Research Publications

ABCD Study® research publications cover a wide range of topics related to adolescent (teen) brain development, behavior, and health, including mental health and stress, physical activity, substance use, and psychosocial factors.

Our publications are authored by ABCD investigators, collaborators, and other researchers. The analysis methodologies, findings, and interpretations expressed in these publications are those of the authors and do not constitute an endorsement by the ABCD Study. The research publications listed here include empirical as well as non-empirical papers (e.g., focused review articles, editorials).

To align with widely accepted quality standards, this list includes only papers from journals that are indexed in one or more of the databases listed below. Learn about the selection process for each database:

MEDLINE
Web of Science
Scopus
Directory of Open Access Journals
NIH Library (Journal must be marked as “peer reviewed.” NIH librarians evaluate the peer review process of each journal on a case-by-case basis.)

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Showing 1727 results

Read More	Title	Journal	Authors	Year
Toggle	Uncovering functional connectivity patterns predictive of cognition in youth using interpretable predictive modeling.	Proceedings of the National Academy of Sciences of the United States of America	Li H, Cieslak M, Salo T, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Proceedings of the National Academy of Sciences of the United States of America Published 2025/10/16 Authors Li H, Cieslak M, Salo T, Shinohara RT, Oathes DJ, Davatzikos C, Satterthwaite TD, Fan Y Keywords cognition, functional connectivity, generalizability, interpretability, predictive modeling DOI 10.1073/pnas.2505600122
Toggle	Multisystem Environmental Factors Elucidate Shared and Distinct Associations With Brain and Behavior in Adolescents.	Journal of the American Academy of Child and Adolescent Psychiatry	Ramduny J, Paskewitz S, Brazil IA, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Journal of the American Academy of Child and Adolescent Psychiatry Published 2025/10/15 Authors Ramduny J, Paskewitz S, Brazil IA, Baskin-Sommers A Keywords adolescence, environment, externalizing, psychopathology, subcortical brain volume DOI 10.1016/j.jaac.2025.10.008
Toggle	Evaluation of environmental-genetic factors and mental health outcomes for sleep disturbance from late childhood to early adolescence.	European child & adolescent psychiatry	Yan J, Bai H, Sun Y, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal European child & adolescent psychiatry Published 2025/10/15 Authors Yan J, Bai H, Sun Y, Wang M, Li Q, Pan Y, Liu X, Li Y, Yao Z, Chen Y, Zhang Z, Hu Z, He C, Liu B, Zhang X Keywords Environmental factors, Genetics, Mental health outcomes, Trajectory of sleep disturbance DOI 10.1007/s00787-025-02888-2
Toggle	Addictive Screen Use and Youth Mental Health-Reply.	JAMA	Xiao Y, Keyes KM, Mann JJ	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal JAMA Published 2025/10/15 Authors Xiao Y, Keyes KM, Mann JJ Keywords DOI 10.1001/jama.2025.14443
Toggle	Developmental Trajectories of Nonsuicidal Self-injury and Risk for Suicide Attempt	JAACAP Open	Thompson AJ, Sarkisian K, Llamocca EN, et al.	2025
Link to publication Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal JAACAP Open Published 2025/10/15 Authors Thompson AJ, Sarkisian K, Llamocca EN, Henrich CC, Hughes JL, Youngstrom EA, Ruch DA, Bridge JA, & Fontanella CA Keywords suicide attemptnon; suicidal self-injury; developmental trajectories; NSSI; self-injury DOI https://doi.org/10.1016/j.jaacop.2025.10.004
Toggle	Sexual Minority Adolescents and the COVID-19 Pandemic: Examining School and Coping Factors to Promote Well-being.	The Journal of adolescent health : official publication of the Society for Adolescent Medicine	Raney JH, Memon Z, Otmar CD, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal The Journal of adolescent health : official publication of the Society for Adolescent Medicine Published 2025/10/14 Authors Raney JH, Memon Z, Otmar CD, Ganson KT, Testa A, Baker FC, Brindis CD, Nagata JM Keywords Adolescent development, Adolescent mental health, Lesbian gay bisexual DOI 10.1016/j.jadohealth.2025.09.009
Toggle	Social Media Use Trajectories and Cognitive Performance in Adolescents.	JAMA	Nagata JM, Wong JH, Kim KE, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal JAMA Published 2025/10/13 Authors Nagata JM, Wong JH, Kim KE, Richardson RA, Nayak S, Potes C, Rauschecker AM, Scheffler A, Sugrue LP, Baker FC, Testa A Keywords DOI 10.1001/jama.2025.16613
Toggle	Machine learning prediction of conduct problems in children using the longitudinal ABCD study.	Journal of child psychology and psychiatry, and allied disciplines	Berluti K, Amormino P, Potter A, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Journal of child psychology and psychiatry, and allied disciplines Published 2025/10/12 Authors Berluti K, Amormino P, Potter A, Wshah S, Marsh A Keywords ABCD study, Conduct disorder, conduct problems, machine learning DOI 10.1111/jcpp.70057
Toggle	Demographic, genetic, neuroimaging, and behavioral correlates of short social responsiveness scale in a large pediatric cohort.	Translational psychiatry	Huang L, Huang R, Sui G, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Translational psychiatry Published 2025/10/10 Authors Huang L, Huang R, Sui G, Du W, Zhou L, Luo Q, Ren T, Li F Keywords DOI 10.1038/s41398-025-03648-1
Toggle	Meaningful Associations Redux: Quantifying and interpreting effect size in the context of the Adolescent Brain and Cognitive Development study.	Developmental cognitive neuroscience	Dick AS, Comer JS, Bayat M, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Developmental cognitive neuroscience Published 2025/10/10 Authors Dick AS, Comer JS, Bayat M, Curtis M, Hayes T, Pruden SM, Hawes SW, Gonzalez R, Laird AR, Graziano PA Keywords ABCD study, Big data, Effect size, Equivalence testing, Estimation, SESOI DOI 10.1016/j.dcn.2025.101630
Toggle	Riemannian diffusion kernel-smoothed continuous structural connectivity on cortical surface.	Imaging neuroscience (Cambridge, Mass.)	Wang L, Li D, Zhang Z	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Imaging neuroscience (Cambridge, Mass.) Published 2025/10/09 Authors Wang L, Li D, Zhang Z Keywords Laplace–Beltrami operator, connectome smoothing, cortical geometry, heat kernel, structural connectivity DOI 10.1162/IMAG.a.912
