, Metz TD, Karlson EW, Chibnik LB, Pant DB, Krishnamoorthy A, Gallagher R, Lamendola-Essel MF, Hasson DC, Katz SD, Yin S, Dreyer BP, Carmilani M, Coombs K, Fitzgerald ML, Güthe N, Hornig M, Letts RJ, Peddie AK, Taylor BD, Foulkes AS, Stockwell MS, , , Balaraman V, Bogie A, Bukulmez H, Dozor AJ, Eckrich D, Elliott AJ, Evans DN, Farkas JS, Faustino EVS, Fischer L, Gaur S, Harahsheh AS, Hasan UN, Hsia DS, Huerta-Montañez G, Hummel KD, Kadish MP, Kaelber DC, Krishnan S, Kosut JS, Larrabee J, Lim PPC, Michelow IC, Oliveira CR, Raissy H, Rosario-Pabon Z, Ross JL, Sato AI, Stevenson MD, Talavera-Barber MM, Teufel RJ, Weakley KE, Zimmerman E, Bind MC, Chan J, Guan Z, Morse RE, Reeder HT, Akshoomoff N, Aschner JL, Bhattacharjee R, Cottrell LA, Cowan K, D'Sa VA, Fiks AG, Gennaro ML, Irby K, Khare M, Guttierrez JL, McCulloh RJ, Narang S, Ness-Cochinwala M, Nolan S, Palumbo P, Ryu J, Salazar JC, Selvarangan R, Stein CR, Werzberger A, Zempsky WT, Aupperle R, Baker FC, Banich MT, Barch DM, Baskin-Sommers A, Bjork JM, Bookheimer SY, Brown SA, Casey BJ, Chang L, Clark DB, Dale AM, Dapretto M, Ernst TM, Fair DA, Feldstein Ewing SW, Foxe JJ, Freedman EG, Friedman NP, Garavan H, Gee DG, Gonzalez R, Gray KM, Heitzeg MM, Herting MM, Jacobus J, Laird AR, Larson CL, Lisdahl KM, Luciana M, Luna B, Madden PAF, McGlade EC, Müller-Oehring EM, Nagel BJ, Neale MC, Paulus MP, Potter AS, Renshaw PF, Sowell ER, Squeglia LM, Tapert S, Uddin LQ, Wilson S, Yurgelun-Todd DA

Keywords

DOI

10.1001/jama.2024.12747
Toggle Factors Affecting Health Care Utilization Associations Among Young Adolescents With Persistent or Recurrent Pain. Western journal of nursing research Ahn RE, Senger-Carpenter T, Voepel-Lewis T 2024
PubMed Record

Abstract

It is unclear how family factors affect health care utilization among youth with persistent or recurrent pain, despite potential relevance to interventions targeting treatment barriers.

Journal

Western journal of nursing research

Published

2024/08/20

Authors

Ahn RE, Senger-Carpenter T, Voepel-Lewis T

Keywords

child health, family socioeconomic status, parents, persistent pain, young adolescents

DOI

10.1177/01939459241273361
Toggle Amygdala connectivity is associated with withdrawn/depressed behavior in a large sample of children from the Adolescent Brain Cognitive Development (ABCD) Study®. Psychiatry research. Neuroimaging Thomas E, Juliano A, Owens M, et al. 2024
PubMed Record

Abstract

Many psychopathologies tied to internalizing symptomatology emerge during adolescence, therefore identifying neural markers of internalizing behavior in childhood may allow for early intervention. We utilized data from the Adolescent Brain and Cognitive Development (ABCD) Study® to evaluate associations between cortico-amygdalar functional connectivity, polygenic risk for depression (PRS), traumatic events experienced, internalizing behavior, and internalizing subscales: withdrawn/depressed behavior, somatic complaints, and anxious/depressed behaviors. Data from 6371 children (ages 9-11) were used to analyze amygdala resting-state fMRI connectivity to Gordon parcellation based whole-brain regions of interest (ROIs). Internalizing behaviors were measured using the parent-reported Child Behavior Checklist. Linear mixed-effects models were used to identify patterns of cortico-amygdalar connectivity associated with internalizing behaviors. Results indicated left amygdala connections to auditory, frontoparietal network (FPN), and dorsal attention network (DAN) ROIs were significantly associated with withdrawn/depressed symptomatology. Connections relevant for withdrawn/depressed behavior were linked to social behaviors. Specifically, amygdala connections to DAN were associated with social anxiety, social impairment, and social problems. Additionally, an amygdala connection to the FPN ROI and the auditory network ROI was associated with social anxiety and social problems, respectively. Therefore, it may be important to account for social behaviors when looking for brain correlates of depression.

Journal

Psychiatry research. Neuroimaging

Published

2024/08/20

Authors

Thomas E, Juliano A, Owens M, Cupertino RB, Mackey S, Hermosillo R, Miranda-Dominguez O, Conan G, Ahmed M, Fair DA, Graham AM, Goode NJ, Kandjoze UP, Potter A, Garavan H, Albaugh MD

Keywords

ABCD study, Amygdala connectivity, Depression, Internalizing, Resting-state fMRI, Social behaviors

DOI

10.1016/j.pscychresns.2024.111877