Childhood Obesity and the Brain: What a Landmark Study Reveals About Kids’ Health
- Adise S, Boutelle KN, Rezvan PH, et al. Sex-specific impulsivity, but not other facets of executive function, predicts fat and sugar intake 2 years later among adolescents with a healthy weight: findings from the ABCD study. Appetite. 2024;192:107081. doi:10.1016/j.appet.2023.107081
- Adise S, Marshall AT, Kan E, Gonzalez MR, Sowell ER. Relating neighborhood deprivation to childhood obesity in the ABCD study: evidence for theories of neuroinflammation and neuronal stress. Health Psychol. 2023;42(12):868-877. doi:10.1037/hea0001250
- Adise S, Marshall AT, Kan E, Sowell ER. Access to quality health resources and environmental toxins affect the relationship between brain structure and BMI in a sample of preadolescents and early adolescents. Front Public Health. 2022;10:1061049. doi:10.3389/fpubh.2022.1061049
- Centers for Disease Control and Prevention. Childhood obesity facts. Updated April 2, 2024. Accessed April 9, 2026. https://www.cdc.gov/obesity/childhood-obesity-facts/childhood-obesity-facts.html
- Centers for Disease Control and Prevention. Consequences of obesity. Updated December 5, 2025. Accessed April 9, 2026. https://www.cdc.gov/obesity/php/about/consequences.html
- Cuevas AG, Krobath DM, Rhodes-Bratton B, et al. Association of racial discrimination with adiposity in children and adolescents. JAMA Netw Open. 2023;6(7):e2322839. doi:10.1001/jamanetworkopen.2023.22839
- Décarie-Spain L, Sharma S, Hryhorczuk C, et al. Nucleus accumbens inflammation mediates anxiodepressive behavior and compulsive sucrose seeking elicited by saturated dietary fat. Mol Metab. 2018;10:1-13. doi:10.1016/j.molmet.2018.01.018
- Ertel KA, Okuzono SS, Beyer LN, Pintro K, Cuevas AG, Slopen N. Neighborhood opportunity and obesity in early adolescence: differential associations by sex. J Adolesc Health. 2024;75(2):314-322. doi:10.1016/j.jadohealth.2024.04.009
- Jiang F, Li G, Ji W, et al. Obesity is associated with decreased gray matter volume in children: a longitudinal study. Cereb Cortex. 2023;33(7):3674-3682. doi:10.1093/cercor/bhac300
- Kaltenhauser S, Weber CF, Lin H, et al. Association of body mass index and waist circumference with imaging metrics of brain integrity and functional connectivity in children aged 9 to 10 years in the US, 2016–2018. JAMA Netw Open. 2023;6(5):e2314193. doi:10.1001/jamanetworkopen.2023.14193
- Kansra AR, Lakkunarajah S, Jay MS. Childhood and adolescent obesity: a review. Front Pediatr. 2021;8:581461. doi:10.3389/fped.2020.581461
- Kulisch LK, Arumäe K, Briley DA, Vainik U. Triangulating causality between childhood obesity and neurobehavior: behavioral genetic and longitudinal evidence. Dev Sci. 2023;26(6):e13392. doi:10.1111/desc.13392
- Li ZA, Samara A, Ray MK, et al. Childhood obesity is linked to putative neuroinflammation in brain white matter, hypothalamus, and striatum. Cereb Cortex Commun. 2023;4(2):tgad007. doi:10.1093/texcom/tgad007
- Morys F, Yu E, Shishikura M, et al. Neuroanatomical correlates of genetic risk for obesity in children. Transl Psychiatry. 2023;13(1):1. doi:10.1038/s41398-022-02301-5
- National Heart, Lung, and Blood Institute. Overweight and obesity: childhood obesity. Updated March 24, 2022. Accessed April 9, 2026. https://www.nhlbi.nih.gov/health/overweight-and-obesity/childhood-obesity
- Rapuano KM, Laurent JS, Hagler DJ Jr, et al. Nucleus accumbens cytoarchitecture predicts weight gain in children. Proc Natl Acad Sci U S A. 2020;117(43):26977-26984. doi:10.1073/pnas.2007918117
- Rapuano KM, Berrian N, Baskin-Sommers A, et al. Longitudinal evidence of a vicious cycle between nucleus accumbens microstructure and childhood weight gain. J Adolesc Health. 2022;70(6):961-969. doi:10.1016/j.jadohealth.2022.01.002
- Tomasi D, Volkow ND. Childhood obesity’s effect on cognition and brain connectivity worsens with low family income. JCI Insight. 2024;9(16):e181690. doi:10.1172/jci.insight.181690
- Ward ZJ, Bleich SN, Long MW, Gortmaker SL. Association of body mass index with health care expenditures in the United States by age and sex. PLoS One. 2021;16(3):e0247307. doi:10.1371/journal.pone.0247307
- Yang A, Lu HJ, Chang L. The impacts of early environmental adversity on cognitive functioning, body mass, and life-history behavioral profiles. Brain Cogn. 2024;177:106159. doi:10.1016/j.bandc.2024.106159
- Zhang Y, Ji W, Jiang F, et al. Associations among body mass index, working memory performance, gray matter volume, and brain activation in healthy children. Cereb Cortex. 2023;33(10):6335-6344. doi:10.1093/cercor/bhac507