Toggle	Modeling psychopathology in high-dimensional vector space using the high-dimensional symptom space (HDSS) model can operationalize precision psychiatry in US adolescents.	Scientific reports	Wild MG, Cutler RA	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Scientific reports Published 2025/10/08 Authors Wild MG, Cutler RA Keywords HiTOP, High-dimensional space, P-factor, Precision psychiatry, Psychopathology models DOI 10.1038/s41598-025-18975-y
Toggle	Gender Diversity, Substance Cognitions, and Alcohol, Nicotine/Tobacco, and Cannabis Use Among Youth.	LGBT health	Kcomt L, Veliz PT, Jardine J, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal LGBT health Published 2025/10/08 Authors Kcomt L, Veliz PT, Jardine J, Evans-Polce RJ, Clift J, McCabe SE, Arslanian-Engoren C Keywords alcohol, cannabis, gender, nicotine, substance use cognitions, tobacco DOI 10.1177/23258292251385564
Toggle	Predicting the onset of internalizing disorders in early adolescence using deep learning optimized with AI.	Frontiers in psychiatry	de Lacy N, Ramshaw M, Lam WY	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Frontiers in psychiatry Published 2025/10/08 Authors de Lacy N, Ramshaw M, Lam WY Keywords AI, adolescence, anxiety, deep learning, depression, evolutionary algorithm, internalizing disorders, somatic symptom disorder DOI 10.3389/fpsyt.2025.1487894
Toggle	Racial/ethnic discrimination shapes adolescent brain connectivity: Social buffers and implications for executive function.	Developmental cognitive neuroscience	Duell N, Alvarez GM, Telzer EH, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Developmental cognitive neuroscience Published 2025/10/03 Authors Duell N, Alvarez GM, Telzer EH, Muscatell KA Keywords Adolescent brain development, Executive function, Racial and ethnic discrimination, Resting state functional connectivity, Risk and resilience DOI 10.1016/j.dcn.2025.101625
Toggle	Longitudinal Effects of Continuous Music Training on Cognitive Development: Evidence From the Adolescent Brain Cognitive Development (ABCD) Study.	Annals of the New York Academy of Sciences	Habibi A, Hsu E, Villanueva J, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Annals of the New York Academy of Sciences Published 2025/10/03 Authors Habibi A, Hsu E, Villanueva J, Luo S Keywords Adolescent Brain Cognitive Development (ABCD) Study \| classification models \| cognitive development \| language \| music training \| socioeconomic factors DOI 10.1111/nyas.70086
Toggle	Brain functional connectivity, but not neuroanatomy, captures the interrelationship between sex and gender in preadolescents.	Developmental cognitive neuroscience	Metoki A, Chauvin RJ, Gordon EM, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Developmental cognitive neuroscience Published 2025/10/03 Authors Metoki A, Chauvin RJ, Gordon EM, Laumann TO, Kay BP, Adeyemo B, Krimmel SR, Marek S, Wang A, Van AN, Baden NJ, Suljic V, Scheidter KM, Monk J, Whiting FI, Ramirez-Perez NJ, Barch DM, Sotiras A, Dosenbach NUF Keywords Adolescence, Adolescent brain cognitive development study, Brain networks, Cortical thickness, Gender, Resting-state functional connectivity, Sex DOI 10.1016/j.dcn.2025.101624
Toggle	Neural correlates of social withdrawal and preference for solitude in adolescence.	Cerebral cortex (New York, N.Y. : 1991)	Risner M, Stamouls C	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Cerebral cortex (New York, N.Y. : 1991) Published 2025/10/02 Authors Risner M, Stamouls C Keywords adolescent brain, brain structures, preference for solitude, resting-state brain networks, social withdrawal DOI 10.1093/cercor/bhaf260
Toggle	Beyond discrete classifications: a computational approach to the continuum of cognition and behavior in children	npj Mental Health Research	Gagnon A, Gillet V, Desautels A-S, et al.	2025
Link to publication Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal npj Mental Health Research Published 2025/10/01 Authors Gagnon A, Gillet V, Desautels A-S, Lepage J-F, Baccarelli AA, Posner J, Descoteaux M, Brunet MA, & Takser L Keywords DOI https://doi.org/10.1038/s44184-025-00163-5
Toggle	Hippocampal SGK1 promotes vulnerability to depression: the role of early life adversity, stress, and genetic risk.	Molecular psychiatry	Millette A, van Dijk MT, Pokhvisneva I, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Molecular psychiatry Published 2025/10/01 Authors Millette A, van Dijk MT, Pokhvisneva I, Li Y, Thompson R, Patel S, Bagot RC, Naray-Fejes-Toth A, Fejes-Toth G, Silveira PP, Turecki G, Lopez JP, Anacker C Keywords DOI 10.1038/s41380-025-03269-6
Toggle	Task and resting state fMRI modelling of brain-behavior relationships in developmental cohorts.	Biological psychiatry	Uddin LQ, Garavan H	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Biological psychiatry Published 2025/10/01 Authors Uddin LQ, Garavan H Keywords DOI 10.1016/j.biopsych.2025.09.012
Toggle	Family History of Substance Use and Stressful Life Events Impact Adolescent Maturation of Cerebral White Matter.	Addiction biology	Ma Y, Acheson A, Bolbocean C, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Addiction biology Published 2025/10/01 Authors Ma Y, Acheson A, Bolbocean C, Mithaiwala MN, Gao S, Jahanshad N, Thompson PM, Adhikari BM, Du X, Ankeeta A, Warner A, Pagán AF, Hong LE, Kochunov P Keywords ABCD, family history, fractional anisotropy, longitudinal design, stressful life events, substance use disorders, white matter DOI 10.1111/adb.70089
Toggle	What's Behind the Increased Risk of Suicidal Behavior in Black Girls?	The American journal of psychiatry	Melhem NM	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal The American journal of psychiatry Published 2025/10/01 Authors Melhem NM Keywords Child/Adolescent Psychiatry, Disparities, Suicide and Self-Harm DOI 10.1176/appi.ajp.20250790
Toggle	Macroeconomic income inequality, brain structure and function, and mental health	Nature Mental Health	Rakesh D, Tsomokos DI, Vargas T, et al.	2025
Link to publication Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Nature Mental Health Published 2025/09/30 Authors Rakesh D, Tsomokos DI, Vargas T, Pickett KE, & Patel V Keywords DOI https://doi.org/10.1038/s44220-025-00508-1
Toggle	Eviction, inability to pay rent, and youth mental health: a fixed effects study.	American journal of epidemiology	Schwartz GL, Harriman NW, Ramphal B, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal American journal of epidemiology Published 2025/09/30 Authors Schwartz GL, Harriman NW, Ramphal B, Slopen N Keywords eviction, fixed effects analysis, housing costs, mental health, youth DOI 10.1093/aje/kwaf212
Toggle	Motion impact score for detecting spurious brain-behavior associations.	Nature communications	Kay BP, Montez DF, Marek S, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Nature communications Published 2025/09/29 Authors Kay BP, Montez DF, Marek S, Tervo-Clemmens B, Siegel JS, Adeyemo B, Laumann TO, Metoki A, Chauvin RJ, Van AN, Suljic V, Krimmel SR, Miller RL, Newbold DJ, Zheng A, Seider NA, Scheidter KM, Monk JS, Feczko E, Randolph A, Miranda-Domínguez Ó, Moore LA, Perrone AJ, Conan GM, Earl EA, Malone SM, Cordova M, Doyle O, Lynch BJ, Wilgenbusch JC, Pengo T, Graham AM, Roland JL, Gordon EM, Snyder AZ, Barch DM, Fair DA, Dosenbach NUF Keywords DOI 10.1038/s41467-025-63661-2
Toggle	Weight discrimination and eating disorder symptoms in early adolescence: a prospective cohort study.	Journal of eating disorders	Nagata JM, Thompson A, Helmer CK, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Journal of eating disorders Published 2025/09/29 Authors Nagata JM, Thompson A, Helmer CK, Ganson KT, Testa A, Barnhart WR, He J, Baker FC, Lavender JM Keywords Adolescence, Binge eating, Discrimination, Disordered eating, Eating disorder, Weight, Weight stigma DOI 10.1186/s40337-025-01404-w
Toggle	Polygenic architecture of brain structure and function, behaviors, and psychopathologies in children.	Nature communications	Joo YY, Kim BG, Kim G, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Nature communications Published 2025/09/26 Authors Joo YY, Kim BG, Kim G, Lee E, Seo J, Cha J Keywords DOI 10.1038/s41467-025-63312-6
Toggle	Longitudinal Peer-Based Perceived Discrimination and Adolescent Impulsivity	Archives of Clinical Neuropsychology	Hickson R, Totah N, Müller-Oehring EM, et al.	2025
Link to publication Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Archives of Clinical Neuropsychology Published 2025/09/26 Authors Hickson R, Totah N, Müller-Oehring EM, & Schulte T Keywords DOI https://doi.org/10.1093/arclin/acaf084.019
Toggle	Social-spatial residence patterns and adolescent mental health: Investigating the influences of residential segregation, neighborhood social cohesion, and race on persistent, distressing psychotic-like experiences in the United States.	Social science & medicine (1982)	Wade KL, Kramer M, Ku B	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Social science & medicine (1982) Published 2025/09/26 Authors Wade KL, Kramer M, Ku B Keywords ABCD study, Mental health, Psychosis, Residential segregation, Social cohesion DOI 10.1016/j.socscimed.2025.118623
Toggle	Adverse Childhood Experiences and Adolescent Early Non-Coital Sexual and Relationship Behaviors: A Latent Class Analysis.	The Journal of early adolescence	Wang X, Clear KL, Vasilenko SA	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal The Journal of early adolescence Published 2025/09/26 Authors Wang X, Clear KL, Vasilenko SA Keywords Adverse childhood experiences, early sexual behaviors, trauma-informed sexuality education DOI 10.1177/02724316251384269
Toggle	Adolescent suicide behaviors associate with accelerated reductions in cortical gray matter volume and slower decay of behavioral activation Fun-Seeking scores.	Scientific reports	Zhou Y, Neale MC	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Scientific reports Published 2025/09/25 Authors Zhou Y, Neale MC Keywords DOI 10.1038/s41598-025-16856-y
Toggle	Differences in patterns of attention deficit/hyperactivity disorder medication use in US children	JCPP Advances	Ryan JE, Weigard A, McCabe SE, et al.	2025
Link to publication Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal JCPP Advances Published 2025/09/25 Authors Ryan JE, Weigard A, McCabe SE, Wilens TE, & Veliz PT Keywords DOI https://doi.org/10.1002/jcv2.70040
Toggle	Academic success and mental health: The paradox of Frontoparietal-Default Mode Network coupling among children facing poverty.	Developmental cognitive neuroscience	Pacheco S, Bunge SA, Ellwood-Lowe ME	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Developmental cognitive neuroscience Published 2025/09/25 Authors Pacheco S, Bunge SA, Ellwood-Lowe ME Keywords Academic performance, Adolescent brain cognitive development (ABCD) study, Cognitive resilience, Default mode network (DMN), Internalizing, Lateral frontoparietal network (LFPN), Socioeconomic status (SES) DOI 10.1016/j.dcn.2025.101618
Toggle	A Comparison of Brain MRI Outcomes in Youth American Football versus Non-Contact Sport Athletes.	Medicine and science in sports and exercise	Ichesco E, Li Y, Shih CH, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Medicine and science in sports and exercise Published 2025/09/25 Authors Ichesco E, Li Y, Shih CH, Ichesco I, Almeida A, Varangis E, Schrepf A, Kaplan C, Popovich M, Peltier SJ, Harris RE, Lorincz MT, He X, Eckner J Keywords ADOLESCENTS, BRAIN, DIFFUSION MRI, FOOTBALL, FUNCTIONAL MRI, STRUCTURAL MRI DOI 10.1249/MSS.0000000000003856
Toggle	Musical rhythm abilities and risk for developmental speech-language problems and disorders: epidemiological and polygenic associations.	Nature communications	Nayak S, Ladányi E, Eising E, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Nature communications Published 2025/09/24 Authors Nayak S, Ladányi E, Eising E, Mekki Y, Nitin R, Bush CT, Gustavson DE, Anglada-Tort M, Lancaster HS, Mosing MA, Ullén F, Magne CL, Fisher SE, Jacoby N, Gordon RL Keywords DOI 10.1038/s41467-025-60867-2
Toggle	Understanding the development of neural abnormalities in adolescents with mental health problems: A longitudinal study.	NeuroImage. Clinical	Hou J, van de Mortel L, Liu W, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal NeuroImage. Clinical Published 2025/09/23 Authors Hou J, van de Mortel L, Liu W, Liu S, Popma A, Smit DJA, van Wingen G Keywords Adolescent, Mental health problems, Multi-modalities, Neuro abnormalities, Neurodevelopment DOI 10.1016/j.nicl.2025.103885
Toggle	Hormonal contraceptive intake during adolescence and cortical brain measures in the ABCD Study	npj Women's Health	Heller C, Dhamala E, Bottenhorn KL, et al.	2025
Link to publication Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal npj Women's Health Published 2025/09/22 Authors Heller C, Dhamala E, Bottenhorn KL, Herting MM, Bossé B, De La Rosa JS, Farland LV, Allen AM, Barth C, & Petersen N Keywords DOI https://doi.org/10.1038/s44294-025-00105-8
Toggle	Shared and Unique Connectivity Signatures of Reading and Language Deficits.	Journal of cognitive neuroscience	Daucourt MC, Rosenblatt M, Frijters JC, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Journal of cognitive neuroscience Published 2025/09/22 Authors Daucourt MC, Rosenblatt M, Frijters JC, Bosson-Heenan JM, Gruen JR, Scheinost D Keywords DOI 10.1162/JOCN.a.98
Toggle	Genetic and Environmental Associations Among Pain, Sleep Disturbances, and Substance Use Intent in Early Adolescence.	Journal of adolescence	Elam KK, Trevino A, Kutzner J, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Journal of adolescence Published 2025/09/21 Authors Elam KK, Trevino A, Kutzner J, Su J, Quinn PD Keywords early adolescence, pain, sleep, substance use, twin DOI 10.1002/jad.70054
Toggle	Screen time, problematic media use, and clinical concerns in the ABCD Study: Differences by sex and race/ethnicity.	Development and psychopathology	Eales L, Wiglesworth A, Cullen KR, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Development and psychopathology Published 2025/09/19 Authors Eales L, Wiglesworth A, Cullen KR, Klimes-Dougan B Keywords Internalizing problems, non-suicidal self-injury, problematic media use, screen time, suicidal ideation DOI 10.1017/S0954579425100655
Toggle	Dynamic fluctuations of intrinsic brain activity are associated with consistent topological patterns in puberty and are biomarkers of neural maturation.	Network neuroscience (Cambridge, Mass.)	Lim J, Cooper K, Stamoulis C	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Network neuroscience (Cambridge, Mass.) Published 2025/09/19 Authors Lim J, Cooper K, Stamoulis C Keywords Connectome, Developing brain, Fluctuation amplitude, Intrinsic dynamics, Resting-state topology DOI 10.1162/netn_a_00452
Toggle	Immigrant Status, Socioeconomic Status, and Sleep Disparities in Early Adolescence: Findings From the National Adolescent Brain Cognitive Development Study.	The Journal of adolescent health : official publication of the Society for Adolescent Medicine	Zhang MR, Wang Y, Zhao Z, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal The Journal of adolescent health : official publication of the Society for Adolescent Medicine Published 2025/09/18 Authors Zhang MR, Wang Y, Zhao Z, Yan J, Zhang Y, Cham H, Alegría M, Yip T Keywords ABCD study, Early adolescents, Immigrant status, SES, Sleep disparities DOI 10.1016/j.jadohealth.2025.08.010
Toggle	Social threat, neural connectivity, and adolescent mental health: a population-based longitudinal study	Psychological Medicine	Tsomokos DI, Tiemeier H, Slavich GM, et al.	2025
Link to publication Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Psychological Medicine Published 2025/09/18 Authors Tsomokos DI, Tiemeier H, Slavich GM, & Rakesh D Keywords adolescent psychopathology; externalizing problems; functional connectivity; internalizing problems; neuroimaging; social safety theory DOI https://doi.org/10.1017/S0033291725101384
Toggle	Hillclimb-Causal Inference: a data-driven approach to identify causal pathways among parental behaviors, genetic risk, and externalizing behaviors in children.	Journal of the American Medical Informatics Association : JAMIA	Wei M, Peng Q	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Journal of the American Medical Informatics Association : JAMIA Published 2025/09/17 Authors Wei M, Peng Q Keywords PRS, causal inference, externalizing behaviors, parental behavior DOI 10.1093/jamia/ocaf153
Toggle	Connecting the Dots: The Role of Pediatric Concussion on Pubertal Hormones and Psychological Health.	The Journal of adolescent health : official publication of the Society for Adolescent Medicine	Lima Santos JP, Shirtcliff EA, Kontos AP, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal The Journal of adolescent health : official publication of the Society for Adolescent Medicine Published 2025/09/16 Authors Lima Santos JP, Shirtcliff EA, Kontos AP, Ladouceur CD, Versace A Keywords Adolescents, Concussion, Hormones, Mental health, Pediatrics, Psychological health, Puberty DOI 10.1016/j.jadohealth.2025.07.020
Toggle	Differences in Resting-State Functional Connectivity of Temperament-Based Profiles Among Youths With Attention-Deficit/Hyperactivity Disorder in the Adolescent Brain Cognitive Development Study	Clinical Psychological Science	Sangoi JA, Kozlowski M, Feeney KE, et al.	2025
Link to publication Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Clinical Psychological Science Published 2025/09/15 Authors Sangoi JA, Kozlowski M, Feeney KE, Karalunas SL, Riopelle C, Peraza JA, Smith JN, Lobo RP, Gonzalez R, Laird AR, & Musser ED Keywords DOI https://doi.org/10.1177/21677026251369850
Toggle	Mapping Multimodal Risk Factors to Mental Health Outcomes.	Nature. Mental health	Jirsaraie RJ, Barch DM, Bogdan R, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Nature. Mental health Published 2025/09/15 Authors Jirsaraie RJ, Barch DM, Bogdan R, Marek SA, Bijsterbosch JD, Sotiras A, Karcher NR Keywords Biomarkers, Computational Models, Data Mining, Psychology, Risk Factors DOI 10.1038/s44220-025-00500-9
Toggle	Age-Related Trends in Self-Identification of Sexual Orientation During Early Adolescence.	The Journal of adolescent health : official publication of the Society for Adolescent Medicine	Nagata JM, Otmar CD, Lopez A, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal The Journal of adolescent health : official publication of the Society for Adolescent Medicine Published 2025/09/14 Authors Nagata JM, Otmar CD, Lopez A, Kim AE, Sui SS, Li K, Shao IY Keywords Adolescent, Age trends, LGB youth, Sexual minority, Sexual orientation DOI 10.1016/j.jadohealth.2025.07.001
Toggle	Brain functional connectivity predicts depression and anxiety during childhood and adolescence: A connectome-based predictive modeling approach.	Imaging neuroscience (Cambridge, Mass.)	Morfini F, Kucyi A, Zhang J, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Imaging neuroscience (Cambridge, Mass.) Published 2025/09/12 Authors Morfini F, Kucyi A, Zhang J, Bauer CCC, Bloom PA, Pagliaccio D, Hubbard NA, Rosso IM, Yendiki A, Ghosh SS, Pizzagalli DA, Gabrieli JDE, Whitfield-Gabrieli S, Auerbach RP Keywords adolescence, anxiety, depression, functional connectivity, functional magnetic resonance imaging, longitudinal studies, machine learning DOI 10.1162/IMAG.a.145
Toggle	Trajectory Moderators of Functional Outcomes and ADHD Symptoms in Children With ADHD.	Journal of attention disorders	Fletcher M, Silva S, Pan W, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Journal of attention disorders Published 2025/09/11 Authors Fletcher M, Silva S, Pan W, Reuter-Rice K Keywords ADHD, ADHD-associated problems, adolescent ADHD, functional outcomes, symptoms DOI 10.1177/10870547251367284
Toggle	Examination of the Association Between History of Self-Reported Mild Traumatic Brain Injury and Neurocognitive Performance.	The Journal of head trauma rehabilitation	Meng W, Vaida F, de Souza NL, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal The Journal of head trauma rehabilitation Published 2025/09/11 Authors Meng W, Vaida F, de Souza NL, Dennis EL, Wilde EA, Jacobus J, Yang X, Cheng M, Troyer EA, Delfel EL, Abildskov T, Hesselink JR, Bigler ED, Max JE Keywords ABCD study, children, controlled study, mild traumatic brain injury, neurocognition, retrospective cohort study DOI 10.1097/HTR.0000000000001109
Toggle	FUNCTIONAL CONNECTIVITY PATTERNS OF THE FRONTO-PARIETAL AND CINGULO-OPERCULAR NETWORKS DEMONSTRATE DISTINCT ASSOCIATIONS WITH INDIVIDUAL DIFFERENCES IN COGNITIVE CONTROL DURING EARLY ADOLESCENCE.	NeuroImage	Smith LL, Friedman NP, Luciana M, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal NeuroImage Published 2025/09/10 Authors Smith LL, Friedman NP, Luciana M, Banich MT Keywords NA DOI 10.1016/j.neuroimage.2025.121454
Toggle	The effect of caffeine use in the relationship between gaming and sleep in adolescents: A mediation analysis.	Journal of behavioral addictions	Park JJ, Han X, Potenza MN, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Journal of behavioral addictions Published 2025/09/10 Authors Park JJ, Han X, Potenza MN, Zhao Y Keywords Internet addiction, addictive behaviors, caffeine use, compulsive behaviors, gaming, sleep DOI 10.1556/2006.2025.00076
Toggle	A between- and within-group approach to examine sleep, discrimination, and mental health among sexual-minority youth.	Sleep health	Gillis BT, Erath SA, Hinnant B, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Sleep health Published 2025/09/08 Authors Gillis BT, Erath SA, Hinnant B, El-Sheikh M Keywords Discrimination, LGBTQ+, Mental health, Minority stress, Sexual minority DOI 10.1016/j.sleh.2025.08.002
Toggle	The role of smartphones in adolescent-parent discrepancy in reporting adolescents' internalizing problems.	Development and psychopathology	Carvalho C, Koss K, Ravindran N	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Development and psychopathology Published 2025/09/08 Authors Carvalho C, Koss K, Ravindran N Keywords Adolescence, family technology, internalizing problems, parent-child informant discrepancy, parent-child relationships, smartphones DOI 10.1017/S0954579425100618
Toggle	Polygenic scores for psychiatric traits mediate the impact of multigenerational history for depression on offspring psychopathology.	Molecular psychiatry	Lee E, van Dijk MT, Kim BG, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Molecular psychiatry Published 2025/09/08 Authors Lee E, van Dijk MT, Kim BG, Kim G, Murphy E, Talati A, Joo YY, Weissman MM, Cha J Keywords DOI 10.1038/s41380-025-03221-8
Toggle	Impulsivity and neuroticism share distinct functional connectivity signatures with alcohol-use risk in youth.	Molecular psychiatry	Cheng A, Lichenstein S, Chaarani B, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Molecular psychiatry Published 2025/09/05 Authors Cheng A, Lichenstein S, Chaarani B, Liang Q, Babaeianjelodar M, Riley SJ, Luo W, Horien C, Greene AS, Banaschewski T, Bokde ALW, Desrivières S, Flor H, Grigis A, Gowland P, Heinz A, Brühl R, Martinot JL, Martinot MP, Artiges E, Nees F, Papadopoulos Orfanos D, Poustka L, Hohmann S, Holz N, Baeuchl C, Smolka MN, Vaidya N, Walter H, Whelan R, Schumann G, Constable RT, Pearlson G, Garavan H, Yip SW Keywords DOI 10.1038/s41380-025-03196-6
Toggle	Sex-specific pathways from early irritability trajectories to later suicidal ideations and behaviors: Findings from the ABCD study®.	Journal of child psychology and psychiatry, and allied disciplines	Bellaert N, Simeone A, Zhang L, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Journal of child psychology and psychiatry, and allied disciplines Published 2025/09/04 Authors Bellaert N, Simeone A, Zhang L, Zhuo H, Orri M, Liew Z, Tseng WL Keywords Irritability, developmental trajectories, sex differences, suicidal ideations and behaviors DOI 10.1111/jcpp.70044
Toggle	Associations between resting state functional connectivity of large-scale brain networks and parent-reported symptoms of social anxiety in early adolescence.	Journal of affective disorders	Hickson R, Hernandez A, Barbera ER, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Journal of affective disorders Published 2025/09/03 Authors Hickson R, Hernandez A, Barbera ER, Pozo-Neira JL, Totah N, Edwards NL, Müller-Oehring EM, Schulte T Keywords Default mode network, Developmental biomarker, Functional network connectivity, Large-scale brain networks, Salience network, Social anxiety, rs-fMRI DOI 10.1016/j.jad.2025.120238
Toggle	Impact of puberty timing, status and oestradiol on psychotic experiences in the context of exposomic and genomic vulnerability to schizophrenia in female adolescents: longitudinal ABCD study.	The British journal of psychiatry : the journal of mental science	Pries LK, Prachason T, Arias-Magnasco A, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal The British journal of psychiatry : the journal of mental science Published 2025/09/03 Authors Pries LK, Prachason T, Arias-Magnasco A, Lin BD, Rutten BPF, Guloksuz S Keywords Puberty and menarche, environment, genetics, oestrogen, psychosis DOI 10.1192/bjp.2025.36
Toggle	Distinct neural mechanisms underlying cognitive difficulties in preterm children born at different stages of prematurity.	NeuroImage. Clinical	Nivins S, Padilla N, Kvanta H, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal NeuroImage. Clinical Published 2025/09/03 Authors Nivins S, Padilla N, Kvanta H, Mårtensson G, Ådén U Keywords ADHD, ASD, Altered brain structures, Brain development, Lower cognitive performance, Preterm birth, SCN DOI 10.1016/j.nicl.2025.103876
Toggle	More similarity than difference: Comparison of within- and between-sex variance in early adolescent brain structure.	Imaging neuroscience (Cambridge, Mass.)	Torgerson C, Bottenhorn K, Ahmadi H, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Imaging neuroscience (Cambridge, Mass.) Published 2025/09/02 Authors Torgerson C, Bottenhorn K, Ahmadi H, Choupan J, Herting MM Keywords adolescence, diffusion, gray matter, neuroimaging, sex differences, white matter DOI 10.1162/IMAG.a.127
Toggle	Modifiable Parental Factors and Adolescent Sleep During Early Adolescence.	JAMA network open	Ge R, Whittle S, Khor SPH, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal JAMA network open Published 2025/09/02 Authors Ge R, Whittle S, Khor SPH, Yap MBH, Bei B, Cropley V Keywords DOI 10.1001/jamanetworkopen.2025.31333
Toggle	Modification of Brain Connectome on Association Between Adverse Childhood Experiences and Development of Mental Disorders in Preadolescence.	JAMA network open	Xiao X, Hammond CJ, Salmeron BJ, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal JAMA network open Published 2025/09/02 Authors Xiao X, Hammond CJ, Salmeron BJ, Wang D, Gu H, Zhai T, Murray L, Quam A, Hill J, Nguyen H, Lu H, Hoffman EA, Janes AC, Ross TJ, Yang Y Keywords DOI 10.1001/jamanetworkopen.2025.33136
Toggle	Testing Moderators for Associations of Neighborhood Adversity With Psychopathology and Cognitive Outcomes.	Developmental science	Vargas TG, McLaughlin KA, Rakesh D	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Developmental science Published 2025/09/01 Authors Vargas TG, McLaughlin KA, Rakesh D Keywords buffer, cognitive, mental health, neighborhood, structural DOI 10.1111/desc.70055
Toggle	Differential effects of sport type on brain versus orthopedic injury and sports benefits in the adolescent brain cognitive development study.	Brain injury	Meng W, Vaida F, Dennis EL, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Brain injury Published 2025/09/01 Authors Meng W, Vaida F, Dennis EL, Wilde EA, Jacobus J, Yang X, Cheng M, Troyer EA, Delfel EL, Abildskov T, Hesselink JR, Bigler ED, Max JE Keywords Mild traumatic brain injury, behavior, neurocognition, orthopedic injury, sports DOI 10.1080/02699052.2025.2553324
Toggle	Impact of Childhood Neighborhood Deprivation on White Matter and Functional Connectivity During Adolescence.	Journal of neuroimaging : official journal of the American Society of Neuroimaging	Acosta-Rodriguez H, Bobba P, Stephan A, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Journal of neuroimaging : official journal of the American Society of Neuroimaging Published 2025/09/01 Authors Acosta-Rodriguez H, Bobba P, Stephan A, Zeevi T, Malhotra A, Tran AT, Kaltenhauser S, Ment L, Payabvash S Keywords Area Deprivation Index, adolescent health, brain development, diffusion MRI, executive function, functional connectivity DOI 10.1111/jon.70087
Toggle	Neurostructural Differences Associated With Prodromal Mania Symptoms in Children.	Brain and behavior	Archer C, Milewski A, Jeong HJ, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Brain and behavior Published 2025/09/01 Authors Archer C, Milewski A, Jeong HJ, Reimann GE, Durham EL, Kaczkurkin AN Keywords brain structure, children, gray matter volume, mania, pathophysiology DOI 10.1002/brb3.70894
Toggle	Examining parent and youth experiences of familism: Effects on youth well-being and family dynamics.	Journal of research on adolescence : the official journal of the Society for Research on Adolescence	Rea-Sandin G, Wilson S	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Journal of research on adolescence : the official journal of the Society for Research on Adolescence Published 2025/09/01 Authors Rea-Sandin G, Wilson S Keywords cultural values, early adolescence, familism, measurement DOI 10.1111/jora.70082
Toggle	The Impact of Neighborhood and Family Socioeconomic Status on Adolescents' Internalizing Symptoms: The Mediating Role of Pubertal Development Trajectory.	Journal of youth and adolescence	Ren Y, Sun L, Qiu S, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Journal of youth and adolescence Published 2025/08/31 Authors Ren Y, Sun L, Qiu S, Ming H, Zhang Y, Zuo C, Zhou Y, Mei K, Huang S Keywords ABCD study, Adolescent, Family SES, Internalizing symptoms, Neighborhood SES, Pubertal development DOI 10.1007/s10964-025-02247-z
Toggle	Developmental Patterns of Offending Seriousness During Childhood and Adolescence: Examining Variety as a Proxy Measure and Neurodevelopmental Disorders as Predictors	Journal of Developmental and Life-Course Criminology	Thomas Wojciechowski	2025
Link to publication Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Journal of Developmental and Life-Course Criminology Published 2025/08/29 Authors Thomas Wojciechowski Keywords DOI https://doi.org/10.1007/s40865-025-00274-9
Toggle	Using deep learning to predict internalizing problems from brain structure in youth.	Translational psychiatry	Vandewouw MM, Syed B, Barnett N, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Translational psychiatry Published 2025/08/29 Authors Vandewouw MM, Syed B, Barnett N, Arias A, Kelley E, Jones J, Ayub M, Iaboni A, Arnold PD, Crosbie J, Schachar RJ, Taylor MJ, Lerch JP, Anagnostou E, Kushki A Keywords DOI 10.1038/s41398-025-03565-3
Toggle	Predicting sugar-sweetened beverage intake from the brain and known risk factors in adolescents.	Physiology & behavior	Akhmadjonova M, Shearrer GE	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Physiology & behavior Published 2025/08/28 Authors Akhmadjonova M, Shearrer GE Keywords Adolescents, Functional magnetic resonance imaging, Resting-state functional connectivity, Socio-economic status, Sugar-sweetened beverages DOI 10.1016/j.physbeh.2025.115079
Toggle	Preadolescent Family Conflict, Parental Depression, and Neural Circuitry Interact to Predict Adolescent Symptoms.	Journal of the American Academy of Child and Adolescent Psychiatry	Holt-Gosselin B, Basol EZ, Keding TJ, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Journal of the American Academy of Child and Adolescent Psychiatry Published 2025/08/26 Authors Holt-Gosselin B, Basol EZ, Keding TJ, Rodrigues K, Joormann J, Gee DG Keywords ABCD Study, adolescent psychopathology, familial risk for depression, family conflict, resting-state fMRI DOI 10.1016/j.jaac.2025.08.014
Toggle	Research Review: On the (mis)use of puberty data in the ABCD Study® - a systematic review, problem illustration, and path forward.	Journal of child psychology and psychiatry, and allied disciplines	Beltz AM, Pham H, Smith T, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Journal of child psychology and psychiatry, and allied disciplines Published 2025/08/25 Authors Beltz AM, Pham H, Smith T, Hidalgo-Lopez E, Becker H, Portengen CM, Heitzeg MM, Kaplan C, Berenbaum SA Keywords Adolescence, Adolescent Brain Cognitive Development Study®, Pubertal Development Scale, measurement, pubertal status, sex differences, systematic review DOI 10.1111/jcpp.70035
Toggle	Perinatal insult dimensions and developmental trajectories of psychotic-like experiences.	Schizophrenia (Heidelberg, Germany)	Larson ER, Karcher NR, Moussa-Tooks AB	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Schizophrenia (Heidelberg, Germany) Published 2025/08/25 Authors Larson ER, Karcher NR, Moussa-Tooks AB Keywords DOI 10.1038/s41537-025-00662-6
Toggle	Measurement Invariance of The Perceived Discrimination Scale across Race/Ethnicity and Sex: Findings from The Adolescent Brain and Cognitive Development (ABCD) Study	SSM - Mental Health	Xu S, Widaman KF, Patippe C, et al.	2025
Link to publication Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal SSM - Mental Health Published 2025/08/22 Authors Xu S, Widaman KF, Patippe C, Cui L, Shi X, Krobath DM, Cuevas A, & Chang VW Keywords measurement invariance; factor analysis; perceived racial discrimination; youth; reliability and predictive validity DOI https://doi.org/10.1016/j.ssmmh.2025.100512
Toggle	Early pubertal timing is a risk factor for adolescent dysmenorrhea.	npj women's health	Portengen CM, Smith T, Hidalgo-Lopez E, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal npj women's health Published 2025/08/22 Authors Portengen CM, Smith T, Hidalgo-Lopez E, Becker H, Lenert ME, Schrepf A, Harte SE, Kaplan CM, Beltz AM Keywords Endocrine reproductive disorders DOI 10.1038/s44294-025-00097-5
Toggle	A common neural signature between genetic and environmental risk for mental illness.	Translational psychiatry	Vedechkina M, Holmes J, Warrier V, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Translational psychiatry Published 2025/08/21 Authors Vedechkina M, Holmes J, Warrier V, Astle DE Keywords DOI 10.1038/s41398-025-03513-1
Toggle	Inconsistent reporting of past self-injurious thoughts and behaviors in children: A longitudinal analysis of data from the adolescent Brain Cognitive Development study.	Journal of psychopathology and clinical science	Wiglesworth A, Ostrand C, Mirza S, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Journal of psychopathology and clinical science Published 2025/08/21 Authors Wiglesworth A, Ostrand C, Mirza S, Xu M, Mueller BA, Fiecas MB, Luciana M, Cullen KR, Klimes-Dougan B Keywords DOI 10.1037/abn0001014
Toggle	Assessing orbitofrontal cortex volume as a predictor of subjective response to alcohol during early adolescence.	Alcohol (Fayetteville, N.Y.)	Aguilar LS, Wallace AL, Courtney KE, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Alcohol (Fayetteville, N.Y.) Published 2025/08/20 Authors Aguilar LS, Wallace AL, Courtney KE, Wade NE Keywords Adolescence, Alcohol use, Neurodevelopment, Orbitofrontal cortex, Subjective response DOI 10.1016/j.alcohol.2025.08.002
Toggle	The Bidirectional Association Between Racial Discrimination and Pubertal Development: A Prospective Investigation Among Black & Latinx Adolescents.	The Journal of adolescent health : official publication of the Society for Adolescent Medicine	Curtis MG, Reck A, Collins C, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal The Journal of adolescent health : official publication of the Society for Adolescent Medicine Published 2025/08/20 Authors Curtis MG, Reck A, Collins C, Kwon E, Pinson NM, Koss KJ, Kogan SM Keywords Black, Latinx, Pubertal development, Puberty, Racial discrimination DOI 10.1016/j.jadohealth.2025.05.026
Toggle	Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies.	Molecular psychiatry	Shen X, Toenders YJ, Han LKM, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Molecular psychiatry Published 2025/08/19 Authors Shen X, Toenders YJ, Han LKM, Weihs A, Alexander N, Andlauer TFM, Brosch K, Forstner AJ, Grotegerd D, Hahn T, Hermesdorf M, Hosten N, Jamalabadi H, Meinert S, Milaneschi Y, Sämann PG, Stein F, Stolicyn A, Teutenberg L, Thng G, Adams MJ, Thomas-Odenthal F, Usemann P, Völker U, Wittfeld K, Herrera-Rivero M, Jiang Y, Tian C, , Groenewold NA, Koopowitz SM, Strike LT, Dannlowski U, Jansen A, Kircher T, Nenadić I, Sim K, Straube B, Völzke H, Stein DJ, Medland SE, Berger K, Grabe HJ, Krug A, McMahon KL, de Zubicaray G, Pozzi E, Veltman DJ, Thomopoulos SI, Jahanshad N, Thompson PM, Schmaal L, McIntosh AM, Whalley HC Keywords DOI 10.1038/s41380-025-03136-4
Toggle	Characterizing Delinquent Behavior in Early Adolescence: Results from the Adolescent Brain Cognitive Development- Social Development Study	Journal of Child and Family Studies	Brislin SJ, Choi M, & Hicks BM	2025
Link to publication Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Journal of Child and Family Studies Published 2025/08/19 Authors Brislin SJ, Choi M, & Hicks BM Keywords DOI https://doi.org/10.1007/s10826-025-03148-2
Toggle	The impact of physical activity on substance use experimentation and initiation among adolescents: Results from the ABCD Study® cohort.	Drug and alcohol dependence reports	Kaiver CM, Thompson EL, Hawes SW, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Drug and alcohol dependence reports Published 2025/08/18 Authors Kaiver CM, Thompson EL, Hawes SW, Lehman SM, Adams AR, Wing D, Laird AR, Gonzalez R Keywords ABCD Study, Adolescence, Physical activity, Substance use, Substance use initiation DOI 10.1016/j.dadr.2025.100373
Toggle	Associations between epilepsy-related polygenic risk and brain morphology in childhood.	Brain : a journal of neurology	Ngo A, Liu L, Larivière S, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Brain : a journal of neurology Published 2025/08/14 Authors Ngo A, Liu L, Larivière S, Kebets V, Fett S, Weber CF, Royer J, Yu E, Rodríguez-Cruces R, Zhang Z, Ooi LQR, Yeo BTT, Frauscher B, Paquola C, Caligiuri ME, Gambardella A, Concha L, Keller SS, Cendes F, Yasuda CL, Bonilha L, Gleichgerrcht E, Focke NK, Kotikalapudi R, O'Brien TJ, Sinclair B, Vivash L, Desmond PM, Lui E, Vaudano AE, Meletti S, Kälviäinen R, Soltanian-Zadeh H, Winston GP, Tiwari VK, Kreilkamp BAK, Lenge M, Guerrini R, Hamandi K, Rüber T, Bauer T, Devinsky O, Striano P, Kaestner E, Hatton SN, Caciagli L, Kirschner M, Duncan JS, Thompson PM, , McDonald CR, Sisodiya SM, Bernasconi N, Bernasconi A, Gan-Or Z, Bernhardt BC Keywords brain structure, childhood, genetic risk, imaging-genetics, temporal lobe epilepsy DOI 10.1093/brain/awaf259
Toggle	Evidence on the effect of in-utero cannabis exposure in neonates.	Journal of perinatology : official journal of the California Perinatal Association	Thayyil B, Yusuf K	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Journal of perinatology : official journal of the California Perinatal Association Published 2025/08/13 Authors Thayyil B, Yusuf K Keywords DOI 10.1038/s41372-025-02383-1
Toggle	Deep learning reveals that multidimensional social status drives population variation in 11,875 US participant cohort.	PloS one	Marotta J, Aggarwal S, Osayande N, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal PloS one Published 2025/08/13 Authors Marotta J, Aggarwal S, Osayande N, Saltoun K, Kopal J, Holmes AJ, Yip SW, Bzdok D Keywords DOI 10.1371/journal.pone.0327729
Toggle	Functional connectivity heterogeneity and consequences for clinical and cognitive prediction: Stage 2 registered report.	Imaging neuroscience (Cambridge, Mass.)	Mattoni M, Smith DV, Chein J, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Imaging neuroscience (Cambridge, Mass.) Published 2025/08/12 Authors Mattoni M, Smith DV, Chein J, Olino TM Keywords adolescence, clinical prediction, ergodicity, heterogeneity, resting state DOI 10.1162/IMAG.a.107
Toggle	Associations between pain experiences and gray matter volume in youth in the adolescent brain cognitive development (ABCD) study.	The journal of pain	Bango CI, Jones SA, Shao S, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal The journal of pain Published 2025/08/12 Authors Bango CI, Jones SA, Shao S, Del Rubin DY, Flores AL, Nagel BJ, Holley AL, Wilson AC Keywords ABCD study, Gray matter volume, Magnetic resonance imaging, Pain, Youth DOI 10.1016/j.jpain.2025.105527
Toggle	Cognitive and Global Morphometry Trajectories as Predictors of Youth Persistent Distressing Psychotic-Like Experiences.	Nature. Mental health	Karcher NR, Dong F, Paul SE, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Nature. Mental health Published 2025/08/12 Authors Karcher NR, Dong F, Paul SE, Johnson EC, Kilciksiz CM, Oh H, Schiffman J, Agrawal A, Bogdan R, Jackson JJ, Barch DM Keywords Adolescent Brain Cognitive Development Study, adolescence, environment, genetic liability, psychotic-like experiences, trajectories DOI 10.1038/s44220-025-00481-9
Toggle	Multidimensional Assessment of Gender Diversity in a Large National Sample of US Early Adolescents.	JAMA pediatrics	Nagata JM, Sui SS, Li K, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal JAMA pediatrics Published 2025/08/11 Authors Nagata JM, Sui SS, Li K, Low P, Talebloo J, Shao IY, Otmar C, Ganson KT, Testa A, He J, Kiss O, Brindis CD, Baker FC Keywords DOI 10.1001/jamapediatrics.2025.2458
Toggle	Multidimensional Experiences of Gender Among US Adolescents-Beyond the Transgender-Cisgender Binary.	JAMA pediatrics	Chen D, Strang JF	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal JAMA pediatrics Published 2025/08/11 Authors Chen D, Strang JF Keywords DOI 10.1001/jamapediatrics.2025.2455
Toggle	Spatiotemporal patterns in cortical development: Age, puberty, and individual variability from 9 to 13 years of age.	The Journal of neuroscience : the official journal of the Society for Neuroscience	Bottenhorn KL, Corbett JD, Ahmadi H, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal The Journal of neuroscience : the official journal of the Society for Neuroscience Published 2025/08/11 Authors Bottenhorn KL, Corbett JD, Ahmadi H, Herting MM Keywords DOI 10.1523/JNEUROSCI.1002-24.2025
Toggle	The overlapping genetic architecture of psychiatric disorders and cortical brain structure	Nature Mental Health	Sha Z, Warrier V, Bethlehem RAI, et al.	2025
Link to publication Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Nature Mental Health Published 2025/08/11 Authors Sha Z, Warrier V, Bethlehem RAI, Schultz LM, Merikangas A, Sun KY, Gur RC, Gur RE, Shinohara RT, Gandal MJ, Seidlitz J, Almasy L, Andreassen OA, & Alexander-Bloch AF Keywords DOI https://doi.org/10.1038/s44220-025-00475-7
Toggle	Timing of and Disparities in Initiation into Deviant Peer Groups Among Youth in the Adolescent Brain Cognitive Development Study: Do these Effects Vary Across the Life-Course?	Crime & Delinquency	Wojciechowski T	2025
Link to publication Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Crime & Delinquency Published 2025/08/09 Authors Wojciechowski T Keywords DOI https://doi.org/10.1177/00111287251363559
Toggle	Statistical variability in comparing accuracy of neuroimaging based classification models via cross validation.	Scientific reports	Jafrasteh B, Adeli E, Pohl KM, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Scientific reports Published 2025/08/06 Authors Jafrasteh B, Adeli E, Pohl KM, Kuceyeski A, Sabuncu MR, Zhao Q Keywords Cross validation, Machine learning, Reproducibility crisis, Statistical hypothesis testing DOI 10.1038/s41598-025-12026-2
Toggle	Prospective prediction of the initiation of non-suicidal self-injury in adolescents with and without depressive Disorders: A US population-based study.	Journal of psychiatric research	Yu Y, Schoenleber M, Huang C, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Journal of psychiatric research Published 2025/08/05 Authors Yu Y, Schoenleber M, Huang C, Yue Y, Wang Z, Yao N, Mu W Keywords Adolescence, Depression, First onset, Non-suicidal self-injury, Prospective prediction DOI 10.1016/j.jpsychires.2025.07.015
Toggle	Neuroimaging markers of cognition in late childhood associated with moderate to late preterm birth.	Pediatric research	Acosta-Rodriguez H, Bobba P, Zeevi T, et al.	2025
PubMed Record Abstract One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States. Journal Pediatric research Published 2025/08/02 Authors Acosta-Rodriguez H, Bobba P, Zeevi T, Ment LR, Payabvash S Keywords DOI 10.1038/s41390-025-04286-5

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